Amino acid dipepetide frequency for Pyrolobus fumarii (strain DSM 11204 / 1A)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.978AlaAla: 10.978 ± 0.204
0.911AlaCys: 0.911 ± 0.045
2.803AlaAsp: 2.803 ± 0.079
6.362AlaGlu: 6.362 ± 0.119
2.5AlaPhe: 2.5 ± 0.077
7.003AlaGly: 7.003 ± 0.128
1.443AlaHis: 1.443 ± 0.059
5.573AlaIle: 5.573 ± 0.116
4.677AlaLys: 4.677 ± 0.093
11.447AlaLeu: 11.447 ± 0.197
2.166AlaMet: 2.166 ± 0.072
1.656AlaAsn: 1.656 ± 0.055
3.807AlaPro: 3.807 ± 0.093
1.57AlaGln: 1.57 ± 0.057
9.069AlaArg: 9.069 ± 0.138
6.016AlaSer: 6.016 ± 0.135
4.489AlaThr: 4.489 ± 0.112
8.203AlaVal: 8.203 ± 0.125
1.611AlaTrp: 1.611 ± 0.059
3.248AlaTyr: 3.248 ± 0.079
0.0AlaXaa: 0.0 ± 0.0
Cys
0.62CysAla: 0.62 ± 0.037
0.207CysCys: 0.207 ± 0.024
0.399CysAsp: 0.399 ± 0.03
0.626CysGlu: 0.626 ± 0.038
0.259CysPhe: 0.259 ± 0.026
1.181CysGly: 1.181 ± 0.062
0.255CysHis: 0.255 ± 0.047
0.678CysIle: 0.678 ± 0.037
0.585CysLys: 0.585 ± 0.035
0.752CysLeu: 0.752 ± 0.04
0.251CysMet: 0.251 ± 0.021
0.378CysAsn: 0.378 ± 0.026
0.866CysPro: 0.866 ± 0.046
0.129CysGln: 0.129 ± 0.013
0.859CysArg: 0.859 ± 0.045
0.738CysSer: 0.738 ± 0.041
0.559CysThr: 0.559 ± 0.035
0.745CysVal: 0.745 ± 0.045
0.14CysTrp: 0.14 ± 0.016
0.305CysTyr: 0.305 ± 0.023
0.0CysXaa: 0.0 ± 0.0
Asp
4.625AspAla: 4.625 ± 0.087
0.343AspCys: 0.343 ± 0.027
1.786AspAsp: 1.786 ± 0.062
3.898AspGlu: 3.898 ± 0.088
1.114AspPhe: 1.114 ± 0.05
2.988AspGly: 2.988 ± 0.072
0.622AspHis: 0.622 ± 0.034
2.988AspIle: 2.988 ± 0.083
2.01AspLys: 2.01 ± 0.062
3.638AspLeu: 3.638 ± 0.09
0.894AspMet: 0.894 ± 0.039
0.955AspAsn: 0.955 ± 0.043
3.191AspPro: 3.191 ± 0.087
0.522AspGln: 0.522 ± 0.033
2.49AspArg: 2.49 ± 0.066
1.822AspSer: 1.822 ± 0.059
2.146AspThr: 2.146 ± 0.065
4.768AspVal: 4.768 ± 0.096
0.639AspTrp: 0.639 ± 0.041
1.79AspTyr: 1.79 ± 0.059
0.0AspXaa: 0.0 ± 0.0
Glu
9.452GluAla: 9.452 ± 0.138
0.855GluCys: 0.855 ± 0.048
2.932GluAsp: 2.932 ± 0.086
7.895GluGlu: 7.895 ± 0.19
1.809GluPhe: 1.809 ± 0.065
5.124GluGly: 5.124 ± 0.096
1.579GluHis: 1.579 ± 0.056
4.081GluIle: 4.081 ± 0.12
5.221GluLys: 5.221 ± 0.13
7.702GluLeu: 7.702 ± 0.134
1.544GluMet: 1.544 ± 0.056
1.63GluAsn: 1.63 ± 0.062
3.71GluPro: 3.71 ± 0.091
1.611GluGln: 1.611 ± 0.057
6.545GluArg: 6.545 ± 0.145
3.127GluSer: 3.127 ± 0.075
3.328GluThr: 3.328 ± 0.091
6.482GluVal: 6.482 ± 0.125
1.112GluTrp: 1.112 ± 0.046
2.909GluTyr: 2.909 ± 0.088
0.0GluXaa: 0.0 ± 0.0
Phe
2.418PheAla: 2.418 ± 0.074
0.266PheCys: 0.266 ± 0.021
1.471PheAsp: 1.471 ± 0.061
2.228PheGlu: 2.228 ± 0.066
0.821PhePhe: 0.821 ± 0.04
1.728PheGly: 1.728 ± 0.067
0.576PheHis: 0.576 ± 0.032
1.686PheIle: 1.686 ± 0.055
1.054PheLys: 1.054 ± 0.047
2.323PheLeu: 2.323 ± 0.077
0.613PheMet: 0.613 ± 0.031
0.881PheAsn: 0.881 ± 0.041
0.901PhePro: 0.901 ± 0.036
0.507PheGln: 0.507 ± 0.028
1.909PheArg: 1.909 ± 0.061
1.402PheSer: 1.402 ± 0.057
1.784PheThr: 1.784 ± 0.069
2.308PheVal: 2.308 ± 0.064
0.317PheTrp: 0.317 ± 0.021
1.116PheTyr: 1.116 ± 0.048
0.0PheXaa: 0.0 ± 0.0
Gly
5.936GlyAla: 5.936 ± 0.101
1.043GlyCys: 1.043 ± 0.052
3.442GlyAsp: 3.442 ± 0.08
5.48GlyGlu: 5.48 ± 0.101
3.163GlyPhe: 3.163 ± 0.075
5.908GlyGly: 5.908 ± 0.115
1.276GlyHis: 1.276 ± 0.056
4.668GlyIle: 4.668 ± 0.105
3.636GlyLys: 3.636 ± 0.095
8.085GlyLeu: 8.085 ± 0.145
1.857GlyMet: 1.857 ± 0.06
1.442GlyAsn: 1.442 ± 0.058
2.706GlyPro: 2.706 ± 0.075
1.043GlyGln: 1.043 ± 0.047
5.64GlyArg: 5.64 ± 0.12
4.098GlySer: 4.098 ± 0.1
2.781GlyThr: 2.781 ± 0.082
8.486GlyVal: 8.486 ± 0.14
1.229GlyTrp: 1.229 ± 0.047
3.096GlyTyr: 3.096 ± 0.082
0.0GlyXaa: 0.0 ± 0.0
His
1.753HisAla: 1.753 ± 0.059
0.231HisCys: 0.231 ± 0.022
0.827HisAsp: 0.827 ± 0.041
1.283HisGlu: 1.283 ± 0.049
0.402HisPhe: 0.402 ± 0.027
1.784HisGly: 1.784 ± 0.05
0.503HisHis: 0.503 ± 0.036
1.049HisIle: 1.049 ± 0.049
0.574HisLys: 0.574 ± 0.032
1.922HisLeu: 1.922 ± 0.065
0.447HisMet: 0.447 ± 0.026
0.408HisAsn: 0.408 ± 0.028
1.38HisPro: 1.38 ± 0.057
0.3HisGln: 0.3 ± 0.024
1.287HisArg: 1.287 ± 0.048
0.814HisSer: 0.814 ± 0.041
0.847HisThr: 0.847 ± 0.041
2.032HisVal: 2.032 ± 0.064
0.259HisTrp: 0.259 ± 0.022
0.706HisTyr: 0.706 ± 0.037
0.0HisXaa: 0.0 ± 0.0
Ile
6.534IleAla: 6.534 ± 0.12
0.466IleCys: 0.466 ± 0.035
3.572IleAsp: 3.572 ± 0.084
5.26IleGlu: 5.26 ± 0.123
1.188IlePhe: 1.188 ± 0.049
3.986IleGly: 3.986 ± 0.102
1.322IleHis: 1.322 ± 0.06
3.591IleIle: 3.591 ± 0.097
1.879IleLys: 1.879 ± 0.073
6.355IleLeu: 6.355 ± 0.116
1.013IleMet: 1.013 ± 0.048
1.328IleAsn: 1.328 ± 0.059
2.969IlePro: 2.969 ± 0.082
0.885IleGln: 0.885 ± 0.043
4.088IleArg: 4.088 ± 0.102
2.313IleSer: 2.313 ± 0.071
2.539IleThr: 2.539 ± 0.075
7.236IleVal: 7.236 ± 0.112
0.469IleTrp: 0.469 ± 0.03
1.887IleTyr: 1.887 ± 0.06
0.0IleXaa: 0.0 ± 0.0
Lys
3.943LysAla: 3.943 ± 0.091
0.549LysCys: 0.549 ± 0.034
1.287LysAsp: 1.287 ± 0.054
2.632LysGlu: 2.632 ± 0.088
1.002LysPhe: 1.002 ± 0.047
3.062LysGly: 3.062 ± 0.084
0.969LysHis: 0.969 ± 0.043
2.598LysIle: 2.598 ± 0.084
2.38LysLys: 2.38 ± 0.097
6.806LysLeu: 6.806 ± 0.115
1.0LysMet: 1.0 ± 0.052
0.78LysAsn: 0.78 ± 0.037
3.282LysPro: 3.282 ± 0.08
0.834LysGln: 0.834 ± 0.045
4.319LysArg: 4.319 ± 0.091
2.099LysSer: 2.099 ± 0.069
2.093LysThr: 2.093 ± 0.059
3.494LysVal: 3.494 ± 0.084
0.63LysTrp: 0.63 ± 0.037
1.36LysTyr: 1.36 ± 0.055
0.0LysXaa: 0.0 ± 0.0
Leu
12.548LeuAla: 12.548 ± 0.201
0.898LeuCys: 0.898 ± 0.042
5.496LeuAsp: 5.496 ± 0.103
10.101LeuGlu: 10.101 ± 0.162
2.49LeuPhe: 2.49 ± 0.066
8.633LeuGly: 8.633 ± 0.128
2.323LeuHis: 2.323 ± 0.072
5.169LeuIle: 5.169 ± 0.098
4.302LeuLys: 4.302 ± 0.091
13.071LeuLeu: 13.071 ± 0.244
2.013LeuMet: 2.013 ± 0.07
2.22LeuAsn: 2.22 ± 0.074
5.102LeuPro: 5.102 ± 0.114
2.127LeuGln: 2.127 ± 0.067
9.423LeuArg: 9.423 ± 0.162
5.738LeuSer: 5.738 ± 0.118
4.44LeuThr: 4.44 ± 0.111
11.294LeuVal: 11.294 ± 0.171
1.315LeuTrp: 1.315 ± 0.062
4.029LeuTyr: 4.029 ± 0.097
0.0LeuXaa: 0.0 ± 0.0
Met
2.038MetAla: 2.038 ± 0.063
0.21MetCys: 0.21 ± 0.019
0.78MetAsp: 0.78 ± 0.04
1.313MetGlu: 1.313 ± 0.054
0.492MetPhe: 0.492 ± 0.029
1.689MetGly: 1.689 ± 0.056
0.492MetHis: 0.492 ± 0.028
1.257MetIle: 1.257 ± 0.048
1.056MetLys: 1.056 ± 0.048
3.069MetLeu: 3.069 ± 0.082
0.469MetMet: 0.469 ± 0.029
0.408MetAsn: 0.408 ± 0.025
1.203MetPro: 1.203 ± 0.044
0.458MetGln: 0.458 ± 0.028
1.779MetArg: 1.779 ± 0.063
1.345MetSer: 1.345 ± 0.049
0.941MetThr: 0.941 ± 0.042
1.902MetVal: 1.902 ± 0.067
0.19MetTrp: 0.19 ± 0.018
0.583MetTyr: 0.583 ± 0.032
0.0MetXaa: 0.0 ± 0.0
Asn
2.105AsnAla: 2.105 ± 0.063
0.216AsnCys: 0.216 ± 0.02
0.915AsnAsp: 0.915 ± 0.044
1.382AsnGlu: 1.382 ± 0.058
0.464AsnPhe: 0.464 ± 0.031
1.496AsnGly: 1.496 ± 0.053
0.302AsnHis: 0.302 ± 0.024
1.663AsnIle: 1.663 ± 0.062
0.769AsnLys: 0.769 ± 0.047
2.142AsnLeu: 2.142 ± 0.06
0.6AsnMet: 0.6 ± 0.035
0.535AsnAsn: 0.535 ± 0.035
1.877AsnPro: 1.877 ± 0.065
0.324AsnGln: 0.324 ± 0.024
1.179AsnArg: 1.179 ± 0.054
0.883AsnSer: 0.883 ± 0.043
1.216AsnThr: 1.216 ± 0.055
2.423AsnVal: 2.423 ± 0.076
0.222AsnTrp: 0.222 ± 0.02
0.65AsnTyr: 0.65 ± 0.036
0.0AsnXaa: 0.0 ± 0.0
Pro
3.381ProAla: 3.381 ± 0.088
0.596ProCys: 0.596 ± 0.037
2.434ProAsp: 2.434 ± 0.064
4.105ProGlu: 4.105 ± 0.084
1.326ProPhe: 1.326 ± 0.048
4.457ProGly: 4.457 ± 0.106
1.099ProHis: 1.099 ± 0.045
2.3ProIle: 2.3 ± 0.066
1.727ProLys: 1.727 ± 0.063
5.491ProLeu: 5.491 ± 0.106
0.849ProMet: 0.849 ± 0.038
1.019ProAsn: 1.019 ± 0.053
3.308ProPro: 3.308 ± 0.102
1.024ProGln: 1.024 ± 0.048
4.58ProArg: 4.58 ± 0.101
3.043ProSer: 3.043 ± 0.075
2.01ProThr: 2.01 ± 0.06
4.505ProVal: 4.505 ± 0.101
0.976ProTrp: 0.976 ± 0.044
1.73ProTyr: 1.73 ± 0.066
0.0ProXaa: 0.0 ± 0.0
Gln
1.807GlnAla: 1.807 ± 0.052
0.177GlnCys: 0.177 ± 0.021
0.579GlnAsp: 0.579 ± 0.03
1.213GlnGlu: 1.213 ± 0.052
0.333GlnPhe: 0.333 ± 0.024
1.313GlnGly: 1.313 ± 0.055
0.387GlnHis: 0.387 ± 0.026
0.732GlnIle: 0.732 ± 0.042
0.691GlnLys: 0.691 ± 0.036
2.289GlnLeu: 2.289 ± 0.057
0.423GlnMet: 0.423 ± 0.024
0.333GlnAsn: 0.333 ± 0.026
1.036GlnPro: 1.036 ± 0.053
0.602GlnGln: 0.602 ± 0.048
1.516GlnArg: 1.516 ± 0.052
0.708GlnSer: 0.708 ± 0.036
0.693GlnThr: 0.693 ± 0.038
1.646GlnVal: 1.646 ± 0.06
0.192GlnTrp: 0.192 ± 0.021
0.494GlnTyr: 0.494 ± 0.028
0.0GlnXaa: 0.0 ± 0.0
Arg
6.046ArgAla: 6.046 ± 0.107
0.916ArgCys: 0.916 ± 0.047
3.701ArgAsp: 3.701 ± 0.094
7.018ArgGlu: 7.018 ± 0.141
2.194ArgPhe: 2.194 ± 0.073
6.85ArgGly: 6.85 ± 0.114
1.265ArgHis: 1.265 ± 0.052
5.461ArgIle: 5.461 ± 0.109
3.192ArgLys: 3.192 ± 0.1
10.957ArgLeu: 10.957 ± 0.172
1.995ArgMet: 1.995 ± 0.064
1.458ArgAsn: 1.458 ± 0.047
2.945ArgPro: 2.945 ± 0.079
1.114ArgGln: 1.114 ± 0.047
7.551ArgArg: 7.551 ± 0.164
3.686ArgSer: 3.686 ± 0.085
2.177ArgThr: 2.177 ± 0.066
9.404ArgVal: 9.404 ± 0.169
1.071ArgTrp: 1.071 ± 0.041
2.434ArgTyr: 2.434 ± 0.075
0.0ArgXaa: 0.0 ± 0.0
Ser
3.341SerAla: 3.341 ± 0.091
0.587SerCys: 0.587 ± 0.035
2.032SerAsp: 2.032 ± 0.059
3.123SerGlu: 3.123 ± 0.089
1.563SerPhe: 1.563 ± 0.048
4.118SerGly: 4.118 ± 0.099
0.896SerHis: 0.896 ± 0.046
3.949SerIle: 3.949 ± 0.103
2.393SerLys: 2.393 ± 0.069
6.264SerLeu: 6.264 ± 0.113
1.499SerMet: 1.499 ± 0.054
1.17SerAsn: 1.17 ± 0.05
2.486SerPro: 2.486 ± 0.064
0.931SerGln: 0.931 ± 0.038
4.392SerArg: 4.392 ± 0.09
3.217SerSer: 3.217 ± 0.1
2.548SerThr: 2.548 ± 0.082
4.77SerVal: 4.77 ± 0.106
0.738SerTrp: 0.738 ± 0.037
1.514SerTyr: 1.514 ± 0.059
0.0SerXaa: 0.0 ± 0.0
Thr
3.718ThrAla: 3.718 ± 0.101
0.555ThrCys: 0.555 ± 0.034
1.358ThrAsp: 1.358 ± 0.048
2.017ThrGlu: 2.017 ± 0.075
1.058ThrPhe: 1.058 ± 0.046
4.172ThrGly: 4.172 ± 0.097
0.881ThrHis: 0.881 ± 0.043
3.015ThrIle: 3.015 ± 0.08
1.306ThrLys: 1.306 ± 0.058
6.253ThrLeu: 6.253 ± 0.149
0.965ThrMet: 0.965 ± 0.046
0.946ThrAsn: 0.946 ± 0.041
2.995ThrPro: 2.995 ± 0.082
0.68ThrGln: 0.68 ± 0.04
3.846ThrArg: 3.846 ± 0.081
2.786ThrSer: 2.786 ± 0.089
2.464ThrThr: 2.464 ± 0.126
4.217ThrVal: 4.217 ± 0.112
0.603ThrTrp: 0.603 ± 0.033
1.134ThrTyr: 1.134 ± 0.052
0.0ThrXaa: 0.0 ± 0.0
Val
9.724ValAla: 9.724 ± 0.157
0.944ValCys: 0.944 ± 0.046
5.172ValAsp: 5.172 ± 0.106
9.352ValGlu: 9.352 ± 0.144
2.917ValPhe: 2.917 ± 0.075
5.72ValGly: 5.72 ± 0.13
1.721ValHis: 1.721 ± 0.053
5.675ValIle: 5.675 ± 0.117
5.481ValLys: 5.481 ± 0.103
9.503ValLeu: 9.503 ± 0.138
1.9ValMet: 1.9 ± 0.057
2.442ValAsn: 2.442 ± 0.066
3.844ValPro: 3.844 ± 0.08
1.553ValGln: 1.553 ± 0.053
6.701ValArg: 6.701 ± 0.109
4.969ValSer: 4.969 ± 0.093
4.975ValThr: 4.975 ± 0.13
9.976ValVal: 9.976 ± 0.152
1.064ValTrp: 1.064 ± 0.041
4.599ValTyr: 4.599 ± 0.094
0.0ValXaa: 0.0 ± 0.0
Trp
1.015TrpAla: 1.015 ± 0.051
0.203TrpCys: 0.203 ± 0.021
0.607TrpAsp: 0.607 ± 0.036
0.831TrpGlu: 0.831 ± 0.039
0.445TrpPhe: 0.445 ± 0.034
1.064TrpGly: 1.064 ± 0.042
0.25TrpHis: 0.25 ± 0.024
0.685TrpIle: 0.685 ± 0.039
0.652TrpLys: 0.652 ± 0.032
1.781TrpLeu: 1.781 ± 0.056
0.343TrpMet: 0.343 ± 0.025
0.276TrpAsn: 0.276 ± 0.023
0.568TrpPro: 0.568 ± 0.035
0.242TrpGln: 0.242 ± 0.021
1.501TrpArg: 1.501 ± 0.049
0.831TrpSer: 0.831 ± 0.044
0.419TrpThr: 0.419 ± 0.031
1.203TrpVal: 1.203 ± 0.047
0.27TrpTrp: 0.27 ± 0.028
0.417TrpTyr: 0.417 ± 0.029
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.552TyrAla: 3.552 ± 0.08
0.358TyrCys: 0.358 ± 0.027
1.632TyrAsp: 1.632 ± 0.061
2.529TyrGlu: 2.529 ± 0.065
0.769TyrPhe: 0.769 ± 0.037
2.736TyrGly: 2.736 ± 0.075
0.648TyrHis: 0.648 ± 0.036
2.066TyrIle: 2.066 ± 0.065
1.535TyrLys: 1.535 ± 0.055
2.883TyrLeu: 2.883 ± 0.061
0.831TyrMet: 0.831 ± 0.035
1.097TyrAsn: 1.097 ± 0.052
1.784TyrPro: 1.784 ± 0.07
0.708TyrGln: 0.708 ± 0.038
2.762TyrArg: 2.762 ± 0.064
1.896TyrSer: 1.896 ± 0.063
2.52TyrThr: 2.52 ± 0.078
3.138TyrVal: 3.138 ± 0.083
0.557TyrTrp: 0.557 ± 0.033
1.27TyrTyr: 1.27 ± 0.049
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1967 proteins (536901 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski