Amino acid dipepetide frequency for Acetoanaerobium sticklandii (strain ATCC 12662 / DSM 519 / JCM 1433 / NCIMB 10654) (Clostridium sticklandii)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.177AlaAla: 4.177 ± 0.094
0.639AlaCys: 0.639 ± 0.031
3.35AlaAsp: 3.35 ± 0.072
3.746AlaGlu: 3.746 ± 0.094
2.885AlaPhe: 2.885 ± 0.078
4.337AlaGly: 4.337 ± 0.095
0.993AlaHis: 0.993 ± 0.041
6.161AlaIle: 6.161 ± 0.101
5.3AlaLys: 5.3 ± 0.087
6.606AlaLeu: 6.606 ± 0.097
2.145AlaMet: 2.145 ± 0.057
3.02AlaAsn: 3.02 ± 0.067
1.594AlaPro: 1.594 ± 0.045
1.891AlaGln: 1.891 ± 0.054
2.158AlaArg: 2.158 ± 0.055
4.329AlaSer: 4.329 ± 0.083
2.918AlaThr: 2.918 ± 0.067
4.6AlaVal: 4.6 ± 0.094
0.369AlaTrp: 0.369 ± 0.02
2.399AlaTyr: 2.399 ± 0.055
0.0AlaXaa: 0.0 ± 0.0
Cys
0.528CysAla: 0.528 ± 0.031
0.109CysCys: 0.109 ± 0.013
0.552CysAsp: 0.552 ± 0.028
0.641CysGlu: 0.641 ± 0.029
0.384CysPhe: 0.384 ± 0.026
0.729CysGly: 0.729 ± 0.034
0.222CysHis: 0.222 ± 0.018
0.905CysIle: 0.905 ± 0.039
0.672CysLys: 0.672 ± 0.028
0.621CysLeu: 0.621 ± 0.029
0.225CysMet: 0.225 ± 0.019
0.465CysAsn: 0.465 ± 0.024
0.464CysPro: 0.464 ± 0.026
0.22CysGln: 0.22 ± 0.017
0.28CysArg: 0.28 ± 0.02
0.703CysSer: 0.703 ± 0.03
0.431CysThr: 0.431 ± 0.023
0.486CysVal: 0.486 ± 0.028
0.042CysTrp: 0.042 ± 0.007
0.312CysTyr: 0.312 ± 0.02
0.0CysXaa: 0.0 ± 0.0
Asp
3.343AspAla: 3.343 ± 0.066
0.486AspCys: 0.486 ± 0.023
2.999AspAsp: 2.999 ± 0.079
5.486AspGlu: 5.486 ± 0.112
3.084AspPhe: 3.084 ± 0.062
3.301AspGly: 3.301 ± 0.079
0.662AspHis: 0.662 ± 0.028
6.704AspIle: 6.704 ± 0.09
5.41AspLys: 5.41 ± 0.087
5.245AspLeu: 5.245 ± 0.083
1.976AspMet: 1.976 ± 0.042
2.915AspAsn: 2.915 ± 0.062
1.436AspPro: 1.436 ± 0.048
0.97AspGln: 0.97 ± 0.037
1.946AspArg: 1.946 ± 0.051
3.813AspSer: 3.813 ± 0.069
2.785AspThr: 2.785 ± 0.063
3.636AspVal: 3.636 ± 0.07
0.37AspTrp: 0.37 ± 0.024
2.902AspTyr: 2.902 ± 0.067
0.0AspXaa: 0.0 ± 0.0
Glu
5.076GluAla: 5.076 ± 0.087
0.427GluCys: 0.427 ± 0.026
4.562GluAsp: 4.562 ± 0.09
6.254GluGlu: 6.254 ± 0.128
3.139GluPhe: 3.139 ± 0.064
3.764GluGly: 3.764 ± 0.078
1.136GluHis: 1.136 ± 0.041
7.798GluIle: 7.798 ± 0.108
7.264GluLys: 7.264 ± 0.101
7.396GluLeu: 7.396 ± 0.103
2.098GluMet: 2.098 ± 0.048
4.829GluAsn: 4.829 ± 0.083
1.713GluPro: 1.713 ± 0.052
2.182GluGln: 2.182 ± 0.062
2.455GluArg: 2.455 ± 0.07
4.111GluSer: 4.111 ± 0.079
3.205GluThr: 3.205 ± 0.073
4.869GluVal: 4.869 ± 0.08
0.34GluTrp: 0.34 ± 0.019
2.87GluTyr: 2.87 ± 0.063
0.0GluXaa: 0.0 ± 0.0
Phe
2.682PheAla: 2.682 ± 0.064
0.421PheCys: 0.421 ± 0.025
2.808PheAsp: 2.808 ± 0.06
3.365PheGlu: 3.365 ± 0.065
1.959PhePhe: 1.959 ± 0.058
2.749PheGly: 2.749 ± 0.061
0.556PheHis: 0.556 ± 0.026
4.119PheIle: 4.119 ± 0.085
3.146PheLys: 3.146 ± 0.067
3.752PheLeu: 3.752 ± 0.083
1.35PheMet: 1.35 ± 0.037
2.17PheAsn: 2.17 ± 0.055
1.178PhePro: 1.178 ± 0.036
0.946PheGln: 0.946 ± 0.04
1.234PheArg: 1.234 ± 0.043
3.234PheSer: 3.234 ± 0.072
2.38PheThr: 2.38 ± 0.06
2.729PheVal: 2.729 ± 0.065
0.292PheTrp: 0.292 ± 0.022
1.647PheTyr: 1.647 ± 0.055
0.0PheXaa: 0.0 ± 0.0
Gly
4.322GlyAla: 4.322 ± 0.09
0.807GlyCys: 0.807 ± 0.04
3.192GlyAsp: 3.192 ± 0.071
4.007GlyGlu: 4.007 ± 0.078
3.184GlyPhe: 3.184 ± 0.062
4.168GlyGly: 4.168 ± 0.118
1.097GlyHis: 1.097 ± 0.037
6.392GlyIle: 6.392 ± 0.104
4.948GlyLys: 4.948 ± 0.071
5.512GlyLeu: 5.512 ± 0.089
2.052GlyMet: 2.052 ± 0.061
2.908GlyAsn: 2.908 ± 0.065
1.319GlyPro: 1.319 ± 0.046
1.631GlyGln: 1.631 ± 0.05
2.177GlyArg: 2.177 ± 0.052
3.792GlySer: 3.792 ± 0.076
3.287GlyThr: 3.287 ± 0.074
4.278GlyVal: 4.278 ± 0.083
0.391GlyTrp: 0.391 ± 0.026
3.035GlyTyr: 3.035 ± 0.058
0.0GlyXaa: 0.0 ± 0.0
His
0.804HisAla: 0.804 ± 0.033
0.183HisCys: 0.183 ± 0.015
0.874HisAsp: 0.874 ± 0.038
1.089HisGlu: 1.089 ± 0.038
0.653HisPhe: 0.653 ± 0.027
1.035HisGly: 1.035 ± 0.039
0.344HisHis: 0.344 ± 0.022
1.514HisIle: 1.514 ± 0.041
1.166HisLys: 1.166 ± 0.036
1.262HisLeu: 1.262 ± 0.049
0.489HisMet: 0.489 ± 0.026
0.812HisAsn: 0.812 ± 0.031
0.788HisPro: 0.788 ± 0.03
0.377HisGln: 0.377 ± 0.024
0.568HisArg: 0.568 ± 0.029
0.988HisSer: 0.988 ± 0.043
0.731HisThr: 0.731 ± 0.029
0.873HisVal: 0.873 ± 0.037
0.092HisTrp: 0.092 ± 0.01
0.639HisTyr: 0.639 ± 0.031
0.0HisXaa: 0.0 ± 0.0
Ile
6.376IleAla: 6.376 ± 0.101
0.875IleCys: 0.875 ± 0.032
6.396IleAsp: 6.396 ± 0.104
7.345IleGlu: 7.345 ± 0.118
3.874IlePhe: 3.874 ± 0.081
6.066IleGly: 6.066 ± 0.098
1.381IleHis: 1.381 ± 0.044
8.021IleIle: 8.021 ± 0.131
8.02IleLys: 8.02 ± 0.101
8.469IleLeu: 8.469 ± 0.119
2.49IleMet: 2.49 ± 0.057
5.348IleAsn: 5.348 ± 0.089
3.171IlePro: 3.171 ± 0.069
2.292IleGln: 2.292 ± 0.054
3.021IleArg: 3.021 ± 0.066
7.302IleSer: 7.302 ± 0.103
4.656IleThr: 4.656 ± 0.08
5.903IleVal: 5.903 ± 0.081
0.469IleTrp: 0.469 ± 0.024
3.291IleTyr: 3.291 ± 0.072
0.0IleXaa: 0.0 ± 0.0
Lys
5.543LysAla: 5.543 ± 0.083
0.532LysCys: 0.532 ± 0.03
5.481LysAsp: 5.481 ± 0.089
7.481LysGlu: 7.481 ± 0.102
2.661LysPhe: 2.661 ± 0.065
4.72LysGly: 4.72 ± 0.083
1.158LysHis: 1.158 ± 0.036
7.667LysIle: 7.667 ± 0.103
7.186LysLys: 7.186 ± 0.105
7.782LysLeu: 7.782 ± 0.109
2.412LysMet: 2.412 ± 0.062
5.381LysAsn: 5.381 ± 0.089
2.28LysPro: 2.28 ± 0.057
2.426LysGln: 2.426 ± 0.055
2.912LysArg: 2.912 ± 0.068
5.495LysSer: 5.495 ± 0.086
4.401LysThr: 4.401 ± 0.076
5.218LysVal: 5.218 ± 0.088
0.5LysTrp: 0.5 ± 0.026
3.321LysTyr: 3.321 ± 0.067
0.0LysXaa: 0.0 ± 0.0
Leu
5.927LeuAla: 5.927 ± 0.107
0.813LeuCys: 0.813 ± 0.033
5.866LeuAsp: 5.866 ± 0.097
7.283LeuGlu: 7.283 ± 0.106
3.712LeuPhe: 3.712 ± 0.078
6.204LeuGly: 6.204 ± 0.096
1.22LeuHis: 1.22 ± 0.04
7.981LeuIle: 7.981 ± 0.116
8.061LeuLys: 8.061 ± 0.111
8.004LeuLeu: 8.004 ± 0.119
2.649LeuMet: 2.649 ± 0.06
5.147LeuAsn: 5.147 ± 0.094
3.005LeuPro: 3.005 ± 0.058
1.965LeuGln: 1.965 ± 0.051
3.333LeuArg: 3.333 ± 0.061
7.469LeuSer: 7.469 ± 0.095
4.408LeuThr: 4.408 ± 0.085
5.517LeuVal: 5.517 ± 0.079
0.491LeuTrp: 0.491 ± 0.027
3.17LeuTyr: 3.17 ± 0.061
0.0LeuXaa: 0.0 ± 0.0
Met
2.121MetAla: 2.121 ± 0.052
0.223MetCys: 0.223 ± 0.019
1.907MetAsp: 1.907 ± 0.045
1.99MetGlu: 1.99 ± 0.06
0.921MetPhe: 0.921 ± 0.031
1.984MetGly: 1.984 ± 0.055
0.442MetHis: 0.442 ± 0.024
2.592MetIle: 2.592 ± 0.06
2.717MetLys: 2.717 ± 0.053
2.696MetLeu: 2.696 ± 0.058
0.887MetMet: 0.887 ± 0.034
1.79MetAsn: 1.79 ± 0.048
1.093MetPro: 1.093 ± 0.037
0.907MetGln: 0.907 ± 0.038
1.017MetArg: 1.017 ± 0.038
1.834MetSer: 1.834 ± 0.049
1.488MetThr: 1.488 ± 0.042
1.822MetVal: 1.822 ± 0.048
0.147MetTrp: 0.147 ± 0.012
0.824MetTyr: 0.824 ± 0.033
0.0MetXaa: 0.0 ± 0.0
Asn
3.041AsnAla: 3.041 ± 0.051
0.511AsnCys: 0.511 ± 0.029
2.694AsnAsp: 2.694 ± 0.057
3.965AsnGlu: 3.965 ± 0.089
2.198AsnPhe: 2.198 ± 0.053
2.8AsnGly: 2.8 ± 0.069
0.929AsnHis: 0.929 ± 0.031
5.705AsnIle: 5.705 ± 0.092
4.644AsnLys: 4.644 ± 0.092
5.54AsnLeu: 5.54 ± 0.085
1.678AsnMet: 1.678 ± 0.045
3.057AsnAsn: 3.057 ± 0.07
2.407AsnPro: 2.407 ± 0.058
1.897AsnGln: 1.897 ± 0.051
1.774AsnArg: 1.774 ± 0.048
3.467AsnSer: 3.467 ± 0.066
2.501AsnThr: 2.501 ± 0.057
3.03AsnVal: 3.03 ± 0.064
0.37AsnTrp: 0.37 ± 0.023
2.282AsnTyr: 2.282 ± 0.055
0.0AsnXaa: 0.0 ± 0.0
Pro
1.75ProAla: 1.75 ± 0.053
0.285ProCys: 0.285 ± 0.019
1.807ProAsp: 1.807 ± 0.054
2.577ProGlu: 2.577 ± 0.072
1.422ProPhe: 1.422 ± 0.045
1.838ProGly: 1.838 ± 0.055
0.527ProHis: 0.527 ± 0.029
2.634ProIle: 2.634 ± 0.058
2.266ProLys: 2.266 ± 0.058
2.649ProLeu: 2.649 ± 0.059
0.832ProMet: 0.832 ± 0.03
1.449ProAsn: 1.449 ± 0.039
0.712ProPro: 0.712 ± 0.034
0.866ProGln: 0.866 ± 0.03
0.933ProArg: 0.933 ± 0.032
1.985ProSer: 1.985 ± 0.045
1.557ProThr: 1.557 ± 0.049
2.423ProVal: 2.423 ± 0.067
0.215ProTrp: 0.215 ± 0.016
1.4ProTyr: 1.4 ± 0.048
0.0ProXaa: 0.0 ± 0.0
Gln
1.861GlnAla: 1.861 ± 0.052
0.181GlnCys: 0.181 ± 0.016
1.405GlnAsp: 1.405 ± 0.044
1.975GlnGlu: 1.975 ± 0.062
0.946GlnPhe: 0.946 ± 0.036
1.63GlnGly: 1.63 ± 0.045
0.344GlnHis: 0.344 ± 0.022
2.588GlnIle: 2.588 ± 0.058
2.381GlnLys: 2.381 ± 0.061
2.349GlnLeu: 2.349 ± 0.053
0.941GlnMet: 0.941 ± 0.033
1.701GlnAsn: 1.701 ± 0.045
0.678GlnPro: 0.678 ± 0.034
0.746GlnGln: 0.746 ± 0.035
1.108GlnArg: 1.108 ± 0.039
1.672GlnSer: 1.672 ± 0.048
1.245GlnThr: 1.245 ± 0.046
1.574GlnVal: 1.574 ± 0.042
0.199GlnTrp: 0.199 ± 0.016
0.942GlnTyr: 0.942 ± 0.038
0.0GlnXaa: 0.0 ± 0.0
Arg
2.121ArgAla: 2.121 ± 0.056
0.345ArgCys: 0.345 ± 0.022
1.917ArgAsp: 1.917 ± 0.048
2.692ArgGlu: 2.692 ± 0.065
1.545ArgPhe: 1.545 ± 0.051
2.028ArgGly: 2.028 ± 0.053
0.527ArgHis: 0.527 ± 0.027
3.165ArgIle: 3.165 ± 0.057
2.714ArgLys: 2.714 ± 0.052
3.26ArgLeu: 3.26 ± 0.071
0.978ArgMet: 0.978 ± 0.03
1.817ArgAsn: 1.817 ± 0.037
1.021ArgPro: 1.021 ± 0.037
0.998ArgGln: 0.998 ± 0.039
1.443ArgArg: 1.443 ± 0.05
1.577ArgSer: 1.577 ± 0.042
1.754ArgThr: 1.754 ± 0.045
2.286ArgVal: 2.286 ± 0.053
0.231ArgTrp: 0.231 ± 0.018
1.42ArgTyr: 1.42 ± 0.045
0.0ArgXaa: 0.0 ± 0.0
Ser
3.896SerAla: 3.896 ± 0.079
0.616SerCys: 0.616 ± 0.032
3.786SerAsp: 3.786 ± 0.065
4.658SerGlu: 4.658 ± 0.087
3.151SerPhe: 3.151 ± 0.06
4.486SerGly: 4.486 ± 0.094
1.12SerHis: 1.12 ± 0.04
6.387SerIle: 6.387 ± 0.1
6.046SerLys: 6.046 ± 0.085
6.427SerLeu: 6.427 ± 0.091
1.943SerMet: 1.943 ± 0.047
3.614SerAsn: 3.614 ± 0.07
1.879SerPro: 1.879 ± 0.054
2.0SerGln: 2.0 ± 0.048
2.199SerArg: 2.199 ± 0.057
5.068SerSer: 5.068 ± 0.104
3.152SerThr: 3.152 ± 0.061
4.168SerVal: 4.168 ± 0.072
0.457SerTrp: 0.457 ± 0.029
2.817SerTyr: 2.817 ± 0.07
0.0SerXaa: 0.0 ± 0.0
Thr
3.296ThrAla: 3.296 ± 0.071
0.423ThrCys: 0.423 ± 0.026
2.756ThrAsp: 2.756 ± 0.071
2.993ThrGlu: 2.993 ± 0.062
2.015ThrPhe: 2.015 ± 0.052
3.698ThrGly: 3.698 ± 0.074
0.916ThrHis: 0.916 ± 0.028
4.344ThrIle: 4.344 ± 0.084
3.889ThrLys: 3.889 ± 0.069
4.66ThrLeu: 4.66 ± 0.087
1.235ThrMet: 1.235 ± 0.041
2.354ThrAsn: 2.354 ± 0.057
1.829ThrPro: 1.829 ± 0.053
1.429ThrGln: 1.429 ± 0.046
1.595ThrArg: 1.595 ± 0.044
3.307ThrSer: 3.307 ± 0.063
2.676ThrThr: 2.676 ± 0.064
3.389ThrVal: 3.389 ± 0.081
0.313ThrTrp: 0.313 ± 0.021
1.848ThrTyr: 1.848 ± 0.052
0.0ThrXaa: 0.0 ± 0.0
Val
4.239ValAla: 4.239 ± 0.087
0.655ValCys: 0.655 ± 0.028
4.205ValAsp: 4.205 ± 0.076
4.447ValGlu: 4.447 ± 0.088
2.772ValPhe: 2.772 ± 0.059
4.129ValGly: 4.129 ± 0.087
0.974ValHis: 0.974 ± 0.034
5.783ValIle: 5.783 ± 0.081
4.97ValLys: 4.97 ± 0.073
5.978ValLeu: 5.978 ± 0.092
1.754ValMet: 1.754 ± 0.049
3.235ValAsn: 3.235 ± 0.065
2.028ValPro: 2.028 ± 0.054
1.488ValGln: 1.488 ± 0.044
2.149ValArg: 2.149 ± 0.058
4.478ValSer: 4.478 ± 0.075
3.24ValThr: 3.24 ± 0.076
4.525ValVal: 4.525 ± 0.086
0.369ValTrp: 0.369 ± 0.019
2.416ValTyr: 2.416 ± 0.057
0.0ValXaa: 0.0 ± 0.0
Trp
0.371TrpAla: 0.371 ± 0.025
0.068TrpCys: 0.068 ± 0.009
0.389TrpAsp: 0.389 ± 0.025
0.448TrpGlu: 0.448 ± 0.024
0.302TrpPhe: 0.302 ± 0.022
0.428TrpGly: 0.428 ± 0.023
0.103TrpHis: 0.103 ± 0.013
0.553TrpIle: 0.553 ± 0.029
0.427TrpLys: 0.427 ± 0.024
0.457TrpLeu: 0.457 ± 0.029
0.197TrpMet: 0.197 ± 0.016
0.335TrpAsn: 0.335 ± 0.02
0.166TrpPro: 0.166 ± 0.015
0.223TrpGln: 0.223 ± 0.018
0.187TrpArg: 0.187 ± 0.015
0.38TrpSer: 0.38 ± 0.021
0.278TrpThr: 0.278 ± 0.019
0.347TrpVal: 0.347 ± 0.021
0.062TrpTrp: 0.062 ± 0.008
0.222TrpTyr: 0.222 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.141TyrAla: 2.141 ± 0.05
0.392TyrCys: 0.392 ± 0.023
2.522TyrAsp: 2.522 ± 0.056
3.043TyrGlu: 3.043 ± 0.057
1.911TyrPhe: 1.911 ± 0.052
2.408TyrGly: 2.408 ± 0.06
0.63TyrHis: 0.63 ± 0.033
3.752TyrIle: 3.752 ± 0.073
3.334TyrLys: 3.334 ± 0.068
3.562TyrLeu: 3.562 ± 0.072
1.069TyrMet: 1.069 ± 0.035
2.144TyrAsn: 2.144 ± 0.057
1.365TyrPro: 1.365 ± 0.046
1.01TyrGln: 1.01 ± 0.038
1.349TyrArg: 1.349 ± 0.039
2.869TyrSer: 2.869 ± 0.065
1.87TyrThr: 1.87 ± 0.053
2.16TyrVal: 2.16 ± 0.056
0.222TyrTrp: 0.222 ± 0.015
1.697TyrTyr: 1.697 ± 0.058
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2572 proteins (807997 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski