Amino acid dipepetide frequency for Influenza A virus (A/Shanghai/02/2013(H7N9))

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.763AlaAla: 3.763 ± 1.049
1.254AlaCys: 1.254 ± 0.452
3.345AlaAsp: 3.345 ± 0.704
4.809AlaGlu: 4.809 ± 0.929
1.882AlaPhe: 1.882 ± 0.651
2.927AlaGly: 2.927 ± 0.884
0.627AlaHis: 0.627 ± 0.378
3.763AlaIle: 3.763 ± 0.729
2.3AlaLys: 2.3 ± 0.507
6.69AlaLeu: 6.69 ± 0.952
3.972AlaMet: 3.972 ± 0.583
3.136AlaAsn: 3.136 ± 0.725
2.091AlaPro: 2.091 ± 0.555
1.464AlaGln: 1.464 ± 0.432
3.136AlaArg: 3.136 ± 0.4
5.227AlaSer: 5.227 ± 1.231
5.227AlaThr: 5.227 ± 0.699
3.345AlaVal: 3.345 ± 0.662
0.627AlaTrp: 0.627 ± 0.328
0.836AlaTyr: 0.836 ± 0.317
0.0AlaXaa: 0.0 ± 0.0
Cys
0.627CysAla: 0.627 ± 0.337
0.209CysCys: 0.209 ± 0.172
0.627CysAsp: 0.627 ± 0.393
0.836CysGlu: 0.836 ± 0.292
1.673CysPhe: 1.673 ± 0.564
0.209CysGly: 0.209 ± 0.189
1.045CysHis: 1.045 ± 0.414
1.254CysIle: 1.254 ± 0.464
0.836CysLys: 0.836 ± 0.32
1.254CysLeu: 1.254 ± 0.409
0.836CysMet: 0.836 ± 0.3
1.673CysAsn: 1.673 ± 0.543
0.418CysPro: 0.418 ± 0.243
0.209CysGln: 0.209 ± 0.226
1.254CysArg: 1.254 ± 0.54
1.882CysSer: 1.882 ± 0.767
1.464CysThr: 1.464 ± 0.514
1.045CysVal: 1.045 ± 0.242
0.418CysTrp: 0.418 ± 0.207
0.836CysTyr: 0.836 ± 0.485
0.0CysXaa: 0.0 ± 0.0
Asp
2.718AspAla: 2.718 ± 0.409
1.673AspCys: 1.673 ± 0.383
1.673AspAsp: 1.673 ± 0.381
3.345AspGlu: 3.345 ± 0.684
2.3AspPhe: 2.3 ± 0.847
2.927AspGly: 2.927 ± 0.925
0.627AspHis: 0.627 ± 0.333
1.254AspIle: 1.254 ± 0.515
2.509AspLys: 2.509 ± 0.586
4.181AspLeu: 4.181 ± 0.841
1.254AspMet: 1.254 ± 0.384
2.927AspAsn: 2.927 ± 0.639
4.181AspPro: 4.181 ± 0.777
1.882AspGln: 1.882 ± 0.606
2.3AspArg: 2.3 ± 0.395
3.136AspSer: 3.136 ± 0.772
1.673AspThr: 1.673 ± 0.441
3.345AspVal: 3.345 ± 0.439
0.627AspTrp: 0.627 ± 0.31
1.673AspTyr: 1.673 ± 0.563
0.0AspXaa: 0.0 ± 0.0
Glu
3.554GluAla: 3.554 ± 0.625
1.254GluCys: 1.254 ± 0.786
4.6GluAsp: 4.6 ± 0.722
6.899GluGlu: 6.899 ± 0.8
2.091GluPhe: 2.091 ± 0.509
5.436GluGly: 5.436 ± 1.063
0.836GluHis: 0.836 ± 0.521
5.227GluIle: 5.227 ± 0.798
5.645GluLys: 5.645 ± 1.577
4.809GluLeu: 4.809 ± 0.733
3.345GluMet: 3.345 ± 0.552
3.763GluAsn: 3.763 ± 0.864
2.927GluPro: 2.927 ± 1.106
3.763GluGln: 3.763 ± 1.087
5.018GluArg: 5.018 ± 1.037
5.854GluSer: 5.854 ± 0.983
2.927GluThr: 2.927 ± 0.411
4.809GluVal: 4.809 ± 1.096
0.836GluTrp: 0.836 ± 0.399
1.673GluTyr: 1.673 ± 0.382
0.0GluXaa: 0.0 ± 0.0
Phe
1.882PheAla: 1.882 ± 0.493
0.0PheCys: 0.0 ± 0.0
0.836PheAsp: 0.836 ± 0.407
5.018PheGlu: 5.018 ± 1.066
1.254PhePhe: 1.254 ± 0.498
1.464PheGly: 1.464 ± 0.356
1.045PheHis: 1.045 ± 0.472
2.3PheIle: 2.3 ± 0.825
1.254PheLys: 1.254 ± 0.596
4.391PheLeu: 4.391 ± 0.675
0.836PheMet: 0.836 ± 0.368
2.509PheAsn: 2.509 ± 0.609
0.836PhePro: 0.836 ± 0.336
2.509PheGln: 2.509 ± 0.7
1.464PheArg: 1.464 ± 0.332
3.972PheSer: 3.972 ± 0.468
2.927PheThr: 2.927 ± 0.431
3.136PheVal: 3.136 ± 0.699
0.209PheTrp: 0.209 ± 0.2
1.254PheTyr: 1.254 ± 0.453
0.0PheXaa: 0.0 ± 0.0
Gly
3.972GlyAla: 3.972 ± 0.948
0.627GlyCys: 0.627 ± 0.247
2.927GlyAsp: 2.927 ± 0.316
4.391GlyGlu: 4.391 ± 1.253
2.927GlyPhe: 2.927 ± 0.546
2.509GlyGly: 2.509 ± 0.694
0.836GlyHis: 0.836 ± 0.36
4.6GlyIle: 4.6 ± 0.703
5.227GlyLys: 5.227 ± 0.856
5.227GlyLeu: 5.227 ± 0.957
2.509GlyMet: 2.509 ± 0.447
2.509GlyAsn: 2.509 ± 0.72
3.136GlyPro: 3.136 ± 0.627
2.3GlyGln: 2.3 ± 0.546
4.6GlyArg: 4.6 ± 0.902
3.763GlySer: 3.763 ± 0.968
5.436GlyThr: 5.436 ± 0.78
3.763GlyVal: 3.763 ± 0.322
1.045GlyTrp: 1.045 ± 0.429
1.882GlyTyr: 1.882 ± 0.527
0.0GlyXaa: 0.0 ± 0.0
His
0.627HisAla: 0.627 ± 0.251
0.209HisCys: 0.209 ± 0.175
0.418HisAsp: 0.418 ± 0.373
1.045HisGlu: 1.045 ± 0.348
1.254HisPhe: 1.254 ± 0.386
0.836HisGly: 0.836 ± 0.33
0.418HisHis: 0.418 ± 0.379
2.509HisIle: 2.509 ± 0.907
1.464HisLys: 1.464 ± 0.389
1.464HisLeu: 1.464 ± 0.408
0.209HisMet: 0.209 ± 0.173
0.209HisAsn: 0.209 ± 0.186
0.836HisPro: 0.836 ± 0.376
0.418HisGln: 0.418 ± 0.25
1.464HisArg: 1.464 ± 0.668
2.091HisSer: 2.091 ± 0.635
0.627HisThr: 0.627 ± 0.29
0.209HisVal: 0.209 ± 0.185
0.209HisTrp: 0.209 ± 0.189
0.418HisTyr: 0.418 ± 0.289
0.0HisXaa: 0.0 ± 0.0
Ile
3.136IleAla: 3.136 ± 0.546
2.718IleCys: 2.718 ± 0.706
4.391IleAsp: 4.391 ± 1.461
6.899IleGlu: 6.899 ± 1.875
1.254IlePhe: 1.254 ± 0.34
4.391IleGly: 4.391 ± 1.003
0.836IleHis: 0.836 ± 0.277
4.181IleIle: 4.181 ± 0.768
3.554IleLys: 3.554 ± 0.981
6.063IleLeu: 6.063 ± 1.37
1.673IleMet: 1.673 ± 0.342
3.763IleAsn: 3.763 ± 0.715
2.3IlePro: 2.3 ± 0.619
2.718IleGln: 2.718 ± 0.539
5.645IleArg: 5.645 ± 1.134
1.882IleSer: 1.882 ± 0.551
3.972IleThr: 3.972 ± 0.899
3.763IleVal: 3.763 ± 0.607
0.418IleTrp: 0.418 ± 0.4
1.464IleTyr: 1.464 ± 0.507
0.0IleXaa: 0.0 ± 0.0
Lys
4.181LysAla: 4.181 ± 1.064
1.464LysCys: 1.464 ± 0.466
2.927LysAsp: 2.927 ± 0.318
5.018LysGlu: 5.018 ± 0.968
1.882LysPhe: 1.882 ± 0.684
2.927LysGly: 2.927 ± 0.537
1.254LysHis: 1.254 ± 0.378
3.972LysIle: 3.972 ± 0.663
3.972LysLys: 3.972 ± 1.391
4.6LysLeu: 4.6 ± 1.075
2.509LysMet: 2.509 ± 0.716
2.091LysAsn: 2.091 ± 0.638
1.045LysPro: 1.045 ± 0.435
2.091LysGln: 2.091 ± 0.592
4.391LysArg: 4.391 ± 1.229
3.554LysSer: 3.554 ± 0.802
3.554LysThr: 3.554 ± 0.943
2.091LysVal: 2.091 ± 0.433
2.3LysTrp: 2.3 ± 0.527
1.673LysTyr: 1.673 ± 0.509
0.0LysXaa: 0.0 ± 0.0
Leu
4.391LeuAla: 4.391 ± 0.76
0.836LeuCys: 0.836 ± 0.443
1.464LeuAsp: 1.464 ± 0.541
5.854LeuGlu: 5.854 ± 1.369
2.091LeuPhe: 2.091 ± 0.503
3.763LeuGly: 3.763 ± 0.732
1.045LeuHis: 1.045 ± 0.425
7.527LeuIle: 7.527 ± 1.06
6.69LeuLys: 6.69 ± 1.421
6.272LeuLeu: 6.272 ± 1.559
2.509LeuMet: 2.509 ± 0.52
3.554LeuAsn: 3.554 ± 0.751
3.554LeuPro: 3.554 ± 0.659
2.927LeuGln: 2.927 ± 0.715
6.69LeuArg: 6.69 ± 1.151
5.227LeuSer: 5.227 ± 0.678
6.272LeuThr: 6.272 ± 1.156
3.345LeuVal: 3.345 ± 0.832
1.464LeuTrp: 1.464 ± 0.357
2.927LeuTyr: 2.927 ± 0.949
0.0LeuXaa: 0.0 ± 0.0
Met
4.181MetAla: 4.181 ± 0.733
1.045MetCys: 1.045 ± 0.632
3.763MetAsp: 3.763 ± 0.833
4.809MetGlu: 4.809 ± 0.788
1.045MetPhe: 1.045 ± 0.703
2.509MetGly: 2.509 ± 0.91
0.418MetHis: 0.418 ± 0.289
2.509MetIle: 2.509 ± 0.559
2.718MetLys: 2.718 ± 0.813
1.673MetLeu: 1.673 ± 0.35
1.464MetMet: 1.464 ± 0.502
0.836MetAsn: 0.836 ± 0.261
0.418MetPro: 0.418 ± 0.302
1.254MetGln: 1.254 ± 0.535
2.091MetArg: 2.091 ± 0.547
2.3MetSer: 2.3 ± 0.499
1.673MetThr: 1.673 ± 0.484
2.927MetVal: 2.927 ± 0.993
0.418MetTrp: 0.418 ± 0.26
0.836MetTyr: 0.836 ± 0.285
0.0MetXaa: 0.0 ± 0.0
Asn
5.227AsnAla: 5.227 ± 0.982
0.627AsnCys: 0.627 ± 0.349
2.509AsnAsp: 2.509 ± 0.441
3.763AsnGlu: 3.763 ± 0.62
1.673AsnPhe: 1.673 ± 0.447
4.391AsnGly: 4.391 ± 1.118
0.209AsnHis: 0.209 ± 0.172
3.136AsnIle: 3.136 ± 1.018
2.509AsnLys: 2.509 ± 0.783
3.136AsnLeu: 3.136 ± 0.463
2.509AsnMet: 2.509 ± 0.524
2.927AsnAsn: 2.927 ± 1.329
3.972AsnPro: 3.972 ± 0.561
1.882AsnGln: 1.882 ± 0.461
3.763AsnArg: 3.763 ± 0.671
3.345AsnSer: 3.345 ± 0.692
5.018AsnThr: 5.018 ± 0.816
1.882AsnVal: 1.882 ± 0.849
1.045AsnTrp: 1.045 ± 0.486
1.045AsnTyr: 1.045 ± 0.329
0.0AsnXaa: 0.0 ± 0.0
Pro
2.718ProAla: 2.718 ± 0.693
0.418ProCys: 0.418 ± 0.276
1.464ProAsp: 1.464 ± 0.392
2.509ProGlu: 2.509 ± 0.463
1.673ProPhe: 1.673 ± 0.354
2.509ProGly: 2.509 ± 0.433
0.418ProHis: 0.418 ± 0.349
2.091ProIle: 2.091 ± 0.409
2.718ProLys: 2.718 ± 0.476
2.927ProLeu: 2.927 ± 0.666
1.464ProMet: 1.464 ± 0.63
4.181ProAsn: 4.181 ± 1.003
1.254ProPro: 1.254 ± 0.312
1.045ProGln: 1.045 ± 0.551
2.509ProArg: 2.509 ± 0.699
2.509ProSer: 2.509 ± 0.543
1.882ProThr: 1.882 ± 0.496
2.509ProVal: 2.509 ± 0.999
0.418ProTrp: 0.418 ± 0.278
0.836ProTyr: 0.836 ± 0.494
0.0ProXaa: 0.0 ± 0.0
Gln
2.091GlnAla: 2.091 ± 0.814
0.836GlnCys: 0.836 ± 0.427
1.464GlnAsp: 1.464 ± 0.511
2.3GlnGlu: 2.3 ± 0.773
0.836GlnPhe: 0.836 ± 0.513
2.927GlnGly: 2.927 ± 0.847
0.418GlnHis: 0.418 ± 0.282
2.927GlnIle: 2.927 ± 0.84
2.091GlnLys: 2.091 ± 0.66
3.763GlnLeu: 3.763 ± 1.013
2.509GlnMet: 2.509 ± 0.586
2.927GlnAsn: 2.927 ± 0.638
0.836GlnPro: 0.836 ± 0.377
1.464GlnGln: 1.464 ± 0.345
3.763GlnArg: 3.763 ± 0.962
3.136GlnSer: 3.136 ± 0.875
2.509GlnThr: 2.509 ± 0.766
2.091GlnVal: 2.091 ± 0.499
0.836GlnTrp: 0.836 ± 0.447
0.836GlnTyr: 0.836 ± 0.368
0.0GlnXaa: 0.0 ± 0.0
Arg
4.6ArgAla: 4.6 ± 0.672
0.836ArgCys: 0.836 ± 0.325
2.927ArgAsp: 2.927 ± 0.524
3.763ArgGlu: 3.763 ± 0.747
3.136ArgPhe: 3.136 ± 0.662
6.481ArgGly: 6.481 ± 1.041
0.836ArgHis: 0.836 ± 0.413
4.391ArgIle: 4.391 ± 0.663
1.882ArgLys: 1.882 ± 0.475
4.6ArgLeu: 4.6 ± 0.578
4.181ArgMet: 4.181 ± 1.507
4.391ArgAsn: 4.391 ± 0.846
2.509ArgPro: 2.509 ± 0.737
3.345ArgGln: 3.345 ± 0.572
6.063ArgArg: 6.063 ± 0.845
4.809ArgSer: 4.809 ± 1.063
7.527ArgThr: 7.527 ± 1.078
3.136ArgVal: 3.136 ± 1.141
0.418ArgTrp: 0.418 ± 0.334
1.464ArgTyr: 1.464 ± 0.382
0.0ArgXaa: 0.0 ± 0.0
Ser
3.554SerAla: 3.554 ± 1.117
1.673SerCys: 1.673 ± 0.526
2.718SerAsp: 2.718 ± 0.55
2.927SerGlu: 2.927 ± 0.48
5.018SerPhe: 5.018 ± 1.109
6.481SerGly: 6.481 ± 1.171
1.882SerHis: 1.882 ± 0.68
4.6SerIle: 4.6 ± 0.463
3.136SerLys: 3.136 ± 0.707
5.854SerLeu: 5.854 ± 1.101
2.509SerMet: 2.509 ± 0.872
3.345SerAsn: 3.345 ± 0.806
2.927SerPro: 2.927 ± 0.468
4.391SerGln: 4.391 ± 0.911
3.972SerArg: 3.972 ± 0.703
6.899SerSer: 6.899 ± 1.213
5.018SerThr: 5.018 ± 0.77
2.927SerVal: 2.927 ± 0.694
1.045SerTrp: 1.045 ± 0.464
1.882SerTyr: 1.882 ± 0.52
0.0SerXaa: 0.0 ± 0.0
Thr
4.6ThrAla: 4.6 ± 0.358
1.045ThrCys: 1.045 ± 0.395
2.3ThrAsp: 2.3 ± 0.598
4.391ThrGlu: 4.391 ± 0.877
2.509ThrPhe: 2.509 ± 0.563
5.645ThrGly: 5.645 ± 0.821
2.3ThrHis: 2.3 ± 0.724
4.809ThrIle: 4.809 ± 0.879
4.391ThrLys: 4.391 ± 0.557
3.554ThrLeu: 3.554 ± 0.864
1.882ThrMet: 1.882 ± 0.495
3.554ThrAsn: 3.554 ± 0.573
1.254ThrPro: 1.254 ± 0.415
3.136ThrGln: 3.136 ± 1.002
5.436ThrArg: 5.436 ± 0.723
3.972ThrSer: 3.972 ± 1.045
3.345ThrThr: 3.345 ± 0.811
4.6ThrVal: 4.6 ± 1.053
1.045ThrTrp: 1.045 ± 0.42
2.3ThrTyr: 2.3 ± 0.598
0.0ThrXaa: 0.0 ± 0.0
Val
2.927ValAla: 2.927 ± 0.548
1.673ValCys: 1.673 ± 0.409
3.345ValAsp: 3.345 ± 0.955
3.554ValGlu: 3.554 ± 0.517
2.509ValPhe: 2.509 ± 0.564
2.927ValGly: 2.927 ± 0.466
1.045ValHis: 1.045 ± 0.502
1.254ValIle: 1.254 ± 0.4
2.509ValLys: 2.509 ± 0.768
5.018ValLeu: 5.018 ± 1.601
1.464ValMet: 1.464 ± 0.46
3.554ValAsn: 3.554 ± 0.877
2.091ValPro: 2.091 ± 0.439
2.3ValGln: 2.3 ± 0.733
4.391ValArg: 4.391 ± 1.277
5.854ValSer: 5.854 ± 0.618
1.882ValThr: 1.882 ± 0.372
2.927ValVal: 2.927 ± 0.687
1.045ValTrp: 1.045 ± 0.486
1.464ValTyr: 1.464 ± 0.362
0.0ValXaa: 0.0 ± 0.0
Trp
0.836TrpAla: 0.836 ± 0.414
0.0TrpCys: 0.0 ± 0.0
0.627TrpAsp: 0.627 ± 0.319
1.882TrpGlu: 1.882 ± 0.491
0.627TrpPhe: 0.627 ± 0.261
0.627TrpGly: 0.627 ± 0.251
0.627TrpHis: 0.627 ± 0.338
1.254TrpIle: 1.254 ± 0.38
0.836TrpLys: 0.836 ± 0.556
1.254TrpLeu: 1.254 ± 0.554
0.627TrpMet: 0.627 ± 0.311
0.836TrpAsn: 0.836 ± 0.301
0.627TrpPro: 0.627 ± 0.37
0.209TrpGln: 0.209 ± 0.186
0.836TrpArg: 0.836 ± 0.478
1.045TrpSer: 1.045 ± 0.486
1.464TrpThr: 1.464 ± 0.408
0.627TrpVal: 0.627 ± 0.376
0.627TrpTrp: 0.627 ± 0.253
0.418TrpTyr: 0.418 ± 0.243
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.836TyrAla: 0.836 ± 0.268
0.209TyrCys: 0.209 ± 0.175
1.882TyrAsp: 1.882 ± 0.576
1.254TyrGlu: 1.254 ± 0.383
1.464TyrPhe: 1.464 ± 0.42
2.3TyrGly: 2.3 ± 0.368
0.209TyrHis: 0.209 ± 0.189
1.464TyrIle: 1.464 ± 0.378
1.464TyrLys: 1.464 ± 0.606
1.673TyrLeu: 1.673 ± 0.477
0.418TyrMet: 0.418 ± 0.199
1.882TyrAsn: 1.882 ± 0.506
0.836TyrPro: 0.836 ± 0.397
1.254TyrGln: 1.254 ± 0.298
2.509TyrArg: 2.509 ± 1.009
2.3TyrSer: 2.3 ± 0.316
1.673TyrThr: 1.673 ± 0.657
1.254TyrVal: 1.254 ± 0.434
0.836TyrTrp: 0.836 ± 0.35
0.836TyrTyr: 0.836 ± 0.369
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 12 proteins (4784 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski