Amino acid dipepetide frequency for Bdellovibrio exovorus JSS

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.787AlaAla: 6.787 ± 0.123
0.805AlaCys: 0.805 ± 0.038
3.993AlaAsp: 3.993 ± 0.075
5.259AlaGlu: 5.259 ± 0.086
3.316AlaPhe: 3.316 ± 0.07
5.372AlaGly: 5.372 ± 0.1
1.581AlaHis: 1.581 ± 0.046
4.519AlaIle: 4.519 ± 0.086
4.833AlaLys: 4.833 ± 0.099
8.133AlaLeu: 8.133 ± 0.109
1.709AlaMet: 1.709 ± 0.045
3.046AlaAsn: 3.046 ± 0.074
2.722AlaPro: 2.722 ± 0.07
4.046AlaGln: 4.046 ± 0.076
3.577AlaArg: 3.577 ± 0.063
5.058AlaSer: 5.058 ± 0.1
4.101AlaThr: 4.101 ± 0.089
5.036AlaVal: 5.036 ± 0.083
0.721AlaTrp: 0.721 ± 0.029
2.293AlaTyr: 2.293 ± 0.061
0.001AlaXaa: 0.001 ± 0.001
Cys
0.691CysAla: 0.691 ± 0.035
0.099CysCys: 0.099 ± 0.01
0.535CysAsp: 0.535 ± 0.025
0.629CysGlu: 0.629 ± 0.031
0.483CysPhe: 0.483 ± 0.025
0.732CysGly: 0.732 ± 0.034
0.254CysHis: 0.254 ± 0.017
0.446CysIle: 0.446 ± 0.021
0.481CysLys: 0.481 ± 0.027
0.943CysLeu: 0.943 ± 0.038
0.181CysMet: 0.181 ± 0.016
0.395CysAsn: 0.395 ± 0.032
0.513CysPro: 0.513 ± 0.031
0.365CysGln: 0.365 ± 0.024
0.473CysArg: 0.473 ± 0.026
0.726CysSer: 0.726 ± 0.04
0.516CysThr: 0.516 ± 0.032
0.645CysVal: 0.645 ± 0.031
0.106CysTrp: 0.106 ± 0.011
0.335CysTyr: 0.335 ± 0.022
0.0CysXaa: 0.0 ± 0.0
Asp
3.228AspAla: 3.228 ± 0.064
0.445AspCys: 0.445 ± 0.022
2.253AspAsp: 2.253 ± 0.064
3.445AspGlu: 3.445 ± 0.075
3.038AspPhe: 3.038 ± 0.07
3.04AspGly: 3.04 ± 0.072
1.12AspHis: 1.12 ± 0.04
3.523AspIle: 3.523 ± 0.062
3.065AspLys: 3.065 ± 0.074
5.826AspLeu: 5.826 ± 0.089
1.19AspMet: 1.19 ± 0.038
1.795AspAsn: 1.795 ± 0.046
2.175AspPro: 2.175 ± 0.055
2.259AspGln: 2.259 ± 0.057
2.492AspArg: 2.492 ± 0.063
3.335AspSer: 3.335 ± 0.064
2.149AspThr: 2.149 ± 0.057
3.541AspVal: 3.541 ± 0.066
0.663AspTrp: 0.663 ± 0.032
1.863AspTyr: 1.863 ± 0.049
0.001AspXaa: 0.001 ± 0.001
Glu
5.262GluAla: 5.262 ± 0.082
0.434GluCys: 0.434 ± 0.024
3.098GluAsp: 3.098 ± 0.071
4.002GluGlu: 4.002 ± 0.082
2.801GluPhe: 2.801 ± 0.058
3.401GluGly: 3.401 ± 0.073
1.156GluHis: 1.156 ± 0.041
4.602GluIle: 4.602 ± 0.084
5.489GluLys: 5.489 ± 0.091
6.396GluLeu: 6.396 ± 0.114
1.658GluMet: 1.658 ± 0.043
3.23GluAsn: 3.23 ± 0.064
1.817GluPro: 1.817 ± 0.048
2.832GluGln: 2.832 ± 0.057
3.002GluArg: 3.002 ± 0.06
4.19GluSer: 4.19 ± 0.073
3.107GluThr: 3.107 ± 0.06
4.838GluVal: 4.838 ± 0.087
0.665GluTrp: 0.665 ± 0.028
1.853GluTyr: 1.853 ± 0.048
0.0GluXaa: 0.0 ± 0.0
Phe
3.395PheAla: 3.395 ± 0.071
0.55PheCys: 0.55 ± 0.023
2.711PheAsp: 2.711 ± 0.058
2.971PheGlu: 2.971 ± 0.059
2.658PhePhe: 2.658 ± 0.068
3.004PheGly: 3.004 ± 0.073
0.938PheHis: 0.938 ± 0.032
3.044PheIle: 3.044 ± 0.073
3.198PheLys: 3.198 ± 0.063
4.939PheLeu: 4.939 ± 0.103
1.095PheMet: 1.095 ± 0.04
2.121PheAsn: 2.121 ± 0.057
1.685PhePro: 1.685 ± 0.052
1.836PheGln: 1.836 ± 0.045
1.978PheArg: 1.978 ± 0.055
3.889PheSer: 3.889 ± 0.068
2.309PheThr: 2.309 ± 0.056
3.2PheVal: 3.2 ± 0.071
0.55PheTrp: 0.55 ± 0.026
1.677PheTyr: 1.677 ± 0.051
0.001PheXaa: 0.001 ± 0.001
Gly
4.853GlyAla: 4.853 ± 0.093
0.671GlyCys: 0.671 ± 0.027
2.996GlyAsp: 2.996 ± 0.06
3.327GlyGlu: 3.327 ± 0.08
3.39GlyPhe: 3.39 ± 0.071
4.573GlyGly: 4.573 ± 0.122
1.445GlyHis: 1.445 ± 0.044
3.967GlyIle: 3.967 ± 0.085
3.831GlyLys: 3.831 ± 0.077
6.716GlyLeu: 6.716 ± 0.097
1.531GlyMet: 1.531 ± 0.063
2.255GlyAsn: 2.255 ± 0.064
1.927GlyPro: 1.927 ± 0.06
2.744GlyGln: 2.744 ± 0.068
2.974GlyArg: 2.974 ± 0.065
4.452GlySer: 4.452 ± 0.095
3.5GlyThr: 3.5 ± 0.089
4.432GlyVal: 4.432 ± 0.08
0.744GlyTrp: 0.744 ± 0.028
2.302GlyTyr: 2.302 ± 0.051
0.002GlyXaa: 0.002 ± 0.002
His
1.29HisAla: 1.29 ± 0.037
0.244HisCys: 0.244 ± 0.018
1.008HisAsp: 1.008 ± 0.039
1.229HisGlu: 1.229 ± 0.039
1.174HisPhe: 1.174 ± 0.042
1.256HisGly: 1.256 ± 0.05
0.55HisHis: 0.55 ± 0.028
1.352HisIle: 1.352 ± 0.034
1.026HisLys: 1.026 ± 0.038
2.315HisLeu: 2.315 ± 0.052
0.436HisMet: 0.436 ± 0.022
0.755HisAsn: 0.755 ± 0.032
1.108HisPro: 1.108 ± 0.04
0.971HisGln: 0.971 ± 0.038
1.038HisArg: 1.038 ± 0.04
1.321HisSer: 1.321 ± 0.042
0.887HisThr: 0.887 ± 0.03
1.295HisVal: 1.295 ± 0.043
0.244HisTrp: 0.244 ± 0.017
0.798HisTyr: 0.798 ± 0.032
0.0HisXaa: 0.0 ± 0.0
Ile
4.858IleAla: 4.858 ± 0.097
0.727IleCys: 0.727 ± 0.027
3.209IleAsp: 3.209 ± 0.07
4.713IleGlu: 4.713 ± 0.088
2.942IlePhe: 2.942 ± 0.08
4.073IleGly: 4.073 ± 0.082
1.245IleHis: 1.245 ± 0.038
3.55IleIle: 3.55 ± 0.074
4.23IleLys: 4.23 ± 0.079
6.309IleLeu: 6.309 ± 0.108
1.18IleMet: 1.18 ± 0.041
2.68IleAsn: 2.68 ± 0.057
2.867IlePro: 2.867 ± 0.057
2.943IleGln: 2.943 ± 0.06
3.137IleArg: 3.137 ± 0.066
5.033IleSer: 5.033 ± 0.095
3.33IleThr: 3.33 ± 0.063
4.008IleVal: 4.008 ± 0.082
0.646IleTrp: 0.646 ± 0.026
1.993IleTyr: 1.993 ± 0.044
0.0IleXaa: 0.0 ± 0.0
Lys
5.335LysAla: 5.335 ± 0.103
0.421LysCys: 0.421 ± 0.026
3.45LysAsp: 3.45 ± 0.075
4.558LysGlu: 4.558 ± 0.091
2.547LysPhe: 2.547 ± 0.049
3.517LysGly: 3.517 ± 0.066
1.069LysHis: 1.069 ± 0.038
5.112LysIle: 5.112 ± 0.089
6.627LysLys: 6.627 ± 0.115
5.933LysLeu: 5.933 ± 0.095
1.993LysMet: 1.993 ± 0.056
3.919LysAsn: 3.919 ± 0.061
2.535LysPro: 2.535 ± 0.06
2.47LysGln: 2.47 ± 0.056
2.977LysArg: 2.977 ± 0.063
4.986LysSer: 4.986 ± 0.097
4.297LysThr: 4.297 ± 0.067
4.407LysVal: 4.407 ± 0.091
0.786LysTrp: 0.786 ± 0.036
2.071LysTyr: 2.071 ± 0.055
0.001LysXaa: 0.001 ± 0.001
Leu
7.952LeuAla: 7.952 ± 0.098
0.905LeuCys: 0.905 ± 0.037
4.953LeuAsp: 4.953 ± 0.075
6.0LeuGlu: 6.0 ± 0.1
4.669LeuPhe: 4.669 ± 0.103
6.401LeuGly: 6.401 ± 0.102
1.883LeuHis: 1.883 ± 0.053
6.437LeuIle: 6.437 ± 0.118
8.111LeuLys: 8.111 ± 0.12
9.254LeuLeu: 9.254 ± 0.147
2.553LeuMet: 2.553 ± 0.057
5.085LeuAsn: 5.085 ± 0.093
3.907LeuPro: 3.907 ± 0.071
4.426LeuGln: 4.426 ± 0.088
4.542LeuArg: 4.542 ± 0.071
8.156LeuSer: 8.156 ± 0.116
5.471LeuThr: 5.471 ± 0.098
6.498LeuVal: 6.498 ± 0.1
0.922LeuTrp: 0.922 ± 0.036
2.545LeuTyr: 2.545 ± 0.067
0.0LeuXaa: 0.0 ± 0.0
Met
2.161MetAla: 2.161 ± 0.058
0.187MetCys: 0.187 ± 0.017
1.086MetAsp: 1.086 ± 0.039
1.042MetGlu: 1.042 ± 0.035
0.795MetPhe: 0.795 ± 0.038
1.642MetGly: 1.642 ± 0.049
0.365MetHis: 0.365 ± 0.018
1.429MetIle: 1.429 ± 0.041
2.231MetLys: 2.231 ± 0.055
1.956MetLeu: 1.956 ± 0.055
0.683MetMet: 0.683 ± 0.026
1.266MetAsn: 1.266 ± 0.045
0.963MetPro: 0.963 ± 0.037
1.024MetGln: 1.024 ± 0.035
1.133MetArg: 1.133 ± 0.042
2.062MetSer: 2.062 ± 0.052
1.57MetThr: 1.57 ± 0.042
1.344MetVal: 1.344 ± 0.046
0.204MetTrp: 0.204 ± 0.016
0.512MetTyr: 0.512 ± 0.026
0.0MetXaa: 0.0 ± 0.0
Asn
2.9AsnAla: 2.9 ± 0.055
0.506AsnCys: 0.506 ± 0.027
1.835AsnAsp: 1.835 ± 0.05
2.707AsnGlu: 2.707 ± 0.057
2.197AsnPhe: 2.197 ± 0.057
2.729AsnGly: 2.729 ± 0.081
0.847AsnHis: 0.847 ± 0.034
2.817AsnIle: 2.817 ± 0.06
2.904AsnLys: 2.904 ± 0.066
4.622AsnLeu: 4.622 ± 0.07
1.008AsnMet: 1.008 ± 0.033
1.922AsnAsn: 1.922 ± 0.056
2.436AsnPro: 2.436 ± 0.053
2.072AsnGln: 2.072 ± 0.051
2.206AsnArg: 2.206 ± 0.054
3.256AsnSer: 3.256 ± 0.073
2.523AsnThr: 2.523 ± 0.067
2.603AsnVal: 2.603 ± 0.061
0.618AsnTrp: 0.618 ± 0.027
1.707AsnTyr: 1.707 ± 0.044
0.0AsnXaa: 0.0 ± 0.0
Pro
3.021ProAla: 3.021 ± 0.074
0.296ProCys: 0.296 ± 0.02
2.147ProAsp: 2.147 ± 0.051
3.261ProGlu: 3.261 ± 0.064
1.826ProPhe: 1.826 ± 0.05
1.619ProGly: 1.619 ± 0.054
0.936ProHis: 0.936 ± 0.036
2.25ProIle: 2.25 ± 0.059
2.211ProLys: 2.211 ± 0.057
3.868ProLeu: 3.868 ± 0.072
0.809ProMet: 0.809 ± 0.031
1.771ProAsn: 1.771 ± 0.05
1.461ProPro: 1.461 ± 0.064
2.16ProGln: 2.16 ± 0.053
1.591ProArg: 1.591 ± 0.054
2.706ProSer: 2.706 ± 0.059
2.211ProThr: 2.211 ± 0.054
2.804ProVal: 2.804 ± 0.065
0.425ProTrp: 0.425 ± 0.022
1.23ProTyr: 1.23 ± 0.037
0.0ProXaa: 0.0 ± 0.0
Gln
3.514GlnAla: 3.514 ± 0.076
0.308GlnCys: 0.308 ± 0.021
2.237GlnAsp: 2.237 ± 0.057
2.619GlnGlu: 2.619 ± 0.067
1.982GlnPhe: 1.982 ± 0.049
2.393GlnGly: 2.393 ± 0.054
0.939GlnHis: 0.939 ± 0.037
3.323GlnIle: 3.323 ± 0.069
3.787GlnLys: 3.787 ± 0.077
4.419GlnLeu: 4.419 ± 0.077
1.362GlnMet: 1.362 ± 0.044
2.421GlnAsn: 2.421 ± 0.058
1.41GlnPro: 1.41 ± 0.046
2.304GlnGln: 2.304 ± 0.059
2.063GlnArg: 2.063 ± 0.051
3.023GlnSer: 3.023 ± 0.069
2.463GlnThr: 2.463 ± 0.06
3.023GlnVal: 3.023 ± 0.062
0.52GlnTrp: 0.52 ± 0.024
1.351GlnTyr: 1.351 ± 0.047
0.0GlnXaa: 0.0 ± 0.0
Arg
3.354ArgAla: 3.354 ± 0.066
0.385ArgCys: 0.385 ± 0.023
2.373ArgAsp: 2.373 ± 0.054
2.88ArgGlu: 2.88 ± 0.07
2.242ArgPhe: 2.242 ± 0.053
2.674ArgGly: 2.674 ± 0.068
1.069ArgHis: 1.069 ± 0.036
3.22ArgIle: 3.22 ± 0.065
2.953ArgLys: 2.953 ± 0.067
4.905ArgLeu: 4.905 ± 0.064
1.187ArgMet: 1.187 ± 0.036
2.012ArgAsn: 2.012 ± 0.046
1.753ArgPro: 1.753 ± 0.046
2.326ArgGln: 2.326 ± 0.06
2.425ArgArg: 2.425 ± 0.062
3.099ArgSer: 3.099 ± 0.063
2.289ArgThr: 2.289 ± 0.06
3.295ArgVal: 3.295 ± 0.061
0.539ArgTrp: 0.539 ± 0.026
1.62ArgTyr: 1.62 ± 0.044
0.0ArgXaa: 0.0 ± 0.0
Ser
5.556SerAla: 5.556 ± 0.089
0.872SerCys: 0.872 ± 0.056
3.694SerAsp: 3.694 ± 0.065
4.893SerGlu: 4.893 ± 0.085
3.918SerPhe: 3.918 ± 0.075
5.076SerGly: 5.076 ± 0.102
1.608SerHis: 1.608 ± 0.042
4.26SerIle: 4.26 ± 0.079
4.085SerLys: 4.085 ± 0.075
7.659SerLeu: 7.659 ± 0.106
1.532SerMet: 1.532 ± 0.045
2.771SerAsn: 2.771 ± 0.061
2.528SerPro: 2.528 ± 0.056
3.393SerGln: 3.393 ± 0.069
3.249SerArg: 3.249 ± 0.068
5.853SerSer: 5.853 ± 0.116
3.836SerThr: 3.836 ± 0.075
4.849SerVal: 4.849 ± 0.086
0.844SerTrp: 0.844 ± 0.035
2.568SerTyr: 2.568 ± 0.055
0.0SerXaa: 0.0 ± 0.0
Thr
4.574ThrAla: 4.574 ± 0.104
0.566ThrCys: 0.566 ± 0.041
2.845ThrAsp: 2.845 ± 0.057
3.559ThrGlu: 3.559 ± 0.07
2.25ThrPhe: 2.25 ± 0.05
3.828ThrGly: 3.828 ± 0.077
1.144ThrHis: 1.144 ± 0.037
3.008ThrIle: 3.008 ± 0.069
2.928ThrLys: 2.928 ± 0.062
5.349ThrLeu: 5.349 ± 0.087
1.041ThrMet: 1.041 ± 0.037
2.156ThrAsn: 2.156 ± 0.058
2.696ThrPro: 2.696 ± 0.057
2.515ThrGln: 2.515 ± 0.053
2.341ThrArg: 2.341 ± 0.051
3.784ThrSer: 3.784 ± 0.072
3.142ThrThr: 3.142 ± 0.082
3.631ThrVal: 3.631 ± 0.075
0.572ThrTrp: 0.572 ± 0.027
1.642ThrTyr: 1.642 ± 0.043
0.0ThrXaa: 0.0 ± 0.0
Val
5.324ValAla: 5.324 ± 0.097
0.644ValCys: 0.644 ± 0.028
3.725ValAsp: 3.725 ± 0.068
4.314ValGlu: 4.314 ± 0.072
3.213ValPhe: 3.213 ± 0.072
4.463ValGly: 4.463 ± 0.087
1.244ValHis: 1.244 ± 0.042
4.35ValIle: 4.35 ± 0.074
4.233ValLys: 4.233 ± 0.069
6.694ValLeu: 6.694 ± 0.107
1.585ValMet: 1.585 ± 0.047
2.77ValAsn: 2.77 ± 0.058
2.424ValPro: 2.424 ± 0.067
2.74ValGln: 2.74 ± 0.057
3.11ValArg: 3.11 ± 0.068
4.923ValSer: 4.923 ± 0.085
3.693ValThr: 3.693 ± 0.086
5.071ValVal: 5.071 ± 0.093
0.66ValTrp: 0.66 ± 0.026
1.935ValTyr: 1.935 ± 0.058
0.0ValXaa: 0.0 ± 0.0
Trp
0.849TrpAla: 0.849 ± 0.035
0.115TrpCys: 0.115 ± 0.012
0.535TrpAsp: 0.535 ± 0.022
0.419TrpGlu: 0.419 ± 0.021
0.467TrpPhe: 0.467 ± 0.022
0.753TrpGly: 0.753 ± 0.032
0.195TrpHis: 0.195 ± 0.016
0.72TrpIle: 0.72 ± 0.032
0.832TrpLys: 0.832 ± 0.034
1.202TrpLeu: 1.202 ± 0.041
0.34TrpMet: 0.34 ± 0.021
0.6TrpAsn: 0.6 ± 0.029
0.426TrpPro: 0.426 ± 0.024
0.465TrpGln: 0.465 ± 0.031
0.445TrpArg: 0.445 ± 0.023
0.863TrpSer: 0.863 ± 0.035
0.607TrpThr: 0.607 ± 0.024
0.739TrpVal: 0.739 ± 0.034
0.145TrpTrp: 0.145 ± 0.014
0.303TrpTyr: 0.303 ± 0.019
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.004TyrAla: 2.004 ± 0.055
0.369TyrCys: 0.369 ± 0.026
1.764TyrAsp: 1.764 ± 0.055
2.004TyrGlu: 2.004 ± 0.053
1.841TyrPhe: 1.841 ± 0.052
2.085TyrGly: 2.085 ± 0.06
0.711TyrHis: 0.711 ± 0.033
1.743TyrIle: 1.743 ± 0.052
1.954TyrLys: 1.954 ± 0.051
3.233TyrLeu: 3.233 ± 0.082
0.582TyrMet: 0.582 ± 0.028
1.445TyrAsn: 1.445 ± 0.047
1.251TyrPro: 1.251 ± 0.043
1.569TyrGln: 1.569 ± 0.043
1.845TyrArg: 1.845 ± 0.054
2.33TyrSer: 2.33 ± 0.054
1.569TyrThr: 1.569 ± 0.046
1.856TyrVal: 1.856 ± 0.044
0.445TyrTrp: 0.445 ± 0.022
1.135TyrTyr: 1.135 ± 0.043
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.001XaaGlu: 0.001 ± 0.001
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.001XaaLeu: 0.001 ± 0.001
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.001XaaGln: 0.001 ± 0.001
0.002XaaArg: 0.002 ± 0.002
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.001XaaVal: 0.001 ± 0.001
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.001XaaXaa: 0.001 ± 0.001
Statistics based on 2618 proteins (818528 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski