Amino acid dipepetide frequency for Synechococcus phage S-CBP4

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.81AlaAla: 11.81 ± 1.298
0.342AlaCys: 0.342 ± 0.212
5.22AlaAsp: 5.22 ± 1.036
6.675AlaGlu: 6.675 ± 0.846
3.423AlaPhe: 3.423 ± 0.554
6.504AlaGly: 6.504 ± 0.614
0.77AlaHis: 0.77 ± 0.292
5.392AlaIle: 5.392 ± 0.558
4.964AlaLys: 4.964 ± 0.891
8.729AlaLeu: 8.729 ± 0.94
2.311AlaMet: 2.311 ± 0.35
4.022AlaAsn: 4.022 ± 0.611
4.022AlaPro: 4.022 ± 0.583
5.734AlaGln: 5.734 ± 0.859
4.279AlaArg: 4.279 ± 0.556
6.504AlaSer: 6.504 ± 0.792
4.536AlaThr: 4.536 ± 0.691
4.45AlaVal: 4.45 ± 0.574
0.856AlaTrp: 0.856 ± 0.219
3.594AlaTyr: 3.594 ± 0.79
0.0AlaXaa: 0.0 ± 0.0
Cys
0.257CysAla: 0.257 ± 0.156
0.342CysCys: 0.342 ± 0.181
0.513CysAsp: 0.513 ± 0.204
0.685CysGlu: 0.685 ± 0.262
0.342CysPhe: 0.342 ± 0.167
0.342CysGly: 0.342 ± 0.167
0.171CysHis: 0.171 ± 0.12
0.685CysIle: 0.685 ± 0.283
0.086CysLys: 0.086 ± 0.077
0.77CysLeu: 0.77 ± 0.345
0.171CysMet: 0.171 ± 0.118
0.428CysAsn: 0.428 ± 0.23
0.342CysPro: 0.342 ± 0.141
0.257CysGln: 0.257 ± 0.192
0.428CysArg: 0.428 ± 0.21
0.685CysSer: 0.685 ± 0.288
0.342CysThr: 0.342 ± 0.191
0.428CysVal: 0.428 ± 0.183
0.0CysTrp: 0.0 ± 0.0
0.513CysTyr: 0.513 ± 0.212
0.0CysXaa: 0.0 ± 0.0
Asp
5.819AspAla: 5.819 ± 0.802
0.428AspCys: 0.428 ± 0.176
3.937AspAsp: 3.937 ± 0.63
4.536AspGlu: 4.536 ± 0.639
3.252AspPhe: 3.252 ± 0.583
4.45AspGly: 4.45 ± 0.911
0.77AspHis: 0.77 ± 0.279
2.739AspIle: 2.739 ± 0.272
1.968AspLys: 1.968 ± 0.488
6.076AspLeu: 6.076 ± 0.646
1.797AspMet: 1.797 ± 0.438
2.91AspAsn: 2.91 ± 0.482
2.567AspPro: 2.567 ± 0.484
1.54AspGln: 1.54 ± 0.348
2.567AspArg: 2.567 ± 0.497
4.022AspSer: 4.022 ± 0.766
3.509AspThr: 3.509 ± 0.55
3.766AspVal: 3.766 ± 0.462
1.284AspTrp: 1.284 ± 0.25
2.139AspTyr: 2.139 ± 0.372
0.0AspXaa: 0.0 ± 0.0
Glu
6.504GluAla: 6.504 ± 0.826
0.856GluCys: 0.856 ± 0.299
2.995GluAsp: 2.995 ± 0.6
4.707GluGlu: 4.707 ± 0.924
2.054GluPhe: 2.054 ± 0.46
2.824GluGly: 2.824 ± 0.552
0.77GluHis: 0.77 ± 0.254
3.252GluIle: 3.252 ± 0.595
2.995GluLys: 2.995 ± 0.538
5.563GluLeu: 5.563 ± 0.799
1.54GluMet: 1.54 ± 0.411
2.567GluAsn: 2.567 ± 0.489
1.968GluPro: 1.968 ± 0.527
3.594GluGln: 3.594 ± 0.617
3.509GluArg: 3.509 ± 0.531
3.509GluSer: 3.509 ± 0.684
4.193GluThr: 4.193 ± 0.668
4.45GluVal: 4.45 ± 0.481
0.941GluTrp: 0.941 ± 0.272
2.311GluTyr: 2.311 ± 0.541
0.0GluXaa: 0.0 ± 0.0
Phe
2.739PheAla: 2.739 ± 0.564
0.257PheCys: 0.257 ± 0.123
1.883PheAsp: 1.883 ± 0.457
1.54PheGlu: 1.54 ± 0.603
1.712PhePhe: 1.712 ± 0.356
3.081PheGly: 3.081 ± 0.518
0.342PheHis: 0.342 ± 0.202
1.797PheIle: 1.797 ± 0.373
1.797PheLys: 1.797 ± 0.351
3.766PheLeu: 3.766 ± 0.598
0.599PheMet: 0.599 ± 0.256
2.567PheAsn: 2.567 ± 0.52
1.455PhePro: 1.455 ± 0.334
1.712PheGln: 1.712 ± 0.497
1.883PheArg: 1.883 ± 0.324
2.739PheSer: 2.739 ± 0.383
2.567PheThr: 2.567 ± 0.557
3.081PheVal: 3.081 ± 0.535
0.171PheTrp: 0.171 ± 0.157
1.284PheTyr: 1.284 ± 0.36
0.0PheXaa: 0.0 ± 0.0
Gly
5.991GlyAla: 5.991 ± 1.073
0.599GlyCys: 0.599 ± 0.268
4.621GlyAsp: 4.621 ± 0.611
3.338GlyGlu: 3.338 ± 0.562
2.139GlyPhe: 2.139 ± 0.382
3.937GlyGly: 3.937 ± 0.613
0.513GlyHis: 0.513 ± 0.237
5.306GlyIle: 5.306 ± 0.655
3.68GlyLys: 3.68 ± 0.609
5.648GlyLeu: 5.648 ± 0.976
2.139GlyMet: 2.139 ± 0.471
3.68GlyAsn: 3.68 ± 0.491
1.712GlyPro: 1.712 ± 0.49
3.594GlyGln: 3.594 ± 0.577
4.279GlyArg: 4.279 ± 0.68
5.819GlySer: 5.819 ± 0.923
4.964GlyThr: 4.964 ± 1.105
5.991GlyVal: 5.991 ± 0.527
1.113GlyTrp: 1.113 ± 0.258
3.166GlyTyr: 3.166 ± 0.581
0.0GlyXaa: 0.0 ± 0.0
His
0.599HisAla: 0.599 ± 0.248
0.171HisCys: 0.171 ± 0.166
0.941HisAsp: 0.941 ± 0.281
0.77HisGlu: 0.77 ± 0.242
0.342HisPhe: 0.342 ± 0.261
1.198HisGly: 1.198 ± 0.334
0.171HisHis: 0.171 ± 0.166
0.428HisIle: 0.428 ± 0.187
0.513HisLys: 0.513 ± 0.212
1.284HisLeu: 1.284 ± 0.347
0.513HisMet: 0.513 ± 0.178
0.856HisAsn: 0.856 ± 0.29
0.77HisPro: 0.77 ± 0.206
0.77HisGln: 0.77 ± 0.218
0.513HisArg: 0.513 ± 0.237
0.599HisSer: 0.599 ± 0.199
0.685HisThr: 0.685 ± 0.253
0.77HisVal: 0.77 ± 0.231
0.428HisTrp: 0.428 ± 0.195
0.428HisTyr: 0.428 ± 0.19
0.0HisXaa: 0.0 ± 0.0
Ile
6.076IleAla: 6.076 ± 0.783
0.513IleCys: 0.513 ± 0.246
3.338IleAsp: 3.338 ± 0.466
3.766IleGlu: 3.766 ± 0.495
1.027IlePhe: 1.027 ± 0.258
4.193IleGly: 4.193 ± 0.646
1.027IleHis: 1.027 ± 0.262
2.225IleIle: 2.225 ± 0.432
3.338IleLys: 3.338 ± 0.546
3.252IleLeu: 3.252 ± 0.491
1.113IleMet: 1.113 ± 0.313
2.482IleAsn: 2.482 ± 0.53
2.567IlePro: 2.567 ± 0.51
3.166IleGln: 3.166 ± 0.519
3.338IleArg: 3.338 ± 0.432
4.108IleSer: 4.108 ± 0.688
4.193IleThr: 4.193 ± 0.658
2.995IleVal: 2.995 ± 0.553
0.599IleTrp: 0.599 ± 0.247
1.883IleTyr: 1.883 ± 0.405
0.0IleXaa: 0.0 ± 0.0
Lys
5.135LysAla: 5.135 ± 0.869
0.342LysCys: 0.342 ± 0.194
3.081LysAsp: 3.081 ± 0.498
3.509LysGlu: 3.509 ± 0.564
2.311LysPhe: 2.311 ± 0.469
3.252LysGly: 3.252 ± 0.606
0.428LysHis: 0.428 ± 0.22
2.396LysIle: 2.396 ± 0.387
3.166LysLys: 3.166 ± 0.528
5.306LysLeu: 5.306 ± 0.788
1.198LysMet: 1.198 ± 0.323
2.567LysAsn: 2.567 ± 0.435
2.054LysPro: 2.054 ± 0.549
2.482LysGln: 2.482 ± 0.528
3.252LysArg: 3.252 ± 0.493
3.081LysSer: 3.081 ± 0.395
2.139LysThr: 2.139 ± 0.361
2.995LysVal: 2.995 ± 0.58
0.685LysTrp: 0.685 ± 0.2
1.883LysTyr: 1.883 ± 0.407
0.0LysXaa: 0.0 ± 0.0
Leu
8.387LeuAla: 8.387 ± 0.652
0.342LeuCys: 0.342 ± 0.162
5.734LeuAsp: 5.734 ± 0.795
5.392LeuGlu: 5.392 ± 0.83
2.567LeuPhe: 2.567 ± 0.36
6.076LeuGly: 6.076 ± 0.701
1.712LeuHis: 1.712 ± 0.4
3.594LeuIle: 3.594 ± 0.719
4.707LeuLys: 4.707 ± 0.812
6.162LeuLeu: 6.162 ± 0.874
2.225LeuMet: 2.225 ± 0.462
5.563LeuAsn: 5.563 ± 0.563
4.279LeuPro: 4.279 ± 0.697
4.193LeuGln: 4.193 ± 0.737
4.964LeuArg: 4.964 ± 0.754
6.247LeuSer: 6.247 ± 0.806
4.878LeuThr: 4.878 ± 0.72
4.022LeuVal: 4.022 ± 0.739
0.599LeuTrp: 0.599 ± 0.19
2.653LeuTyr: 2.653 ± 0.596
0.0LeuXaa: 0.0 ± 0.0
Met
2.567MetAla: 2.567 ± 0.512
0.171MetCys: 0.171 ± 0.125
1.284MetAsp: 1.284 ± 0.362
1.455MetGlu: 1.455 ± 0.312
0.428MetPhe: 0.428 ± 0.193
1.968MetGly: 1.968 ± 0.376
0.428MetHis: 0.428 ± 0.278
0.941MetIle: 0.941 ± 0.359
1.369MetLys: 1.369 ± 0.283
2.482MetLeu: 2.482 ± 0.782
0.685MetMet: 0.685 ± 0.187
1.113MetAsn: 1.113 ± 0.43
0.941MetPro: 0.941 ± 0.275
1.369MetGln: 1.369 ± 0.366
1.968MetArg: 1.968 ± 0.43
2.054MetSer: 2.054 ± 0.412
1.797MetThr: 1.797 ± 0.499
1.027MetVal: 1.027 ± 0.318
0.171MetTrp: 0.171 ± 0.119
0.685MetTyr: 0.685 ± 0.28
0.0MetXaa: 0.0 ± 0.0
Asn
3.766AsnAla: 3.766 ± 0.634
0.342AsnCys: 0.342 ± 0.165
3.338AsnAsp: 3.338 ± 0.459
2.139AsnGlu: 2.139 ± 0.559
1.968AsnPhe: 1.968 ± 0.565
4.45AsnGly: 4.45 ± 1.018
1.027AsnHis: 1.027 ± 0.412
2.824AsnIle: 2.824 ± 0.578
1.797AsnLys: 1.797 ± 0.349
4.621AsnLeu: 4.621 ± 0.818
0.856AsnMet: 0.856 ± 0.203
3.081AsnAsn: 3.081 ± 0.732
2.567AsnPro: 2.567 ± 0.37
2.396AsnGln: 2.396 ± 0.423
2.91AsnArg: 2.91 ± 0.521
2.995AsnSer: 2.995 ± 0.558
3.423AsnThr: 3.423 ± 0.496
3.338AsnVal: 3.338 ± 0.52
0.685AsnTrp: 0.685 ± 0.2
2.054AsnTyr: 2.054 ± 0.485
0.0AsnXaa: 0.0 ± 0.0
Pro
2.653ProAla: 2.653 ± 0.461
0.257ProCys: 0.257 ± 0.158
2.567ProAsp: 2.567 ± 0.458
2.91ProGlu: 2.91 ± 0.56
1.968ProPhe: 1.968 ± 0.41
4.022ProGly: 4.022 ± 0.559
0.428ProHis: 0.428 ± 0.187
2.824ProIle: 2.824 ± 0.48
2.225ProLys: 2.225 ± 0.45
2.311ProLeu: 2.311 ± 0.417
0.941ProMet: 0.941 ± 0.308
2.139ProAsn: 2.139 ± 0.337
2.054ProPro: 2.054 ± 0.399
2.482ProGln: 2.482 ± 0.479
1.198ProArg: 1.198 ± 0.237
3.166ProSer: 3.166 ± 0.521
3.252ProThr: 3.252 ± 0.694
2.995ProVal: 2.995 ± 0.699
1.369ProTrp: 1.369 ± 0.387
1.54ProTyr: 1.54 ± 0.295
0.0ProXaa: 0.0 ± 0.0
Gln
6.076GlnAla: 6.076 ± 0.875
0.257GlnCys: 0.257 ± 0.159
1.712GlnAsp: 1.712 ± 0.334
3.766GlnGlu: 3.766 ± 0.508
1.883GlnPhe: 1.883 ± 0.399
2.91GlnGly: 2.91 ± 0.543
0.685GlnHis: 0.685 ± 0.26
2.995GlnIle: 2.995 ± 0.55
2.482GlnLys: 2.482 ± 0.517
4.279GlnLeu: 4.279 ± 0.739
0.856GlnMet: 0.856 ± 0.433
1.883GlnAsn: 1.883 ± 0.554
1.968GlnPro: 1.968 ± 0.572
4.022GlnGln: 4.022 ± 0.651
2.91GlnArg: 2.91 ± 0.924
2.225GlnSer: 2.225 ± 0.587
3.252GlnThr: 3.252 ± 0.609
2.653GlnVal: 2.653 ± 0.345
0.257GlnTrp: 0.257 ± 0.117
2.396GlnTyr: 2.396 ± 0.305
0.0GlnXaa: 0.0 ± 0.0
Arg
4.792ArgAla: 4.792 ± 0.559
0.257ArgCys: 0.257 ± 0.141
3.166ArgAsp: 3.166 ± 0.612
2.739ArgGlu: 2.739 ± 0.46
2.482ArgPhe: 2.482 ± 0.528
3.252ArgGly: 3.252 ± 0.638
0.428ArgHis: 0.428 ± 0.177
3.166ArgIle: 3.166 ± 0.554
2.91ArgLys: 2.91 ± 0.715
5.22ArgLeu: 5.22 ± 0.643
0.941ArgMet: 0.941 ± 0.187
2.311ArgAsn: 2.311 ± 0.509
2.054ArgPro: 2.054 ± 0.349
2.739ArgGln: 2.739 ± 0.682
2.567ArgArg: 2.567 ± 0.478
3.081ArgSer: 3.081 ± 0.55
2.995ArgThr: 2.995 ± 0.493
2.739ArgVal: 2.739 ± 0.38
0.599ArgTrp: 0.599 ± 0.193
2.139ArgTyr: 2.139 ± 0.472
0.0ArgXaa: 0.0 ± 0.0
Ser
6.247SerAla: 6.247 ± 0.841
0.257SerCys: 0.257 ± 0.142
3.766SerAsp: 3.766 ± 0.746
2.567SerGlu: 2.567 ± 0.497
2.91SerPhe: 2.91 ± 0.553
6.247SerGly: 6.247 ± 0.794
0.856SerHis: 0.856 ± 0.26
4.193SerIle: 4.193 ± 0.678
3.594SerLys: 3.594 ± 0.523
5.22SerLeu: 5.22 ± 0.64
2.054SerMet: 2.054 ± 0.466
4.621SerAsn: 4.621 ± 0.763
3.081SerPro: 3.081 ± 0.508
2.482SerGln: 2.482 ± 0.618
3.509SerArg: 3.509 ± 0.6
5.049SerSer: 5.049 ± 0.897
4.878SerThr: 4.878 ± 0.833
4.707SerVal: 4.707 ± 0.688
1.027SerTrp: 1.027 ± 0.318
2.225SerTyr: 2.225 ± 0.489
0.0SerXaa: 0.0 ± 0.0
Thr
5.734ThrAla: 5.734 ± 0.988
0.599ThrCys: 0.599 ± 0.258
4.45ThrAsp: 4.45 ± 0.595
3.338ThrGlu: 3.338 ± 0.607
2.824ThrPhe: 2.824 ± 0.472
4.878ThrGly: 4.878 ± 0.751
0.513ThrHis: 0.513 ± 0.202
4.108ThrIle: 4.108 ± 0.875
3.766ThrLys: 3.766 ± 0.56
5.477ThrLeu: 5.477 ± 0.726
1.113ThrMet: 1.113 ± 0.3
2.482ThrAsn: 2.482 ± 0.496
4.365ThrPro: 4.365 ± 0.479
1.712ThrGln: 1.712 ± 0.374
1.797ThrArg: 1.797 ± 0.363
5.392ThrSer: 5.392 ± 0.639
5.049ThrThr: 5.049 ± 1.282
3.851ThrVal: 3.851 ± 0.729
0.513ThrTrp: 0.513 ± 0.223
2.396ThrTyr: 2.396 ± 0.595
0.0ThrXaa: 0.0 ± 0.0
Val
5.477ValAla: 5.477 ± 0.707
0.941ValCys: 0.941 ± 0.337
4.707ValAsp: 4.707 ± 0.604
4.536ValGlu: 4.536 ± 0.605
1.968ValPhe: 1.968 ± 0.513
4.964ValGly: 4.964 ± 0.69
0.77ValHis: 0.77 ± 0.232
3.509ValIle: 3.509 ± 0.578
3.252ValLys: 3.252 ± 0.544
3.338ValLeu: 3.338 ± 0.548
1.883ValMet: 1.883 ± 0.369
2.311ValAsn: 2.311 ± 0.459
2.567ValPro: 2.567 ± 0.406
2.567ValGln: 2.567 ± 0.411
2.311ValArg: 2.311 ± 0.564
4.707ValSer: 4.707 ± 0.713
4.707ValThr: 4.707 ± 0.96
4.964ValVal: 4.964 ± 0.856
0.77ValTrp: 0.77 ± 0.181
1.968ValTyr: 1.968 ± 0.41
0.0ValXaa: 0.0 ± 0.0
Trp
0.685TrpAla: 0.685 ± 0.2
0.257TrpCys: 0.257 ± 0.151
0.685TrpAsp: 0.685 ± 0.226
1.113TrpGlu: 1.113 ± 0.344
0.599TrpPhe: 0.599 ± 0.243
0.171TrpGly: 0.171 ± 0.105
0.257TrpHis: 0.257 ± 0.155
0.941TrpIle: 0.941 ± 0.322
0.513TrpLys: 0.513 ± 0.224
1.284TrpLeu: 1.284 ± 0.387
0.342TrpMet: 0.342 ± 0.175
0.941TrpAsn: 0.941 ± 0.272
0.428TrpPro: 0.428 ± 0.159
0.513TrpGln: 0.513 ± 0.172
0.342TrpArg: 0.342 ± 0.186
1.113TrpSer: 1.113 ± 0.332
0.685TrpThr: 0.685 ± 0.28
1.198TrpVal: 1.198 ± 0.253
0.257TrpTrp: 0.257 ± 0.149
0.342TrpTyr: 0.342 ± 0.22
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.824TyrAla: 2.824 ± 0.622
0.257TyrCys: 0.257 ± 0.211
2.139TyrAsp: 2.139 ± 0.581
1.626TyrGlu: 1.626 ± 0.327
0.77TyrPhe: 0.77 ± 0.235
3.509TyrGly: 3.509 ± 0.54
0.685TyrHis: 0.685 ± 0.222
1.883TyrIle: 1.883 ± 0.367
2.139TyrLys: 2.139 ± 0.382
3.509TyrLeu: 3.509 ± 0.654
1.54TyrMet: 1.54 ± 0.419
2.054TyrAsn: 2.054 ± 0.394
1.54TyrPro: 1.54 ± 0.396
2.225TyrGln: 2.225 ± 0.499
2.054TyrArg: 2.054 ± 0.471
2.396TyrSer: 2.396 ± 0.551
2.311TyrThr: 2.311 ± 0.551
1.797TyrVal: 1.797 ± 0.429
0.342TyrTrp: 0.342 ± 0.22
1.027TyrTyr: 1.027 ± 0.345
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 46 proteins (11686 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski