Amino acid dipepetide frequency for Vibrio pectenicida

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.408AlaAla: 6.408 ± 0.092	0.828AlaCys: 0.828 ± 0.027	3.923AlaAsp: 3.923 ± 0.063	4.945AlaGlu: 4.945 ± 0.074	3.076AlaPhe: 3.076 ± 0.058	5.264AlaGly: 5.264 ± 0.075	1.496AlaHis: 1.496 ± 0.041	5.789AlaIle: 5.789 ± 0.079	4.814AlaLys: 4.814 ± 0.079	8.922AlaLeu: 8.922 ± 0.083	2.395AlaMet: 2.395 ± 0.049	3.337AlaAsn: 3.337 ± 0.054	2.478AlaPro: 2.478 ± 0.053	3.63AlaGln: 3.63 ± 0.055	3.418AlaArg: 3.418 ± 0.057	5.297AlaSer: 5.297 ± 0.06	4.145AlaThr: 4.145 ± 0.059	5.13AlaVal: 5.13 ± 0.075	0.837AlaTrp: 0.837 ± 0.029	2.268AlaTyr: 2.268 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	0.726CysAla: 0.726 ± 0.026	0.163CysCys: 0.163 ± 0.012	0.653CysAsp: 0.653 ± 0.028	0.617CysGlu: 0.617 ± 0.024	0.519CysPhe: 0.519 ± 0.019	0.867CysGly: 0.867 ± 0.03	0.332CysHis: 0.332 ± 0.02	0.673CysIle: 0.673 ± 0.024	0.45CysLys: 0.45 ± 0.019	1.028CysLeu: 1.028 ± 0.033	0.238CysMet: 0.238 ± 0.014	0.415CysAsn: 0.415 ± 0.021	0.435CysPro: 0.435 ± 0.018	0.525CysGln: 0.525 ± 0.02	0.472CysArg: 0.472 ± 0.02	0.768CysSer: 0.768 ± 0.022	0.511CysThr: 0.511 ± 0.021	0.695CysVal: 0.695 ± 0.022	0.154CysTrp: 0.154 ± 0.013	0.368CysTyr: 0.368 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	3.895AspAla: 3.895 ± 0.065	0.564AspCys: 0.564 ± 0.023	2.993AspAsp: 2.993 ± 0.069	3.748AspGlu: 3.748 ± 0.057	2.506AspPhe: 2.506 ± 0.043	3.548AspGly: 3.548 ± 0.072	1.028AspHis: 1.028 ± 0.028	4.424AspIle: 4.424 ± 0.064	3.526AspLys: 3.526 ± 0.051	5.339AspLeu: 5.339 ± 0.077	1.441AspMet: 1.441 ± 0.035	2.606AspAsn: 2.606 ± 0.047	1.958AspPro: 1.958 ± 0.044	2.024AspGln: 2.024 ± 0.037	2.216AspArg: 2.216 ± 0.047	3.604AspSer: 3.604 ± 0.066	2.824AspThr: 2.824 ± 0.053	3.933AspVal: 3.933 ± 0.066	0.863AspTrp: 0.863 ± 0.027	2.139AspTyr: 2.139 ± 0.043	0.0AspXaa: 0.0 ± 0.0
Glu	4.733GluAla: 4.733 ± 0.067	0.591GluCys: 0.591 ± 0.024	2.875GluAsp: 2.875 ± 0.05	3.85GluGlu: 3.85 ± 0.069	2.577GluPhe: 2.577 ± 0.047	3.498GluGly: 3.498 ± 0.055	1.674GluHis: 1.674 ± 0.039	3.972GluIle: 3.972 ± 0.057	3.986GluLys: 3.986 ± 0.064	7.191GluLeu: 7.191 ± 0.08	1.718GluMet: 1.718 ± 0.04	2.737GluAsn: 2.737 ± 0.051	2.012GluPro: 2.012 ± 0.042	4.006GluGln: 4.006 ± 0.061	3.326GluArg: 3.326 ± 0.066	4.097GluSer: 4.097 ± 0.068	3.073GluThr: 3.073 ± 0.056	4.485GluVal: 4.485 ± 0.067	0.779GluTrp: 0.779 ± 0.026	1.816GluTyr: 1.816 ± 0.04	0.0GluXaa: 0.0 ± 0.0
Phe	3.201PheAla: 3.201 ± 0.053	0.511PheCys: 0.511 ± 0.018	2.797PheAsp: 2.797 ± 0.052	2.754PheGlu: 2.754 ± 0.045	1.672PhePhe: 1.672 ± 0.043	3.07PheGly: 3.07 ± 0.052	0.815PheHis: 0.815 ± 0.029	2.825PheIle: 2.825 ± 0.049	2.045PheLys: 2.045 ± 0.043	3.385PheLeu: 3.385 ± 0.059	0.919PheMet: 0.919 ± 0.029	2.09PheAsn: 2.09 ± 0.04	1.425PhePro: 1.425 ± 0.037	1.261PheGln: 1.261 ± 0.028	1.54PheArg: 1.54 ± 0.035	3.572PheSer: 3.572 ± 0.051	2.322PheThr: 2.322 ± 0.053	2.753PheVal: 2.753 ± 0.048	0.531PheTrp: 0.531 ± 0.025	1.336PheTyr: 1.336 ± 0.035	0.0PheXaa: 0.0 ± 0.0
Gly	4.765GlyAla: 4.765 ± 0.061	0.818GlyCys: 0.818 ± 0.031	3.571GlyAsp: 3.571 ± 0.067	4.381GlyGlu: 4.381 ± 0.067	3.083GlyPhe: 3.083 ± 0.049	4.63GlyGly: 4.63 ± 0.077	1.561GlyHis: 1.561 ± 0.04	4.669GlyIle: 4.669 ± 0.076	4.016GlyLys: 4.016 ± 0.057	6.614GlyLeu: 6.614 ± 0.087	1.879GlyMet: 1.879 ± 0.042	2.764GlyAsn: 2.764 ± 0.055	1.585GlyPro: 1.585 ± 0.039	2.94GlyGln: 2.94 ± 0.053	3.023GlyArg: 3.023 ± 0.054	4.277GlySer: 4.277 ± 0.065	3.298GlyThr: 3.298 ± 0.052	4.848GlyVal: 4.848 ± 0.064	0.885GlyTrp: 0.885 ± 0.028	2.559GlyTyr: 2.559 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	1.507HisAla: 1.507 ± 0.035	0.352HisCys: 0.352 ± 0.016	1.129HisAsp: 1.129 ± 0.032	1.129HisGlu: 1.129 ± 0.03	1.086HisPhe: 1.086 ± 0.032	1.442HisGly: 1.442 ± 0.041	0.718HisHis: 0.718 ± 0.028	1.516HisIle: 1.516 ± 0.035	1.16HisLys: 1.16 ± 0.031	2.304HisLeu: 2.304 ± 0.045	0.519HisMet: 0.519 ± 0.024	0.978HisAsn: 0.978 ± 0.031	1.113HisPro: 1.113 ± 0.031	1.318HisGln: 1.318 ± 0.031	1.033HisArg: 1.033 ± 0.033	1.601HisSer: 1.601 ± 0.04	1.121HisThr: 1.121 ± 0.033	1.284HisVal: 1.284 ± 0.031	0.313HisTrp: 0.313 ± 0.016	0.947HisTyr: 0.947 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	6.087IleAla: 6.087 ± 0.082	0.79IleCys: 0.79 ± 0.025	4.414IleAsp: 4.414 ± 0.062	5.069IleGlu: 5.069 ± 0.07	2.428IlePhe: 2.428 ± 0.052	4.743IleGly: 4.743 ± 0.06	1.382IleHis: 1.382 ± 0.033	3.975IleIle: 3.975 ± 0.061	3.725IleLys: 3.725 ± 0.057	5.688IleLeu: 5.688 ± 0.081	1.387IleMet: 1.387 ± 0.037	3.315IleAsn: 3.315 ± 0.051	2.741IlePro: 2.741 ± 0.054	2.504IleGln: 2.504 ± 0.044	2.965IleArg: 2.965 ± 0.051	5.029IleSer: 5.029 ± 0.068	3.874IleThr: 3.874 ± 0.059	4.297IleVal: 4.297 ± 0.062	0.664IleTrp: 0.664 ± 0.025	1.822IleTyr: 1.822 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	4.761LysAla: 4.761 ± 0.068	0.381LysCys: 0.381 ± 0.018	2.974LysAsp: 2.974 ± 0.055	3.514LysGlu: 3.514 ± 0.059	1.73LysPhe: 1.73 ± 0.04	3.53LysGly: 3.53 ± 0.056	1.364LysHis: 1.364 ± 0.036	3.322LysIle: 3.322 ± 0.057	3.304LysLys: 3.304 ± 0.064	5.839LysLeu: 5.839 ± 0.074	1.486LysMet: 1.486 ± 0.04	2.513LysAsn: 2.513 ± 0.048	2.432LysPro: 2.432 ± 0.047	3.257LysGln: 3.257 ± 0.057	2.782LysArg: 2.782 ± 0.051	3.636LysSer: 3.636 ± 0.059	3.041LysThr: 3.041 ± 0.056	4.235LysVal: 4.235 ± 0.067	0.602LysTrp: 0.602 ± 0.024	1.633LysTyr: 1.633 ± 0.038	0.0LysXaa: 0.0 ± 0.0
Leu	8.955LeuAla: 8.955 ± 0.094	1.089LeuCys: 1.089 ± 0.032	6.029LeuAsp: 6.029 ± 0.089	6.432LeuGlu: 6.432 ± 0.076	4.106LeuPhe: 4.106 ± 0.075	6.743LeuGly: 6.743 ± 0.086	1.996LeuHis: 1.996 ± 0.042	6.483LeuIle: 6.483 ± 0.081	5.691LeuLys: 5.691 ± 0.074	10.037LeuLeu: 10.037 ± 0.123	2.72LeuMet: 2.72 ± 0.052	4.859LeuAsn: 4.859 ± 0.074	4.582LeuPro: 4.582 ± 0.066	3.546LeuGln: 3.546 ± 0.056	4.252LeuArg: 4.252 ± 0.064	8.634LeuSer: 8.634 ± 0.088	5.939LeuThr: 5.939 ± 0.069	6.966LeuVal: 6.966 ± 0.099	1.051LeuTrp: 1.051 ± 0.03	2.766LeuTyr: 2.766 ± 0.055	0.0LeuXaa: 0.0 ± 0.0
Met	2.335MetAla: 2.335 ± 0.043	0.248MetCys: 0.248 ± 0.012	1.288MetAsp: 1.288 ± 0.034	1.325MetGlu: 1.325 ± 0.035	0.971MetPhe: 0.971 ± 0.03	1.707MetGly: 1.707 ± 0.037	0.512MetHis: 0.512 ± 0.017	1.541MetIle: 1.541 ± 0.039	1.596MetLys: 1.596 ± 0.031	2.734MetLeu: 2.734 ± 0.05	0.775MetMet: 0.775 ± 0.027	1.139MetAsn: 1.139 ± 0.029	1.179MetPro: 1.179 ± 0.033	1.11MetGln: 1.11 ± 0.031	1.186MetArg: 1.186 ± 0.033	2.078MetSer: 2.078 ± 0.05	1.544MetThr: 1.544 ± 0.038	1.858MetVal: 1.858 ± 0.04	0.231MetTrp: 0.231 ± 0.013	0.576MetTyr: 0.576 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	3.268AsnAla: 3.268 ± 0.052	0.449AsnCys: 0.449 ± 0.021	2.433AsnAsp: 2.433 ± 0.051	2.537AsnGlu: 2.537 ± 0.048	1.66AsnPhe: 1.66 ± 0.035	2.972AsnGly: 2.972 ± 0.054	1.116AsnHis: 1.116 ± 0.032	3.315AsnIle: 3.315 ± 0.055	2.582AsnLys: 2.582 ± 0.044	4.197AsnLeu: 4.197 ± 0.049	1.078AsnMet: 1.078 ± 0.027	2.231AsnAsn: 2.231 ± 0.045	2.102AsnPro: 2.102 ± 0.042	2.459AsnGln: 2.459 ± 0.048	2.004AsnArg: 2.004 ± 0.043	2.932AsnSer: 2.932 ± 0.048	2.493AsnThr: 2.493 ± 0.043	2.786AsnVal: 2.786 ± 0.05	0.654AsnTrp: 0.654 ± 0.025	1.567AsnTyr: 1.567 ± 0.036	0.0AsnXaa: 0.0 ± 0.0
Pro	2.611ProAla: 2.611 ± 0.046	0.352ProCys: 0.352 ± 0.017	2.315ProAsp: 2.315 ± 0.046	2.989ProGlu: 2.989 ± 0.051	1.662ProPhe: 1.662 ± 0.041	1.972ProGly: 1.972 ± 0.04	0.848ProHis: 0.848 ± 0.027	2.754ProIle: 2.754 ± 0.055	2.165ProLys: 2.165 ± 0.041	3.96ProLeu: 3.96 ± 0.064	1.017ProMet: 1.017 ± 0.033	1.856ProAsn: 1.856 ± 0.04	1.129ProPro: 1.129 ± 0.033	1.634ProGln: 1.634 ± 0.039	1.341ProArg: 1.341 ± 0.032	2.704ProSer: 2.704 ± 0.05	2.091ProThr: 2.091 ± 0.044	2.77ProVal: 2.77 ± 0.048	0.482ProTrp: 0.482 ± 0.023	1.293ProTyr: 1.293 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	4.055GlnAla: 4.055 ± 0.062	0.424GlnCys: 0.424 ± 0.02	2.232GlnAsp: 2.232 ± 0.044	2.641GlnGlu: 2.641 ± 0.046	1.756GlnPhe: 1.756 ± 0.032	3.111GlnGly: 3.111 ± 0.057	1.205GlnHis: 1.205 ± 0.034	2.745GlnIle: 2.745 ± 0.048	2.306GlnLys: 2.306 ± 0.047	5.168GlnLeu: 5.168 ± 0.069	1.167GlnMet: 1.167 ± 0.032	1.804GlnAsn: 1.804 ± 0.041	1.741GlnPro: 1.741 ± 0.039	2.781GlnGln: 2.781 ± 0.056	2.281GlnArg: 2.281 ± 0.043	3.19GlnSer: 3.19 ± 0.057	2.341GlnThr: 2.341 ± 0.048	3.369GlnVal: 3.369 ± 0.066	0.658GlnTrp: 0.658 ± 0.024	1.503GlnTyr: 1.503 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	3.197ArgAla: 3.197 ± 0.052	0.499ArgCys: 0.499 ± 0.019	2.476ArgAsp: 2.476 ± 0.05	2.924ArgGlu: 2.924 ± 0.053	2.117ArgPhe: 2.117 ± 0.044	2.534ArgGly: 2.534 ± 0.048	1.114ArgHis: 1.114 ± 0.03	3.075ArgIle: 3.075 ± 0.046	2.426ArgLys: 2.426 ± 0.046	4.947ArgLeu: 4.947 ± 0.063	1.121ArgMet: 1.121 ± 0.031	1.942ArgAsn: 1.942 ± 0.035	1.478ArgPro: 1.478 ± 0.036	2.147ArgGln: 2.147 ± 0.045	2.307ArgArg: 2.307 ± 0.051	2.775ArgSer: 2.775 ± 0.044	2.097ArgThr: 2.097 ± 0.044	3.08ArgVal: 3.08 ± 0.052	0.6ArgTrp: 0.6 ± 0.024	1.764ArgTyr: 1.764 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	5.195SerAla: 5.195 ± 0.058	0.677SerCys: 0.677 ± 0.024	4.021SerAsp: 4.021 ± 0.062	4.309SerGlu: 4.309 ± 0.057	3.022SerPhe: 3.022 ± 0.051	5.303SerGly: 5.303 ± 0.073	1.667SerHis: 1.667 ± 0.038	4.919SerIle: 4.919 ± 0.075	3.858SerLys: 3.858 ± 0.058	7.602SerLeu: 7.602 ± 0.091	1.888SerMet: 1.888 ± 0.037	3.139SerAsn: 3.139 ± 0.058	2.691SerPro: 2.691 ± 0.046	3.504SerGln: 3.504 ± 0.063	2.989SerArg: 2.989 ± 0.052	5.248SerSer: 5.248 ± 0.078	3.65SerThr: 3.65 ± 0.053	4.792SerVal: 4.792 ± 0.067	0.877SerTrp: 0.877 ± 0.031	2.22SerTyr: 2.22 ± 0.045	0.002SerXaa: 0.002 ± 0.001
Thr	3.994ThrAla: 3.994 ± 0.062	0.506ThrCys: 0.506 ± 0.022	2.791ThrAsp: 2.791 ± 0.058	3.074ThrGlu: 3.074 ± 0.052	2.069ThrPhe: 2.069 ± 0.047	3.876ThrGly: 3.876 ± 0.062	1.259ThrHis: 1.259 ± 0.036	3.648ThrIle: 3.648 ± 0.054	2.741ThrLys: 2.741 ± 0.053	6.217ThrLeu: 6.217 ± 0.067	1.2ThrMet: 1.2 ± 0.031	2.285ThrAsn: 2.285 ± 0.046	2.531ThrPro: 2.531 ± 0.048	2.603ThrGln: 2.603 ± 0.047	2.203ThrArg: 2.203 ± 0.056	3.779ThrSer: 3.779 ± 0.066	2.928ThrThr: 2.928 ± 0.056	3.595ThrVal: 3.595 ± 0.065	0.583ThrTrp: 0.583 ± 0.025	1.59ThrTyr: 1.59 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	5.7ValAla: 5.7 ± 0.075	0.801ValCys: 0.801 ± 0.025	4.011ValAsp: 4.011 ± 0.06	4.727ValGlu: 4.727 ± 0.072	2.766ValPhe: 2.766 ± 0.055	4.571ValGly: 4.571 ± 0.067	1.222ValHis: 1.222 ± 0.033	4.738ValIle: 4.738 ± 0.068	3.833ValLys: 3.833 ± 0.068	6.566ValLeu: 6.566 ± 0.076	1.948ValMet: 1.948 ± 0.039	3.082ValAsn: 3.082 ± 0.056	2.482ValPro: 2.482 ± 0.044	2.253ValGln: 2.253 ± 0.041	2.904ValArg: 2.904 ± 0.048	5.24ValSer: 5.24 ± 0.073	4.106ValThr: 4.106 ± 0.067	5.034ValVal: 5.034 ± 0.068	0.736ValTrp: 0.736 ± 0.023	1.858ValTyr: 1.858 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	0.827TrpAla: 0.827 ± 0.031	0.157TrpCys: 0.157 ± 0.012	0.596TrpAsp: 0.596 ± 0.022	0.565TrpGlu: 0.565 ± 0.024	0.588TrpPhe: 0.588 ± 0.024	0.735TrpGly: 0.735 ± 0.025	0.347TrpHis: 0.347 ± 0.018	0.679TrpIle: 0.679 ± 0.024	0.59TrpLys: 0.59 ± 0.021	1.697TrpLeu: 1.697 ± 0.04	0.348TrpMet: 0.348 ± 0.015	0.483TrpAsn: 0.483 ± 0.019	0.436TrpPro: 0.436 ± 0.02	0.866TrpGln: 0.866 ± 0.03	0.66TrpArg: 0.66 ± 0.023	0.802TrpSer: 0.802 ± 0.028	0.454TrpThr: 0.454 ± 0.02	0.79TrpVal: 0.79 ± 0.027	0.193TrpTrp: 0.193 ± 0.014	0.392TrpTyr: 0.392 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.179TyrAla: 2.179 ± 0.041	0.413TyrCys: 0.413 ± 0.019	1.654TyrAsp: 1.654 ± 0.037	1.463TyrGlu: 1.463 ± 0.036	1.427TyrPhe: 1.427 ± 0.036	2.051TyrGly: 2.051 ± 0.041	0.914TyrHis: 0.914 ± 0.027	1.837TyrIle: 1.837 ± 0.043	1.52TyrLys: 1.52 ± 0.036	3.441TyrLeu: 3.441 ± 0.053	0.689TyrMet: 0.689 ± 0.027	1.263TyrAsn: 1.263 ± 0.031	1.414TyrPro: 1.414 ± 0.035	2.114TyrGln: 2.114 ± 0.05	1.72TyrArg: 1.72 ± 0.039	2.309TyrSer: 2.309 ± 0.045	1.617TyrThr: 1.617 ± 0.039	1.877TyrVal: 1.877 ± 0.039	0.512TyrTrp: 0.512 ± 0.02	1.093TyrTyr: 1.093 ± 0.033	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.001XaaAsp: 0.001 ± 0.001	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.001	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3823 proteins (1245720 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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