Amino acid dipepetide frequency for Calderihabitans maritimus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.001AlaAla: 8.001 ± 0.114
0.963AlaCys: 0.963 ± 0.045
3.686AlaAsp: 3.686 ± 0.07
6.059AlaGlu: 6.059 ± 0.087
3.045AlaPhe: 3.045 ± 0.064
7.384AlaGly: 7.384 ± 0.119
1.348AlaHis: 1.348 ± 0.04
5.107AlaIle: 5.107 ± 0.085
4.114AlaLys: 4.114 ± 0.08
8.913AlaLeu: 8.913 ± 0.124
2.037AlaMet: 2.037 ± 0.052
2.234AlaAsn: 2.234 ± 0.05
2.36AlaPro: 2.36 ± 0.052
2.717AlaGln: 2.717 ± 0.06
5.524AlaArg: 5.524 ± 0.082
3.796AlaSer: 3.796 ± 0.076
3.586AlaThr: 3.586 ± 0.069
7.497AlaVal: 7.497 ± 0.089
0.761AlaTrp: 0.761 ± 0.03
2.367AlaTyr: 2.367 ± 0.047
0.0AlaXaa: 0.0 ± 0.0
Cys
0.744CysAla: 0.744 ± 0.03
0.207CysCys: 0.207 ± 0.018
0.419CysAsp: 0.419 ± 0.023
0.508CysGlu: 0.508 ± 0.025
0.401CysPhe: 0.401 ± 0.02
1.203CysGly: 1.203 ± 0.041
0.578CysHis: 0.578 ± 0.06
0.632CysIle: 0.632 ± 0.03
0.41CysLys: 0.41 ± 0.021
1.034CysLeu: 1.034 ± 0.037
0.272CysMet: 0.272 ± 0.02
0.376CysAsn: 0.376 ± 0.018
0.811CysPro: 0.811 ± 0.039
0.37CysGln: 0.37 ± 0.021
0.887CysArg: 0.887 ± 0.034
0.736CysSer: 0.736 ± 0.034
0.535CysThr: 0.535 ± 0.029
0.623CysVal: 0.623 ± 0.028
0.126CysTrp: 0.126 ± 0.011
0.37CysTyr: 0.37 ± 0.019
0.0CysXaa: 0.0 ± 0.0
Asp
3.08AspAla: 3.08 ± 0.075
0.516AspCys: 0.516 ± 0.028
1.826AspAsp: 1.826 ± 0.051
3.062AspGlu: 3.062 ± 0.06
2.035AspPhe: 2.035 ± 0.05
3.176AspGly: 3.176 ± 0.071
0.76AspHis: 0.76 ± 0.028
3.5AspIle: 3.5 ± 0.071
2.57AspLys: 2.57 ± 0.055
5.22AspLeu: 5.22 ± 0.073
1.1AspMet: 1.1 ± 0.038
1.46AspAsn: 1.46 ± 0.044
2.518AspPro: 2.518 ± 0.052
1.308AspGln: 1.308 ± 0.037
2.824AspArg: 2.824 ± 0.058
1.796AspSer: 1.796 ± 0.041
2.141AspThr: 2.141 ± 0.058
3.274AspVal: 3.274 ± 0.067
0.577AspTrp: 0.577 ± 0.026
1.855AspTyr: 1.855 ± 0.052
0.0AspXaa: 0.0 ± 0.0
Glu
6.723GluAla: 6.723 ± 0.098
0.531GluCys: 0.531 ± 0.026
3.31GluAsp: 3.31 ± 0.074
7.914GluGlu: 7.914 ± 0.132
2.472GluPhe: 2.472 ± 0.051
5.081GluGly: 5.081 ± 0.078
1.192GluHis: 1.192 ± 0.037
6.037GluIle: 6.037 ± 0.09
6.391GluLys: 6.391 ± 0.09
7.666GluLeu: 7.666 ± 0.114
2.027GluMet: 2.027 ± 0.042
2.747GluAsn: 2.747 ± 0.059
2.399GluPro: 2.399 ± 0.051
2.837GluGln: 2.837 ± 0.051
4.787GluArg: 4.787 ± 0.079
2.374GluSer: 2.374 ± 0.057
3.549GluThr: 3.549 ± 0.069
6.363GluVal: 6.363 ± 0.089
0.621GluTrp: 0.621 ± 0.027
2.107GluTyr: 2.107 ± 0.055
0.0GluXaa: 0.0 ± 0.0
Phe
2.839PheAla: 2.839 ± 0.051
0.536PheCys: 0.536 ± 0.03
1.818PheAsp: 1.818 ± 0.044
2.162PheGlu: 2.162 ± 0.056
1.77PhePhe: 1.77 ± 0.051
3.097PheGly: 3.097 ± 0.066
0.793PheHis: 0.793 ± 0.026
2.601PheIle: 2.601 ± 0.053
1.872PheLys: 1.872 ± 0.043
4.549PheLeu: 4.549 ± 0.087
0.884PheMet: 0.884 ± 0.033
1.434PheAsn: 1.434 ± 0.048
1.847PhePro: 1.847 ± 0.04
1.247PheGln: 1.247 ± 0.036
2.156PheArg: 2.156 ± 0.047
2.459PheSer: 2.459 ± 0.061
2.098PheThr: 2.098 ± 0.048
2.552PheVal: 2.552 ± 0.059
0.514PheTrp: 0.514 ± 0.022
1.473PheTyr: 1.473 ± 0.042
0.0PheXaa: 0.0 ± 0.0
Gly
5.812GlyAla: 5.812 ± 0.086
1.116GlyCys: 1.116 ± 0.043
3.235GlyAsp: 3.235 ± 0.062
5.319GlyGlu: 5.319 ± 0.075
3.136GlyPhe: 3.136 ± 0.064
5.638GlyGly: 5.638 ± 0.076
1.343GlyHis: 1.343 ± 0.037
6.241GlyIle: 6.241 ± 0.086
5.268GlyLys: 5.268 ± 0.075
8.022GlyLeu: 8.022 ± 0.109
2.3GlyMet: 2.3 ± 0.058
2.676GlyAsn: 2.676 ± 0.053
2.512GlyPro: 2.512 ± 0.052
2.468GlyGln: 2.468 ± 0.045
4.657GlyArg: 4.657 ± 0.08
4.079GlySer: 4.079 ± 0.08
4.18GlyThr: 4.18 ± 0.071
6.022GlyVal: 6.022 ± 0.09
0.909GlyTrp: 0.909 ± 0.033
2.888GlyTyr: 2.888 ± 0.06
0.0GlyXaa: 0.0 ± 0.0
His
1.185HisAla: 1.185 ± 0.037
0.28HisCys: 0.28 ± 0.019
0.794HisAsp: 0.794 ± 0.033
0.96HisGlu: 0.96 ± 0.031
0.773HisPhe: 0.773 ± 0.03
1.546HisGly: 1.546 ± 0.045
0.461HisHis: 0.461 ± 0.026
1.074HisIle: 1.074 ± 0.038
0.787HisLys: 0.787 ± 0.027
2.041HisLeu: 2.041 ± 0.053
0.376HisMet: 0.376 ± 0.021
0.598HisAsn: 0.598 ± 0.027
1.188HisPro: 1.188 ± 0.04
0.729HisGln: 0.729 ± 0.031
1.209HisArg: 1.209 ± 0.032
0.941HisSer: 0.941 ± 0.034
0.841HisThr: 0.841 ± 0.028
1.186HisVal: 1.186 ± 0.031
0.25HisTrp: 0.25 ± 0.015
0.665HisTyr: 0.665 ± 0.033
0.0HisXaa: 0.0 ± 0.0
Ile
5.629IleAla: 5.629 ± 0.083
0.773IleCys: 0.773 ± 0.033
3.355IleAsp: 3.355 ± 0.07
4.587IleGlu: 4.587 ± 0.079
2.814IlePhe: 2.814 ± 0.059
4.939IleGly: 4.939 ± 0.079
1.125IleHis: 1.125 ± 0.035
4.983IleIle: 4.983 ± 0.08
3.988IleLys: 3.988 ± 0.07
6.902IleLeu: 6.902 ± 0.096
1.519IleMet: 1.519 ± 0.041
2.665IleAsn: 2.665 ± 0.059
3.582IlePro: 3.582 ± 0.06
1.902IleGln: 1.902 ± 0.048
3.831IleArg: 3.831 ± 0.067
3.914IleSer: 3.914 ± 0.06
3.776IleThr: 3.776 ± 0.067
4.817IleVal: 4.817 ± 0.079
0.622IleTrp: 0.622 ± 0.029
2.229IleTyr: 2.229 ± 0.056
0.0IleXaa: 0.0 ± 0.0
Lys
4.734LysAla: 4.734 ± 0.078
0.549LysCys: 0.549 ± 0.032
2.695LysAsp: 2.695 ± 0.061
5.653LysGlu: 5.653 ± 0.083
1.886LysPhe: 1.886 ± 0.048
4.258LysGly: 4.258 ± 0.07
0.981LysHis: 0.981 ± 0.032
4.531LysIle: 4.531 ± 0.073
4.323LysLys: 4.323 ± 0.085
5.774LysLeu: 5.774 ± 0.094
1.549LysMet: 1.549 ± 0.044
2.207LysAsn: 2.207 ± 0.055
2.431LysPro: 2.431 ± 0.05
1.974LysGln: 1.974 ± 0.042
3.3LysArg: 3.3 ± 0.064
2.403LysSer: 2.403 ± 0.051
2.805LysThr: 2.805 ± 0.059
5.054LysVal: 5.054 ± 0.081
0.517LysTrp: 0.517 ± 0.026
1.831LysTyr: 1.831 ± 0.046
0.0LysXaa: 0.0 ± 0.0
Leu
9.833LeuAla: 9.833 ± 0.126
0.963LeuCys: 0.963 ± 0.038
4.686LeuAsp: 4.686 ± 0.081
8.41LeuGlu: 8.41 ± 0.132
3.831LeuPhe: 3.831 ± 0.075
8.069LeuGly: 8.069 ± 0.11
1.716LeuHis: 1.716 ± 0.043
6.37LeuIle: 6.37 ± 0.094
6.582LeuLys: 6.582 ± 0.1
10.937LeuLeu: 10.937 ± 0.145
2.369LeuMet: 2.369 ± 0.054
3.525LeuAsn: 3.525 ± 0.061
5.0LeuPro: 5.0 ± 0.077
3.627LeuGln: 3.627 ± 0.072
6.161LeuArg: 6.161 ± 0.095
5.734LeuSer: 5.734 ± 0.075
5.172LeuThr: 5.172 ± 0.079
8.637LeuVal: 8.637 ± 0.113
1.067LeuTrp: 1.067 ± 0.044
2.755LeuTyr: 2.755 ± 0.058
0.0LeuXaa: 0.0 ± 0.0
Met
2.459MetAla: 2.459 ± 0.064
0.185MetCys: 0.185 ± 0.017
1.07MetAsp: 1.07 ± 0.035
1.898MetGlu: 1.898 ± 0.046
0.79MetPhe: 0.79 ± 0.029
1.996MetGly: 1.996 ± 0.046
0.381MetHis: 0.381 ± 0.023
1.449MetIle: 1.449 ± 0.037
1.603MetLys: 1.603 ± 0.041
2.335MetLeu: 2.335 ± 0.051
0.531MetMet: 0.531 ± 0.029
0.85MetAsn: 0.85 ± 0.031
1.064MetPro: 1.064 ± 0.036
0.787MetGln: 0.787 ± 0.032
1.398MetArg: 1.398 ± 0.04
1.232MetSer: 1.232 ± 0.04
1.172MetThr: 1.172 ± 0.035
2.115MetVal: 2.115 ± 0.047
0.197MetTrp: 0.197 ± 0.015
0.55MetTyr: 0.55 ± 0.028
0.0MetXaa: 0.0 ± 0.0
Asn
2.258AsnAla: 2.258 ± 0.051
0.519AsnCys: 0.519 ± 0.03
1.292AsnAsp: 1.292 ± 0.042
1.868AsnGlu: 1.868 ± 0.053
1.408AsnPhe: 1.408 ± 0.042
2.384AsnGly: 2.384 ± 0.058
0.643AsnHis: 0.643 ± 0.028
2.462AsnIle: 2.462 ± 0.055
1.716AsnLys: 1.716 ± 0.044
4.031AsnLeu: 4.031 ± 0.069
0.853AsnMet: 0.853 ± 0.03
1.198AsnAsn: 1.198 ± 0.041
2.224AsnPro: 2.224 ± 0.053
1.22AsnGln: 1.22 ± 0.035
2.263AsnArg: 2.263 ± 0.053
1.749AsnSer: 1.749 ± 0.042
1.594AsnThr: 1.594 ± 0.048
2.385AsnVal: 2.385 ± 0.049
0.458AsnTrp: 0.458 ± 0.021
1.289AsnTyr: 1.289 ± 0.042
0.0AsnXaa: 0.0 ± 0.0
Pro
3.469ProAla: 3.469 ± 0.061
0.437ProCys: 0.437 ± 0.021
2.345ProAsp: 2.345 ± 0.054
4.441ProGlu: 4.441 ± 0.069
1.755ProPhe: 1.755 ± 0.044
3.996ProGly: 3.996 ± 0.065
0.893ProHis: 0.893 ± 0.032
2.153ProIle: 2.153 ± 0.055
1.994ProLys: 1.994 ± 0.053
4.224ProLeu: 4.224 ± 0.078
0.808ProMet: 0.808 ± 0.03
1.317ProAsn: 1.317 ± 0.04
1.877ProPro: 1.877 ± 0.054
1.592ProGln: 1.592 ± 0.045
2.33ProArg: 2.33 ± 0.05
2.095ProSer: 2.095 ± 0.051
1.814ProThr: 1.814 ± 0.045
4.428ProVal: 4.428 ± 0.073
0.536ProTrp: 0.536 ± 0.025
1.485ProTyr: 1.485 ± 0.04
0.0ProXaa: 0.0 ± 0.0
Gln
3.022GlnAla: 3.022 ± 0.065
0.311GlnCys: 0.311 ± 0.021
1.376GlnAsp: 1.376 ± 0.042
3.299GlnGlu: 3.299 ± 0.067
1.093GlnPhe: 1.093 ± 0.033
2.448GlnGly: 2.448 ± 0.051
0.557GlnHis: 0.557 ± 0.022
2.264GlnIle: 2.264 ± 0.048
2.4GlnLys: 2.4 ± 0.055
3.477GlnLeu: 3.477 ± 0.067
0.858GlnMet: 0.858 ± 0.029
1.107GlnAsn: 1.107 ± 0.034
1.303GlnPro: 1.303 ± 0.035
1.464GlnGln: 1.464 ± 0.05
1.939GlnArg: 1.939 ± 0.049
1.295GlnSer: 1.295 ± 0.035
1.426GlnThr: 1.426 ± 0.05
3.105GlnVal: 3.105 ± 0.064
0.357GlnTrp: 0.357 ± 0.02
0.956GlnTyr: 0.956 ± 0.028
0.0GlnXaa: 0.0 ± 0.0
Arg
4.255ArgAla: 4.255 ± 0.073
0.723ArgCys: 0.723 ± 0.028
2.538ArgAsp: 2.538 ± 0.049
5.751ArgGlu: 5.751 ± 0.091
2.339ArgPhe: 2.339 ± 0.055
4.076ArgGly: 4.076 ± 0.074
1.126ArgHis: 1.126 ± 0.033
4.075ArgIle: 4.075 ± 0.075
4.085ArgLys: 4.085 ± 0.073
6.554ArgLeu: 6.554 ± 0.096
1.587ArgMet: 1.587 ± 0.041
2.018ArgAsn: 2.018 ± 0.047
2.297ArgPro: 2.297 ± 0.055
2.787ArgGln: 2.787 ± 0.06
4.336ArgArg: 4.336 ± 0.085
2.623ArgSer: 2.623 ± 0.052
2.439ArgThr: 2.439 ± 0.047
4.796ArgVal: 4.796 ± 0.08
0.779ArgTrp: 0.779 ± 0.031
2.15ArgTyr: 2.15 ± 0.05
0.0ArgXaa: 0.0 ± 0.0
Ser
3.325SerAla: 3.325 ± 0.073
0.661SerCys: 0.661 ± 0.034
1.935SerAsp: 1.935 ± 0.046
2.857SerGlu: 2.857 ± 0.063
2.225SerPhe: 2.225 ± 0.054
4.34SerGly: 4.34 ± 0.058
0.984SerHis: 0.984 ± 0.032
3.172SerIle: 3.172 ± 0.062
2.385SerLys: 2.385 ± 0.05
5.786SerLeu: 5.786 ± 0.09
1.258SerMet: 1.258 ± 0.038
1.528SerAsn: 1.528 ± 0.046
2.48SerPro: 2.48 ± 0.054
1.633SerGln: 1.633 ± 0.039
3.486SerArg: 3.486 ± 0.058
2.971SerSer: 2.971 ± 0.07
2.358SerThr: 2.358 ± 0.055
3.361SerVal: 3.361 ± 0.069
0.669SerTrp: 0.669 ± 0.027
1.716SerTyr: 1.716 ± 0.041
0.0SerXaa: 0.0 ± 0.0
Thr
4.128ThrAla: 4.128 ± 0.073
0.628ThrCys: 0.628 ± 0.033
2.151ThrAsp: 2.151 ± 0.055
3.153ThrGlu: 3.153 ± 0.066
1.898ThrPhe: 1.898 ± 0.044
4.85ThrGly: 4.85 ± 0.074
0.817ThrHis: 0.817 ± 0.029
3.092ThrIle: 3.092 ± 0.058
2.101ThrLys: 2.101 ± 0.049
4.882ThrLeu: 4.882 ± 0.086
0.993ThrMet: 0.993 ± 0.035
1.487ThrAsn: 1.487 ± 0.046
2.457ThrPro: 2.457 ± 0.047
1.216ThrGln: 1.216 ± 0.037
2.708ThrArg: 2.708 ± 0.055
2.424ThrSer: 2.424 ± 0.052
2.504ThrThr: 2.504 ± 0.065
4.618ThrVal: 4.618 ± 0.082
0.519ThrTrp: 0.519 ± 0.028
1.553ThrTyr: 1.553 ± 0.047
0.0ThrXaa: 0.0 ± 0.0
Val
7.072ValAla: 7.072 ± 0.084
0.813ValCys: 0.813 ± 0.033
3.974ValAsp: 3.974 ± 0.081
6.376ValGlu: 6.376 ± 0.093
3.093ValPhe: 3.093 ± 0.061
5.843ValGly: 5.843 ± 0.091
1.231ValHis: 1.231 ± 0.037
5.776ValIle: 5.776 ± 0.098
4.821ValLys: 4.821 ± 0.078
8.127ValLeu: 8.127 ± 0.088
1.904ValMet: 1.904 ± 0.049
2.825ValAsn: 2.825 ± 0.051
3.534ValPro: 3.534 ± 0.068
2.357ValGln: 2.357 ± 0.048
4.383ValArg: 4.383 ± 0.076
4.36ValSer: 4.36 ± 0.078
4.206ValThr: 4.206 ± 0.075
6.903ValVal: 6.903 ± 0.108
0.712ValTrp: 0.712 ± 0.029
2.345ValTyr: 2.345 ± 0.049
0.0ValXaa: 0.0 ± 0.0
Trp
0.783TrpAla: 0.783 ± 0.037
0.11TrpCys: 0.11 ± 0.01
0.574TrpAsp: 0.574 ± 0.028
0.9TrpGlu: 0.9 ± 0.03
0.427TrpPhe: 0.427 ± 0.023
0.826TrpGly: 0.826 ± 0.03
0.193TrpHis: 0.193 ± 0.015
0.592TrpIle: 0.592 ± 0.029
0.662TrpLys: 0.662 ± 0.026
1.21TrpLeu: 1.21 ± 0.048
0.254TrpMet: 0.254 ± 0.016
0.41TrpAsn: 0.41 ± 0.02
0.446TrpPro: 0.446 ± 0.022
0.5TrpGln: 0.5 ± 0.023
0.644TrpArg: 0.644 ± 0.027
0.518TrpSer: 0.518 ± 0.024
0.47TrpThr: 0.47 ± 0.024
0.769TrpVal: 0.769 ± 0.03
0.196TrpTrp: 0.196 ± 0.017
0.342TrpTyr: 0.342 ± 0.018
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.145TyrAla: 2.145 ± 0.048
0.424TyrCys: 0.424 ± 0.023
1.521TyrAsp: 1.521 ± 0.045
1.951TyrGlu: 1.951 ± 0.053
1.509TyrPhe: 1.509 ± 0.041
2.672TyrGly: 2.672 ± 0.059
0.763TyrHis: 0.763 ± 0.029
1.838TyrIle: 1.838 ± 0.045
1.386TyrLys: 1.386 ± 0.043
3.76TyrLeu: 3.76 ± 0.068
0.583TyrMet: 0.583 ± 0.025
1.154TyrAsn: 1.154 ± 0.033
1.659TyrPro: 1.659 ± 0.049
1.322TyrGln: 1.322 ± 0.04
2.511TyrArg: 2.511 ± 0.059
1.631TyrSer: 1.631 ± 0.044
1.51TyrThr: 1.51 ± 0.043
2.149TyrVal: 2.149 ± 0.047
0.437TyrTrp: 0.437 ± 0.025
1.306TyrTyr: 1.306 ± 0.039
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3537 proteins (909730 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski