Amino acid dipepetide frequency for Bifidobacterium scardovii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
15.458AlaAla: 15.458 ± 0.22
1.201AlaCys: 1.201 ± 0.042
8.22AlaAsp: 8.22 ± 0.13
6.03AlaGlu: 6.03 ± 0.108
3.818AlaPhe: 3.818 ± 0.079
10.111AlaGly: 10.111 ± 0.137
2.148AlaHis: 2.148 ± 0.053
5.786AlaIle: 5.786 ± 0.086
4.534AlaLys: 4.534 ± 0.083
10.719AlaLeu: 10.719 ± 0.127
3.423AlaMet: 3.423 ± 0.068
3.257AlaAsn: 3.257 ± 0.068
4.553AlaPro: 4.553 ± 0.104
3.928AlaGln: 3.928 ± 0.085
6.613AlaArg: 6.613 ± 0.103
6.855AlaSer: 6.855 ± 0.106
5.923AlaThr: 5.923 ± 0.097
9.084AlaVal: 9.084 ± 0.111
1.624AlaTrp: 1.624 ± 0.044
2.833AlaTyr: 2.833 ± 0.064
0.0AlaXaa: 0.0 ± 0.0
Cys
1.145CysAla: 1.145 ± 0.039
0.158CysCys: 0.158 ± 0.017
0.564CysAsp: 0.564 ± 0.025
0.516CysGlu: 0.516 ± 0.025
0.342CysPhe: 0.342 ± 0.023
1.06CysGly: 1.06 ± 0.034
0.215CysHis: 0.215 ± 0.018
0.399CysIle: 0.399 ± 0.022
0.204CysLys: 0.204 ± 0.016
0.741CysLeu: 0.741 ± 0.033
0.229CysMet: 0.229 ± 0.015
0.24CysAsn: 0.24 ± 0.018
0.447CysPro: 0.447 ± 0.024
0.226CysGln: 0.226 ± 0.015
0.603CysArg: 0.603 ± 0.029
0.527CysSer: 0.527 ± 0.028
0.503CysThr: 0.503 ± 0.022
0.799CysVal: 0.799 ± 0.034
0.134CysTrp: 0.134 ± 0.013
0.256CysTyr: 0.256 ± 0.017
0.0CysXaa: 0.0 ± 0.0
Asp
8.087AspAla: 8.087 ± 0.11
0.549AspCys: 0.549 ± 0.026
4.883AspAsp: 4.883 ± 0.101
4.62AspGlu: 4.62 ± 0.08
2.207AspPhe: 2.207 ± 0.052
6.618AspGly: 6.618 ± 0.123
1.345AspHis: 1.345 ± 0.045
3.107AspIle: 3.107 ± 0.07
2.317AspLys: 2.317 ± 0.058
5.475AspLeu: 5.475 ± 0.08
1.688AspMet: 1.688 ± 0.041
1.723AspAsn: 1.723 ± 0.049
3.912AspPro: 3.912 ± 0.072
1.97AspGln: 1.97 ± 0.052
4.022AspArg: 4.022 ± 0.096
3.263AspSer: 3.263 ± 0.065
3.331AspThr: 3.331 ± 0.068
4.947AspVal: 4.947 ± 0.078
1.071AspTrp: 1.071 ± 0.035
2.007AspTyr: 2.007 ± 0.055
0.0AspXaa: 0.0 ± 0.0
Glu
6.142GluAla: 6.142 ± 0.089
0.468GluCys: 0.468 ± 0.025
2.926GluAsp: 2.926 ± 0.06
2.848GluGlu: 2.848 ± 0.063
1.762GluPhe: 1.762 ± 0.045
3.798GluGly: 3.798 ± 0.074
1.523GluHis: 1.523 ± 0.044
2.527GluIle: 2.527 ± 0.055
1.735GluLys: 1.735 ± 0.055
5.047GluLeu: 5.047 ± 0.097
1.297GluMet: 1.297 ± 0.038
1.671GluAsn: 1.671 ± 0.049
2.662GluPro: 2.662 ± 0.062
2.281GluGln: 2.281 ± 0.054
4.515GluArg: 4.515 ± 0.092
3.275GluSer: 3.275 ± 0.07
3.094GluThr: 3.094 ± 0.06
3.181GluVal: 3.181 ± 0.062
0.705GluTrp: 0.705 ± 0.032
1.719GluTyr: 1.719 ± 0.047
0.001GluXaa: 0.001 ± 0.001
Phe
4.153PheAla: 4.153 ± 0.069
0.367PheCys: 0.367 ± 0.019
2.743PheAsp: 2.743 ± 0.065
1.683PheGlu: 1.683 ± 0.05
1.259PhePhe: 1.259 ± 0.047
3.438PheGly: 3.438 ± 0.069
0.696PheHis: 0.696 ± 0.028
1.626PheIle: 1.626 ± 0.055
1.078PheLys: 1.078 ± 0.041
2.727PheLeu: 2.727 ± 0.072
0.777PheMet: 0.777 ± 0.034
1.178PheAsn: 1.178 ± 0.034
1.433PhePro: 1.433 ± 0.049
0.873PheGln: 0.873 ± 0.031
1.805PheArg: 1.805 ± 0.058
2.199PheSer: 2.199 ± 0.052
2.28PheThr: 2.28 ± 0.051
2.709PheVal: 2.709 ± 0.059
0.496PheTrp: 0.496 ± 0.027
0.978PheTyr: 0.978 ± 0.037
0.0PheXaa: 0.0 ± 0.0
Gly
8.756GlyAla: 8.756 ± 0.123
0.851GlyCys: 0.851 ± 0.031
5.276GlyAsp: 5.276 ± 0.084
4.918GlyGlu: 4.918 ± 0.082
3.262GlyPhe: 3.262 ± 0.064
6.954GlyGly: 6.954 ± 0.104
1.752GlyHis: 1.752 ± 0.046
4.699GlyIle: 4.699 ± 0.077
3.629GlyLys: 3.629 ± 0.069
7.484GlyLeu: 7.484 ± 0.111
2.343GlyMet: 2.343 ± 0.055
2.739GlyAsn: 2.739 ± 0.065
2.852GlyPro: 2.852 ± 0.063
2.599GlyGln: 2.599 ± 0.065
5.125GlyArg: 5.125 ± 0.086
5.59GlySer: 5.59 ± 0.096
5.503GlyThr: 5.503 ± 0.088
6.708GlyVal: 6.708 ± 0.097
1.322GlyTrp: 1.322 ± 0.041
2.882GlyTyr: 2.882 ± 0.064
0.001GlyXaa: 0.001 ± 0.001
His
2.296HisAla: 2.296 ± 0.058
0.206HisCys: 0.206 ± 0.017
1.594HisAsp: 1.594 ± 0.043
1.19HisGlu: 1.19 ± 0.038
0.583HisPhe: 0.583 ± 0.025
2.033HisGly: 2.033 ± 0.052
0.499HisHis: 0.499 ± 0.026
1.081HisIle: 1.081 ± 0.034
0.519HisLys: 0.519 ± 0.023
1.581HisLeu: 1.581 ± 0.044
0.568HisMet: 0.568 ± 0.028
0.515HisAsn: 0.515 ± 0.024
1.291HisPro: 1.291 ± 0.041
0.589HisGln: 0.589 ± 0.029
1.43HisArg: 1.43 ± 0.049
0.908HisSer: 0.908 ± 0.032
1.115HisThr: 1.115 ± 0.037
1.637HisVal: 1.637 ± 0.044
0.358HisTrp: 0.358 ± 0.022
0.638HisTyr: 0.638 ± 0.024
0.0HisXaa: 0.0 ± 0.0
Ile
6.759IleAla: 6.759 ± 0.101
0.538IleCys: 0.538 ± 0.024
3.986IleAsp: 3.986 ± 0.074
2.901IleGlu: 2.901 ± 0.061
1.49IlePhe: 1.49 ± 0.053
4.931IleGly: 4.931 ± 0.086
0.861IleHis: 0.861 ± 0.03
2.695IleIle: 2.695 ± 0.067
1.554IleLys: 1.554 ± 0.046
3.734IleLeu: 3.734 ± 0.072
1.2IleMet: 1.2 ± 0.041
1.675IleAsn: 1.675 ± 0.049
2.728IlePro: 2.728 ± 0.07
1.205IleGln: 1.205 ± 0.039
3.018IleArg: 3.018 ± 0.062
2.934IleSer: 2.934 ± 0.062
3.202IleThr: 3.202 ± 0.066
4.677IleVal: 4.677 ± 0.075
0.626IleTrp: 0.626 ± 0.025
1.161IleTyr: 1.161 ± 0.039
0.0IleXaa: 0.0 ± 0.0
Lys
4.443LysAla: 4.443 ± 0.099
0.138LysCys: 0.138 ± 0.012
2.335LysAsp: 2.335 ± 0.059
1.868LysGlu: 1.868 ± 0.058
0.92LysPhe: 0.92 ± 0.035
2.531LysGly: 2.531 ± 0.063
0.734LysHis: 0.734 ± 0.03
1.583LysIle: 1.583 ± 0.045
1.521LysLys: 1.521 ± 0.052
2.852LysLeu: 2.852 ± 0.066
0.79LysMet: 0.79 ± 0.031
1.268LysAsn: 1.268 ± 0.045
2.065LysPro: 2.065 ± 0.053
1.222LysGln: 1.222 ± 0.042
2.349LysArg: 2.349 ± 0.055
2.024LysSer: 2.024 ± 0.047
2.346LysThr: 2.346 ± 0.05
2.459LysVal: 2.459 ± 0.058
0.474LysTrp: 0.474 ± 0.024
1.021LysTyr: 1.021 ± 0.038
0.0LysXaa: 0.0 ± 0.0
Leu
10.511LeuAla: 10.511 ± 0.124
0.951LeuCys: 0.951 ± 0.04
6.163LeuAsp: 6.163 ± 0.114
4.132LeuGlu: 4.132 ± 0.072
3.134LeuPhe: 3.134 ± 0.069
7.072LeuGly: 7.072 ± 0.099
1.822LeuHis: 1.822 ± 0.046
4.883LeuIle: 4.883 ± 0.09
3.214LeuLys: 3.214 ± 0.07
7.963LeuLeu: 7.963 ± 0.11
2.26LeuMet: 2.26 ± 0.056
2.794LeuAsn: 2.794 ± 0.056
4.602LeuPro: 4.602 ± 0.074
2.36LeuGln: 2.36 ± 0.05
5.466LeuArg: 5.466 ± 0.091
5.645LeuSer: 5.645 ± 0.098
5.424LeuThr: 5.424 ± 0.074
6.441LeuVal: 6.441 ± 0.087
1.099LeuTrp: 1.099 ± 0.04
2.157LeuTyr: 2.157 ± 0.051
0.0LeuXaa: 0.0 ± 0.0
Met
3.01MetAla: 3.01 ± 0.065
0.236MetCys: 0.236 ± 0.016
1.435MetAsp: 1.435 ± 0.042
1.055MetGlu: 1.055 ± 0.034
0.86MetPhe: 0.86 ± 0.036
1.911MetGly: 1.911 ± 0.049
0.529MetHis: 0.529 ± 0.023
1.416MetIle: 1.416 ± 0.044
0.878MetLys: 0.878 ± 0.032
2.639MetLeu: 2.639 ± 0.054
0.739MetMet: 0.739 ± 0.035
0.921MetAsn: 0.921 ± 0.037
1.498MetPro: 1.498 ± 0.043
0.788MetGln: 0.788 ± 0.03
1.813MetArg: 1.813 ± 0.049
1.861MetSer: 1.861 ± 0.051
2.025MetThr: 2.025 ± 0.044
1.913MetVal: 1.913 ± 0.047
0.35MetTrp: 0.35 ± 0.021
0.552MetTyr: 0.552 ± 0.027
0.0MetXaa: 0.0 ± 0.0
Asn
3.711AsnAla: 3.711 ± 0.063
0.209AsnCys: 0.209 ± 0.016
2.048AsnAsp: 2.048 ± 0.051
1.608AsnGlu: 1.608 ± 0.044
0.899AsnPhe: 0.899 ± 0.032
3.374AsnGly: 3.374 ± 0.073
0.598AsnHis: 0.598 ± 0.027
1.499AsnIle: 1.499 ± 0.04
1.046AsnLys: 1.046 ± 0.033
2.432AsnLeu: 2.432 ± 0.054
0.733AsnMet: 0.733 ± 0.031
0.988AsnAsn: 0.988 ± 0.044
2.04AsnPro: 2.04 ± 0.045
0.977AsnGln: 0.977 ± 0.031
1.836AsnArg: 1.836 ± 0.045
1.518AsnSer: 1.518 ± 0.045
1.832AsnThr: 1.832 ± 0.046
2.303AsnVal: 2.303 ± 0.043
0.45AsnTrp: 0.45 ± 0.024
0.898AsnTyr: 0.898 ± 0.038
0.0AsnXaa: 0.0 ± 0.0
Pro
5.66ProAla: 5.66 ± 0.097
0.343ProCys: 0.343 ± 0.02
3.826ProAsp: 3.826 ± 0.075
3.218ProGlu: 3.218 ± 0.071
1.776ProPhe: 1.776 ± 0.046
3.994ProGly: 3.994 ± 0.073
1.012ProHis: 1.012 ± 0.036
2.269ProIle: 2.269 ± 0.049
1.634ProLys: 1.634 ± 0.046
3.936ProLeu: 3.936 ± 0.067
1.129ProMet: 1.129 ± 0.039
1.509ProAsn: 1.509 ± 0.044
1.38ProPro: 1.38 ± 0.046
1.792ProGln: 1.792 ± 0.052
2.489ProArg: 2.489 ± 0.067
3.028ProSer: 3.028 ± 0.061
2.77ProThr: 2.77 ± 0.059
4.009ProVal: 4.009 ± 0.075
0.733ProTrp: 0.733 ± 0.033
1.494ProTyr: 1.494 ± 0.045
0.0ProXaa: 0.0 ± 0.0
Gln
3.693GlnAla: 3.693 ± 0.083
0.243GlnCys: 0.243 ± 0.017
1.512GlnAsp: 1.512 ± 0.048
1.377GlnGlu: 1.377 ± 0.042
1.031GlnPhe: 1.031 ± 0.039
2.317GlnGly: 2.317 ± 0.057
0.682GlnHis: 0.682 ± 0.027
1.741GlnIle: 1.741 ± 0.052
0.962GlnLys: 0.962 ± 0.036
3.15GlnLeu: 3.15 ± 0.073
0.868GlnMet: 0.868 ± 0.035
0.9GlnAsn: 0.9 ± 0.035
1.666GlnPro: 1.666 ± 0.058
1.472GlnGln: 1.472 ± 0.056
2.337GlnArg: 2.337 ± 0.062
2.024GlnSer: 2.024 ± 0.052
1.787GlnThr: 1.787 ± 0.044
2.252GlnVal: 2.252 ± 0.051
0.598GlnTrp: 0.598 ± 0.027
1.081GlnTyr: 1.081 ± 0.043
0.0GlnXaa: 0.0 ± 0.0
Arg
5.847ArgAla: 5.847 ± 0.086
0.558ArgCys: 0.558 ± 0.027
3.91ArgAsp: 3.91 ± 0.09
3.81ArgGlu: 3.81 ± 0.077
2.407ArgPhe: 2.407 ± 0.06
4.305ArgGly: 4.305 ± 0.078
1.62ArgHis: 1.62 ± 0.047
3.807ArgIle: 3.807 ± 0.065
2.311ArgLys: 2.311 ± 0.051
5.793ArgLeu: 5.793 ± 0.1
2.076ArgMet: 2.076 ± 0.049
2.016ArgAsn: 2.016 ± 0.054
2.75ArgPro: 2.75 ± 0.056
2.218ArgGln: 2.218 ± 0.056
5.165ArgArg: 5.165 ± 0.108
3.406ArgSer: 3.406 ± 0.068
3.468ArgThr: 3.468 ± 0.072
4.381ArgVal: 4.381 ± 0.076
0.94ArgTrp: 0.94 ± 0.038
2.107ArgTyr: 2.107 ± 0.046
0.0ArgXaa: 0.0 ± 0.0
Ser
6.531SerAla: 6.531 ± 0.108
0.512SerCys: 0.512 ± 0.025
3.915SerAsp: 3.915 ± 0.08
2.784SerGlu: 2.784 ± 0.06
2.182SerPhe: 2.182 ± 0.05
6.208SerGly: 6.208 ± 0.102
1.192SerHis: 1.192 ± 0.036
3.102SerIle: 3.102 ± 0.053
1.987SerLys: 1.987 ± 0.05
5.248SerLeu: 5.248 ± 0.079
1.648SerMet: 1.648 ± 0.042
1.832SerAsn: 1.832 ± 0.044
2.7SerPro: 2.7 ± 0.06
1.911SerGln: 1.911 ± 0.047
3.585SerArg: 3.585 ± 0.069
3.846SerSer: 3.846 ± 0.088
3.545SerThr: 3.545 ± 0.076
4.646SerVal: 4.646 ± 0.082
0.932SerTrp: 0.932 ± 0.032
1.641SerTyr: 1.641 ± 0.046
0.0SerXaa: 0.0 ± 0.0
Thr
6.614ThrAla: 6.614 ± 0.099
0.456ThrCys: 0.456 ± 0.023
3.764ThrAsp: 3.764 ± 0.075
2.517ThrGlu: 2.517 ± 0.051
2.067ThrPhe: 2.067 ± 0.059
5.419ThrGly: 5.419 ± 0.084
1.163ThrHis: 1.163 ± 0.042
3.384ThrIle: 3.384 ± 0.062
1.867ThrLys: 1.867 ± 0.048
5.635ThrLeu: 5.635 ± 0.076
1.526ThrMet: 1.526 ± 0.036
1.757ThrAsn: 1.757 ± 0.05
3.421ThrPro: 3.421 ± 0.074
1.702ThrGln: 1.702 ± 0.043
3.079ThrArg: 3.079 ± 0.053
3.258ThrSer: 3.258 ± 0.064
3.537ThrThr: 3.537 ± 0.066
5.733ThrVal: 5.733 ± 0.09
0.821ThrTrp: 0.821 ± 0.034
1.552ThrTyr: 1.552 ± 0.041
0.0ThrXaa: 0.0 ± 0.0
Val
8.717ValAla: 8.717 ± 0.1
0.852ValCys: 0.852 ± 0.04
5.172ValAsp: 5.172 ± 0.085
3.975ValGlu: 3.975 ± 0.082
2.921ValPhe: 2.921 ± 0.067
5.394ValGly: 5.394 ± 0.096
1.361ValHis: 1.361 ± 0.043
4.373ValIle: 4.373 ± 0.07
2.58ValLys: 2.58 ± 0.057
6.979ValLeu: 6.979 ± 0.099
2.059ValMet: 2.059 ± 0.053
2.506ValAsn: 2.506 ± 0.056
4.094ValPro: 4.094 ± 0.077
1.948ValGln: 1.948 ± 0.046
4.488ValArg: 4.488 ± 0.087
5.209ValSer: 5.209 ± 0.081
5.134ValThr: 5.134 ± 0.086
6.142ValVal: 6.142 ± 0.104
1.023ValTrp: 1.023 ± 0.034
1.985ValTyr: 1.985 ± 0.046
0.0ValXaa: 0.0 ± 0.0
Trp
1.272TrpAla: 1.272 ± 0.04
0.147TrpCys: 0.147 ± 0.012
0.887TrpAsp: 0.887 ± 0.036
0.561TrpGlu: 0.561 ± 0.026
0.595TrpPhe: 0.595 ± 0.028
0.994TrpGly: 0.994 ± 0.032
0.358TrpHis: 0.358 ± 0.021
0.754TrpIle: 0.754 ± 0.031
0.572TrpLys: 0.572 ± 0.026
1.482TrpLeu: 1.482 ± 0.043
0.45TrpMet: 0.45 ± 0.022
0.668TrpAsn: 0.668 ± 0.026
0.595TrpPro: 0.595 ± 0.025
0.679TrpGln: 0.679 ± 0.031
1.102TrpArg: 1.102 ± 0.038
0.97TrpSer: 0.97 ± 0.032
0.833TrpThr: 0.833 ± 0.031
0.853TrpVal: 0.853 ± 0.028
0.291TrpTrp: 0.291 ± 0.018
0.449TrpTyr: 0.449 ± 0.022
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.315TyrAla: 3.315 ± 0.063
0.324TyrCys: 0.324 ± 0.018
1.982TyrAsp: 1.982 ± 0.046
1.57TyrGlu: 1.57 ± 0.045
0.982TyrPhe: 0.982 ± 0.034
2.785TyrGly: 2.785 ± 0.063
0.518TyrHis: 0.518 ± 0.026
1.147TyrIle: 1.147 ± 0.038
0.802TyrLys: 0.802 ± 0.034
2.476TyrLeu: 2.476 ± 0.051
0.626TyrMet: 0.626 ± 0.027
0.843TyrAsn: 0.843 ± 0.034
1.315TyrPro: 1.315 ± 0.04
0.954TyrGln: 0.954 ± 0.035
2.05TyrArg: 2.05 ± 0.052
1.603TyrSer: 1.603 ± 0.039
1.617TyrThr: 1.617 ± 0.055
2.037TyrVal: 2.037 ± 0.045
0.466TyrTrp: 0.466 ± 0.026
0.893TyrTyr: 0.893 ± 0.032
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.001XaaMet: 0.001 ± 0.001
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.001XaaTyr: 0.001 ± 0.001
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2477 proteins (882320 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski