Amino acid dipepetide frequency for Clostridium sp. CAG:492

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.555AlaAla: 2.555 ± 0.13
0.597AlaCys: 0.597 ± 0.04
2.934AlaAsp: 2.934 ± 0.096
4.017AlaGlu: 4.017 ± 0.127
1.933AlaPhe: 1.933 ± 0.091
3.503AlaGly: 3.503 ± 0.118
0.742AlaHis: 0.742 ± 0.05
5.646AlaIle: 5.646 ± 0.162
5.458AlaLys: 5.458 ± 0.152
4.322AlaLeu: 4.322 ± 0.14
1.302AlaMet: 1.302 ± 0.059
3.121AlaAsn: 3.121 ± 0.139
1.262AlaPro: 1.262 ± 0.06
1.539AlaGln: 1.539 ± 0.065
1.973AlaArg: 1.973 ± 0.086
2.681AlaSer: 2.681 ± 0.101
2.881AlaThr: 2.881 ± 0.104
3.405AlaVal: 3.405 ± 0.124
0.286AlaTrp: 0.286 ± 0.032
1.905AlaTyr: 1.905 ± 0.084
0.0AlaXaa: 0.0 ± 0.0
Cys
0.665CysAla: 0.665 ± 0.047
0.191CysCys: 0.191 ± 0.034
0.637CysAsp: 0.637 ± 0.051
0.831CysGlu: 0.831 ± 0.051
0.434CysPhe: 0.434 ± 0.041
1.139CysGly: 1.139 ± 0.068
0.16CysHis: 0.16 ± 0.021
1.222CysIle: 1.222 ± 0.063
1.191CysLys: 1.191 ± 0.062
0.92CysLeu: 0.92 ± 0.063
0.286CysMet: 0.286 ± 0.033
0.81CysAsn: 0.81 ± 0.055
0.437CysPro: 0.437 ± 0.043
0.203CysGln: 0.203 ± 0.026
0.348CysArg: 0.348 ± 0.031
0.745CysSer: 0.745 ± 0.051
0.606CysThr: 0.606 ± 0.049
0.603CysVal: 0.603 ± 0.045
0.083CysTrp: 0.083 ± 0.017
0.468CysTyr: 0.468 ± 0.042
0.0CysXaa: 0.0 ± 0.0
Asp
2.533AspAla: 2.533 ± 0.091
0.637AspCys: 0.637 ± 0.046
3.275AspAsp: 3.275 ± 0.131
5.418AspGlu: 5.418 ± 0.136
2.537AspPhe: 2.537 ± 0.091
3.691AspGly: 3.691 ± 0.169
0.483AspHis: 0.483 ± 0.043
6.4AspIle: 6.4 ± 0.169
5.498AspLys: 5.498 ± 0.156
4.722AspLeu: 4.722 ± 0.13
1.398AspMet: 1.398 ± 0.068
3.832AspAsn: 3.832 ± 0.131
1.287AspPro: 1.287 ± 0.062
0.954AspGln: 0.954 ± 0.059
1.61AspArg: 1.61 ± 0.071
3.266AspSer: 3.266 ± 0.098
2.786AspThr: 2.786 ± 0.105
3.876AspVal: 3.876 ± 0.119
0.409AspTrp: 0.409 ± 0.038
2.703AspTyr: 2.703 ± 0.097
0.0AspXaa: 0.0 ± 0.0
Glu
3.725GluAla: 3.725 ± 0.126
0.807GluCys: 0.807 ± 0.052
4.51GluAsp: 4.51 ± 0.134
6.954GluGlu: 6.954 ± 0.196
3.051GluPhe: 3.051 ± 0.11
3.285GluGly: 3.285 ± 0.113
1.019GluHis: 1.019 ± 0.053
8.136GluIle: 8.136 ± 0.168
9.727GluLys: 9.727 ± 0.218
6.782GluLeu: 6.782 ± 0.177
2.124GluMet: 2.124 ± 0.083
6.969GluAsn: 6.969 ± 0.192
1.431GluPro: 1.431 ± 0.071
2.537GluGln: 2.537 ± 0.106
2.512GluArg: 2.512 ± 0.098
3.614GluSer: 3.614 ± 0.105
3.432GluThr: 3.432 ± 0.114
4.365GluVal: 4.365 ± 0.128
0.425GluTrp: 0.425 ± 0.033
3.595GluTyr: 3.595 ± 0.115
0.0GluXaa: 0.0 ± 0.0
Phe
2.102PheAla: 2.102 ± 0.09
0.643PheCys: 0.643 ± 0.05
2.46PheAsp: 2.46 ± 0.091
3.152PheGlu: 3.152 ± 0.108
1.539PhePhe: 1.539 ± 0.086
2.333PheGly: 2.333 ± 0.103
0.446PheHis: 0.446 ± 0.036
3.842PheIle: 3.842 ± 0.145
3.506PheLys: 3.506 ± 0.113
3.168PheLeu: 3.168 ± 0.128
0.883PheMet: 0.883 ± 0.056
2.573PheAsn: 2.573 ± 0.087
0.967PhePro: 0.967 ± 0.059
0.782PheGln: 0.782 ± 0.047
1.013PheArg: 1.013 ± 0.055
2.749PheSer: 2.749 ± 0.094
1.896PheThr: 1.896 ± 0.079
2.475PheVal: 2.475 ± 0.087
0.289PheTrp: 0.289 ± 0.034
1.672PheTyr: 1.672 ± 0.07
0.0PheXaa: 0.0 ± 0.0
Gly
3.398GlyAla: 3.398 ± 0.124
0.766GlyCys: 0.766 ± 0.051
2.838GlyAsp: 2.838 ± 0.095
3.873GlyGlu: 3.873 ± 0.12
2.561GlyPhe: 2.561 ± 0.104
3.454GlyGly: 3.454 ± 0.151
0.939GlyHis: 0.939 ± 0.06
6.323GlyIle: 6.323 ± 0.166
5.904GlyLys: 5.904 ± 0.143
4.584GlyLeu: 4.584 ± 0.14
1.521GlyMet: 1.521 ± 0.093
3.42GlyAsn: 3.42 ± 0.13
0.988GlyPro: 0.988 ± 0.067
1.345GlyGln: 1.345 ± 0.069
2.032GlyArg: 2.032 ± 0.089
3.152GlySer: 3.152 ± 0.114
3.669GlyThr: 3.669 ± 0.117
3.694GlyVal: 3.694 ± 0.113
0.459GlyTrp: 0.459 ± 0.045
2.94GlyTyr: 2.94 ± 0.111
0.0GlyXaa: 0.0 ± 0.0
His
0.529HisAla: 0.529 ± 0.043
0.169HisCys: 0.169 ± 0.024
0.569HisAsp: 0.569 ± 0.047
0.665HisGlu: 0.665 ± 0.049
0.508HisPhe: 0.508 ± 0.039
0.822HisGly: 0.822 ± 0.057
0.255HisHis: 0.255 ± 0.033
1.265HisIle: 1.265 ± 0.069
0.954HisLys: 0.954 ± 0.054
0.979HisLeu: 0.979 ± 0.059
0.342HisMet: 0.342 ± 0.032
0.754HisAsn: 0.754 ± 0.046
0.569HisPro: 0.569 ± 0.048
0.357HisGln: 0.357 ± 0.029
0.468HisArg: 0.468 ± 0.031
0.785HisSer: 0.785 ± 0.05
0.683HisThr: 0.683 ± 0.052
0.594HisVal: 0.594 ± 0.044
0.092HisTrp: 0.092 ± 0.016
0.548HisTyr: 0.548 ± 0.045
0.0HisXaa: 0.0 ± 0.0
Ile
5.92IleAla: 5.92 ± 0.147
1.391IleCys: 1.391 ± 0.062
6.089IleAsp: 6.089 ± 0.153
7.896IleGlu: 7.896 ± 0.163
3.829IlePhe: 3.829 ± 0.147
5.673IleGly: 5.673 ± 0.176
1.071IleHis: 1.071 ± 0.053
10.22IleIle: 10.22 ± 0.214
9.58IleLys: 9.58 ± 0.178
8.579IleLeu: 8.579 ± 0.219
2.29IleMet: 2.29 ± 0.085
7.102IleAsn: 7.102 ± 0.181
3.217IlePro: 3.217 ± 0.107
2.564IleGln: 2.564 ± 0.09
2.887IleArg: 2.887 ± 0.098
7.136IleSer: 7.136 ± 0.178
5.646IleThr: 5.646 ± 0.139
6.621IleVal: 6.621 ± 0.142
0.502IleTrp: 0.502 ± 0.035
3.953IleTyr: 3.953 ± 0.113
0.0IleXaa: 0.0 ± 0.0
Lys
4.793LysAla: 4.793 ± 0.142
1.09LysCys: 1.09 ± 0.066
5.926LysAsp: 5.926 ± 0.164
9.047LysGlu: 9.047 ± 0.204
3.731LysPhe: 3.731 ± 0.109
4.396LysGly: 4.396 ± 0.117
0.976LysHis: 0.976 ± 0.048
10.54LysIle: 10.54 ± 0.231
10.509LysLys: 10.509 ± 0.229
8.182LysLeu: 8.182 ± 0.147
2.927LysMet: 2.927 ± 0.096
8.456LysAsn: 8.456 ± 0.196
2.099LysPro: 2.099 ± 0.086
3.103LysGln: 3.103 ± 0.11
3.235LysArg: 3.235 ± 0.1
5.615LysSer: 5.615 ± 0.14
5.27LysThr: 5.27 ± 0.146
5.966LysVal: 5.966 ± 0.159
0.536LysTrp: 0.536 ± 0.044
5.282LysTyr: 5.282 ± 0.144
0.0LysXaa: 0.0 ± 0.0
Leu
4.605LeuAla: 4.605 ± 0.126
0.911LeuCys: 0.911 ± 0.053
4.879LeuAsp: 4.879 ± 0.132
6.077LeuGlu: 6.077 ± 0.167
2.9LeuPhe: 2.9 ± 0.122
4.981LeuGly: 4.981 ± 0.146
1.04LeuHis: 1.04 ± 0.064
7.249LeuIle: 7.249 ± 0.172
8.878LeuLys: 8.878 ± 0.177
6.794LeuLeu: 6.794 ± 0.194
1.742LeuMet: 1.742 ± 0.082
6.073LeuAsn: 6.073 ± 0.172
2.533LeuPro: 2.533 ± 0.092
2.29LeuGln: 2.29 ± 0.089
2.383LeuArg: 2.383 ± 0.101
5.322LeuSer: 5.322 ± 0.134
4.193LeuThr: 4.193 ± 0.12
4.981LeuVal: 4.981 ± 0.129
0.471LeuTrp: 0.471 ± 0.04
3.263LeuTyr: 3.263 ± 0.133
0.0LeuXaa: 0.0 ± 0.0
Met
1.518MetAla: 1.518 ± 0.079
0.326MetCys: 0.326 ± 0.032
1.293MetAsp: 1.293 ± 0.061
1.804MetGlu: 1.804 ± 0.078
0.936MetPhe: 0.936 ± 0.058
1.376MetGly: 1.376 ± 0.08
0.332MetHis: 0.332 ± 0.038
2.035MetIle: 2.035 ± 0.087
2.515MetLys: 2.515 ± 0.082
2.019MetLeu: 2.019 ± 0.082
0.603MetMet: 0.603 ± 0.043
1.764MetAsn: 1.764 ± 0.085
0.92MetPro: 0.92 ± 0.051
0.923MetGln: 0.923 ± 0.057
0.702MetArg: 0.702 ± 0.051
1.616MetSer: 1.616 ± 0.066
1.133MetThr: 1.133 ± 0.053
1.33MetVal: 1.33 ± 0.063
0.166MetTrp: 0.166 ± 0.024
0.991MetTyr: 0.991 ± 0.068
0.0MetXaa: 0.0 ± 0.0
Asn
3.1AsnAla: 3.1 ± 0.116
0.908AsnCys: 0.908 ± 0.052
3.885AsnAsp: 3.885 ± 0.116
5.867AsnGlu: 5.867 ± 0.161
2.737AsnPhe: 2.737 ± 0.102
4.359AsnGly: 4.359 ± 0.194
0.671AsnHis: 0.671 ± 0.05
8.179AsnIle: 8.179 ± 0.206
7.523AsnLys: 7.523 ± 0.192
6.157AsnLeu: 6.157 ± 0.159
1.659AsnMet: 1.659 ± 0.065
6.187AsnAsn: 6.187 ± 0.234
2.069AsnPro: 2.069 ± 0.079
1.942AsnGln: 1.942 ± 0.079
1.915AsnArg: 1.915 ± 0.087
4.313AsnSer: 4.313 ± 0.165
3.728AsnThr: 3.728 ± 0.143
4.217AsnVal: 4.217 ± 0.137
0.56AsnTrp: 0.56 ± 0.055
3.115AsnTyr: 3.115 ± 0.11
0.0AsnXaa: 0.0 ± 0.0
Pro
1.256ProAla: 1.256 ± 0.076
0.329ProCys: 0.329 ± 0.036
1.604ProAsp: 1.604 ± 0.074
2.469ProGlu: 2.469 ± 0.106
1.136ProPhe: 1.136 ± 0.069
1.434ProGly: 1.434 ± 0.074
0.394ProHis: 0.394 ± 0.038
2.518ProIle: 2.518 ± 0.094
2.247ProLys: 2.247 ± 0.083
1.742ProLeu: 1.742 ± 0.073
0.603ProMet: 0.603 ± 0.046
1.739ProAsn: 1.739 ± 0.073
0.529ProPro: 0.529 ± 0.049
0.874ProGln: 0.874 ± 0.055
0.699ProArg: 0.699 ± 0.054
1.379ProSer: 1.379 ± 0.069
1.49ProThr: 1.49 ± 0.063
1.816ProVal: 1.816 ± 0.087
0.185ProTrp: 0.185 ± 0.026
1.133ProTyr: 1.133 ± 0.053
0.0ProXaa: 0.0 ± 0.0
Gln
1.45GlnAla: 1.45 ± 0.081
0.249GlnCys: 0.249 ± 0.027
1.518GlnAsp: 1.518 ± 0.061
2.155GlnGlu: 2.155 ± 0.097
0.862GlnPhe: 0.862 ± 0.058
1.385GlnGly: 1.385 ± 0.06
0.243GlnHis: 0.243 ± 0.029
2.891GlnIle: 2.891 ± 0.094
3.134GlnLys: 3.134 ± 0.092
2.056GlnLeu: 2.056 ± 0.08
0.733GlnMet: 0.733 ± 0.046
2.216GlnAsn: 2.216 ± 0.084
0.529GlnPro: 0.529 ± 0.038
0.717GlnGln: 0.717 ± 0.054
0.973GlnArg: 0.973 ± 0.049
1.376GlnSer: 1.376 ± 0.075
1.588GlnThr: 1.588 ± 0.066
1.542GlnVal: 1.542 ± 0.078
0.129GlnTrp: 0.129 ± 0.02
1.262GlnTyr: 1.262 ± 0.073
0.0GlnXaa: 0.0 ± 0.0
Arg
2.001ArgAla: 2.001 ± 0.089
0.4ArgCys: 0.4 ± 0.038
1.619ArgAsp: 1.619 ± 0.08
2.183ArgGlu: 2.183 ± 0.114
1.281ArgPhe: 1.281 ± 0.062
1.724ArgGly: 1.724 ± 0.082
0.385ArgHis: 0.385 ± 0.04
2.891ArgIle: 2.891 ± 0.104
3.223ArgLys: 3.223 ± 0.108
2.604ArgLeu: 2.604 ± 0.094
0.837ArgMet: 0.837 ± 0.056
2.146ArgAsn: 2.146 ± 0.093
0.834ArgPro: 0.834 ± 0.056
0.865ArgGln: 0.865 ± 0.05
1.367ArgArg: 1.367 ± 0.071
1.416ArgSer: 1.416 ± 0.08
1.745ArgThr: 1.745 ± 0.078
1.724ArgVal: 1.724 ± 0.088
0.197ArgTrp: 0.197 ± 0.023
1.373ArgTyr: 1.373 ± 0.07
0.0ArgXaa: 0.0 ± 0.0
Ser
3.128SerAla: 3.128 ± 0.109
0.56SerCys: 0.56 ± 0.038
3.559SerAsp: 3.559 ± 0.133
4.541SerGlu: 4.541 ± 0.121
2.293SerPhe: 2.293 ± 0.097
3.823SerGly: 3.823 ± 0.137
0.68SerHis: 0.68 ± 0.047
5.836SerIle: 5.836 ± 0.158
6.203SerLys: 6.203 ± 0.144
4.587SerLeu: 4.587 ± 0.123
1.259SerMet: 1.259 ± 0.065
4.356SerAsn: 4.356 ± 0.143
1.259SerPro: 1.259 ± 0.068
1.687SerGln: 1.687 ± 0.083
1.795SerArg: 1.795 ± 0.078
4.239SerSer: 4.239 ± 0.2
3.442SerThr: 3.442 ± 0.114
3.679SerVal: 3.679 ± 0.12
0.366SerTrp: 0.366 ± 0.034
2.426SerTyr: 2.426 ± 0.096
0.0SerXaa: 0.0 ± 0.0
Thr
3.054ThrAla: 3.054 ± 0.107
0.486ThrCys: 0.486 ± 0.043
3.155ThrAsp: 3.155 ± 0.112
3.98ThrGlu: 3.98 ± 0.153
1.955ThrPhe: 1.955 ± 0.074
3.682ThrGly: 3.682 ± 0.125
0.69ThrHis: 0.69 ± 0.046
5.402ThrIle: 5.402 ± 0.154
4.827ThrLys: 4.827 ± 0.14
4.199ThrLeu: 4.199 ± 0.134
1.188ThrMet: 1.188 ± 0.065
3.639ThrAsn: 3.639 ± 0.142
1.632ThrPro: 1.632 ± 0.07
1.398ThrGln: 1.398 ± 0.074
1.61ThrArg: 1.61 ± 0.078
3.275ThrSer: 3.275 ± 0.118
3.392ThrThr: 3.392 ± 0.165
3.774ThrVal: 3.774 ± 0.116
0.311ThrTrp: 0.311 ± 0.03
2.318ThrTyr: 2.318 ± 0.093
0.0ThrXaa: 0.0 ± 0.0
Val
3.454ValAla: 3.454 ± 0.128
0.853ValCys: 0.853 ± 0.053
3.549ValAsp: 3.549 ± 0.113
4.473ValGlu: 4.473 ± 0.147
2.232ValPhe: 2.232 ± 0.091
3.691ValGly: 3.691 ± 0.117
0.757ValHis: 0.757 ± 0.053
6.298ValIle: 6.298 ± 0.135
5.96ValLys: 5.96 ± 0.169
5.249ValLeu: 5.249 ± 0.139
1.425ValMet: 1.425 ± 0.079
3.873ValAsn: 3.873 ± 0.145
1.801ValPro: 1.801 ± 0.073
1.65ValGln: 1.65 ± 0.075
1.801ValArg: 1.801 ± 0.088
3.959ValSer: 3.959 ± 0.128
3.651ValThr: 3.651 ± 0.148
4.19ValVal: 4.19 ± 0.13
0.354ValTrp: 0.354 ± 0.035
2.435ValTyr: 2.435 ± 0.094
0.0ValXaa: 0.0 ± 0.0
Trp
0.274TrpAla: 0.274 ± 0.032
0.083TrpCys: 0.083 ± 0.016
0.305TrpAsp: 0.305 ± 0.031
0.382TrpGlu: 0.382 ± 0.032
0.329TrpPhe: 0.329 ± 0.041
0.431TrpGly: 0.431 ± 0.039
0.117TrpHis: 0.117 ± 0.02
0.591TrpIle: 0.591 ± 0.048
0.539TrpLys: 0.539 ± 0.039
0.554TrpLeu: 0.554 ± 0.047
0.166TrpMet: 0.166 ± 0.023
0.486TrpAsn: 0.486 ± 0.043
0.105TrpPro: 0.105 ± 0.023
0.219TrpGln: 0.219 ± 0.032
0.185TrpArg: 0.185 ± 0.026
0.342TrpSer: 0.342 ± 0.038
0.311TrpThr: 0.311 ± 0.029
0.317TrpVal: 0.317 ± 0.032
0.074TrpTrp: 0.074 ± 0.016
0.345TrpTyr: 0.345 ± 0.03
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.004TyrAla: 2.004 ± 0.075
0.582TyrCys: 0.582 ± 0.047
2.712TyrAsp: 2.712 ± 0.107
3.217TyrGlu: 3.217 ± 0.121
1.708TyrPhe: 1.708 ± 0.079
2.678TyrGly: 2.678 ± 0.09
0.508TyrHis: 0.508 ± 0.041
4.682TyrIle: 4.682 ± 0.134
4.303TyrLys: 4.303 ± 0.139
3.371TyrLeu: 3.371 ± 0.099
1.01TyrMet: 1.01 ± 0.054
3.574TyrAsn: 3.574 ± 0.12
1.108TyrPro: 1.108 ± 0.051
1.059TyrGln: 1.059 ± 0.06
1.308TyrArg: 1.308 ± 0.068
2.737TyrSer: 2.737 ± 0.094
2.423TyrThr: 2.423 ± 0.116
2.484TyrVal: 2.484 ± 0.114
0.259TyrTrp: 0.259 ± 0.03
1.961TyrTyr: 1.961 ± 0.105
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1098 proteins (324855 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski