Amino acid dipepetide frequency for Aphanomyces astaci

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.121AlaAla: 11.121 ± 0.049	1.62AlaCys: 1.62 ± 0.014	4.667AlaAsp: 4.667 ± 0.023	3.717AlaGlu: 3.717 ± 0.026	3.408AlaPhe: 3.408 ± 0.019	4.268AlaGly: 4.268 ± 0.031	2.451AlaHis: 2.451 ± 0.016	4.307AlaIle: 4.307 ± 0.02	4.659AlaLys: 4.659 ± 0.031	9.313AlaLeu: 9.313 ± 0.032	2.789AlaMet: 2.789 ± 0.016	3.106AlaAsn: 3.106 ± 0.021	4.539AlaPro: 4.539 ± 0.027	3.338AlaGln: 3.338 ± 0.02	4.378AlaArg: 4.378 ± 0.025	7.711AlaSer: 7.711 ± 0.028	7.427AlaThr: 7.427 ± 0.036	6.839AlaVal: 6.839 ± 0.029	1.197AlaTrp: 1.197 ± 0.012	2.177AlaTyr: 2.177 ± 0.016	0.0AlaXaa: 0.0 ± 0.0
Cys	1.456CysAla: 1.456 ± 0.013	0.423CysCys: 0.423 ± 0.007	1.084CysAsp: 1.084 ± 0.011	0.667CysGlu: 0.667 ± 0.008	0.745CysPhe: 0.745 ± 0.009	1.303CysGly: 1.303 ± 0.014	0.64CysHis: 0.64 ± 0.007	0.885CysIle: 0.885 ± 0.009	0.662CysLys: 0.662 ± 0.008	1.686CysLeu: 1.686 ± 0.016	0.5CysMet: 0.5 ± 0.007	0.571CysAsn: 0.571 ± 0.009	1.018CysPro: 1.018 ± 0.021	0.666CysGln: 0.666 ± 0.008	1.187CysArg: 1.187 ± 0.013	1.276CysSer: 1.276 ± 0.013	1.14CysThr: 1.14 ± 0.013	1.532CysVal: 1.532 ± 0.012	0.232CysTrp: 0.232 ± 0.005	0.421CysTyr: 0.421 ± 0.006	0.0CysXaa: 0.0 ± 0.0
Asp	5.926AspAla: 5.926 ± 0.024	0.809AspCys: 0.809 ± 0.011	5.579AspAsp: 5.579 ± 0.044	3.901AspGlu: 3.901 ± 0.027	1.854AspPhe: 1.854 ± 0.013	3.911AspGly: 3.911 ± 0.019	1.609AspHis: 1.609 ± 0.014	2.703AspIle: 2.703 ± 0.018	2.633AspLys: 2.633 ± 0.019	5.04AspLeu: 5.04 ± 0.023	1.761AspMet: 1.761 ± 0.012	1.956AspAsn: 1.956 ± 0.015	2.654AspPro: 2.654 ± 0.015	2.026AspGln: 2.026 ± 0.013	2.704AspArg: 2.704 ± 0.017	3.477AspSer: 3.477 ± 0.016	3.344AspThr: 3.344 ± 0.019	5.276AspVal: 5.276 ± 0.025	0.673AspTrp: 0.673 ± 0.009	1.191AspTyr: 1.191 ± 0.012	0.0AspXaa: 0.0 ± 0.0
Glu	4.616GluAla: 4.616 ± 0.034	0.902GluCys: 0.902 ± 0.01	2.838GluAsp: 2.838 ± 0.02	2.759GluGlu: 2.759 ± 0.026	1.91GluPhe: 1.91 ± 0.014	2.439GluGly: 2.439 ± 0.017	1.444GluHis: 1.444 ± 0.013	1.989GluIle: 1.989 ± 0.015	2.231GluLys: 2.231 ± 0.02	4.977GluLeu: 4.977 ± 0.028	1.279GluMet: 1.279 ± 0.013	1.469GluAsn: 1.469 ± 0.012	1.922GluPro: 1.922 ± 0.014	1.774GluGln: 1.774 ± 0.015	3.027GluArg: 3.027 ± 0.021	3.42GluSer: 3.42 ± 0.019	2.634GluThr: 2.634 ± 0.015	3.325GluVal: 3.325 ± 0.021	0.79GluTrp: 0.79 ± 0.009	1.482GluTyr: 1.482 ± 0.012	0.0GluXaa: 0.0 ± 0.0
Phe	3.16PheAla: 3.16 ± 0.019	0.732PheCys: 0.732 ± 0.009	2.432PheAsp: 2.432 ± 0.014	1.889PheGlu: 1.889 ± 0.013	1.387PhePhe: 1.387 ± 0.013	2.588PheGly: 2.588 ± 0.019	1.29PheHis: 1.29 ± 0.012	1.316PheIle: 1.316 ± 0.012	1.456PheLys: 1.456 ± 0.011	3.376PheLeu: 3.376 ± 0.021	0.812PheMet: 0.812 ± 0.009	1.387PheAsn: 1.387 ± 0.014	1.774PhePro: 1.774 ± 0.015	1.641PheGln: 1.641 ± 0.012	2.028PheArg: 2.028 ± 0.016	2.406PheSer: 2.406 ± 0.015	2.052PheThr: 2.052 ± 0.017	3.213PheVal: 3.213 ± 0.019	0.442PheTrp: 0.442 ± 0.006	1.035PheTyr: 1.035 ± 0.01	0.0PheXaa: 0.0 ± 0.0
Gly	4.531GlyAla: 4.531 ± 0.035	1.132GlyCys: 1.132 ± 0.011	3.401GlyAsp: 3.401 ± 0.022	2.292GlyGlu: 2.292 ± 0.018	2.28GlyPhe: 2.28 ± 0.013	5.017GlyGly: 5.017 ± 0.051	1.991GlyHis: 1.991 ± 0.016	2.576GlyIle: 2.576 ± 0.015	2.509GlyLys: 2.509 ± 0.019	5.082GlyLeu: 5.082 ± 0.023	1.434GlyMet: 1.434 ± 0.011	2.002GlyAsn: 2.002 ± 0.018	2.221GlyPro: 2.221 ± 0.016	2.025GlyGln: 2.025 ± 0.017	3.351GlyArg: 3.351 ± 0.021	4.228GlySer: 4.228 ± 0.034	3.481GlyThr: 3.481 ± 0.033	4.363GlyVal: 4.363 ± 0.024	0.847GlyTrp: 0.847 ± 0.008	1.731GlyTyr: 1.731 ± 0.015	0.0GlyXaa: 0.0 ± 0.0
His	3.186HisAla: 3.186 ± 0.019	0.582HisCys: 0.582 ± 0.008	2.131HisAsp: 2.131 ± 0.015	1.63HisGlu: 1.63 ± 0.013	1.128HisPhe: 1.128 ± 0.009	2.14HisGly: 2.14 ± 0.016	1.547HisHis: 1.547 ± 0.018	1.292HisIle: 1.292 ± 0.011	1.143HisLys: 1.143 ± 0.012	3.125HisLeu: 3.125 ± 0.02	0.861HisMet: 0.861 ± 0.009	0.991HisAsn: 0.991 ± 0.01	1.999HisPro: 1.999 ± 0.015	1.407HisGln: 1.407 ± 0.011	2.155HisArg: 2.155 ± 0.017	2.023HisSer: 2.023 ± 0.015	1.831HisThr: 1.831 ± 0.012	3.137HisVal: 3.137 ± 0.02	0.416HisTrp: 0.416 ± 0.007	0.714HisTyr: 0.714 ± 0.009	0.0HisXaa: 0.0 ± 0.0
Ile	3.791IleAla: 3.791 ± 0.021	0.748IleCys: 0.748 ± 0.009	2.523IleAsp: 2.523 ± 0.017	2.131IleGlu: 2.131 ± 0.014	1.341IlePhe: 1.341 ± 0.013	2.205IleGly: 2.205 ± 0.016	1.33IleHis: 1.33 ± 0.013	1.296IleIle: 1.296 ± 0.011	1.797IleLys: 1.797 ± 0.014	3.78IleLeu: 3.78 ± 0.023	0.918IleMet: 0.918 ± 0.011	1.33IleAsn: 1.33 ± 0.012	2.293IlePro: 2.293 ± 0.014	2.075IleGln: 2.075 ± 0.015	2.269IleArg: 2.269 ± 0.014	2.713IleSer: 2.713 ± 0.017	2.181IleThr: 2.181 ± 0.019	3.416IleVal: 3.416 ± 0.02	0.458IleTrp: 0.458 ± 0.006	1.077IleTyr: 1.077 ± 0.012	0.0IleXaa: 0.0 ± 0.0
Lys	4.457LysAla: 4.457 ± 0.028	0.807LysCys: 0.807 ± 0.009	2.405LysAsp: 2.405 ± 0.019	2.303LysGlu: 2.303 ± 0.019	1.414LysPhe: 1.414 ± 0.013	2.125LysGly: 2.125 ± 0.016	1.502LysHis: 1.502 ± 0.013	1.548LysIle: 1.548 ± 0.013	2.998LysLys: 2.998 ± 0.03	4.389LysLeu: 4.389 ± 0.026	1.061LysMet: 1.061 ± 0.01	1.333LysAsn: 1.333 ± 0.013	2.365LysPro: 2.365 ± 0.015	2.172LysGln: 2.172 ± 0.017	3.108LysArg: 3.108 ± 0.022	3.152LysSer: 3.152 ± 0.019	2.554LysThr: 2.554 ± 0.018	2.903LysVal: 2.903 ± 0.018	0.676LysTrp: 0.676 ± 0.008	1.3LysTyr: 1.3 ± 0.013	0.0LysXaa: 0.0 ± 0.0
Leu	8.881LeuAla: 8.881 ± 0.03	1.817LeuCys: 1.817 ± 0.014	5.872LeuAsp: 5.872 ± 0.022	5.06LeuGlu: 5.06 ± 0.029	3.49LeuPhe: 3.49 ± 0.022	5.192LeuGly: 5.192 ± 0.023	3.855LeuHis: 3.855 ± 0.026	2.867LeuIle: 2.867 ± 0.018	4.265LeuLys: 4.265 ± 0.03	9.903LeuLeu: 9.903 ± 0.047	2.04LeuMet: 2.04 ± 0.015	3.114LeuAsn: 3.114 ± 0.018	5.37LeuPro: 5.37 ± 0.025	4.887LeuGln: 4.887 ± 0.026	6.06LeuArg: 6.06 ± 0.028	7.084LeuSer: 7.084 ± 0.031	5.628LeuThr: 5.628 ± 0.027	7.821LeuVal: 7.821 ± 0.033	1.276LeuTrp: 1.276 ± 0.012	2.472LeuTyr: 2.472 ± 0.015	0.0LeuXaa: 0.0 ± 0.0
Met	2.564MetAla: 2.564 ± 0.015	0.425MetCys: 0.425 ± 0.006	1.684MetAsp: 1.684 ± 0.013	1.517MetGlu: 1.517 ± 0.012	0.871MetPhe: 0.871 ± 0.008	1.334MetGly: 1.334 ± 0.011	0.869MetHis: 0.869 ± 0.009	0.798MetIle: 0.798 ± 0.009	1.078MetLys: 1.078 ± 0.011	2.546MetLeu: 2.546 ± 0.017	0.699MetMet: 0.699 ± 0.008	0.761MetAsn: 0.761 ± 0.01	1.177MetPro: 1.177 ± 0.01	1.293MetGln: 1.293 ± 0.01	1.304MetArg: 1.304 ± 0.013	1.967MetSer: 1.967 ± 0.013	1.629MetThr: 1.629 ± 0.012	1.664MetVal: 1.664 ± 0.014	0.371MetTrp: 0.371 ± 0.005	0.764MetTyr: 0.764 ± 0.009	0.0MetXaa: 0.0 ± 0.0
Asn	3.295AsnAla: 3.295 ± 0.018	0.549AsnCys: 0.549 ± 0.008	2.204AsnAsp: 2.204 ± 0.014	1.708AsnGlu: 1.708 ± 0.016	1.058AsnPhe: 1.058 ± 0.011	2.176AsnGly: 2.176 ± 0.016	1.054AsnHis: 1.054 ± 0.013	1.444AsnIle: 1.444 ± 0.012	1.349AsnLys: 1.349 ± 0.011	2.834AsnLeu: 2.834 ± 0.019	0.89AsnMet: 0.89 ± 0.01	1.361AsnAsn: 1.361 ± 0.012	1.887AsnPro: 1.887 ± 0.014	1.425AsnGln: 1.425 ± 0.013	1.646AsnArg: 1.646 ± 0.013	2.121AsnSer: 2.121 ± 0.015	1.88AsnThr: 1.88 ± 0.014	2.914AsnVal: 2.914 ± 0.02	0.412AsnTrp: 0.412 ± 0.007	0.829AsnTyr: 0.829 ± 0.01	0.0AsnXaa: 0.0 ± 0.0
Pro	4.361ProAla: 4.361 ± 0.029	0.785ProCys: 0.785 ± 0.014	2.606ProAsp: 2.606 ± 0.017	2.058ProGlu: 2.058 ± 0.016	1.842ProPhe: 1.842 ± 0.015	2.344ProGly: 2.344 ± 0.021	1.804ProHis: 1.804 ± 0.014	1.94ProIle: 1.94 ± 0.016	2.172ProLys: 2.172 ± 0.018	5.064ProLeu: 5.064 ± 0.024	1.188ProMet: 1.188 ± 0.011	1.767ProAsn: 1.767 ± 0.013	5.751ProPro: 5.751 ± 0.045	1.921ProGln: 1.921 ± 0.015	3.058ProArg: 3.058 ± 0.021	6.128ProSer: 6.128 ± 0.033	4.68ProThr: 4.68 ± 0.031	3.707ProVal: 3.707 ± 0.023	0.681ProTrp: 0.681 ± 0.008	1.19ProTyr: 1.19 ± 0.011	0.0ProXaa: 0.0 ± 0.0
Gln	3.782GlnAla: 3.782 ± 0.024	0.831GlnCys: 0.831 ± 0.011	2.136GlnAsp: 2.136 ± 0.013	1.827GlnGlu: 1.827 ± 0.015	1.449GlnPhe: 1.449 ± 0.012	2.119GlnGly: 2.119 ± 0.016	1.722GlnHis: 1.722 ± 0.013	1.388GlnIle: 1.388 ± 0.01	1.595GlnLys: 1.595 ± 0.016	4.608GlnLeu: 4.608 ± 0.025	0.892GlnMet: 0.892 ± 0.009	1.168GlnAsn: 1.168 ± 0.011	2.286GlnPro: 2.286 ± 0.017	2.4GlnGln: 2.4 ± 0.026	2.912GlnArg: 2.912 ± 0.019	3.064GlnSer: 3.064 ± 0.019	2.339GlnThr: 2.339 ± 0.016	3.375GlnVal: 3.375 ± 0.019	0.693GlnTrp: 0.693 ± 0.008	1.175GlnTyr: 1.175 ± 0.009	0.0GlnXaa: 0.0 ± 0.0
Arg	4.366ArgAla: 4.366 ± 0.023	1.069ArgCys: 1.069 ± 0.012	2.973ArgAsp: 2.973 ± 0.02	2.69ArgGlu: 2.69 ± 0.019	2.098ArgPhe: 2.098 ± 0.014	3.275ArgGly: 3.275 ± 0.02	2.358ArgHis: 2.358 ± 0.017	2.358ArgIle: 2.358 ± 0.015	2.682ArgLys: 2.682 ± 0.02	5.8ArgLeu: 5.8 ± 0.027	1.482ArgMet: 1.482 ± 0.012	1.867ArgAsn: 1.867 ± 0.012	2.938ArgPro: 2.938 ± 0.019	2.887ArgGln: 2.887 ± 0.019	5.055ArgArg: 5.055 ± 0.035	4.113ArgSer: 4.113 ± 0.023	3.204ArgThr: 3.204 ± 0.021	4.182ArgVal: 4.182 ± 0.02	0.884ArgTrp: 0.884 ± 0.012	1.462ArgTyr: 1.462 ± 0.012	0.0ArgXaa: 0.0 ± 0.0
Ser	6.288SerAla: 6.288 ± 0.029	1.331SerCys: 1.331 ± 0.013	3.907SerAsp: 3.907 ± 0.02	2.707SerGlu: 2.707 ± 0.018	3.111SerPhe: 3.111 ± 0.019	4.096SerGly: 4.096 ± 0.041	2.251SerHis: 2.251 ± 0.016	3.694SerIle: 3.694 ± 0.02	3.468SerLys: 3.468 ± 0.019	7.083SerLeu: 7.083 ± 0.028	2.145SerMet: 2.145 ± 0.015	2.764SerAsn: 2.764 ± 0.016	4.794SerPro: 4.794 ± 0.031	2.661SerGln: 2.661 ± 0.018	4.028SerArg: 4.028 ± 0.023	9.219SerSer: 9.219 ± 0.047	6.536SerThr: 6.536 ± 0.04	5.51SerVal: 5.51 ± 0.032	1.032SerTrp: 1.032 ± 0.01	1.825SerTyr: 1.825 ± 0.014	0.0SerXaa: 0.0 ± 0.0
Thr	5.906ThrAla: 5.906 ± 0.03	1.274ThrCys: 1.274 ± 0.014	3.136ThrAsp: 3.136 ± 0.016	2.398ThrGlu: 2.398 ± 0.019	2.459ThrPhe: 2.459 ± 0.017	3.187ThrGly: 3.187 ± 0.033	1.798ThrHis: 1.798 ± 0.014	2.834ThrIle: 2.834 ± 0.018	3.1ThrLys: 3.1 ± 0.02	6.385ThrLeu: 6.385 ± 0.029	1.64ThrMet: 1.64 ± 0.011	2.292ThrAsn: 2.292 ± 0.016	4.324ThrPro: 4.324 ± 0.03	2.23ThrGln: 2.23 ± 0.016	3.202ThrArg: 3.202 ± 0.018	6.553ThrSer: 6.553 ± 0.042	6.39ThrThr: 6.39 ± 0.053	4.257ThrVal: 4.257 ± 0.032	1.028ThrTrp: 1.028 ± 0.011	1.664ThrTyr: 1.664 ± 0.014	0.0ThrXaa: 0.0 ± 0.0
Val	8.122ValAla: 8.122 ± 0.034	1.435ValCys: 1.435 ± 0.013	5.129ValAsp: 5.129 ± 0.022	4.203ValGlu: 4.203 ± 0.021	2.776ValPhe: 2.776 ± 0.019	4.388ValGly: 4.388 ± 0.029	2.673ValHis: 2.673 ± 0.016	2.572ValIle: 2.572 ± 0.019	3.008ValLys: 3.008 ± 0.017	8.038ValLeu: 8.038 ± 0.032	1.776ValMet: 1.776 ± 0.015	2.262ValAsn: 2.262 ± 0.014	4.015ValPro: 4.015 ± 0.024	3.446ValGln: 3.446 ± 0.021	3.967ValArg: 3.967 ± 0.02	5.047ValSer: 5.047 ± 0.028	4.47ValThr: 4.47 ± 0.032	7.731ValVal: 7.731 ± 0.042	1.027ValTrp: 1.027 ± 0.01	2.065ValTyr: 2.065 ± 0.016	0.0ValXaa: 0.0 ± 0.0
Trp	0.947TrpAla: 0.947 ± 0.009	0.266TrpCys: 0.266 ± 0.005	0.724TrpAsp: 0.724 ± 0.009	0.587TrpGlu: 0.587 ± 0.007	0.568TrpPhe: 0.568 ± 0.006	0.725TrpGly: 0.725 ± 0.01	0.454TrpHis: 0.454 ± 0.007	0.614TrpIle: 0.614 ± 0.007	0.725TrpLys: 0.725 ± 0.009	1.398TrpLeu: 1.398 ± 0.013	0.397TrpMet: 0.397 ± 0.006	0.595TrpAsn: 0.595 ± 0.008	0.565TrpPro: 0.565 ± 0.007	0.575TrpGln: 0.575 ± 0.007	0.904TrpArg: 0.904 ± 0.012	1.062TrpSer: 1.062 ± 0.009	1.124TrpThr: 1.124 ± 0.012	0.884TrpVal: 0.884 ± 0.009	0.263TrpTrp: 0.263 ± 0.006	0.367TrpTyr: 0.367 ± 0.005	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.278TyrAla: 2.278 ± 0.014	0.555TyrCys: 0.555 ± 0.01	1.597TyrAsp: 1.597 ± 0.012	1.182TyrGlu: 1.182 ± 0.01	1.227TyrPhe: 1.227 ± 0.011	1.66TyrGly: 1.66 ± 0.014	0.798TyrHis: 0.798 ± 0.009	1.252TyrIle: 1.252 ± 0.012	1.04TyrLys: 1.04 ± 0.011	2.527TyrLeu: 2.527 ± 0.017	0.75TyrMet: 0.75 ± 0.008	0.94TyrAsn: 0.94 ± 0.01	1.156TyrPro: 1.156 ± 0.012	0.912TyrGln: 0.912 ± 0.01	1.399TyrArg: 1.399 ± 0.013	1.685TyrSer: 1.685 ± 0.014	1.535TyrThr: 1.535 ± 0.011	2.101TyrVal: 2.101 ± 0.016	0.343TyrTrp: 0.343 ± 0.006	0.831TyrTyr: 0.831 ± 0.01	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 24980 proteins (11550940 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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