Amino acid dipepetide frequency for Roseomonas sp. Z24

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	23.154AlaAla: 23.154 ± 0.171	1.219AlaCys: 1.219 ± 0.028	6.306AlaAsp: 6.306 ± 0.064	9.553AlaGlu: 9.553 ± 0.101	4.359AlaPhe: 4.359 ± 0.06	12.825AlaGly: 12.825 ± 0.093	2.341AlaHis: 2.341 ± 0.04	5.462AlaIle: 5.462 ± 0.062	2.982AlaLys: 2.982 ± 0.053	16.753AlaLeu: 16.753 ± 0.122	4.29AlaMet: 4.29 ± 0.052	2.355AlaAsn: 2.355 ± 0.04	7.445AlaPro: 7.445 ± 0.092	4.7AlaGln: 4.7 ± 0.063	11.196AlaArg: 11.196 ± 0.089	6.398AlaSer: 6.398 ± 0.065	6.502AlaThr: 6.502 ± 0.066	9.845AlaVal: 9.845 ± 0.088	1.948AlaTrp: 1.948 ± 0.033	2.226AlaTyr: 2.226 ± 0.037	0.0AlaXaa: 0.0 ± 0.0
Cys	1.074CysAla: 1.074 ± 0.026	0.12CysCys: 0.12 ± 0.009	0.476CysAsp: 0.476 ± 0.018	0.367CysGlu: 0.367 ± 0.014	0.314CysPhe: 0.314 ± 0.013	0.961CysGly: 0.961 ± 0.028	0.237CysHis: 0.237 ± 0.012	0.394CysIle: 0.394 ± 0.014	0.108CysLys: 0.108 ± 0.007	0.843CysLeu: 0.843 ± 0.023	0.181CysMet: 0.181 ± 0.01	0.175CysAsn: 0.175 ± 0.011	0.458CysPro: 0.458 ± 0.018	0.214CysGln: 0.214 ± 0.011	0.697CysArg: 0.697 ± 0.019	0.393CysSer: 0.393 ± 0.015	0.431CysThr: 0.431 ± 0.015	0.597CysVal: 0.597 ± 0.017	0.131CysTrp: 0.131 ± 0.008	0.172CysTyr: 0.172 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	6.901AspAla: 6.901 ± 0.074	0.382AspCys: 0.382 ± 0.014	2.097AspAsp: 2.097 ± 0.039	2.579AspGlu: 2.579 ± 0.045	1.807AspPhe: 1.807 ± 0.035	4.856AspGly: 4.856 ± 0.062	1.032AspHis: 1.032 ± 0.025	2.23AspIle: 2.23 ± 0.039	1.022AspLys: 1.022 ± 0.024	5.55AspLeu: 5.55 ± 0.066	1.188AspMet: 1.188 ± 0.029	0.937AspAsn: 0.937 ± 0.022	3.585AspPro: 3.585 ± 0.047	1.366AspGln: 1.366 ± 0.027	3.914AspArg: 3.914 ± 0.047	1.927AspSer: 1.927 ± 0.039	2.3AspThr: 2.3 ± 0.042	3.468AspVal: 3.468 ± 0.047	0.963AspTrp: 0.963 ± 0.025	1.191AspTyr: 1.191 ± 0.026	0.0AspXaa: 0.0 ± 0.0
Glu	9.651GluAla: 9.651 ± 0.089	0.312GluCys: 0.312 ± 0.014	2.725GluAsp: 2.725 ± 0.039	3.449GluGlu: 3.449 ± 0.049	1.409GluPhe: 1.409 ± 0.03	4.798GluGly: 4.798 ± 0.06	1.134GluHis: 1.134 ± 0.024	2.644GluIle: 2.644 ± 0.04	1.55GluLys: 1.55 ± 0.033	5.059GluLeu: 5.059 ± 0.061	1.558GluMet: 1.558 ± 0.03	1.197GluAsn: 1.197 ± 0.025	2.934GluPro: 2.934 ± 0.051	2.203GluGln: 2.203 ± 0.04	4.834GluArg: 4.834 ± 0.053	2.13GluSer: 2.13 ± 0.036	2.706GluThr: 2.706 ± 0.042	4.267GluVal: 4.267 ± 0.059	0.775GluTrp: 0.775 ± 0.021	0.83GluTyr: 0.83 ± 0.023	0.0GluXaa: 0.0 ± 0.0
Phe	4.287PheAla: 4.287 ± 0.053	0.378PheCys: 0.378 ± 0.015	2.047PheAsp: 2.047 ± 0.037	1.626PheGlu: 1.626 ± 0.037	1.202PhePhe: 1.202 ± 0.034	3.475PheGly: 3.475 ± 0.05	0.756PheHis: 0.756 ± 0.021	1.299PheIle: 1.299 ± 0.03	0.605PheLys: 0.605 ± 0.019	3.374PheLeu: 3.374 ± 0.051	0.681PheMet: 0.681 ± 0.022	0.899PheAsn: 0.899 ± 0.024	1.663PhePro: 1.663 ± 0.032	0.994PheGln: 0.994 ± 0.021	2.453PheArg: 2.453 ± 0.037	1.946PheSer: 1.946 ± 0.029	1.915PheThr: 1.915 ± 0.033	2.275PheVal: 2.275 ± 0.04	0.571PheTrp: 0.571 ± 0.021	0.688PheTyr: 0.688 ± 0.02	0.0PheXaa: 0.0 ± 0.0
Gly	10.708GlyAla: 10.708 ± 0.087	0.89GlyCys: 0.89 ± 0.023	3.659GlyAsp: 3.659 ± 0.054	4.763GlyGlu: 4.763 ± 0.058	3.678GlyPhe: 3.678 ± 0.053	8.272GlyGly: 8.272 ± 0.103	2.051GlyHis: 2.051 ± 0.035	4.507GlyIle: 4.507 ± 0.056	2.412GlyLys: 2.412 ± 0.045	10.613GlyLeu: 10.613 ± 0.089	2.647GlyMet: 2.647 ± 0.039	1.955GlyAsn: 1.955 ± 0.041	4.365GlyPro: 4.365 ± 0.051	3.475GlyGln: 3.475 ± 0.048	7.193GlyArg: 7.193 ± 0.06	4.582GlySer: 4.582 ± 0.06	5.0GlyThr: 5.0 ± 0.059	6.157GlyVal: 6.157 ± 0.058	1.753GlyTrp: 1.753 ± 0.037	2.073GlyTyr: 2.073 ± 0.036	0.0GlyXaa: 0.0 ± 0.0
His	2.696HisAla: 2.696 ± 0.045	0.214HisCys: 0.214 ± 0.013	1.159HisAsp: 1.159 ± 0.027	0.963HisGlu: 0.963 ± 0.025	0.734HisPhe: 0.734 ± 0.021	2.168HisGly: 2.168 ± 0.036	0.562HisHis: 0.562 ± 0.019	0.73HisIle: 0.73 ± 0.024	0.372HisLys: 0.372 ± 0.015	2.311HisLeu: 2.311 ± 0.039	0.421HisMet: 0.421 ± 0.014	0.422HisAsn: 0.422 ± 0.018	1.58HisPro: 1.58 ± 0.031	0.568HisGln: 0.568 ± 0.018	1.666HisArg: 1.666 ± 0.033	0.889HisSer: 0.889 ± 0.023	0.821HisThr: 0.821 ± 0.022	1.496HisVal: 1.496 ± 0.029	0.391HisTrp: 0.391 ± 0.015	0.442HisTyr: 0.442 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	6.039IleAla: 6.039 ± 0.055	0.443IleCys: 0.443 ± 0.016	2.259IleAsp: 2.259 ± 0.037	2.465IleGlu: 2.465 ± 0.04	1.278IlePhe: 1.278 ± 0.027	4.473IleGly: 4.473 ± 0.055	0.781IleHis: 0.781 ± 0.022	1.537IleIle: 1.537 ± 0.038	0.784IleLys: 0.784 ± 0.022	3.975IleLeu: 3.975 ± 0.051	0.784IleMet: 0.784 ± 0.021	0.987IleAsn: 0.987 ± 0.025	2.216IlePro: 2.216 ± 0.039	1.111IleGln: 1.111 ± 0.025	3.181IleArg: 3.181 ± 0.05	2.145IleSer: 2.145 ± 0.04	2.263IleThr: 2.263 ± 0.039	3.005IleVal: 3.005 ± 0.048	0.538IleTrp: 0.538 ± 0.016	0.797IleTyr: 0.797 ± 0.022	0.0IleXaa: 0.0 ± 0.0
Lys	3.039LysAla: 3.039 ± 0.054	0.089LysCys: 0.089 ± 0.008	1.057LysAsp: 1.057 ± 0.027	1.051LysGlu: 1.051 ± 0.031	0.531LysPhe: 0.531 ± 0.02	1.924LysGly: 1.924 ± 0.037	0.429LysHis: 0.429 ± 0.016	0.915LysIle: 0.915 ± 0.024	0.673LysLys: 0.673 ± 0.025	2.577LysLeu: 2.577 ± 0.048	0.494LysMet: 0.494 ± 0.019	0.493LysAsn: 0.493 ± 0.018	1.691LysPro: 1.691 ± 0.033	0.777LysGln: 0.777 ± 0.021	1.815LysArg: 1.815 ± 0.036	1.03LysSer: 1.03 ± 0.029	1.055LysThr: 1.055 ± 0.027	1.78LysVal: 1.78 ± 0.038	0.21LysTrp: 0.21 ± 0.011	0.336LysTyr: 0.336 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	16.914LeuAla: 16.914 ± 0.132	1.061LeuCys: 1.061 ± 0.024	5.852LeuAsp: 5.852 ± 0.069	5.837LeuGlu: 5.837 ± 0.067	3.23LeuPhe: 3.23 ± 0.047	9.791LeuGly: 9.791 ± 0.084	2.249LeuHis: 2.249 ± 0.037	3.725LeuIle: 3.725 ± 0.059	2.434LeuLys: 2.434 ± 0.038	12.931LeuLeu: 12.931 ± 0.135	2.435LeuMet: 2.435 ± 0.043	2.298LeuAsn: 2.298 ± 0.038	7.84LeuPro: 7.84 ± 0.088	3.068LeuGln: 3.068 ± 0.045	9.922LeuArg: 9.922 ± 0.089	6.172LeuSer: 6.172 ± 0.063	5.292LeuThr: 5.292 ± 0.056	7.843LeuVal: 7.843 ± 0.078	1.399LeuTrp: 1.399 ± 0.028	1.767LeuTyr: 1.767 ± 0.031	0.0LeuXaa: 0.0 ± 0.0
Met	3.762MetAla: 3.762 ± 0.049	0.143MetCys: 0.143 ± 0.009	1.124MetAsp: 1.124 ± 0.025	1.193MetGlu: 1.193 ± 0.027	0.611MetPhe: 0.611 ± 0.017	1.875MetGly: 1.875 ± 0.035	0.411MetHis: 0.411 ± 0.018	1.029MetIle: 1.029 ± 0.026	0.663MetLys: 0.663 ± 0.02	2.932MetLeu: 2.932 ± 0.053	0.625MetMet: 0.625 ± 0.02	0.63MetAsn: 0.63 ± 0.02	1.854MetPro: 1.854 ± 0.034	0.91MetGln: 0.91 ± 0.025	1.99MetArg: 1.99 ± 0.034	1.39MetSer: 1.39 ± 0.027	1.612MetThr: 1.612 ± 0.033	1.841MetVal: 1.841 ± 0.035	0.197MetTrp: 0.197 ± 0.011	0.261MetTyr: 0.261 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	2.713AsnAla: 2.713 ± 0.041	0.178AsnCys: 0.178 ± 0.011	1.006AsnAsp: 1.006 ± 0.028	0.861AsnGlu: 0.861 ± 0.023	0.747AsnPhe: 0.747 ± 0.02	1.978AsnGly: 1.978 ± 0.037	0.483AsnHis: 0.483 ± 0.018	0.985AsnIle: 0.985 ± 0.023	0.47AsnLys: 0.47 ± 0.017	2.36AsnLeu: 2.36 ± 0.035	0.458AsnMet: 0.458 ± 0.016	0.592AsnAsn: 0.592 ± 0.023	1.733AsnPro: 1.733 ± 0.033	0.613AsnGln: 0.613 ± 0.021	1.715AsnArg: 1.715 ± 0.032	0.985AsnSer: 0.985 ± 0.026	1.103AsnThr: 1.103 ± 0.028	1.474AsnVal: 1.474 ± 0.031	0.374AsnTrp: 0.374 ± 0.014	0.483AsnTyr: 0.483 ± 0.017	0.0AsnXaa: 0.0 ± 0.0
Pro	8.878ProAla: 8.878 ± 0.092	0.38ProCys: 0.38 ± 0.016	3.791ProAsp: 3.791 ± 0.047	4.701ProGlu: 4.701 ± 0.056	2.082ProPhe: 2.082 ± 0.033	6.161ProGly: 6.161 ± 0.065	1.239ProHis: 1.239 ± 0.028	1.925ProIle: 1.925 ± 0.036	1.227ProLys: 1.227 ± 0.029	6.192ProLeu: 6.192 ± 0.072	1.409ProMet: 1.409 ± 0.028	1.292ProAsn: 1.292 ± 0.03	4.134ProPro: 4.134 ± 0.083	1.959ProGln: 1.959 ± 0.036	4.149ProArg: 4.149 ± 0.053	2.825ProSer: 2.825 ± 0.046	2.534ProThr: 2.534 ± 0.044	4.826ProVal: 4.826 ± 0.055	0.949ProTrp: 0.949 ± 0.026	1.148ProTyr: 1.148 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	5.168GlnAla: 5.168 ± 0.062	0.18GlnCys: 0.18 ± 0.011	1.736GlnAsp: 1.736 ± 0.038	1.702GlnGlu: 1.702 ± 0.036	0.89GlnPhe: 0.89 ± 0.025	2.987GlnGly: 2.987 ± 0.046	0.763GlnHis: 0.763 ± 0.022	1.391GlnIle: 1.391 ± 0.029	0.802GlnLys: 0.802 ± 0.021	2.798GlnLeu: 2.798 ± 0.041	0.845GlnMet: 0.845 ± 0.023	0.709GlnAsn: 0.709 ± 0.022	2.335GlnPro: 2.335 ± 0.042	1.494GlnGln: 1.494 ± 0.039	2.945GlnArg: 2.945 ± 0.045	1.458GlnSer: 1.458 ± 0.033	1.385GlnThr: 1.385 ± 0.034	2.603GlnVal: 2.603 ± 0.045	0.389GlnTrp: 0.389 ± 0.015	0.52GlnTyr: 0.52 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	10.285ArgAla: 10.285 ± 0.085	0.643ArgCys: 0.643 ± 0.02	4.311ArgAsp: 4.311 ± 0.057	4.379ArgGlu: 4.379 ± 0.063	3.106ArgPhe: 3.106 ± 0.041	5.896ArgGly: 5.896 ± 0.059	2.068ArgHis: 2.068 ± 0.037	3.85ArgIle: 3.85 ± 0.046	1.64ArgLys: 1.64 ± 0.035	9.749ArgLeu: 9.749 ± 0.087	2.18ArgMet: 2.18 ± 0.037	1.795ArgAsn: 1.795 ± 0.038	4.813ArgPro: 4.813 ± 0.057	3.317ArgGln: 3.317 ± 0.053	7.54ArgArg: 7.54 ± 0.074	3.506ArgSer: 3.506 ± 0.045	3.279ArgThr: 3.279 ± 0.049	5.417ArgVal: 5.417 ± 0.054	1.292ArgTrp: 1.292 ± 0.025	1.597ArgTyr: 1.597 ± 0.03	0.0ArgXaa: 0.0 ± 0.0
Ser	6.049SerAla: 6.049 ± 0.069	0.41SerCys: 0.41 ± 0.015	2.123SerAsp: 2.123 ± 0.041	2.138SerGlu: 2.138 ± 0.037	1.994SerPhe: 1.994 ± 0.035	5.183SerGly: 5.183 ± 0.051	1.02SerHis: 1.02 ± 0.024	2.206SerIle: 2.206 ± 0.036	0.901SerLys: 0.901 ± 0.027	5.435SerLeu: 5.435 ± 0.062	1.155SerMet: 1.155 ± 0.026	1.038SerAsn: 1.038 ± 0.021	2.925SerPro: 2.925 ± 0.041	1.363SerGln: 1.363 ± 0.033	3.765SerArg: 3.765 ± 0.043	2.47SerSer: 2.47 ± 0.045	2.438SerThr: 2.438 ± 0.042	3.319SerVal: 3.319 ± 0.049	0.81SerTrp: 0.81 ± 0.024	1.11SerTyr: 1.11 ± 0.027	0.0SerXaa: 0.0 ± 0.0
Thr	6.319ThrAla: 6.319 ± 0.057	0.369ThrCys: 0.369 ± 0.017	2.403ThrAsp: 2.403 ± 0.034	2.444ThrGlu: 2.444 ± 0.04	1.562ThrPhe: 1.562 ± 0.035	4.935ThrGly: 4.935 ± 0.061	0.958ThrHis: 0.958 ± 0.024	2.088ThrIle: 2.088 ± 0.037	0.971ThrLys: 0.971 ± 0.025	6.065ThrLeu: 6.065 ± 0.066	1.09ThrMet: 1.09 ± 0.024	1.011ThrAsn: 1.011 ± 0.025	3.572ThrPro: 3.572 ± 0.046	1.366ThrGln: 1.366 ± 0.025	3.524ThrArg: 3.524 ± 0.055	2.228ThrSer: 2.228 ± 0.038	2.649ThrThr: 2.649 ± 0.043	3.959ThrVal: 3.959 ± 0.049	0.632ThrTrp: 0.632 ± 0.019	0.925ThrTyr: 0.925 ± 0.023	0.0ThrXaa: 0.0 ± 0.0
Val	10.178ValAla: 10.178 ± 0.086	0.577ValCys: 0.577 ± 0.017	3.357ValAsp: 3.357 ± 0.044	4.536ValGlu: 4.536 ± 0.058	2.452ValPhe: 2.452 ± 0.037	5.257ValGly: 5.257 ± 0.061	1.3ValHis: 1.3 ± 0.023	3.013ValIle: 3.013 ± 0.044	1.619ValLys: 1.619 ± 0.034	8.707ValLeu: 8.707 ± 0.082	1.865ValMet: 1.865 ± 0.034	1.672ValAsn: 1.672 ± 0.034	4.684ValPro: 4.684 ± 0.049	2.373ValGln: 2.373 ± 0.037	5.01ValArg: 5.01 ± 0.06	3.705ValSer: 3.705 ± 0.049	4.141ValThr: 4.141 ± 0.045	6.358ValVal: 6.358 ± 0.078	0.893ValTrp: 0.893 ± 0.024	1.087ValTyr: 1.087 ± 0.028	0.0ValXaa: 0.0 ± 0.0
Trp	1.557TrpAla: 1.557 ± 0.034	0.169TrpCys: 0.169 ± 0.009	0.674TrpAsp: 0.674 ± 0.022	0.642TrpGlu: 0.642 ± 0.02	0.523TrpPhe: 0.523 ± 0.017	1.093TrpGly: 1.093 ± 0.027	0.405TrpHis: 0.405 ± 0.016	0.529TrpIle: 0.529 ± 0.018	0.359TrpLys: 0.359 ± 0.014	1.899TrpLeu: 1.899 ± 0.041	0.397TrpMet: 0.397 ± 0.017	0.402TrpAsn: 0.402 ± 0.014	0.899TrpPro: 0.899 ± 0.023	0.681TrpGln: 0.681 ± 0.018	1.529TrpArg: 1.529 ± 0.032	0.797TrpSer: 0.797 ± 0.024	0.768TrpThr: 0.768 ± 0.024	0.919TrpVal: 0.919 ± 0.028	0.25TrpTrp: 0.25 ± 0.013	0.277TrpTyr: 0.277 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.486TyrAla: 2.486 ± 0.045	0.185TyrCys: 0.185 ± 0.011	1.133TyrAsp: 1.133 ± 0.025	0.911TyrGlu: 0.911 ± 0.023	0.626TyrPhe: 0.626 ± 0.018	1.843TyrGly: 1.843 ± 0.032	0.386TyrHis: 0.386 ± 0.013	0.601TyrIle: 0.601 ± 0.017	0.372TyrLys: 0.372 ± 0.016	1.935TyrLeu: 1.935 ± 0.036	0.351TyrMet: 0.351 ± 0.015	0.454TyrAsn: 0.454 ± 0.018	1.076TyrPro: 1.076 ± 0.026	0.548TyrGln: 0.548 ± 0.017	1.623TyrArg: 1.623 ± 0.033	0.879TyrSer: 0.879 ± 0.024	0.876TyrThr: 0.876 ± 0.022	1.34TyrVal: 1.34 ± 0.028	0.303TyrTrp: 0.303 ± 0.014	0.427TyrTyr: 0.427 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5527 proteins (1684659 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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