Amino acid dipepetide frequency for Anaerosphaera aminiphila DSM 21120

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.694AlaAla: 3.694 ± 0.102	0.531AlaCys: 0.531 ± 0.032	2.805AlaAsp: 2.805 ± 0.072	3.785AlaGlu: 3.785 ± 0.095	2.466AlaPhe: 2.466 ± 0.078	3.724AlaGly: 3.724 ± 0.09	0.769AlaHis: 0.769 ± 0.033	5.499AlaIle: 5.499 ± 0.115	4.587AlaLys: 4.587 ± 0.093	5.728AlaLeu: 5.728 ± 0.104	1.731AlaMet: 1.731 ± 0.061	2.612AlaAsn: 2.612 ± 0.074	1.531AlaPro: 1.531 ± 0.055	1.402AlaGln: 1.402 ± 0.053	2.017AlaArg: 2.017 ± 0.065	3.357AlaSer: 3.357 ± 0.079	3.129AlaThr: 3.129 ± 0.087	4.036AlaVal: 4.036 ± 0.084	0.321AlaTrp: 0.321 ± 0.023	1.945AlaTyr: 1.945 ± 0.06	0.0AlaXaa: 0.0 ± 0.0
Cys	0.523CysAla: 0.523 ± 0.029	0.113CysCys: 0.113 ± 0.016	0.536CysAsp: 0.536 ± 0.033	0.595CysGlu: 0.595 ± 0.034	0.337CysPhe: 0.337 ± 0.023	0.908CysGly: 0.908 ± 0.045	0.145CysHis: 0.145 ± 0.015	0.72CysIle: 0.72 ± 0.034	0.544CysLys: 0.544 ± 0.032	0.666CysLeu: 0.666 ± 0.031	0.194CysMet: 0.194 ± 0.017	0.395CysAsn: 0.395 ± 0.025	0.432CysPro: 0.432 ± 0.033	0.146CysGln: 0.146 ± 0.015	0.255CysArg: 0.255 ± 0.021	0.672CysSer: 0.672 ± 0.037	0.416CysThr: 0.416 ± 0.03	0.516CysVal: 0.516 ± 0.03	0.048CysTrp: 0.048 ± 0.008	0.324CysTyr: 0.324 ± 0.021	0.0CysXaa: 0.0 ± 0.0
Asp	2.746AspAla: 2.746 ± 0.078	0.431AspCys: 0.431 ± 0.024	2.917AspAsp: 2.917 ± 0.087	5.404AspGlu: 5.404 ± 0.107	3.129AspPhe: 3.129 ± 0.079	3.776AspGly: 3.776 ± 0.11	0.656AspHis: 0.656 ± 0.034	5.789AspIle: 5.789 ± 0.107	4.794AspLys: 4.794 ± 0.114	5.43AspLeu: 5.43 ± 0.101	1.376AspMet: 1.376 ± 0.053	3.185AspAsn: 3.185 ± 0.085	1.422AspPro: 1.422 ± 0.057	0.786AspGln: 0.786 ± 0.038	2.218AspArg: 2.218 ± 0.069	3.773AspSer: 3.773 ± 0.091	2.708AspThr: 2.708 ± 0.075	3.923AspVal: 3.923 ± 0.081	0.408AspTrp: 0.408 ± 0.028	2.882AspTyr: 2.882 ± 0.065	0.0AspXaa: 0.0 ± 0.0
Glu	3.916GluAla: 3.916 ± 0.089	0.434GluCys: 0.434 ± 0.029	5.328GluAsp: 5.328 ± 0.097	8.158GluGlu: 8.158 ± 0.154	3.267GluPhe: 3.267 ± 0.076	3.974GluGly: 3.974 ± 0.102	0.929GluHis: 0.929 ± 0.042	7.974GluIle: 7.974 ± 0.111	7.915GluLys: 7.915 ± 0.139	7.461GluLeu: 7.461 ± 0.117	2.08GluMet: 2.08 ± 0.062	6.172GluAsn: 6.172 ± 0.126	1.661GluPro: 1.661 ± 0.08	1.721GluGln: 1.721 ± 0.055	2.573GluArg: 2.573 ± 0.074	4.202GluSer: 4.202 ± 0.091	3.28GluThr: 3.28 ± 0.081	5.748GluVal: 5.748 ± 0.098	0.367GluTrp: 0.367 ± 0.03	3.254GluTyr: 3.254 ± 0.092	0.0GluXaa: 0.0 ± 0.0
Phe	2.387PheAla: 2.387 ± 0.064	0.386PheCys: 0.386 ± 0.024	2.752PheAsp: 2.752 ± 0.067	3.344PheGlu: 3.344 ± 0.079	2.012PhePhe: 2.012 ± 0.077	3.056PheGly: 3.056 ± 0.084	0.497PheHis: 0.497 ± 0.029	4.34PheIle: 4.34 ± 0.113	3.928PheLys: 3.928 ± 0.086	4.457PheLeu: 4.457 ± 0.092	1.032PheMet: 1.032 ± 0.042	2.833PheAsn: 2.833 ± 0.073	1.253PhePro: 1.253 ± 0.045	0.894PheGln: 0.894 ± 0.047	1.202PheArg: 1.202 ± 0.045	3.392PheSer: 3.392 ± 0.084	2.346PheThr: 2.346 ± 0.062	2.922PheVal: 2.922 ± 0.082	0.286PheTrp: 0.286 ± 0.023	1.894PheTyr: 1.894 ± 0.059	0.0PheXaa: 0.0 ± 0.0
Gly	4.304GlyAla: 4.304 ± 0.113	0.689GlyCys: 0.689 ± 0.034	3.314GlyAsp: 3.314 ± 0.079	4.668GlyGlu: 4.668 ± 0.097	3.04GlyPhe: 3.04 ± 0.081	4.645GlyGly: 4.645 ± 0.142	0.983GlyHis: 0.983 ± 0.044	6.279GlyIle: 6.279 ± 0.126	5.026GlyLys: 5.026 ± 0.091	5.682GlyLeu: 5.682 ± 0.117	1.753GlyMet: 1.753 ± 0.068	3.331GlyAsn: 3.331 ± 0.1	1.297GlyPro: 1.297 ± 0.05	1.46GlyGln: 1.46 ± 0.048	2.361GlyArg: 2.361 ± 0.065	4.105GlySer: 4.105 ± 0.081	3.535GlyThr: 3.535 ± 0.094	4.725GlyVal: 4.725 ± 0.096	0.508GlyTrp: 0.508 ± 0.041	3.073GlyTyr: 3.073 ± 0.068	0.0GlyXaa: 0.0 ± 0.0
His	0.643HisAla: 0.643 ± 0.034	0.15HisCys: 0.15 ± 0.017	0.575HisAsp: 0.575 ± 0.029	0.76HisGlu: 0.76 ± 0.034	0.585HisPhe: 0.585 ± 0.033	0.94HisGly: 0.94 ± 0.036	0.235HisHis: 0.235 ± 0.019	1.194HisIle: 1.194 ± 0.044	0.837HisLys: 0.837 ± 0.039	1.184HisLeu: 1.184 ± 0.047	0.303HisMet: 0.303 ± 0.024	0.702HisAsn: 0.702 ± 0.036	0.567HisPro: 0.567 ± 0.033	0.296HisGln: 0.296 ± 0.023	0.492HisArg: 0.492 ± 0.033	0.954HisSer: 0.954 ± 0.039	0.602HisThr: 0.602 ± 0.037	0.653HisVal: 0.653 ± 0.032	0.112HisTrp: 0.112 ± 0.014	0.566HisTyr: 0.566 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	5.71IleAla: 5.71 ± 0.122	0.985IleCys: 0.985 ± 0.04	5.827IleAsp: 5.827 ± 0.111	7.564IleGlu: 7.564 ± 0.121	4.301IlePhe: 4.301 ± 0.099	5.986IleGly: 5.986 ± 0.116	1.009IleHis: 1.009 ± 0.043	7.995IleIle: 7.995 ± 0.169	7.324IleLys: 7.324 ± 0.114	9.13IleLeu: 9.13 ± 0.157	2.17IleMet: 2.17 ± 0.061	5.284IleAsn: 5.284 ± 0.109	3.219IlePro: 3.219 ± 0.074	1.81IleGln: 1.81 ± 0.051	2.833IleArg: 2.833 ± 0.069	7.249IleSer: 7.249 ± 0.122	4.643IleThr: 4.643 ± 0.097	6.749IleVal: 6.749 ± 0.123	0.523IleTrp: 0.523 ± 0.032	3.643IleTyr: 3.643 ± 0.075	0.0IleXaa: 0.0 ± 0.0
Lys	4.071LysAla: 4.071 ± 0.088	0.57LysCys: 0.57 ± 0.035	5.564LysAsp: 5.564 ± 0.111	6.871LysGlu: 6.871 ± 0.143	3.231LysPhe: 3.231 ± 0.073	4.434LysGly: 4.434 ± 0.094	0.975LysHis: 0.975 ± 0.046	8.155LysIle: 8.155 ± 0.126	7.839LysLys: 7.839 ± 0.169	7.629LysLeu: 7.629 ± 0.12	2.344LysMet: 2.344 ± 0.057	6.417LysAsn: 6.417 ± 0.103	2.024LysPro: 2.024 ± 0.06	1.654LysGln: 1.654 ± 0.056	2.895LysArg: 2.895 ± 0.079	5.628LysSer: 5.628 ± 0.106	4.207LysThr: 4.207 ± 0.097	5.544LysVal: 5.544 ± 0.1	0.46LysTrp: 0.46 ± 0.026	4.227LysTyr: 4.227 ± 0.1	0.0LysXaa: 0.0 ± 0.0
Leu	5.143LeuAla: 5.143 ± 0.095	0.825LeuCys: 0.825 ± 0.034	5.462LeuAsp: 5.462 ± 0.099	7.033LeuGlu: 7.033 ± 0.124	4.107LeuPhe: 4.107 ± 0.109	6.208LeuGly: 6.208 ± 0.115	1.023LeuHis: 1.023 ± 0.042	8.386LeuIle: 8.386 ± 0.147	8.709LeuLys: 8.709 ± 0.145	8.363LeuLeu: 8.363 ± 0.138	2.427LeuMet: 2.427 ± 0.069	6.507LeuAsn: 6.507 ± 0.132	2.785LeuPro: 2.785 ± 0.075	1.838LeuGln: 1.838 ± 0.055	3.145LeuArg: 3.145 ± 0.081	7.211LeuSer: 7.211 ± 0.121	4.465LeuThr: 4.465 ± 0.09	5.712LeuVal: 5.712 ± 0.114	0.487LeuTrp: 0.487 ± 0.027	3.277LeuTyr: 3.277 ± 0.079	0.0LeuXaa: 0.0 ± 0.0
Met	1.748MetAla: 1.748 ± 0.054	0.194MetCys: 0.194 ± 0.017	1.526MetAsp: 1.526 ± 0.052	1.904MetGlu: 1.904 ± 0.054	1.06MetPhe: 1.06 ± 0.055	1.927MetGly: 1.927 ± 0.062	0.312MetHis: 0.312 ± 0.021	1.892MetIle: 1.892 ± 0.058	2.458MetLys: 2.458 ± 0.054	2.353MetLeu: 2.353 ± 0.073	0.709MetMet: 0.709 ± 0.04	1.555MetAsn: 1.555 ± 0.05	0.845MetPro: 0.845 ± 0.041	0.6MetGln: 0.6 ± 0.03	0.824MetArg: 0.824 ± 0.038	1.81MetSer: 1.81 ± 0.058	1.33MetThr: 1.33 ± 0.049	1.651MetVal: 1.651 ± 0.053	0.13MetTrp: 0.13 ± 0.014	0.834MetTyr: 0.834 ± 0.034	0.0MetXaa: 0.0 ± 0.0
Asn	2.803AsnAla: 2.803 ± 0.076	0.51AsnCys: 0.51 ± 0.031	2.364AsnAsp: 2.364 ± 0.072	3.923AsnGlu: 3.923 ± 0.079	2.907AsnPhe: 2.907 ± 0.067	3.203AsnGly: 3.203 ± 0.082	0.717AsnHis: 0.717 ± 0.035	6.703AsnIle: 6.703 ± 0.121	5.281AsnLys: 5.281 ± 0.1	6.285AsnLeu: 6.285 ± 0.131	1.603AsnMet: 1.603 ± 0.048	3.395AsnAsn: 3.395 ± 0.09	2.175AsnPro: 2.175 ± 0.057	1.149AsnGln: 1.149 ± 0.044	2.34AsnArg: 2.34 ± 0.067	4.523AsnSer: 4.523 ± 0.104	3.326AsnThr: 3.326 ± 0.082	3.515AsnVal: 3.515 ± 0.075	0.452AsnTrp: 0.452 ± 0.036	3.051AsnTyr: 3.051 ± 0.07	0.0AsnXaa: 0.0 ± 0.0
Pro	1.49ProAla: 1.49 ± 0.057	0.233ProCys: 0.233 ± 0.02	1.516ProAsp: 1.516 ± 0.052	2.542ProGlu: 2.542 ± 0.085	1.325ProPhe: 1.325 ± 0.046	1.827ProGly: 1.827 ± 0.063	0.437ProHis: 0.437 ± 0.027	2.89ProIle: 2.89 ± 0.073	2.318ProLys: 2.318 ± 0.068	2.466ProLeu: 2.466 ± 0.067	0.83ProMet: 0.83 ± 0.041	1.544ProAsn: 1.544 ± 0.052	0.612ProPro: 0.612 ± 0.033	0.753ProGln: 0.753 ± 0.041	0.848ProArg: 0.848 ± 0.04	1.83ProSer: 1.83 ± 0.057	1.735ProThr: 1.735 ± 0.058	2.09ProVal: 2.09 ± 0.059	0.201ProTrp: 0.201 ± 0.021	1.141ProTyr: 1.141 ± 0.043	0.0ProXaa: 0.0 ± 0.0
Gln	1.226GlnAla: 1.226 ± 0.053	0.201GlnCys: 0.201 ± 0.02	1.062GlnAsp: 1.062 ± 0.045	1.532GlnGlu: 1.532 ± 0.058	0.802GlnPhe: 0.802 ± 0.038	1.245GlnGly: 1.245 ± 0.049	0.222GlnHis: 0.222 ± 0.019	1.978GlnIle: 1.978 ± 0.062	1.897GlnLys: 1.897 ± 0.059	1.879GlnLeu: 1.879 ± 0.059	0.676GlnMet: 0.676 ± 0.037	1.274GlnAsn: 1.274 ± 0.05	0.513GlnPro: 0.513 ± 0.031	0.487GlnGln: 0.487 ± 0.037	0.988GlnArg: 0.988 ± 0.046	1.448GlnSer: 1.448 ± 0.051	1.034GlnThr: 1.034 ± 0.046	1.462GlnVal: 1.462 ± 0.048	0.176GlnTrp: 0.176 ± 0.022	0.827GlnTyr: 0.827 ± 0.037	0.0GlnXaa: 0.0 ± 0.0
Arg	2.22ArgAla: 2.22 ± 0.063	0.273ArgCys: 0.273 ± 0.021	2.404ArgAsp: 2.404 ± 0.066	4.082ArgGlu: 4.082 ± 0.089	1.37ArgPhe: 1.37 ± 0.045	2.256ArgGly: 2.256 ± 0.058	0.472ArgHis: 0.472 ± 0.028	2.713ArgIle: 2.713 ± 0.072	2.726ArgLys: 2.726 ± 0.071	2.568ArgLeu: 2.568 ± 0.071	0.825ArgMet: 0.825 ± 0.035	1.943ArgAsn: 1.943 ± 0.059	1.034ArgPro: 1.034 ± 0.047	0.886ArgGln: 0.886 ± 0.039	1.476ArgArg: 1.476 ± 0.053	1.695ArgSer: 1.695 ± 0.048	1.669ArgThr: 1.669 ± 0.055	2.298ArgVal: 2.298 ± 0.074	0.179ArgTrp: 0.179 ± 0.013	1.302ArgTyr: 1.302 ± 0.048	0.0ArgXaa: 0.0 ± 0.0
Ser	3.563SerAla: 3.563 ± 0.083	0.49SerCys: 0.49 ± 0.03	3.711SerAsp: 3.711 ± 0.085	5.572SerGlu: 5.572 ± 0.119	3.221SerPhe: 3.221 ± 0.081	5.0SerGly: 5.0 ± 0.086	0.908SerHis: 0.908 ± 0.039	6.509SerIle: 6.509 ± 0.132	6.123SerLys: 6.123 ± 0.105	6.169SerLeu: 6.169 ± 0.119	1.697SerMet: 1.697 ± 0.055	3.837SerAsn: 3.837 ± 0.092	1.8SerPro: 1.8 ± 0.059	1.549SerGln: 1.549 ± 0.054	2.234SerArg: 2.234 ± 0.057	4.753SerSer: 4.753 ± 0.099	3.49SerThr: 3.49 ± 0.079	4.396SerVal: 4.396 ± 0.084	0.418SerTrp: 0.418 ± 0.027	2.778SerTyr: 2.778 ± 0.066	0.0SerXaa: 0.0 ± 0.0
Thr	2.984ThrAla: 2.984 ± 0.092	0.372ThrCys: 0.372 ± 0.025	2.882ThrAsp: 2.882 ± 0.072	3.469ThrGlu: 3.469 ± 0.091	2.455ThrPhe: 2.455 ± 0.079	3.86ThrGly: 3.86 ± 0.097	0.702ThrHis: 0.702 ± 0.039	4.862ThrIle: 4.862 ± 0.093	3.522ThrLys: 3.522 ± 0.064	4.679ThrLeu: 4.679 ± 0.088	1.182ThrMet: 1.182 ± 0.038	2.64ThrAsn: 2.64 ± 0.073	1.804ThrPro: 1.804 ± 0.066	1.156ThrGln: 1.156 ± 0.046	1.677ThrArg: 1.677 ± 0.053	3.407ThrSer: 3.407 ± 0.079	2.844ThrThr: 2.844 ± 0.08	3.878ThrVal: 3.878 ± 0.09	0.321ThrTrp: 0.321 ± 0.029	1.841ThrTyr: 1.841 ± 0.06	0.0ThrXaa: 0.0 ± 0.0
Val	4.059ValAla: 4.059 ± 0.094	0.671ValCys: 0.671 ± 0.032	4.27ValAsp: 4.27 ± 0.081	5.677ValGlu: 5.677 ± 0.12	3.127ValPhe: 3.127 ± 0.074	4.732ValGly: 4.732 ± 0.098	0.806ValHis: 0.806 ± 0.037	5.743ValIle: 5.743 ± 0.087	5.172ValLys: 5.172 ± 0.068	6.568ValLeu: 6.568 ± 0.104	1.542ValMet: 1.542 ± 0.051	3.553ValAsn: 3.553 ± 0.069	2.167ValPro: 2.167 ± 0.064	1.373ValGln: 1.373 ± 0.056	2.16ValArg: 2.16 ± 0.058	4.709ValSer: 4.709 ± 0.096	3.365ValThr: 3.365 ± 0.09	5.228ValVal: 5.228 ± 0.111	0.347ValTrp: 0.347 ± 0.024	2.351ValTyr: 2.351 ± 0.07	0.0ValXaa: 0.0 ± 0.0
Trp	0.4TrpAla: 0.4 ± 0.026	0.048TrpCys: 0.048 ± 0.009	0.367TrpAsp: 0.367 ± 0.028	0.388TrpGlu: 0.388 ± 0.029	0.252TrpPhe: 0.252 ± 0.021	0.446TrpGly: 0.446 ± 0.031	0.099TrpHis: 0.099 ± 0.012	0.613TrpIle: 0.613 ± 0.032	0.436TrpLys: 0.436 ± 0.028	0.429TrpLeu: 0.429 ± 0.03	0.222TrpMet: 0.222 ± 0.022	0.424TrpAsn: 0.424 ± 0.03	0.146TrpPro: 0.146 ± 0.018	0.194TrpGln: 0.194 ± 0.017	0.217TrpArg: 0.217 ± 0.02	0.4TrpSer: 0.4 ± 0.028	0.357TrpThr: 0.357 ± 0.027	0.298TrpVal: 0.298 ± 0.023	0.062TrpTrp: 0.062 ± 0.01	0.233TrpTyr: 0.233 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.042TyrAla: 2.042 ± 0.059	0.38TyrCys: 0.38 ± 0.024	2.571TyrAsp: 2.571 ± 0.072	3.142TyrGlu: 3.142 ± 0.081	2.221TyrPhe: 2.221 ± 0.063	2.632TyrGly: 2.632 ± 0.065	0.452TyrHis: 0.452 ± 0.025	3.721TyrIle: 3.721 ± 0.08	3.303TyrLys: 3.303 ± 0.08	3.987TyrLeu: 3.987 ± 0.091	0.965TyrMet: 0.965 ± 0.04	2.621TyrAsn: 2.621 ± 0.069	1.34TyrPro: 1.34 ± 0.049	0.774TyrGln: 0.774 ± 0.032	1.636TyrArg: 1.636 ± 0.066	3.099TyrSer: 3.099 ± 0.075	2.055TyrThr: 2.055 ± 0.063	2.277TyrVal: 2.277 ± 0.067	0.225TyrTrp: 0.225 ± 0.018	1.866TyrTyr: 1.866 ± 0.063	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 1915 proteins (608245 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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