Amino acid dipepetide frequency for Eggerthella sp. CAG:209

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.487AlaAla: 11.487 ± 0.239	1.939AlaCys: 1.939 ± 0.074	5.443AlaAsp: 5.443 ± 0.104	6.926AlaGlu: 6.926 ± 0.131	4.286AlaPhe: 4.286 ± 0.099	7.732AlaGly: 7.732 ± 0.16	2.087AlaHis: 2.087 ± 0.069	5.909AlaIle: 5.909 ± 0.108	5.304AlaLys: 5.304 ± 0.124	10.773AlaLeu: 10.773 ± 0.187	2.826AlaMet: 2.826 ± 0.08	3.35AlaAsn: 3.35 ± 0.083	3.483AlaPro: 3.483 ± 0.095	3.932AlaGln: 3.932 ± 0.14	5.32AlaArg: 5.32 ± 0.107	6.346AlaSer: 6.346 ± 0.128	5.106AlaThr: 5.106 ± 0.089	7.63AlaVal: 7.63 ± 0.153	0.913AlaTrp: 0.913 ± 0.043	2.852AlaTyr: 2.852 ± 0.07	0.017AlaXaa: 0.017 ± 0.007
Cys	1.66CysAla: 1.66 ± 0.064	0.377CysCys: 0.377 ± 0.029	1.036CysAsp: 1.036 ± 0.043	1.097CysGlu: 1.097 ± 0.047	0.73CysPhe: 0.73 ± 0.037	1.796CysGly: 1.796 ± 0.058	0.399CysHis: 0.399 ± 0.028	0.959CysIle: 0.959 ± 0.052	0.589CysLys: 0.589 ± 0.037	1.434CysLeu: 1.434 ± 0.064	0.418CysMet: 0.418 ± 0.031	0.506CysAsn: 0.506 ± 0.033	0.861CysPro: 0.861 ± 0.046	0.443CysGln: 0.443 ± 0.03	0.949CysArg: 0.949 ± 0.052	1.173CysSer: 1.173 ± 0.049	0.893CysThr: 0.893 ± 0.043	1.338CysVal: 1.338 ± 0.047	0.16CysTrp: 0.16 ± 0.015	0.483CysTyr: 0.483 ± 0.033	0.0CysXaa: 0.0 ± 0.0
Asp	6.254AspAla: 6.254 ± 0.12	0.865AspCys: 0.865 ± 0.039	2.975AspAsp: 2.975 ± 0.084	4.542AspGlu: 4.542 ± 0.113	2.38AspPhe: 2.38 ± 0.077	4.534AspGly: 4.534 ± 0.101	0.997AspHis: 0.997 ± 0.051	3.416AspIle: 3.416 ± 0.087	2.441AspLys: 2.441 ± 0.083	5.077AspLeu: 5.077 ± 0.109	1.5AspMet: 1.5 ± 0.058	1.76AspAsn: 1.76 ± 0.055	2.532AspPro: 2.532 ± 0.065	1.54AspGln: 1.54 ± 0.058	2.653AspArg: 2.653 ± 0.081	3.435AspSer: 3.435 ± 0.087	2.68AspThr: 2.68 ± 0.076	4.265AspVal: 4.265 ± 0.098	0.597AspTrp: 0.597 ± 0.034	1.821AspTyr: 1.821 ± 0.062	0.002AspXaa: 0.002 ± 0.002
Glu	7.157GluAla: 7.157 ± 0.134	0.984GluCys: 0.984 ± 0.051	3.599GluAsp: 3.599 ± 0.085	5.732GluGlu: 5.732 ± 0.133	2.424GluPhe: 2.424 ± 0.074	5.304GluGly: 5.304 ± 0.118	1.506GluHis: 1.506 ± 0.058	3.681GluIle: 3.681 ± 0.078	3.604GluLys: 3.604 ± 0.098	6.286GluLeu: 6.286 ± 0.123	1.881GluMet: 1.881 ± 0.068	2.493GluAsn: 2.493 ± 0.065	2.368GluPro: 2.368 ± 0.076	2.553GluGln: 2.553 ± 0.075	4.082GluArg: 4.082 ± 0.108	3.743GluSer: 3.743 ± 0.083	3.452GluThr: 3.452 ± 0.075	5.014GluVal: 5.014 ± 0.11	0.693GluTrp: 0.693 ± 0.037	1.987GluTyr: 1.987 ± 0.065	0.006GluXaa: 0.006 ± 0.003
Phe	4.369PheAla: 4.369 ± 0.092	0.787PheCys: 0.787 ± 0.04	2.875PheAsp: 2.875 ± 0.082	2.659PheGlu: 2.659 ± 0.083	1.665PhePhe: 1.665 ± 0.07	3.731PheGly: 3.731 ± 0.098	0.745PheHis: 0.745 ± 0.04	2.176PheIle: 2.176 ± 0.077	1.535PheLys: 1.535 ± 0.057	3.348PheLeu: 3.348 ± 0.083	1.063PheMet: 1.063 ± 0.042	1.265PheAsn: 1.265 ± 0.053	1.498PhePro: 1.498 ± 0.058	0.942PheGln: 0.942 ± 0.047	1.729PheArg: 1.729 ± 0.061	2.863PheSer: 2.863 ± 0.081	2.214PheThr: 2.214 ± 0.068	3.144PheVal: 3.144 ± 0.081	0.458PheTrp: 0.458 ± 0.035	1.151PheTyr: 1.151 ± 0.043	0.0PheXaa: 0.0 ± 0.0
Gly	7.261GlyAla: 7.261 ± 0.143	1.548GlyCys: 1.548 ± 0.053	3.833GlyAsp: 3.833 ± 0.101	4.769GlyGlu: 4.769 ± 0.103	3.568GlyPhe: 3.568 ± 0.102	5.657GlyGly: 5.657 ± 0.124	1.527GlyHis: 1.527 ± 0.051	5.553GlyIle: 5.553 ± 0.116	4.633GlyLys: 4.633 ± 0.101	6.783GlyLeu: 6.783 ± 0.127	2.301GlyMet: 2.301 ± 0.072	2.992GlyAsn: 2.992 ± 0.113	2.139GlyPro: 2.139 ± 0.068	2.249GlyGln: 2.249 ± 0.065	3.743GlyArg: 3.743 ± 0.084	5.287GlySer: 5.287 ± 0.102	4.494GlyThr: 4.494 ± 0.109	6.388GlyVal: 6.388 ± 0.127	0.905GlyTrp: 0.905 ± 0.045	2.59GlyTyr: 2.59 ± 0.071	0.021GlyXaa: 0.021 ± 0.006
His	2.01HisAla: 2.01 ± 0.071	0.354HisCys: 0.354 ± 0.023	1.111HisAsp: 1.111 ± 0.047	1.302HisGlu: 1.302 ± 0.046	0.888HisPhe: 0.888 ± 0.044	1.683HisGly: 1.683 ± 0.067	0.537HisHis: 0.537 ± 0.033	1.148HisIle: 1.148 ± 0.052	0.743HisLys: 0.743 ± 0.043	1.714HisLeu: 1.714 ± 0.063	0.522HisMet: 0.522 ± 0.032	0.657HisAsn: 0.657 ± 0.029	1.115HisPro: 1.115 ± 0.048	0.581HisGln: 0.581 ± 0.032	1.194HisArg: 1.194 ± 0.057	1.213HisSer: 1.213 ± 0.051	0.947HisThr: 0.947 ± 0.045	1.548HisVal: 1.548 ± 0.055	0.179HisTrp: 0.179 ± 0.022	0.616HisTyr: 0.616 ± 0.036	0.002HisXaa: 0.002 ± 0.002
Ile	6.843IleAla: 6.843 ± 0.127	1.071IleCys: 1.071 ± 0.053	4.251IleAsp: 4.251 ± 0.092	4.365IleGlu: 4.365 ± 0.099	1.841IlePhe: 1.841 ± 0.074	4.538IleGly: 4.538 ± 0.116	0.945IleHis: 0.945 ± 0.044	3.013IleIle: 3.013 ± 0.084	2.228IleLys: 2.228 ± 0.07	4.226IleLeu: 4.226 ± 0.098	1.486IleMet: 1.486 ± 0.057	1.962IleAsn: 1.962 ± 0.063	2.748IlePro: 2.748 ± 0.079	1.469IleGln: 1.469 ± 0.049	2.73IleArg: 2.73 ± 0.072	3.716IleSer: 3.716 ± 0.09	3.148IleThr: 3.148 ± 0.076	4.765IleVal: 4.765 ± 0.103	0.481IleTrp: 0.481 ± 0.03	1.34IleTyr: 1.34 ± 0.054	0.002IleXaa: 0.002 ± 0.002
Lys	5.006LysAla: 5.006 ± 0.099	0.537LysCys: 0.537 ± 0.035	2.318LysAsp: 2.318 ± 0.071	3.483LysGlu: 3.483 ± 0.089	1.161LysPhe: 1.161 ± 0.042	3.437LysGly: 3.437 ± 0.086	1.036LysHis: 1.036 ± 0.046	2.278LysIle: 2.278 ± 0.08	3.056LysLys: 3.056 ± 0.104	3.88LysLeu: 3.88 ± 0.096	1.355LysMet: 1.355 ± 0.054	1.814LysAsn: 1.814 ± 0.062	2.162LysPro: 2.162 ± 0.068	1.704LysGln: 1.704 ± 0.065	3.217LysArg: 3.217 ± 0.087	2.503LysSer: 2.503 ± 0.073	2.834LysThr: 2.834 ± 0.069	3.539LysVal: 3.539 ± 0.083	0.368LysTrp: 0.368 ± 0.026	1.194LysTyr: 1.194 ± 0.049	0.004LysXaa: 0.004 ± 0.003
Leu	9.658LeuAla: 9.658 ± 0.178	1.64LeuCys: 1.64 ± 0.059	5.364LeuAsp: 5.364 ± 0.108	5.853LeuGlu: 5.853 ± 0.139	3.914LeuPhe: 3.914 ± 0.118	7.168LeuGly: 7.168 ± 0.107	1.758LeuHis: 1.758 ± 0.066	5.033LeuIle: 5.033 ± 0.126	4.013LeuLys: 4.013 ± 0.089	8.127LeuLeu: 8.127 ± 0.149	2.432LeuMet: 2.432 ± 0.079	3.004LeuAsn: 3.004 ± 0.079	4.103LeuPro: 4.103 ± 0.09	2.64LeuGln: 2.64 ± 0.073	5.014LeuArg: 5.014 ± 0.109	6.643LeuSer: 6.643 ± 0.121	4.463LeuThr: 4.463 ± 0.101	7.234LeuVal: 7.234 ± 0.153	0.691LeuTrp: 0.691 ± 0.038	2.337LeuTyr: 2.337 ± 0.074	0.006LeuXaa: 0.006 ± 0.003
Met	2.957MetAla: 2.957 ± 0.064	0.358MetCys: 0.358 ± 0.023	1.357MetAsp: 1.357 ± 0.057	1.654MetGlu: 1.654 ± 0.054	0.816MetPhe: 0.816 ± 0.039	2.301MetGly: 2.301 ± 0.075	0.506MetHis: 0.506 ± 0.031	1.296MetIle: 1.296 ± 0.053	1.382MetLys: 1.382 ± 0.058	2.453MetLeu: 2.453 ± 0.07	0.739MetMet: 0.739 ± 0.043	1.024MetAsn: 1.024 ± 0.047	1.436MetPro: 1.436 ± 0.052	0.943MetGln: 0.943 ± 0.044	1.658MetArg: 1.658 ± 0.06	1.723MetSer: 1.723 ± 0.066	1.421MetThr: 1.421 ± 0.052	2.002MetVal: 2.002 ± 0.062	0.241MetTrp: 0.241 ± 0.02	0.533MetTyr: 0.533 ± 0.029	0.0MetXaa: 0.0 ± 0.0
Asn	3.891AsnAla: 3.891 ± 0.094	0.487AsnCys: 0.487 ± 0.034	1.943AsnAsp: 1.943 ± 0.071	2.376AsnGlu: 2.376 ± 0.063	1.051AsnPhe: 1.051 ± 0.049	2.765AsnGly: 2.765 ± 0.094	0.728AsnHis: 0.728 ± 0.038	1.96AsnIle: 1.96 ± 0.066	1.484AsnLys: 1.484 ± 0.055	3.106AsnLeu: 3.106 ± 0.081	0.968AsnMet: 0.968 ± 0.046	1.263AsnAsn: 1.263 ± 0.053	2.079AsnPro: 2.079 ± 0.065	1.045AsnGln: 1.045 ± 0.043	1.812AsnArg: 1.812 ± 0.06	2.045AsnSer: 2.045 ± 0.069	1.76AsnThr: 1.76 ± 0.059	2.63AsnVal: 2.63 ± 0.067	0.364AsnTrp: 0.364 ± 0.029	1.024AsnTyr: 1.024 ± 0.047	0.0AsnXaa: 0.0 ± 0.0
Pro	3.649ProAla: 3.649 ± 0.099	0.645ProCys: 0.645 ± 0.038	2.592ProAsp: 2.592 ± 0.082	3.531ProGlu: 3.531 ± 0.105	1.862ProPhe: 1.862 ± 0.063	2.93ProGly: 2.93 ± 0.08	0.851ProHis: 0.851 ± 0.042	2.178ProIle: 2.178 ± 0.062	1.82ProLys: 1.82 ± 0.061	3.583ProLeu: 3.583 ± 0.086	0.918ProMet: 0.918 ± 0.041	1.506ProAsn: 1.506 ± 0.054	0.994ProPro: 0.994 ± 0.046	1.398ProGln: 1.398 ± 0.061	1.925ProArg: 1.925 ± 0.062	2.678ProSer: 2.678 ± 0.072	2.224ProThr: 2.224 ± 0.065	3.302ProVal: 3.302 ± 0.083	0.435ProTrp: 0.435 ± 0.029	1.307ProTyr: 1.307 ± 0.047	0.0ProXaa: 0.0 ± 0.0
Gln	3.504GlnAla: 3.504 ± 0.111	0.397GlnCys: 0.397 ± 0.028	1.446GlnAsp: 1.446 ± 0.058	2.026GlnGlu: 2.026 ± 0.077	1.009GlnPhe: 1.009 ± 0.043	2.694GlnGly: 2.694 ± 0.076	0.736GlnHis: 0.736 ± 0.039	1.868GlnIle: 1.868 ± 0.06	1.521GlnLys: 1.521 ± 0.06	2.778GlnLeu: 2.778 ± 0.08	0.934GlnMet: 0.934 ± 0.042	1.178GlnAsn: 1.178 ± 0.051	1.323GlnPro: 1.323 ± 0.054	1.433GlnGln: 1.433 ± 0.061	2.099GlnArg: 2.099 ± 0.067	1.785GlnSer: 1.785 ± 0.057	1.602GlnThr: 1.602 ± 0.066	2.391GlnVal: 2.391 ± 0.073	0.285GlnTrp: 0.285 ± 0.026	0.745GlnTyr: 0.745 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	5.037ArgAla: 5.037 ± 0.113	1.101ArgCys: 1.101 ± 0.053	2.647ArgAsp: 2.647 ± 0.073	3.845ArgGlu: 3.845 ± 0.077	2.439ArgPhe: 2.439 ± 0.066	3.591ArgGly: 3.591 ± 0.084	1.109ArgHis: 1.109 ± 0.05	3.606ArgIle: 3.606 ± 0.085	2.967ArgLys: 2.967 ± 0.075	4.59ArgLeu: 4.59 ± 0.104	1.675ArgMet: 1.675 ± 0.063	2.058ArgAsn: 2.058 ± 0.061	1.8ArgPro: 1.8 ± 0.068	1.677ArgGln: 1.677 ± 0.056	3.271ArgArg: 3.271 ± 0.097	3.26ArgSer: 3.26 ± 0.093	2.882ArgThr: 2.882 ± 0.079	3.849ArgVal: 3.849 ± 0.095	0.447ArgTrp: 0.447 ± 0.03	1.802ArgTyr: 1.802 ± 0.066	0.012ArgXaa: 0.012 ± 0.004
Ser	6.138SerAla: 6.138 ± 0.134	1.101SerCys: 1.101 ± 0.053	3.666SerAsp: 3.666 ± 0.092	3.83SerGlu: 3.83 ± 0.085	3.056SerPhe: 3.056 ± 0.078	5.124SerGly: 5.124 ± 0.117	1.255SerHis: 1.255 ± 0.048	3.86SerIle: 3.86 ± 0.088	2.715SerLys: 2.715 ± 0.073	6.331SerLeu: 6.331 ± 0.115	1.683SerMet: 1.683 ± 0.053	2.255SerAsn: 2.255 ± 0.069	2.337SerPro: 2.337 ± 0.067	2.099SerGln: 2.099 ± 0.069	3.329SerArg: 3.329 ± 0.079	5.018SerSer: 5.018 ± 0.157	3.298SerThr: 3.298 ± 0.074	4.706SerVal: 4.706 ± 0.093	0.741SerTrp: 0.741 ± 0.047	2.126SerTyr: 2.126 ± 0.064	0.0SerXaa: 0.0 ± 0.0
Thr	4.837ThrAla: 4.837 ± 0.111	0.874ThrCys: 0.874 ± 0.036	2.809ThrAsp: 2.809 ± 0.078	3.09ThrGlu: 3.09 ± 0.082	2.081ThrPhe: 2.081 ± 0.062	4.296ThrGly: 4.296 ± 0.103	1.055ThrHis: 1.055 ± 0.045	3.177ThrIle: 3.177 ± 0.078	2.324ThrLys: 2.324 ± 0.066	5.075ThrLeu: 5.075 ± 0.114	1.265ThrMet: 1.265 ± 0.05	1.729ThrAsn: 1.729 ± 0.062	2.659ThrPro: 2.659 ± 0.072	1.66ThrGln: 1.66 ± 0.056	2.484ThrArg: 2.484 ± 0.073	3.138ThrSer: 3.138 ± 0.084	2.865ThrThr: 2.865 ± 0.075	4.478ThrVal: 4.478 ± 0.094	0.556ThrTrp: 0.556 ± 0.034	1.648ThrTyr: 1.648 ± 0.059	0.002ThrXaa: 0.002 ± 0.002
Val	8.118ValAla: 8.118 ± 0.167	1.513ValCys: 1.513 ± 0.053	4.552ValAsp: 4.552 ± 0.095	4.931ValGlu: 4.931 ± 0.103	3.421ValPhe: 3.421 ± 0.096	5.722ValGly: 5.722 ± 0.114	1.461ValHis: 1.461 ± 0.05	4.263ValIle: 4.263 ± 0.094	3.142ValLys: 3.142 ± 0.078	7.551ValLeu: 7.551 ± 0.132	1.972ValMet: 1.972 ± 0.057	2.624ValAsn: 2.624 ± 0.083	3.233ValPro: 3.233 ± 0.082	2.147ValGln: 2.147 ± 0.061	4.014ValArg: 4.014 ± 0.102	5.645ValSer: 5.645 ± 0.115	3.972ValThr: 3.972 ± 0.101	6.928ValVal: 6.928 ± 0.155	0.655ValTrp: 0.655 ± 0.034	2.087ValTyr: 2.087 ± 0.063	0.004ValXaa: 0.004 ± 0.002
Trp	0.909TrpAla: 0.909 ± 0.044	0.189TrpCys: 0.189 ± 0.019	0.543TrpAsp: 0.543 ± 0.033	0.589TrpGlu: 0.589 ± 0.036	0.42TrpPhe: 0.42 ± 0.029	0.782TrpGly: 0.782 ± 0.043	0.218TrpHis: 0.218 ± 0.022	0.558TrpIle: 0.558 ± 0.032	0.427TrpLys: 0.427 ± 0.029	1.005TrpLeu: 1.005 ± 0.048	0.293TrpMet: 0.293 ± 0.022	0.375TrpAsn: 0.375 ± 0.026	0.285TrpPro: 0.285 ± 0.022	0.322TrpGln: 0.322 ± 0.024	0.539TrpArg: 0.539 ± 0.033	0.601TrpSer: 0.601 ± 0.034	0.391TrpThr: 0.391 ± 0.03	0.72TrpVal: 0.72 ± 0.039	0.106TrpTrp: 0.106 ± 0.015	0.27TrpTyr: 0.27 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.902TyrAla: 2.902 ± 0.066	0.533TyrCys: 0.533 ± 0.033	1.904TyrAsp: 1.904 ± 0.065	1.945TyrGlu: 1.945 ± 0.061	1.205TyrPhe: 1.205 ± 0.049	2.445TyrGly: 2.445 ± 0.067	0.607TyrHis: 0.607 ± 0.037	1.232TyrIle: 1.232 ± 0.05	0.955TyrLys: 0.955 ± 0.05	2.971TyrLeu: 2.971 ± 0.069	0.568TyrMet: 0.568 ± 0.033	0.965TyrAsn: 0.965 ± 0.048	1.169TyrPro: 1.169 ± 0.049	0.976TyrGln: 0.976 ± 0.044	1.897TyrArg: 1.897 ± 0.065	1.848TyrSer: 1.848 ± 0.064	1.454TyrThr: 1.454 ± 0.051	2.081TyrVal: 2.081 ± 0.06	0.26TyrTrp: 0.26 ± 0.024	0.866TyrTyr: 0.866 ± 0.05	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.017XaaAla: 0.017 ± 0.005	0.0XaaCys: 0.0 ± 0.0	0.002XaaAsp: 0.002 ± 0.002	0.008XaaGlu: 0.008 ± 0.004	0.0XaaPhe: 0.0 ± 0.0	0.01XaaGly: 0.01 ± 0.004	0.0XaaHis: 0.0 ± 0.0	0.006XaaIle: 0.006 ± 0.003	0.002XaaLys: 0.002 ± 0.002	0.002XaaLeu: 0.002 ± 0.002	0.002XaaMet: 0.002 ± 0.002	0.002XaaAsn: 0.002 ± 0.002	0.004XaaPro: 0.004 ± 0.003	0.0XaaGln: 0.0 ± 0.0	0.008XaaArg: 0.008 ± 0.003	0.004XaaSer: 0.004 ± 0.003	0.002XaaThr: 0.002 ± 0.002	0.002XaaVal: 0.002 ± 0.002	0.006XaaTrp: 0.006 ± 0.003	0.002XaaTyr: 0.002 ± 0.002	0.09XaaXaa: 0.09 ± 0.018

Statistics based on 1726 proteins (519372 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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