Amino acid dipepetide frequency for Changjiang picorna-like virus 8

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.825AlaAla: 7.825 ± 1.087
1.647AlaCys: 1.647 ± 0.137
2.059AlaAsp: 2.059 ± 0.408
3.295AlaGlu: 3.295 ± 1.045
2.471AlaPhe: 2.471 ± 0.953
4.942AlaGly: 4.942 ± 1.134
1.236AlaHis: 1.236 ± 0.681
4.53AlaIle: 4.53 ± 0.955
3.295AlaLys: 3.295 ± 1.817
4.119AlaLeu: 4.119 ± 2.271
2.883AlaMet: 2.883 ± 0.564
2.883AlaAsn: 2.883 ± 0.726
8.237AlaPro: 8.237 ± 0.86
2.471AlaGln: 2.471 ± 1.724
2.883AlaArg: 2.883 ± 1.497
6.178AlaSer: 6.178 ± 0.452
7.002AlaThr: 7.002 ± 3.085
5.354AlaVal: 5.354 ± 2.181
2.059AlaTrp: 2.059 ± 0.364
3.707AlaTyr: 3.707 ± 0.5
0.0AlaXaa: 0.0 ± 0.0
Cys
1.647CysAla: 1.647 ± 0.137
0.412CysCys: 0.412 ± 0.227
0.824CysAsp: 0.824 ± 0.454
0.824CysGlu: 0.824 ± 0.454
1.236CysPhe: 1.236 ± 0.09
0.824CysGly: 0.824 ± 0.318
0.412CysHis: 0.412 ± 0.227
1.236CysIle: 1.236 ± 0.681
0.824CysLys: 0.824 ± 0.454
0.412CysLeu: 0.412 ± 0.545
0.412CysMet: 0.412 ± 0.227
0.824CysAsn: 0.824 ± 0.318
0.824CysPro: 0.824 ± 0.318
0.412CysGln: 0.412 ± 0.227
2.059CysArg: 2.059 ± 0.364
0.0CysSer: 0.0 ± 0.0
0.824CysThr: 0.824 ± 0.454
0.824CysVal: 0.824 ± 0.454
0.0CysTrp: 0.0 ± 0.0
1.647CysTyr: 1.647 ± 0.635
0.0CysXaa: 0.0 ± 0.0
Asp
3.707AspAla: 3.707 ± 2.044
1.236AspCys: 1.236 ± 0.681
4.119AspAsp: 4.119 ± 0.044
3.707AspGlu: 3.707 ± 1.272
2.471AspPhe: 2.471 ± 0.591
1.236AspGly: 1.236 ± 0.09
0.412AspHis: 0.412 ± 0.227
2.059AspIle: 2.059 ± 0.364
2.471AspLys: 2.471 ± 0.181
7.825AspLeu: 7.825 ± 2.0
1.647AspMet: 1.647 ± 0.137
3.295AspAsn: 3.295 ± 0.273
2.883AspPro: 2.883 ± 0.818
1.647AspGln: 1.647 ± 0.137
3.295AspArg: 3.295 ± 0.273
3.707AspSer: 3.707 ± 1.043
1.647AspThr: 1.647 ± 0.635
2.471AspVal: 2.471 ± 0.953
0.412AspTrp: 0.412 ± 0.227
2.471AspTyr: 2.471 ± 0.181
0.0AspXaa: 0.0 ± 0.0
Glu
3.295GluAla: 3.295 ± 1.817
0.824GluCys: 0.824 ± 0.318
1.647GluAsp: 1.647 ± 0.908
2.059GluGlu: 2.059 ± 1.136
1.647GluPhe: 1.647 ± 0.635
2.883GluGly: 2.883 ± 0.818
0.824GluHis: 0.824 ± 0.454
2.471GluIle: 2.471 ± 1.363
4.53GluLys: 4.53 ± 2.498
4.53GluLeu: 4.53 ± 0.955
2.059GluMet: 2.059 ± 0.364
4.942GluAsn: 4.942 ± 0.362
2.059GluPro: 2.059 ± 1.136
3.295GluGln: 3.295 ± 0.498
2.059GluArg: 2.059 ± 0.364
3.707GluSer: 3.707 ± 2.044
0.824GluThr: 0.824 ± 0.454
2.883GluVal: 2.883 ± 0.726
0.0GluTrp: 0.0 ± 0.0
4.119GluTyr: 4.119 ± 1.499
0.0GluXaa: 0.0 ± 0.0
Phe
2.471PheAla: 2.471 ± 0.181
0.824PheCys: 0.824 ± 0.318
2.883PheAsp: 2.883 ± 0.046
2.883PheGlu: 2.883 ± 0.046
1.647PhePhe: 1.647 ± 0.635
4.53PheGly: 4.53 ± 0.183
1.647PheHis: 1.647 ± 0.635
2.059PheIle: 2.059 ± 0.364
1.647PheLys: 1.647 ± 0.137
3.707PheLeu: 3.707 ± 2.044
0.824PheMet: 0.824 ± 0.454
1.647PheAsn: 1.647 ± 0.635
2.471PhePro: 2.471 ± 0.953
1.236PheGln: 1.236 ± 0.681
2.471PheArg: 2.471 ± 0.591
5.354PheSer: 5.354 ± 0.135
4.53PheThr: 4.53 ± 2.904
2.471PheVal: 2.471 ± 0.591
0.412PheTrp: 0.412 ± 0.227
2.059PheTyr: 2.059 ± 0.408
0.0PheXaa: 0.0 ± 0.0
Gly
4.53GlyAla: 4.53 ± 0.955
1.647GlyCys: 1.647 ± 0.908
3.707GlyAsp: 3.707 ± 0.5
4.119GlyGlu: 4.119 ± 0.044
0.824GlyPhe: 0.824 ± 0.318
6.178GlyGly: 6.178 ± 1.996
0.824GlyHis: 0.824 ± 0.454
4.942GlyIle: 4.942 ± 1.182
2.883GlyLys: 2.883 ± 0.818
7.002GlyLeu: 7.002 ± 0.77
0.824GlyMet: 0.824 ± 0.318
3.707GlyAsn: 3.707 ± 2.587
1.647GlyPro: 1.647 ± 0.635
1.236GlyGln: 1.236 ± 0.09
1.647GlyArg: 1.647 ± 1.407
3.295GlySer: 3.295 ± 0.273
2.883GlyThr: 2.883 ± 2.269
7.414GlyVal: 7.414 ± 0.543
0.824GlyTrp: 0.824 ± 0.454
2.471GlyTyr: 2.471 ± 0.181
0.0GlyXaa: 0.0 ± 0.0
His
2.471HisAla: 2.471 ± 0.181
0.412HisCys: 0.412 ± 0.227
1.236HisAsp: 1.236 ± 0.681
0.824HisGlu: 0.824 ± 0.318
0.824HisPhe: 0.824 ± 0.318
0.412HisGly: 0.412 ± 0.545
0.412HisHis: 0.412 ± 0.227
0.412HisIle: 0.412 ± 0.545
0.0HisLys: 0.0 ± 0.0
2.471HisLeu: 2.471 ± 0.181
0.0HisMet: 0.0 ± 0.0
0.824HisAsn: 0.824 ± 0.318
0.412HisPro: 0.412 ± 0.227
0.0HisGln: 0.0 ± 0.0
2.059HisArg: 2.059 ± 0.364
1.236HisSer: 1.236 ± 0.09
0.412HisThr: 0.412 ± 0.227
2.059HisVal: 2.059 ± 0.408
0.412HisTrp: 0.412 ± 0.227
0.412HisTyr: 0.412 ± 0.227
0.0HisXaa: 0.0 ± 0.0
Ile
7.002IleAla: 7.002 ± 0.774
1.236IleCys: 1.236 ± 0.09
2.471IleAsp: 2.471 ± 0.953
2.883IleGlu: 2.883 ± 0.818
3.295IlePhe: 3.295 ± 0.273
2.883IleGly: 2.883 ± 0.046
0.824IleHis: 0.824 ± 0.454
1.236IleIle: 1.236 ± 0.862
2.059IleLys: 2.059 ± 1.136
2.883IleLeu: 2.883 ± 1.59
0.824IleMet: 0.824 ± 0.318
3.707IleAsn: 3.707 ± 1.043
2.471IlePro: 2.471 ± 0.953
0.824IleGln: 0.824 ± 0.454
1.236IleArg: 1.236 ± 0.09
4.942IleSer: 4.942 ± 2.725
3.707IleThr: 3.707 ± 0.5
4.119IleVal: 4.119 ± 0.728
0.824IleTrp: 0.824 ± 0.318
0.824IleTyr: 0.824 ± 0.318
0.0IleXaa: 0.0 ± 0.0
Lys
2.471LysAla: 2.471 ± 0.181
0.824LysCys: 0.824 ± 0.454
3.707LysAsp: 3.707 ± 1.272
2.471LysGlu: 2.471 ± 1.363
2.883LysPhe: 2.883 ± 0.818
3.707LysGly: 3.707 ± 1.272
0.412LysHis: 0.412 ± 0.227
1.647LysIle: 1.647 ± 0.137
2.471LysLys: 2.471 ± 1.363
2.471LysLeu: 2.471 ± 1.363
1.236LysMet: 1.236 ± 0.09
1.647LysAsn: 1.647 ± 0.635
3.295LysPro: 3.295 ± 0.498
1.236LysGln: 1.236 ± 0.09
3.295LysArg: 3.295 ± 1.817
5.766LysSer: 5.766 ± 1.636
2.059LysThr: 2.059 ± 1.136
4.53LysVal: 4.53 ± 1.727
2.471LysTrp: 2.471 ± 0.591
2.059LysTyr: 2.059 ± 0.408
0.0LysXaa: 0.0 ± 0.0
Leu
6.178LeuAla: 6.178 ± 1.224
1.236LeuCys: 1.236 ± 0.681
8.237LeuAsp: 8.237 ± 0.088
5.354LeuGlu: 5.354 ± 0.135
4.942LeuPhe: 4.942 ± 1.182
4.942LeuGly: 4.942 ± 0.41
1.236LeuHis: 1.236 ± 0.09
3.707LeuIle: 3.707 ± 0.271
7.414LeuLys: 7.414 ± 1.773
6.178LeuLeu: 6.178 ± 1.091
1.236LeuMet: 1.236 ± 0.862
2.059LeuAsn: 2.059 ± 0.364
3.707LeuPro: 3.707 ± 0.271
1.647LeuGln: 1.647 ± 0.908
2.471LeuArg: 2.471 ± 1.363
9.473LeuSer: 9.473 ± 1.722
5.354LeuThr: 5.354 ± 0.637
4.942LeuVal: 4.942 ± 2.725
1.236LeuTrp: 1.236 ± 0.09
2.471LeuTyr: 2.471 ± 0.181
0.0LeuXaa: 0.0 ± 0.0
Met
2.883MetAla: 2.883 ± 0.046
0.824MetCys: 0.824 ± 0.318
2.059MetAsp: 2.059 ± 0.364
1.647MetGlu: 1.647 ± 0.908
2.059MetPhe: 2.059 ± 0.364
0.412MetGly: 0.412 ± 0.545
0.0MetHis: 0.0 ± 0.0
0.824MetIle: 0.824 ± 0.454
1.647MetLys: 1.647 ± 0.908
2.471MetLeu: 2.471 ± 1.363
0.0MetMet: 0.0 ± 0.0
1.236MetAsn: 1.236 ± 0.09
1.647MetPro: 1.647 ± 1.407
1.236MetGln: 1.236 ± 0.681
0.824MetArg: 0.824 ± 0.454
1.647MetSer: 1.647 ± 0.635
1.236MetThr: 1.236 ± 0.862
2.471MetVal: 2.471 ± 0.181
1.236MetTrp: 1.236 ± 0.09
1.236MetTyr: 1.236 ± 0.862
0.0MetXaa: 0.0 ± 0.0
Asn
3.707AsnAla: 3.707 ± 1.043
0.824AsnCys: 0.824 ± 0.318
2.883AsnAsp: 2.883 ± 0.818
1.236AsnGlu: 1.236 ± 0.09
2.059AsnPhe: 2.059 ± 0.408
3.707AsnGly: 3.707 ± 1.815
0.412AsnHis: 0.412 ± 0.545
2.059AsnIle: 2.059 ± 0.408
0.824AsnLys: 0.824 ± 0.454
4.942AsnLeu: 4.942 ± 1.134
0.824AsnMet: 0.824 ± 0.454
3.295AsnAsn: 3.295 ± 0.273
3.295AsnPro: 3.295 ± 0.498
1.647AsnGln: 1.647 ± 0.635
2.471AsnArg: 2.471 ± 0.591
4.119AsnSer: 4.119 ± 1.588
5.354AsnThr: 5.354 ± 2.45
4.119AsnVal: 4.119 ± 0.044
0.412AsnTrp: 0.412 ± 0.227
0.412AsnTyr: 0.412 ± 0.545
0.0AsnXaa: 0.0 ± 0.0
Pro
4.942ProAla: 4.942 ± 1.134
0.412ProCys: 0.412 ± 0.227
0.824ProAsp: 0.824 ± 0.454
1.647ProGlu: 1.647 ± 0.908
5.354ProPhe: 5.354 ± 0.906
2.471ProGly: 2.471 ± 0.953
2.059ProHis: 2.059 ± 0.408
4.119ProIle: 4.119 ± 0.044
1.236ProLys: 1.236 ± 0.681
6.59ProLeu: 6.59 ± 0.225
1.647ProMet: 1.647 ± 0.635
2.059ProAsn: 2.059 ± 0.408
3.295ProPro: 3.295 ± 1.27
1.647ProGln: 1.647 ± 1.407
2.059ProArg: 2.059 ± 0.408
4.119ProSer: 4.119 ± 1.499
4.119ProThr: 4.119 ± 0.816
4.942ProVal: 4.942 ± 1.905
0.824ProTrp: 0.824 ± 0.318
2.883ProTyr: 2.883 ± 1.497
0.0ProXaa: 0.0 ± 0.0
Gln
2.059GlnAla: 2.059 ± 0.364
0.412GlnCys: 0.412 ± 0.227
0.824GlnAsp: 0.824 ± 0.454
1.647GlnGlu: 1.647 ± 0.908
2.059GlnPhe: 2.059 ± 1.18
0.824GlnGly: 0.824 ± 0.318
0.412GlnHis: 0.412 ± 0.545
2.471GlnIle: 2.471 ± 0.181
2.059GlnLys: 2.059 ± 1.136
3.295GlnLeu: 3.295 ± 0.498
0.412GlnMet: 0.412 ± 0.227
0.824GlnAsn: 0.824 ± 1.089
2.059GlnPro: 2.059 ± 0.408
0.824GlnGln: 0.824 ± 0.454
0.412GlnArg: 0.412 ± 0.227
4.942GlnSer: 4.942 ± 0.41
2.471GlnThr: 2.471 ± 0.181
1.647GlnVal: 1.647 ± 0.635
1.236GlnTrp: 1.236 ± 0.681
0.824GlnTyr: 0.824 ± 0.318
0.0GlnXaa: 0.0 ± 0.0
Arg
2.471ArgAla: 2.471 ± 0.591
0.0ArgCys: 0.0 ± 0.0
2.883ArgAsp: 2.883 ± 0.818
4.53ArgGlu: 4.53 ± 2.498
2.059ArgPhe: 2.059 ± 0.364
2.059ArgGly: 2.059 ± 1.136
0.824ArgHis: 0.824 ± 0.318
2.471ArgIle: 2.471 ± 1.363
0.824ArgLys: 0.824 ± 0.454
4.119ArgLeu: 4.119 ± 0.728
3.707ArgMet: 3.707 ± 1.272
3.295ArgAsn: 3.295 ± 0.273
1.647ArgPro: 1.647 ± 0.137
1.236ArgGln: 1.236 ± 0.862
2.883ArgArg: 2.883 ± 0.818
2.883ArgSer: 2.883 ± 0.818
3.295ArgThr: 3.295 ± 1.27
5.766ArgVal: 5.766 ± 2.995
0.824ArgTrp: 0.824 ± 0.318
0.412ArgTyr: 0.412 ± 0.227
0.0ArgXaa: 0.0 ± 0.0
Ser
4.119SerAla: 4.119 ± 0.816
0.412SerCys: 0.412 ± 0.227
2.883SerAsp: 2.883 ± 0.818
4.119SerGlu: 4.119 ± 0.728
3.707SerPhe: 3.707 ± 1.272
8.649SerGly: 8.649 ± 0.633
1.236SerHis: 1.236 ± 0.681
4.53SerIle: 4.53 ± 0.589
8.237SerLys: 8.237 ± 0.088
4.53SerLeu: 4.53 ± 0.955
1.647SerMet: 1.647 ± 0.137
2.059SerAsn: 2.059 ± 0.364
5.354SerPro: 5.354 ± 0.637
4.119SerGln: 4.119 ± 0.728
4.942SerArg: 4.942 ± 1.182
5.354SerSer: 5.354 ± 1.678
6.178SerThr: 6.178 ± 1.996
3.295SerVal: 3.295 ± 0.273
0.412SerTrp: 0.412 ± 0.227
2.883SerTyr: 2.883 ± 0.726
0.0SerXaa: 0.0 ± 0.0
Thr
6.178ThrAla: 6.178 ± 0.452
0.824ThrCys: 0.824 ± 1.089
4.53ThrAsp: 4.53 ± 1.361
0.824ThrGlu: 0.824 ± 0.318
2.059ThrPhe: 2.059 ± 0.408
4.942ThrGly: 4.942 ± 2.677
0.824ThrHis: 0.824 ± 0.318
4.53ThrIle: 4.53 ± 0.955
2.471ThrLys: 2.471 ± 0.181
5.766ThrLeu: 5.766 ± 2.223
4.119ThrMet: 4.119 ± 2.36
2.059ThrAsn: 2.059 ± 1.18
1.647ThrPro: 1.647 ± 0.635
1.236ThrGln: 1.236 ± 0.681
4.53ThrArg: 4.53 ± 1.727
4.53ThrSer: 4.53 ± 0.183
4.942ThrThr: 4.942 ± 2.677
6.59ThrVal: 6.59 ± 4.084
0.0ThrTrp: 0.0 ± 0.0
3.295ThrTyr: 3.295 ± 1.27
0.0ThrXaa: 0.0 ± 0.0
Val
7.825ValAla: 7.825 ± 1.859
2.059ValCys: 2.059 ± 0.364
3.295ValAsp: 3.295 ± 1.045
4.942ValGlu: 4.942 ± 1.182
3.295ValPhe: 3.295 ± 0.498
5.354ValGly: 5.354 ± 0.637
2.059ValHis: 2.059 ± 1.18
2.883ValIle: 2.883 ± 0.046
4.53ValLys: 4.53 ± 0.589
6.178ValLeu: 6.178 ± 1.224
2.059ValMet: 2.059 ± 1.136
4.942ValAsn: 4.942 ± 0.41
6.59ValPro: 6.59 ± 2.54
2.471ValGln: 2.471 ± 0.591
3.295ValArg: 3.295 ± 0.498
4.53ValSer: 4.53 ± 0.589
3.295ValThr: 3.295 ± 0.273
4.119ValVal: 4.119 ± 0.816
0.0ValTrp: 0.0 ± 0.0
2.059ValTyr: 2.059 ± 0.408
0.0ValXaa: 0.0 ± 0.0
Trp
1.236TrpAla: 1.236 ± 0.862
0.412TrpCys: 0.412 ± 0.227
0.824TrpAsp: 0.824 ± 0.454
0.824TrpGlu: 0.824 ± 0.454
0.824TrpPhe: 0.824 ± 0.454
0.0TrpGly: 0.0 ± 0.0
0.824TrpHis: 0.824 ± 0.454
0.0TrpIle: 0.0 ± 0.0
0.824TrpLys: 0.824 ± 0.454
1.647TrpLeu: 1.647 ± 0.137
0.0TrpMet: 0.0 ± 0.0
1.236TrpAsn: 1.236 ± 0.09
0.0TrpPro: 0.0 ± 0.0
1.236TrpGln: 1.236 ± 0.09
0.412TrpArg: 0.412 ± 0.227
1.236TrpSer: 1.236 ± 0.09
0.824TrpThr: 0.824 ± 0.318
1.647TrpVal: 1.647 ± 0.137
0.412TrpTrp: 0.412 ± 0.227
1.236TrpTyr: 1.236 ± 0.09
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.471TyrAla: 2.471 ± 0.591
0.0TyrCys: 0.0 ± 0.0
0.824TyrAsp: 0.824 ± 0.318
0.824TyrGlu: 0.824 ± 0.454
2.059TyrPhe: 2.059 ± 0.408
1.647TyrGly: 1.647 ± 0.908
0.412TyrHis: 0.412 ± 0.545
2.059TyrIle: 2.059 ± 0.408
0.412TyrLys: 0.412 ± 0.227
2.883TyrLeu: 2.883 ± 1.497
0.824TyrMet: 0.824 ± 0.364
2.059TyrAsn: 2.059 ± 1.18
3.707TyrPro: 3.707 ± 0.271
2.059TyrGln: 2.059 ± 0.408
2.883TyrArg: 2.883 ± 0.726
1.647TyrSer: 1.647 ± 0.137
4.942TyrThr: 4.942 ± 1.905
4.119TyrVal: 4.119 ± 0.044
1.647TyrTrp: 1.647 ± 0.635
1.647TyrTyr: 1.647 ± 0.635
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2 proteins (2429 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski