Amino acid dipepetide frequency for Nocardioides lianchengensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.325AlaAla: 20.325 ± 0.167	0.925AlaCys: 0.925 ± 0.023	8.749AlaAsp: 8.749 ± 0.077	8.078AlaGlu: 8.078 ± 0.097	3.393AlaPhe: 3.393 ± 0.057	13.185AlaGly: 13.185 ± 0.116	2.407AlaHis: 2.407 ± 0.047	4.051AlaIle: 4.051 ± 0.061	2.375AlaLys: 2.375 ± 0.046	13.493AlaLeu: 13.493 ± 0.122	2.511AlaMet: 2.511 ± 0.04	1.943AlaAsn: 1.943 ± 0.041	6.494AlaPro: 6.494 ± 0.089	3.39AlaGln: 3.39 ± 0.043	9.579AlaArg: 9.579 ± 0.105	6.659AlaSer: 6.659 ± 0.068	8.475AlaThr: 8.475 ± 0.101	12.59AlaVal: 12.59 ± 0.101	2.084AlaTrp: 2.084 ± 0.04	2.525AlaTyr: 2.525 ± 0.037	0.001AlaXaa: 0.001 ± 0.001
Cys	0.842CysAla: 0.842 ± 0.022	0.085CysCys: 0.085 ± 0.008	0.459CysAsp: 0.459 ± 0.019	0.334CysGlu: 0.334 ± 0.014	0.194CysPhe: 0.194 ± 0.011	0.757CysGly: 0.757 ± 0.02	0.153CysHis: 0.153 ± 0.01	0.152CysIle: 0.152 ± 0.011	0.072CysLys: 0.072 ± 0.007	0.652CysLeu: 0.652 ± 0.023	0.08CysMet: 0.08 ± 0.007	0.116CysAsn: 0.116 ± 0.007	0.424CysPro: 0.424 ± 0.018	0.177CysGln: 0.177 ± 0.011	0.523CysArg: 0.523 ± 0.021	0.4CysSer: 0.4 ± 0.017	0.466CysThr: 0.466 ± 0.019	0.557CysVal: 0.557 ± 0.019	0.116CysTrp: 0.116 ± 0.009	0.129CysTyr: 0.129 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	8.33AspAla: 8.33 ± 0.086	0.371AspCys: 0.371 ± 0.014	4.816AspAsp: 4.816 ± 0.069	4.553AspGlu: 4.553 ± 0.052	1.55AspPhe: 1.55 ± 0.027	6.891AspGly: 6.891 ± 0.085	1.489AspHis: 1.489 ± 0.033	1.62AspIle: 1.62 ± 0.04	0.972AspLys: 0.972 ± 0.028	7.838AspLeu: 7.838 ± 0.073	0.721AspMet: 0.721 ± 0.023	0.896AspAsn: 0.896 ± 0.024	4.869AspPro: 4.869 ± 0.065	1.833AspGln: 1.833 ± 0.033	5.197AspArg: 5.197 ± 0.065	2.394AspSer: 2.394 ± 0.037	3.037AspThr: 3.037 ± 0.055	6.363AspVal: 6.363 ± 0.065	1.038AspTrp: 1.038 ± 0.027	1.144AspTyr: 1.144 ± 0.03	0.0AspXaa: 0.0 ± 0.0
Glu	6.99GluAla: 6.99 ± 0.081	0.283GluCys: 0.283 ± 0.015	3.123GluAsp: 3.123 ± 0.049	3.25GluGlu: 3.25 ± 0.051	1.351GluPhe: 1.351 ± 0.032	3.992GluGly: 3.992 ± 0.057	1.588GluHis: 1.588 ± 0.034	2.273GluIle: 2.273 ± 0.04	1.205GluLys: 1.205 ± 0.031	6.617GluLeu: 6.617 ± 0.081	0.958GluMet: 0.958 ± 0.023	0.951GluAsn: 0.951 ± 0.026	3.313GluPro: 3.313 ± 0.057	2.358GluGln: 2.358 ± 0.04	5.105GluArg: 5.105 ± 0.074	2.627GluSer: 2.627 ± 0.043	3.085GluThr: 3.085 ± 0.05	5.665GluVal: 5.665 ± 0.063	0.736GluTrp: 0.736 ± 0.021	1.013GluTyr: 1.013 ± 0.023	0.0GluXaa: 0.0 ± 0.0
Phe	3.49PheAla: 3.49 ± 0.049	0.234PheCys: 0.234 ± 0.011	1.98PheAsp: 1.98 ± 0.034	1.524PheGlu: 1.524 ± 0.035	0.843PhePhe: 0.843 ± 0.027	2.787PheGly: 2.787 ± 0.053	0.527PheHis: 0.527 ± 0.019	0.667PheIle: 0.667 ± 0.025	0.45PheLys: 0.45 ± 0.016	2.536PheLeu: 2.536 ± 0.043	0.379PheMet: 0.379 ± 0.018	0.536PheAsn: 0.536 ± 0.019	1.267PhePro: 1.267 ± 0.029	0.621PheGln: 0.621 ± 0.021	1.748PheArg: 1.748 ± 0.034	1.441PheSer: 1.441 ± 0.028	1.883PheThr: 1.883 ± 0.035	2.568PheVal: 2.568 ± 0.045	0.395PheTrp: 0.395 ± 0.017	0.576PheTyr: 0.576 ± 0.019	0.0PheXaa: 0.0 ± 0.0
Gly	10.805GlyAla: 10.805 ± 0.105	0.758GlyCys: 0.758 ± 0.021	5.641GlyAsp: 5.641 ± 0.069	5.089GlyGlu: 5.089 ± 0.061	2.861GlyPhe: 2.861 ± 0.047	8.26GlyGly: 8.26 ± 0.108	2.043GlyHis: 2.043 ± 0.038	3.452GlyIle: 3.452 ± 0.049	2.03GlyLys: 2.03 ± 0.041	9.817GlyLeu: 9.817 ± 0.104	1.854GlyMet: 1.854 ± 0.033	1.692GlyAsn: 1.692 ± 0.04	4.795GlyPro: 4.795 ± 0.055	2.523GlyGln: 2.523 ± 0.04	7.477GlyArg: 7.477 ± 0.078	5.665GlySer: 5.665 ± 0.068	6.346GlyThr: 6.346 ± 0.078	8.279GlyVal: 8.279 ± 0.076	1.765GlyTrp: 1.765 ± 0.035	2.193GlyTyr: 2.193 ± 0.037	0.0GlyXaa: 0.0 ± 0.0
His	2.464HisAla: 2.464 ± 0.048	0.158HisCys: 0.158 ± 0.011	1.494HisAsp: 1.494 ± 0.03	1.212HisGlu: 1.212 ± 0.027	0.521HisPhe: 0.521 ± 0.018	2.109HisGly: 2.109 ± 0.041	0.661HisHis: 0.661 ± 0.024	0.359HisIle: 0.359 ± 0.015	0.237HisLys: 0.237 ± 0.011	2.45HisLeu: 2.45 ± 0.04	0.247HisMet: 0.247 ± 0.013	0.286HisAsn: 0.286 ± 0.015	1.532HisPro: 1.532 ± 0.033	0.585HisGln: 0.585 ± 0.02	1.782HisArg: 1.782 ± 0.036	0.745HisSer: 0.745 ± 0.024	1.004HisThr: 1.004 ± 0.025	1.986HisVal: 1.986 ± 0.036	0.303HisTrp: 0.303 ± 0.013	0.4HisTyr: 0.4 ± 0.015	0.0HisXaa: 0.0 ± 0.0
Ile	4.611IleAla: 4.611 ± 0.07	0.245IleCys: 0.245 ± 0.013	2.316IleAsp: 2.316 ± 0.041	2.066IleGlu: 2.066 ± 0.041	0.728IlePhe: 0.728 ± 0.022	3.447IleGly: 3.447 ± 0.056	0.508IleHis: 0.508 ± 0.019	0.87IleIle: 0.87 ± 0.025	0.667IleLys: 0.667 ± 0.024	2.237IleLeu: 2.237 ± 0.043	0.366IleMet: 0.366 ± 0.015	0.664IleAsn: 0.664 ± 0.02	1.582IlePro: 1.582 ± 0.034	0.705IleGln: 0.705 ± 0.023	2.084IleArg: 2.084 ± 0.038	1.79IleSer: 1.79 ± 0.031	2.178IleThr: 2.178 ± 0.04	2.933IleVal: 2.933 ± 0.047	0.386IleTrp: 0.386 ± 0.016	0.52IleTyr: 0.52 ± 0.02	0.0IleXaa: 0.0 ± 0.0
Lys	2.412LysAla: 2.412 ± 0.056	0.082LysCys: 0.082 ± 0.007	1.022LysAsp: 1.022 ± 0.028	0.879LysGlu: 0.879 ± 0.025	0.412LysPhe: 0.412 ± 0.017	1.463LysGly: 1.463 ± 0.033	0.371LysHis: 0.371 ± 0.014	0.728LysIle: 0.728 ± 0.024	0.739LysLys: 0.739 ± 0.033	1.588LysLeu: 1.588 ± 0.032	0.309LysMet: 0.309 ± 0.014	0.426LysAsn: 0.426 ± 0.018	1.164LysPro: 1.164 ± 0.026	0.583LysGln: 0.583 ± 0.022	1.39LysArg: 1.39 ± 0.033	0.975LysSer: 0.975 ± 0.026	1.129LysThr: 1.129 ± 0.033	1.992LysVal: 1.992 ± 0.042	0.192LysTrp: 0.192 ± 0.011	0.384LysTyr: 0.384 ± 0.016	0.0LysXaa: 0.0 ± 0.0
Leu	15.6LeuAla: 15.6 ± 0.147	0.641LeuCys: 0.641 ± 0.02	7.478LeuAsp: 7.478 ± 0.081	5.328LeuGlu: 5.328 ± 0.075	2.396LeuPhe: 2.396 ± 0.044	9.975LeuGly: 9.975 ± 0.094	1.97LeuHis: 1.97 ± 0.035	2.567LeuIle: 2.567 ± 0.049	1.67LeuLys: 1.67 ± 0.037	11.136LeuLeu: 11.136 ± 0.126	1.559LeuMet: 1.559 ± 0.036	1.57LeuAsn: 1.57 ± 0.03	6.012LeuPro: 6.012 ± 0.07	2.43LeuGln: 2.43 ± 0.041	7.951LeuArg: 7.951 ± 0.077	5.124LeuSer: 5.124 ± 0.053	6.675LeuThr: 6.675 ± 0.058	11.319LeuVal: 11.319 ± 0.102	1.11LeuTrp: 1.11 ± 0.031	1.498LeuTyr: 1.498 ± 0.033	0.0LeuXaa: 0.0 ± 0.0
Met	2.008MetAla: 2.008 ± 0.041	0.104MetCys: 0.104 ± 0.008	0.804MetAsp: 0.804 ± 0.022	0.633MetGlu: 0.633 ± 0.018	0.41MetPhe: 0.41 ± 0.016	1.226MetGly: 1.226 ± 0.028	0.325MetHis: 0.325 ± 0.016	0.588MetIle: 0.588 ± 0.019	0.382MetLys: 0.382 ± 0.014	1.711MetLeu: 1.711 ± 0.035	0.28MetMet: 0.28 ± 0.014	0.387MetAsn: 0.387 ± 0.016	0.988MetPro: 0.988 ± 0.026	0.423MetGln: 0.423 ± 0.016	1.299MetArg: 1.299 ± 0.028	1.452MetSer: 1.452 ± 0.029	1.701MetThr: 1.701 ± 0.028	1.378MetVal: 1.378 ± 0.029	0.177MetTrp: 0.177 ± 0.011	0.238MetTyr: 0.238 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	2.078AsnAla: 2.078 ± 0.04	0.115AsnCys: 0.115 ± 0.009	1.027AsnAsp: 1.027 ± 0.035	0.795AsnGlu: 0.795 ± 0.027	0.455AsnPhe: 0.455 ± 0.014	1.697AsnGly: 1.697 ± 0.04	0.359AsnHis: 0.359 ± 0.016	0.586AsnIle: 0.586 ± 0.02	0.32AsnLys: 0.32 ± 0.016	1.743AsnLeu: 1.743 ± 0.038	0.243AsnMet: 0.243 ± 0.011	0.389AsnAsn: 0.389 ± 0.017	1.343AsnPro: 1.343 ± 0.03	0.512AsnGln: 0.512 ± 0.019	1.147AsnArg: 1.147 ± 0.029	0.706AsnSer: 0.706 ± 0.022	0.99AsnThr: 0.99 ± 0.029	1.476AsnVal: 1.476 ± 0.027	0.241AsnTrp: 0.241 ± 0.012	0.362AsnTyr: 0.362 ± 0.017	0.001AsnXaa: 0.001 ± 0.001
Pro	7.993ProAla: 7.993 ± 0.087	0.273ProCys: 0.273 ± 0.011	4.588ProAsp: 4.588 ± 0.06	3.976ProGlu: 3.976 ± 0.06	1.46ProPhe: 1.46 ± 0.031	5.823ProGly: 5.823 ± 0.067	1.097ProHis: 1.097 ± 0.025	1.535ProIle: 1.535 ± 0.032	0.899ProLys: 0.899 ± 0.025	4.954ProLeu: 4.954 ± 0.059	0.949ProMet: 0.949 ± 0.022	0.828ProAsn: 0.828 ± 0.023	2.864ProPro: 2.864 ± 0.058	1.367ProGln: 1.367 ± 0.03	3.607ProArg: 3.607 ± 0.049	3.084ProSer: 3.084 ± 0.054	3.863ProThr: 3.863 ± 0.061	5.62ProVal: 5.62 ± 0.06	0.914ProTrp: 0.914 ± 0.028	1.187ProTyr: 1.187 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	3.487GlnAla: 3.487 ± 0.052	0.142GlnCys: 0.142 ± 0.01	1.362GlnAsp: 1.362 ± 0.029	1.381GlnGlu: 1.381 ± 0.034	0.638GlnPhe: 0.638 ± 0.021	2.107GlnGly: 2.107 ± 0.036	0.66GlnHis: 0.66 ± 0.02	0.928GlnIle: 0.928 ± 0.024	0.507GlnLys: 0.507 ± 0.023	3.026GlnLeu: 3.026 ± 0.043	0.477GlnMet: 0.477 ± 0.017	0.434GlnAsn: 0.434 ± 0.018	1.562GlnPro: 1.562 ± 0.03	1.219GlnGln: 1.219 ± 0.028	2.335GlnArg: 2.335 ± 0.034	1.128GlnSer: 1.128 ± 0.028	1.349GlnThr: 1.349 ± 0.031	3.084GlnVal: 3.084 ± 0.047	0.431GlnTrp: 0.431 ± 0.017	0.508GlnTyr: 0.508 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	9.138ArgAla: 9.138 ± 0.089	0.481ArgCys: 0.481 ± 0.016	4.537ArgAsp: 4.537 ± 0.06	4.408ArgGlu: 4.408 ± 0.059	2.208ArgPhe: 2.208 ± 0.037	5.709ArgGly: 5.709 ± 0.074	1.751ArgHis: 1.751 ± 0.035	2.942ArgIle: 2.942 ± 0.045	1.362ArgLys: 1.362 ± 0.036	8.291ArgLeu: 8.291 ± 0.084	1.666ArgMet: 1.666 ± 0.034	1.194ArgAsn: 1.194 ± 0.027	4.45ArgPro: 4.45 ± 0.06	2.094ArgGln: 2.094 ± 0.032	7.364ArgArg: 7.364 ± 0.094	4.385ArgSer: 4.385 ± 0.056	5.027ArgThr: 5.027 ± 0.056	6.926ArgVal: 6.926 ± 0.075	1.361ArgTrp: 1.361 ± 0.024	1.602ArgTyr: 1.602 ± 0.029	0.0ArgXaa: 0.0 ± 0.0
Ser	6.522SerAla: 6.522 ± 0.068	0.369SerCys: 0.369 ± 0.018	3.003SerAsp: 3.003 ± 0.05	2.473SerGlu: 2.473 ± 0.039	1.67SerPhe: 1.67 ± 0.03	5.759SerGly: 5.759 ± 0.069	0.941SerHis: 0.941 ± 0.023	1.73SerIle: 1.73 ± 0.037	0.915SerLys: 0.915 ± 0.025	5.059SerLeu: 5.059 ± 0.054	1.111SerMet: 1.111 ± 0.029	0.88SerAsn: 0.88 ± 0.025	2.964SerPro: 2.964 ± 0.047	1.268SerGln: 1.268 ± 0.032	3.581SerArg: 3.581 ± 0.051	3.308SerSer: 3.308 ± 0.059	3.589SerThr: 3.589 ± 0.052	4.691SerVal: 4.691 ± 0.053	0.963SerTrp: 0.963 ± 0.026	1.709SerTyr: 1.709 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	8.179ThrAla: 8.179 ± 0.089	0.464ThrCys: 0.464 ± 0.02	3.982ThrAsp: 3.982 ± 0.073	3.033ThrGlu: 3.033 ± 0.046	1.922ThrPhe: 1.922 ± 0.035	6.665ThrGly: 6.665 ± 0.084	1.108ThrHis: 1.108 ± 0.027	2.224ThrIle: 2.224 ± 0.043	1.173ThrLys: 1.173 ± 0.03	6.17ThrLeu: 6.17 ± 0.057	0.973ThrMet: 0.973 ± 0.023	1.101ThrAsn: 1.101 ± 0.029	4.054ThrPro: 4.054 ± 0.062	1.413ThrGln: 1.413 ± 0.026	4.199ThrArg: 4.199 ± 0.054	3.726ThrSer: 3.726 ± 0.053	4.736ThrThr: 4.736 ± 0.068	6.513ThrVal: 6.513 ± 0.094	1.123ThrTrp: 1.123 ± 0.029	1.586ThrTyr: 1.586 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	13.649ValAla: 13.649 ± 0.106	0.642ValCys: 0.642 ± 0.023	6.684ValAsp: 6.684 ± 0.069	5.787ValGlu: 5.787 ± 0.065	2.329ValPhe: 2.329 ± 0.043	8.407ValGly: 8.407 ± 0.084	1.925ValHis: 1.925 ± 0.037	2.747ValIle: 2.747 ± 0.045	1.63ValLys: 1.63 ± 0.037	10.831ValLeu: 10.831 ± 0.109	1.396ValMet: 1.396 ± 0.032	1.652ValAsn: 1.652 ± 0.038	5.507ValPro: 5.507 ± 0.058	2.174ValGln: 2.174 ± 0.038	7.69ValArg: 7.69 ± 0.084	4.88ValSer: 4.88 ± 0.058	6.624ValThr: 6.624 ± 0.096	11.46ValVal: 11.46 ± 0.112	1.17ValTrp: 1.17 ± 0.027	1.508ValTyr: 1.508 ± 0.031	0.0ValXaa: 0.0 ± 0.0
Trp	1.644TrpAla: 1.644 ± 0.037	0.172TrpCys: 0.172 ± 0.011	0.886TrpAsp: 0.886 ± 0.025	0.687TrpGlu: 0.687 ± 0.019	0.52TrpPhe: 0.52 ± 0.019	1.071TrpGly: 1.071 ± 0.028	0.343TrpHis: 0.343 ± 0.016	0.537TrpIle: 0.537 ± 0.02	0.327TrpLys: 0.327 ± 0.014	1.739TrpLeu: 1.739 ± 0.033	0.261TrpMet: 0.261 ± 0.014	0.311TrpAsn: 0.311 ± 0.014	0.747TrpPro: 0.747 ± 0.02	0.52TrpGln: 0.52 ± 0.017	1.268TrpArg: 1.268 ± 0.028	1.074TrpSer: 1.074 ± 0.024	1.111TrpThr: 1.111 ± 0.029	1.268TrpVal: 1.268 ± 0.029	0.377TrpTrp: 0.377 ± 0.015	0.317TrpTyr: 0.317 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.664TyrAla: 2.664 ± 0.043	0.144TyrCys: 0.144 ± 0.01	1.969TyrAsp: 1.969 ± 0.037	0.996TyrGlu: 0.996 ± 0.028	0.595TyrPhe: 0.595 ± 0.021	2.013TyrGly: 2.013 ± 0.041	0.309TyrHis: 0.309 ± 0.013	0.349TyrIle: 0.349 ± 0.015	0.307TyrLys: 0.307 ± 0.016	2.119TyrLeu: 2.119 ± 0.043	0.177TyrMet: 0.177 ± 0.01	0.328TyrAsn: 0.328 ± 0.017	0.951TyrPro: 0.951 ± 0.026	0.571TyrGln: 0.571 ± 0.02	1.569TyrArg: 1.569 ± 0.039	0.941TyrSer: 0.941 ± 0.027	1.075TyrThr: 1.075 ± 0.033	2.027TyrVal: 2.027 ± 0.038	0.3TyrTrp: 0.3 ± 0.013	0.418TyrTyr: 0.418 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.001XaaAsp: 0.001 ± 0.001	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.004XaaXaa: 0.004 ± 0.003

Statistics based on 5063 proteins (1642176 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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