Amino acid dipepetide frequency for Oecophyllibacter saccharovorans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.095AlaAla: 14.095 ± 0.196
1.466AlaCys: 1.466 ± 0.058
5.321AlaAsp: 5.321 ± 0.105
7.182AlaGlu: 7.182 ± 0.138
3.95AlaPhe: 3.95 ± 0.082
10.365AlaGly: 10.365 ± 0.155
2.691AlaHis: 2.691 ± 0.078
4.066AlaIle: 4.066 ± 0.096
2.612AlaLys: 2.612 ± 0.098
14.892AlaLeu: 14.892 ± 0.207
2.83AlaMet: 2.83 ± 0.072
2.293AlaAsn: 2.293 ± 0.075
7.448AlaPro: 7.448 ± 0.15
5.416AlaGln: 5.416 ± 0.122
9.694AlaArg: 9.694 ± 0.174
6.283AlaSer: 6.283 ± 0.116
5.408AlaThr: 5.408 ± 0.086
6.989AlaVal: 6.989 ± 0.115
1.627AlaTrp: 1.627 ± 0.063
2.243AlaTyr: 2.243 ± 0.066
0.0AlaXaa: 0.0 ± 0.0
Cys
1.316CysAla: 1.316 ± 0.043
0.148CysCys: 0.148 ± 0.017
0.482CysAsp: 0.482 ± 0.031
0.452CysGlu: 0.452 ± 0.029
0.332CysPhe: 0.332 ± 0.023
1.1CysGly: 1.1 ± 0.048
0.243CysHis: 0.243 ± 0.022
0.382CysIle: 0.382 ± 0.028
0.184CysLys: 0.184 ± 0.02
1.291CysLeu: 1.291 ± 0.053
0.168CysMet: 0.168 ± 0.019
0.259CysAsn: 0.259 ± 0.021
0.596CysPro: 0.596 ± 0.034
0.386CysGln: 0.386 ± 0.025
0.793CysArg: 0.793 ± 0.04
0.489CysSer: 0.489 ± 0.027
0.621CysThr: 0.621 ± 0.034
0.779CysVal: 0.779 ± 0.037
0.171CysTrp: 0.171 ± 0.016
0.184CysTyr: 0.184 ± 0.019
0.0CysXaa: 0.0 ± 0.0
Asp
4.594AspAla: 4.594 ± 0.104
0.489AspCys: 0.489 ± 0.03
2.048AspAsp: 2.048 ± 0.066
2.823AspGlu: 2.823 ± 0.091
1.894AspPhe: 1.894 ± 0.054
4.259AspGly: 4.259 ± 0.102
1.239AspHis: 1.239 ± 0.045
2.382AspIle: 2.382 ± 0.071
1.255AspLys: 1.255 ± 0.055
5.487AspLeu: 5.487 ± 0.109
1.245AspMet: 1.245 ± 0.044
1.089AspAsn: 1.089 ± 0.046
3.285AspPro: 3.285 ± 0.072
1.739AspGln: 1.739 ± 0.061
3.596AspArg: 3.596 ± 0.073
2.402AspSer: 2.402 ± 0.071
2.357AspThr: 2.357 ± 0.073
3.507AspVal: 3.507 ± 0.081
0.891AspTrp: 0.891 ± 0.04
1.284AspTyr: 1.284 ± 0.056
0.0AspXaa: 0.0 ± 0.0
Glu
7.856GluAla: 7.856 ± 0.16
0.35GluCys: 0.35 ± 0.026
2.591GluAsp: 2.591 ± 0.079
4.307GluGlu: 4.307 ± 0.116
1.359GluPhe: 1.359 ± 0.047
5.103GluGly: 5.103 ± 0.109
1.175GluHis: 1.175 ± 0.053
3.05GluIle: 3.05 ± 0.081
3.048GluLys: 3.048 ± 0.077
5.228GluLeu: 5.228 ± 0.11
1.505GluMet: 1.505 ± 0.053
1.869GluAsn: 1.869 ± 0.056
2.337GluPro: 2.337 ± 0.067
2.28GluGln: 2.28 ± 0.077
4.782GluArg: 4.782 ± 0.112
2.507GluSer: 2.507 ± 0.069
3.618GluThr: 3.618 ± 0.091
3.943GluVal: 3.943 ± 0.101
0.561GluTrp: 0.561 ± 0.03
0.793GluTyr: 0.793 ± 0.041
0.0GluXaa: 0.0 ± 0.0
Phe
3.248PheAla: 3.248 ± 0.074
0.555PheCys: 0.555 ± 0.033
1.832PheAsp: 1.832 ± 0.056
1.62PheGlu: 1.62 ± 0.056
1.384PhePhe: 1.384 ± 0.055
3.043PheGly: 3.043 ± 0.079
0.836PheHis: 0.836 ± 0.041
1.418PheIle: 1.418 ± 0.053
0.77PheLys: 0.77 ± 0.041
3.793PheLeu: 3.793 ± 0.09
0.893PheMet: 0.893 ± 0.038
1.02PheAsn: 1.02 ± 0.051
1.896PhePro: 1.896 ± 0.067
1.234PheGln: 1.234 ± 0.049
2.33PheArg: 2.33 ± 0.067
2.575PheSer: 2.575 ± 0.078
2.019PheThr: 2.019 ± 0.061
2.078PheVal: 2.078 ± 0.065
0.614PheTrp: 0.614 ± 0.038
0.861PheTyr: 0.861 ± 0.047
0.0PheXaa: 0.0 ± 0.0
Gly
8.999GlyAla: 8.999 ± 0.127
1.011GlyCys: 1.011 ± 0.045
3.535GlyAsp: 3.535 ± 0.092
4.65GlyGlu: 4.65 ± 0.103
3.173GlyPhe: 3.173 ± 0.081
7.137GlyGly: 7.137 ± 0.155
2.293GlyHis: 2.293 ± 0.072
3.8GlyIle: 3.8 ± 0.096
3.357GlyLys: 3.357 ± 0.076
9.751GlyLeu: 9.751 ± 0.154
2.346GlyMet: 2.346 ± 0.066
2.318GlyAsn: 2.318 ± 0.09
4.137GlyPro: 4.137 ± 0.094
4.073GlyGln: 4.073 ± 0.096
6.451GlyArg: 6.451 ± 0.112
4.626GlySer: 4.626 ± 0.11
4.944GlyThr: 4.944 ± 0.119
5.848GlyVal: 5.848 ± 0.109
1.518GlyTrp: 1.518 ± 0.056
1.884GlyTyr: 1.884 ± 0.064
0.0GlyXaa: 0.0 ± 0.0
His
2.536HisAla: 2.536 ± 0.065
0.25HisCys: 0.25 ± 0.02
1.355HisAsp: 1.355 ± 0.051
1.348HisGlu: 1.348 ± 0.047
0.943HisPhe: 0.943 ± 0.039
2.25HisGly: 2.25 ± 0.063
0.814HisHis: 0.814 ± 0.042
0.934HisIle: 0.934 ± 0.045
0.566HisLys: 0.566 ± 0.029
2.612HisLeu: 2.612 ± 0.071
0.525HisMet: 0.525 ± 0.032
0.664HisAsn: 0.664 ± 0.031
1.725HisPro: 1.725 ± 0.06
0.887HisGln: 0.887 ± 0.043
1.627HisArg: 1.627 ± 0.058
1.187HisSer: 1.187 ± 0.044
1.073HisThr: 1.073 ± 0.047
1.7HisVal: 1.7 ± 0.063
0.414HisTrp: 0.414 ± 0.03
0.709HisTyr: 0.709 ± 0.04
0.0HisXaa: 0.0 ± 0.0
Ile
4.846IleAla: 4.846 ± 0.09
0.564IleCys: 0.564 ± 0.032
2.45IleAsp: 2.45 ± 0.068
2.443IleGlu: 2.443 ± 0.07
1.398IlePhe: 1.398 ± 0.051
3.939IleGly: 3.939 ± 0.102
0.78IleHis: 0.78 ± 0.034
1.841IleIle: 1.841 ± 0.073
1.014IleLys: 1.014 ± 0.048
4.353IleLeu: 4.353 ± 0.109
0.93IleMet: 0.93 ± 0.041
1.221IleAsn: 1.221 ± 0.055
2.23IlePro: 2.23 ± 0.067
1.152IleGln: 1.152 ± 0.055
2.757IleArg: 2.757 ± 0.076
2.657IleSer: 2.657 ± 0.073
2.473IleThr: 2.473 ± 0.067
2.964IleVal: 2.964 ± 0.082
0.529IleTrp: 0.529 ± 0.028
0.903IleTyr: 0.903 ± 0.044
0.0IleXaa: 0.0 ± 0.0
Lys
4.069LysAla: 4.069 ± 0.109
0.171LysCys: 0.171 ± 0.018
1.507LysAsp: 1.507 ± 0.058
1.711LysGlu: 1.711 ± 0.061
0.761LysPhe: 0.761 ± 0.038
2.637LysGly: 2.637 ± 0.072
0.568LysHis: 0.568 ± 0.037
1.48LysIle: 1.48 ± 0.056
1.345LysLys: 1.345 ± 0.056
3.227LysLeu: 3.227 ± 0.091
0.709LysMet: 0.709 ± 0.04
0.937LysAsn: 0.937 ± 0.051
2.021LysPro: 2.021 ± 0.075
1.002LysGln: 1.002 ± 0.041
2.307LysArg: 2.307 ± 0.067
1.511LysSer: 1.511 ± 0.051
1.805LysThr: 1.805 ± 0.061
2.007LysVal: 2.007 ± 0.06
0.286LysTrp: 0.286 ± 0.022
0.609LysTyr: 0.609 ± 0.041
0.0LysXaa: 0.0 ± 0.0
Leu
13.795LeuAla: 13.795 ± 0.178
1.359LeuCys: 1.359 ± 0.046
5.319LeuAsp: 5.319 ± 0.115
6.474LeuGlu: 6.474 ± 0.133
3.659LeuPhe: 3.659 ± 0.096
8.987LeuGly: 8.987 ± 0.143
2.705LeuHis: 2.705 ± 0.085
4.321LeuIle: 4.321 ± 0.106
3.905LeuLys: 3.905 ± 0.087
12.354LeuLeu: 12.354 ± 0.211
2.443LeuMet: 2.443 ± 0.065
2.848LeuAsn: 2.848 ± 0.075
7.898LeuPro: 7.898 ± 0.139
5.085LeuGln: 5.085 ± 0.133
7.862LeuArg: 7.862 ± 0.146
7.099LeuSer: 7.099 ± 0.118
6.319LeuThr: 6.319 ± 0.117
7.165LeuVal: 7.165 ± 0.114
1.371LeuTrp: 1.371 ± 0.052
2.303LeuTyr: 2.303 ± 0.072
0.0LeuXaa: 0.0 ± 0.0
Met
2.984MetAla: 2.984 ± 0.075
0.168MetCys: 0.168 ± 0.017
0.973MetAsp: 0.973 ± 0.044
1.245MetGlu: 1.245 ± 0.048
0.604MetPhe: 0.604 ± 0.032
2.002MetGly: 2.002 ± 0.064
0.437MetHis: 0.437 ± 0.029
1.036MetIle: 1.036 ± 0.046
0.945MetLys: 0.945 ± 0.043
2.337MetLeu: 2.337 ± 0.065
0.55MetMet: 0.55 ± 0.032
0.662MetAsn: 0.662 ± 0.032
1.557MetPro: 1.557 ± 0.055
0.898MetGln: 0.898 ± 0.042
1.666MetArg: 1.666 ± 0.062
1.546MetSer: 1.546 ± 0.047
1.803MetThr: 1.803 ± 0.06
1.523MetVal: 1.523 ± 0.049
0.166MetTrp: 0.166 ± 0.019
0.243MetTyr: 0.243 ± 0.023
0.0MetXaa: 0.0 ± 0.0
Asn
2.993AsnAla: 2.993 ± 0.083
0.229AsnCys: 0.229 ± 0.019
1.212AsnAsp: 1.212 ± 0.052
1.096AsnGlu: 1.096 ± 0.042
0.92AsnPhe: 0.92 ± 0.045
2.559AsnGly: 2.559 ± 0.076
0.562AsnHis: 0.562 ± 0.032
1.205AsnIle: 1.205 ± 0.05
0.675AsnLys: 0.675 ± 0.045
2.637AsnLeu: 2.637 ± 0.067
0.621AsnMet: 0.621 ± 0.033
0.684AsnAsn: 0.684 ± 0.046
1.928AsnPro: 1.928 ± 0.065
0.878AsnGln: 0.878 ± 0.046
1.841AsnArg: 1.841 ± 0.053
1.253AsnSer: 1.253 ± 0.047
1.393AsnThr: 1.393 ± 0.052
1.775AsnVal: 1.775 ± 0.063
0.47AsnTrp: 0.47 ± 0.029
0.677AsnTyr: 0.677 ± 0.043
0.0AsnXaa: 0.0 ± 0.0
Pro
8.14ProAla: 8.14 ± 0.149
0.532ProCys: 0.532 ± 0.037
3.875ProAsp: 3.875 ± 0.078
4.857ProGlu: 4.857 ± 0.105
2.078ProPhe: 2.078 ± 0.064
5.591ProGly: 5.591 ± 0.1
1.65ProHis: 1.65 ± 0.055
1.798ProIle: 1.798 ± 0.056
1.5ProLys: 1.5 ± 0.066
6.369ProLeu: 6.369 ± 0.127
1.27ProMet: 1.27 ± 0.048
1.278ProAsn: 1.278 ± 0.051
4.239ProPro: 4.239 ± 0.119
2.905ProGln: 2.905 ± 0.075
3.341ProArg: 3.341 ± 0.078
3.584ProSer: 3.584 ± 0.088
3.021ProThr: 3.021 ± 0.085
4.817ProVal: 4.817 ± 0.091
0.887ProTrp: 0.887 ± 0.048
1.353ProTyr: 1.353 ± 0.043
0.0ProXaa: 0.0 ± 0.0
Gln
6.603GlnAla: 6.603 ± 0.158
0.229GlnCys: 0.229 ± 0.022
1.843GlnAsp: 1.843 ± 0.063
2.612GlnGlu: 2.612 ± 0.074
1.028GlnPhe: 1.028 ± 0.042
3.344GlnGly: 3.344 ± 0.082
0.945GlnHis: 0.945 ± 0.044
1.793GlnIle: 1.793 ± 0.057
1.628GlnLys: 1.628 ± 0.055
4.305GlnLeu: 4.305 ± 0.106
0.829GlnMet: 0.829 ± 0.036
1.136GlnAsn: 1.136 ± 0.052
2.885GlnPro: 2.885 ± 0.085
1.844GlnGln: 1.844 ± 0.087
2.691GlnArg: 2.691 ± 0.078
1.916GlnSer: 1.916 ± 0.067
2.187GlnThr: 2.187 ± 0.067
2.914GlnVal: 2.914 ± 0.077
0.523GlnTrp: 0.523 ± 0.032
0.636GlnTyr: 0.636 ± 0.039
0.0GlnXaa: 0.0 ± 0.0
Arg
7.587ArgAla: 7.587 ± 0.132
0.639ArgCys: 0.639 ± 0.034
3.378ArgAsp: 3.378 ± 0.084
4.346ArgGlu: 4.346 ± 0.101
2.855ArgPhe: 2.855 ± 0.07
4.607ArgGly: 4.607 ± 0.111
2.211ArgHis: 2.211 ± 0.076
3.269ArgIle: 3.269 ± 0.083
2.732ArgLys: 2.732 ± 0.073
9.301ArgLeu: 9.301 ± 0.166
1.634ArgMet: 1.634 ± 0.054
2.102ArgAsn: 2.102 ± 0.064
4.266ArgPro: 4.266 ± 0.087
3.737ArgGln: 3.737 ± 0.088
5.844ArgArg: 5.844 ± 0.127
3.494ArgSer: 3.494 ± 0.091
3.437ArgThr: 3.437 ± 0.074
4.278ArgVal: 4.278 ± 0.093
0.955ArgTrp: 0.955 ± 0.046
1.7ArgTyr: 1.7 ± 0.056
0.0ArgXaa: 0.0 ± 0.0
Ser
6.391SerAla: 6.391 ± 0.136
0.561SerCys: 0.561 ± 0.028
2.609SerAsp: 2.609 ± 0.078
2.777SerGlu: 2.777 ± 0.066
2.111SerPhe: 2.111 ± 0.064
5.817SerGly: 5.817 ± 0.115
1.277SerHis: 1.277 ± 0.049
2.007SerIle: 2.007 ± 0.07
1.218SerLys: 1.218 ± 0.047
6.319SerLeu: 6.319 ± 0.119
1.257SerMet: 1.257 ± 0.048
1.182SerAsn: 1.182 ± 0.052
3.719SerPro: 3.719 ± 0.09
2.186SerGln: 2.186 ± 0.074
3.794SerArg: 3.794 ± 0.082
3.423SerSer: 3.423 ± 0.095
2.8SerThr: 2.8 ± 0.077
3.671SerVal: 3.671 ± 0.084
0.984SerTrp: 0.984 ± 0.049
1.139SerTyr: 1.139 ± 0.044
0.0SerXaa: 0.0 ± 0.0
Thr
6.099ThrAla: 6.099 ± 0.113
0.466ThrCys: 0.466 ± 0.027
2.634ThrAsp: 2.634 ± 0.064
2.61ThrGlu: 2.61 ± 0.067
1.737ThrPhe: 1.737 ± 0.06
5.121ThrGly: 5.121 ± 0.098
1.262ThrHis: 1.262 ± 0.053
2.048ThrIle: 2.048 ± 0.061
1.071ThrLys: 1.071 ± 0.052
7.053ThrLeu: 7.053 ± 0.125
1.093ThrMet: 1.093 ± 0.048
1.205ThrAsn: 1.205 ± 0.05
4.728ThrPro: 4.728 ± 0.107
1.975ThrGln: 1.975 ± 0.068
3.705ThrArg: 3.705 ± 0.083
2.864ThrSer: 2.864 ± 0.081
2.669ThrThr: 2.669 ± 0.082
3.893ThrVal: 3.893 ± 0.09
0.623ThrTrp: 0.623 ± 0.033
1.1ThrTyr: 1.1 ± 0.05
0.0ThrXaa: 0.0 ± 0.0
Val
7.199ValAla: 7.199 ± 0.131
0.725ValCys: 0.725 ± 0.035
3.15ValAsp: 3.15 ± 0.08
3.969ValGlu: 3.969 ± 0.092
2.518ValPhe: 2.518 ± 0.082
4.821ValGly: 4.821 ± 0.106
1.473ValHis: 1.473 ± 0.059
3.266ValIle: 3.266 ± 0.084
1.803ValLys: 1.803 ± 0.072
7.894ValLeu: 7.894 ± 0.138
1.739ValMet: 1.739 ± 0.054
1.771ValAsn: 1.771 ± 0.061
4.298ValPro: 4.298 ± 0.105
2.537ValGln: 2.537 ± 0.071
4.451ValArg: 4.451 ± 0.105
4.114ValSer: 4.114 ± 0.087
4.344ValThr: 4.344 ± 0.09
5.007ValVal: 5.007 ± 0.109
0.795ValTrp: 0.795 ± 0.038
1.246ValTyr: 1.246 ± 0.053
0.0ValXaa: 0.0 ± 0.0
Trp
1.264TrpAla: 1.264 ± 0.05
0.184TrpCys: 0.184 ± 0.021
0.539TrpAsp: 0.539 ± 0.035
0.662TrpGlu: 0.662 ± 0.036
0.509TrpPhe: 0.509 ± 0.032
1.039TrpGly: 1.039 ± 0.047
0.405TrpHis: 0.405 ± 0.028
0.6TrpIle: 0.6 ± 0.033
0.541TrpLys: 0.541 ± 0.034
1.882TrpLeu: 1.882 ± 0.069
0.329TrpMet: 0.329 ± 0.026
0.445TrpAsn: 0.445 ± 0.031
0.83TrpPro: 0.83 ± 0.042
0.818TrpGln: 0.818 ± 0.039
1.216TrpArg: 1.216 ± 0.041
0.72TrpSer: 0.72 ± 0.037
0.641TrpThr: 0.641 ± 0.031
0.775TrpVal: 0.775 ± 0.04
0.227TrpTrp: 0.227 ± 0.023
0.296TrpTyr: 0.296 ± 0.027
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.253TyrAla: 2.253 ± 0.066
0.28TyrCys: 0.28 ± 0.024
1.212TyrAsp: 1.212 ± 0.044
1.078TyrGlu: 1.078 ± 0.051
0.805TyrPhe: 0.805 ± 0.042
2.13TyrGly: 2.13 ± 0.072
0.554TyrHis: 0.554 ± 0.033
0.75TyrIle: 0.75 ± 0.044
0.5TyrLys: 0.5 ± 0.035
2.187TyrLeu: 2.187 ± 0.067
0.429TyrMet: 0.429 ± 0.025
0.625TyrAsn: 0.625 ± 0.035
1.061TyrPro: 1.061 ± 0.047
0.859TyrGln: 0.859 ± 0.044
1.625TyrArg: 1.625 ± 0.055
0.989TyrSer: 0.989 ± 0.051
1.023TyrThr: 1.023 ± 0.043
1.489TyrVal: 1.489 ± 0.061
0.311TyrTrp: 0.311 ± 0.024
0.552TyrTyr: 0.552 ± 0.03
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1612 proteins (560048 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski