Amino acid dipepetide frequency for Firmicutes bacterium CAG:145

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.737AlaAla: 8.737 ± 0.154
1.259AlaCys: 1.259 ± 0.05
4.795AlaAsp: 4.795 ± 0.096
6.025AlaGlu: 6.025 ± 0.107
3.227AlaPhe: 3.227 ± 0.091
6.918AlaGly: 6.918 ± 0.11
1.119AlaHis: 1.119 ± 0.045
5.598AlaIle: 5.598 ± 0.117
4.796AlaLys: 4.796 ± 0.091
7.237AlaLeu: 7.237 ± 0.12
2.653AlaMet: 2.653 ± 0.076
2.209AlaAsn: 2.209 ± 0.06
2.034AlaPro: 2.034 ± 0.067
2.147AlaGln: 2.147 ± 0.065
3.178AlaArg: 3.178 ± 0.07
4.379AlaSer: 4.379 ± 0.083
3.228AlaThr: 3.228 ± 0.074
7.053AlaVal: 7.053 ± 0.111
0.479AlaTrp: 0.479 ± 0.029
2.552AlaTyr: 2.552 ± 0.074
0.002AlaXaa: 0.002 ± 0.002
Cys
1.18CysAla: 1.18 ± 0.051
0.327CysCys: 0.327 ± 0.026
0.92CysAsp: 0.92 ± 0.035
0.9CysGlu: 0.9 ± 0.045
0.577CysPhe: 0.577 ± 0.034
1.774CysGly: 1.774 ± 0.065
0.273CysHis: 0.273 ± 0.022
1.105CysIle: 1.105 ± 0.041
0.802CysLys: 0.802 ± 0.042
1.112CysLeu: 1.112 ± 0.043
0.452CysMet: 0.452 ± 0.03
0.515CysAsn: 0.515 ± 0.035
0.633CysPro: 0.633 ± 0.038
0.432CysGln: 0.432 ± 0.03
0.932CysArg: 0.932 ± 0.047
0.96CysSer: 0.96 ± 0.042
0.662CysThr: 0.662 ± 0.041
0.996CysVal: 0.996 ± 0.039
0.125CysTrp: 0.125 ± 0.015
0.494CysTyr: 0.494 ± 0.03
0.0CysXaa: 0.0 ± 0.0
Asp
3.655AspAla: 3.655 ± 0.096
0.802AspCys: 0.802 ± 0.041
3.215AspAsp: 3.215 ± 0.083
4.854AspGlu: 4.854 ± 0.107
2.899AspPhe: 2.899 ± 0.079
4.552AspGly: 4.552 ± 0.105
0.893AspHis: 0.893 ± 0.042
5.22AspIle: 5.22 ± 0.1
4.317AspLys: 4.317 ± 0.086
4.906AspLeu: 4.906 ± 0.086
2.292AspMet: 2.292 ± 0.069
2.113AspAsn: 2.113 ± 0.063
2.099AspPro: 2.099 ± 0.06
1.504AspGln: 1.504 ± 0.059
2.93AspArg: 2.93 ± 0.079
3.272AspSer: 3.272 ± 0.082
2.845AspThr: 2.845 ± 0.067
4.006AspVal: 4.006 ± 0.09
0.462AspTrp: 0.462 ± 0.029
2.552AspTyr: 2.552 ± 0.076
0.0AspXaa: 0.0 ± 0.0
Glu
6.163GluAla: 6.163 ± 0.097
0.736GluCys: 0.736 ± 0.037
4.882GluAsp: 4.882 ± 0.1
7.497GluGlu: 7.497 ± 0.153
2.491GluPhe: 2.491 ± 0.066
5.076GluGly: 5.076 ± 0.102
1.033GluHis: 1.033 ± 0.042
5.995GluIle: 5.995 ± 0.117
7.01GluLys: 7.01 ± 0.125
5.716GluLeu: 5.716 ± 0.11
2.437GluMet: 2.437 ± 0.065
3.949GluAsn: 3.949 ± 0.077
1.819GluPro: 1.819 ± 0.055
1.968GluGln: 1.968 ± 0.063
3.667GluArg: 3.667 ± 0.084
3.627GluSer: 3.627 ± 0.086
3.612GluThr: 3.612 ± 0.076
4.126GluVal: 4.126 ± 0.093
0.473GluTrp: 0.473 ± 0.031
2.923GluTyr: 2.923 ± 0.072
0.0GluXaa: 0.0 ± 0.0
Phe
3.245PheAla: 3.245 ± 0.064
0.743PheCys: 0.743 ± 0.036
2.704PheAsp: 2.704 ± 0.07
2.813PheGlu: 2.813 ± 0.062
1.917PhePhe: 1.917 ± 0.073
3.37PheGly: 3.37 ± 0.087
0.581PheHis: 0.581 ± 0.031
3.19PheIle: 3.19 ± 0.071
2.348PheLys: 2.348 ± 0.059
3.401PheLeu: 3.401 ± 0.085
1.283PheMet: 1.283 ± 0.055
1.603PheAsn: 1.603 ± 0.05
1.374PhePro: 1.374 ± 0.051
0.908PheGln: 0.908 ± 0.036
1.715PheArg: 1.715 ± 0.043
3.028PheSer: 3.028 ± 0.077
2.295PheThr: 2.295 ± 0.057
2.665PheVal: 2.665 ± 0.064
0.353PheTrp: 0.353 ± 0.025
1.563PheTyr: 1.563 ± 0.051
0.0PheXaa: 0.0 ± 0.0
Gly
5.829GlyAla: 5.829 ± 0.106
1.372GlyCys: 1.372 ± 0.064
4.182GlyAsp: 4.182 ± 0.088
5.198GlyGlu: 5.198 ± 0.097
3.509GlyPhe: 3.509 ± 0.081
6.072GlyGly: 6.072 ± 0.129
1.213GlyHis: 1.213 ± 0.052
6.707GlyIle: 6.707 ± 0.111
5.62GlyLys: 5.62 ± 0.095
6.335GlyLeu: 6.335 ± 0.106
2.425GlyMet: 2.425 ± 0.078
2.823GlyAsn: 2.823 ± 0.073
1.543GlyPro: 1.543 ± 0.048
2.214GlyGln: 2.214 ± 0.063
3.787GlyArg: 3.787 ± 0.083
4.53GlySer: 4.53 ± 0.106
4.165GlyThr: 4.165 ± 0.099
5.33GlyVal: 5.33 ± 0.097
0.655GlyTrp: 0.655 ± 0.039
3.19GlyTyr: 3.19 ± 0.076
0.002GlyXaa: 0.002 ± 0.002
His
0.95HisAla: 0.95 ± 0.039
0.27HisCys: 0.27 ± 0.022
0.805HisAsp: 0.805 ± 0.04
0.842HisGlu: 0.842 ± 0.036
0.584HisPhe: 0.584 ± 0.027
1.164HisGly: 1.164 ± 0.05
0.349HisHis: 0.349 ± 0.031
1.348HisIle: 1.348 ± 0.055
0.938HisLys: 0.938 ± 0.043
1.352HisLeu: 1.352 ± 0.053
0.542HisMet: 0.542 ± 0.029
0.569HisAsn: 0.569 ± 0.033
0.776HisPro: 0.776 ± 0.036
0.464HisGln: 0.464 ± 0.029
0.758HisArg: 0.758 ± 0.036
0.822HisSer: 0.822 ± 0.038
0.813HisThr: 0.813 ± 0.036
0.867HisVal: 0.867 ± 0.04
0.127HisTrp: 0.127 ± 0.016
0.548HisTyr: 0.548 ± 0.033
0.0HisXaa: 0.0 ± 0.0
Ile
6.551IleAla: 6.551 ± 0.121
1.431IleCys: 1.431 ± 0.053
4.977IleAsp: 4.977 ± 0.099
5.903IleGlu: 5.903 ± 0.107
3.409IlePhe: 3.409 ± 0.076
5.846IleGly: 5.846 ± 0.125
1.139IleHis: 1.139 ± 0.04
6.219IleIle: 6.219 ± 0.111
5.169IleLys: 5.169 ± 0.106
7.031IleLeu: 7.031 ± 0.145
2.435IleMet: 2.435 ± 0.066
3.009IleAsn: 3.009 ± 0.078
3.093IlePro: 3.093 ± 0.08
1.867IleGln: 1.867 ± 0.065
3.596IleArg: 3.596 ± 0.093
5.343IleSer: 5.343 ± 0.094
4.406IleThr: 4.406 ± 0.09
5.124IleVal: 5.124 ± 0.097
0.616IleTrp: 0.616 ± 0.035
2.884IleTyr: 2.884 ± 0.078
0.0IleXaa: 0.0 ± 0.0
Lys
5.549LysAla: 5.549 ± 0.107
0.656LysCys: 0.656 ± 0.036
4.373LysAsp: 4.373 ± 0.081
6.163LysGlu: 6.163 ± 0.123
2.088LysPhe: 2.088 ± 0.058
4.516LysGly: 4.516 ± 0.086
0.871LysHis: 0.871 ± 0.037
5.885LysIle: 5.885 ± 0.1
6.197LysLys: 6.197 ± 0.122
5.434LysLeu: 5.434 ± 0.093
2.327LysMet: 2.327 ± 0.065
3.536LysAsn: 3.536 ± 0.09
1.936LysPro: 1.936 ± 0.067
1.77LysGln: 1.77 ± 0.06
3.212LysArg: 3.212 ± 0.086
3.507LysSer: 3.507 ± 0.088
3.824LysThr: 3.824 ± 0.072
4.477LysVal: 4.477 ± 0.09
0.489LysTrp: 0.489 ± 0.025
2.915LysTyr: 2.915 ± 0.078
0.0LysXaa: 0.0 ± 0.0
Leu
6.899LeuAla: 6.899 ± 0.118
1.423LeuCys: 1.423 ± 0.053
4.528LeuAsp: 4.528 ± 0.085
5.397LeuGlu: 5.397 ± 0.11
3.497LeuPhe: 3.497 ± 0.085
6.018LeuGly: 6.018 ± 0.111
1.215LeuHis: 1.215 ± 0.047
6.828LeuIle: 6.828 ± 0.132
6.437LeuLys: 6.437 ± 0.099
7.362LeuLeu: 7.362 ± 0.147
2.861LeuMet: 2.861 ± 0.067
3.487LeuAsn: 3.487 ± 0.078
3.345LeuPro: 3.345 ± 0.071
2.025LeuGln: 2.025 ± 0.061
4.006LeuArg: 4.006 ± 0.081
6.421LeuSer: 6.421 ± 0.119
5.093LeuThr: 5.093 ± 0.091
4.813LeuVal: 4.813 ± 0.096
0.702LeuTrp: 0.702 ± 0.035
2.881LeuTyr: 2.881 ± 0.076
0.0LeuXaa: 0.0 ± 0.0
Met
2.894MetAla: 2.894 ± 0.065
0.425MetCys: 0.425 ± 0.03
1.912MetAsp: 1.912 ± 0.054
2.535MetGlu: 2.535 ± 0.059
1.11MetPhe: 1.11 ± 0.045
2.466MetGly: 2.466 ± 0.071
0.348MetHis: 0.348 ± 0.025
2.516MetIle: 2.516 ± 0.065
2.717MetLys: 2.717 ± 0.07
2.648MetLeu: 2.648 ± 0.068
1.016MetMet: 1.016 ± 0.04
1.46MetAsn: 1.46 ± 0.045
1.136MetPro: 1.136 ± 0.041
0.813MetGln: 0.813 ± 0.038
1.48MetArg: 1.48 ± 0.047
1.988MetSer: 1.988 ± 0.053
1.964MetThr: 1.964 ± 0.059
1.964MetVal: 1.964 ± 0.062
0.218MetTrp: 0.218 ± 0.022
1.011MetTyr: 1.011 ± 0.04
0.0MetXaa: 0.0 ± 0.0
Asn
2.511AsnAla: 2.511 ± 0.062
0.594AsnCys: 0.594 ± 0.034
1.958AsnAsp: 1.958 ± 0.06
2.275AsnGlu: 2.275 ± 0.07
1.656AsnPhe: 1.656 ± 0.053
2.803AsnGly: 2.803 ± 0.076
0.592AsnHis: 0.592 ± 0.033
3.865AsnIle: 3.865 ± 0.087
2.589AsnLys: 2.589 ± 0.069
3.542AsnLeu: 3.542 ± 0.077
1.342AsnMet: 1.342 ± 0.053
1.575AsnAsn: 1.575 ± 0.057
1.711AsnPro: 1.711 ± 0.061
1.068AsnGln: 1.068 ± 0.044
1.875AsnArg: 1.875 ± 0.058
2.294AsnSer: 2.294 ± 0.063
2.138AsnThr: 2.138 ± 0.057
2.675AsnVal: 2.675 ± 0.064
0.341AsnTrp: 0.341 ± 0.024
1.617AsnTyr: 1.617 ± 0.053
0.0AsnXaa: 0.0 ± 0.0
Pro
2.66ProAla: 2.66 ± 0.064
0.518ProCys: 0.518 ± 0.033
2.27ProAsp: 2.27 ± 0.072
3.093ProGlu: 3.093 ± 0.085
1.445ProPhe: 1.445 ± 0.049
2.459ProGly: 2.459 ± 0.07
0.575ProHis: 0.575 ± 0.027
2.018ProIle: 2.018 ± 0.069
1.971ProLys: 1.971 ± 0.061
2.788ProLeu: 2.788 ± 0.069
0.955ProMet: 0.955 ± 0.036
0.989ProAsn: 0.989 ± 0.037
0.894ProPro: 0.894 ± 0.042
1.149ProGln: 1.149 ± 0.042
1.109ProArg: 1.109 ± 0.045
1.969ProSer: 1.969 ± 0.064
1.392ProThr: 1.392 ± 0.052
3.006ProVal: 3.006 ± 0.075
0.316ProTrp: 0.316 ± 0.018
1.345ProTyr: 1.345 ± 0.049
0.0ProXaa: 0.0 ± 0.0
Gln
2.103GlnAla: 2.103 ± 0.063
0.307GlnCys: 0.307 ± 0.023
1.31GlnAsp: 1.31 ± 0.045
1.978GlnGlu: 1.978 ± 0.059
1.051GlnPhe: 1.051 ± 0.042
1.836GlnGly: 1.836 ± 0.053
0.407GlnHis: 0.407 ± 0.027
2.305GlnIle: 2.305 ± 0.063
1.944GlnLys: 1.944 ± 0.062
2.366GlnLeu: 2.366 ± 0.058
1.035GlnMet: 1.035 ± 0.042
1.141GlnAsn: 1.141 ± 0.044
0.792GlnPro: 0.792 ± 0.035
1.026GlnGln: 1.026 ± 0.047
1.36GlnArg: 1.36 ± 0.05
1.428GlnSer: 1.428 ± 0.052
1.384GlnThr: 1.384 ± 0.044
1.851GlnVal: 1.851 ± 0.061
0.265GlnTrp: 0.265 ± 0.02
1.062GlnTyr: 1.062 ± 0.045
0.0GlnXaa: 0.0 ± 0.0
Arg
3.039ArgAla: 3.039 ± 0.071
0.624ArgCys: 0.624 ± 0.035
2.734ArgAsp: 2.734 ± 0.066
4.442ArgGlu: 4.442 ± 0.09
1.745ArgPhe: 1.745 ± 0.059
3.178ArgGly: 3.178 ± 0.084
0.759ArgHis: 0.759 ± 0.035
3.644ArgIle: 3.644 ± 0.085
3.294ArgLys: 3.294 ± 0.082
4.045ArgLeu: 4.045 ± 0.088
1.534ArgMet: 1.534 ± 0.047
1.9ArgAsn: 1.9 ± 0.061
1.617ArgPro: 1.617 ± 0.062
1.642ArgGln: 1.642 ± 0.055
2.639ArgArg: 2.639 ± 0.075
2.332ArgSer: 2.332 ± 0.076
2.148ArgThr: 2.148 ± 0.068
2.641ArgVal: 2.641 ± 0.061
0.388ArgTrp: 0.388 ± 0.028
1.823ArgTyr: 1.823 ± 0.068
0.0ArgXaa: 0.0 ± 0.0
Ser
4.658SerAla: 4.658 ± 0.091
0.918SerCys: 0.918 ± 0.046
3.563SerAsp: 3.563 ± 0.087
4.054SerGlu: 4.054 ± 0.086
2.668SerPhe: 2.668 ± 0.077
5.613SerGly: 5.613 ± 0.124
1.028SerHis: 1.028 ± 0.038
4.292SerIle: 4.292 ± 0.101
3.625SerLys: 3.625 ± 0.078
5.468SerLeu: 5.468 ± 0.095
1.954SerMet: 1.954 ± 0.066
1.931SerAsn: 1.931 ± 0.059
1.978SerPro: 1.978 ± 0.063
1.951SerGln: 1.951 ± 0.057
2.747SerArg: 2.747 ± 0.083
3.839SerSer: 3.839 ± 0.098
2.449SerThr: 2.449 ± 0.058
4.476SerVal: 4.476 ± 0.088
0.493SerTrp: 0.493 ± 0.027
2.253SerTyr: 2.253 ± 0.074
0.002SerXaa: 0.002 ± 0.002
Thr
4.629ThrAla: 4.629 ± 0.092
0.744ThrCys: 0.744 ± 0.042
3.315ThrAsp: 3.315 ± 0.076
3.686ThrGlu: 3.686 ± 0.075
2.167ThrPhe: 2.167 ± 0.058
4.908ThrGly: 4.908 ± 0.099
0.851ThrHis: 0.851 ± 0.038
3.666ThrIle: 3.666 ± 0.087
2.636ThrLys: 2.636 ± 0.062
4.447ThrLeu: 4.447 ± 0.101
1.445ThrMet: 1.445 ± 0.051
1.597ThrAsn: 1.597 ± 0.057
2.118ThrPro: 2.118 ± 0.063
1.235ThrGln: 1.235 ± 0.046
1.846ThrArg: 1.846 ± 0.057
2.796ThrSer: 2.796 ± 0.082
2.564ThrThr: 2.564 ± 0.08
4.582ThrVal: 4.582 ± 0.089
0.43ThrTrp: 0.43 ± 0.029
1.814ThrTyr: 1.814 ± 0.053
0.0ThrXaa: 0.0 ± 0.0
Val
5.168ValAla: 5.168 ± 0.103
1.301ValCys: 1.301 ± 0.049
3.79ValAsp: 3.79 ± 0.073
4.293ValGlu: 4.293 ± 0.092
2.965ValPhe: 2.965 ± 0.076
4.413ValGly: 4.413 ± 0.092
0.935ValHis: 0.935 ± 0.042
6.02ValIle: 6.02 ± 0.11
4.408ValLys: 4.408 ± 0.081
6.18ValLeu: 6.18 ± 0.1
2.243ValMet: 2.243 ± 0.056
2.65ValAsn: 2.65 ± 0.068
2.472ValPro: 2.472 ± 0.063
1.499ValGln: 1.499 ± 0.049
3.212ValArg: 3.212 ± 0.075
4.732ValSer: 4.732 ± 0.101
4.226ValThr: 4.226 ± 0.082
4.666ValVal: 4.666 ± 0.103
0.548ValTrp: 0.548 ± 0.03
2.452ValTyr: 2.452 ± 0.059
0.0ValXaa: 0.0 ± 0.0
Trp
0.594TrpAla: 0.594 ± 0.033
0.106TrpCys: 0.106 ± 0.016
0.456TrpAsp: 0.456 ± 0.03
0.51TrpGlu: 0.51 ± 0.033
0.378TrpPhe: 0.378 ± 0.027
0.597TrpGly: 0.597 ± 0.034
0.152TrpHis: 0.152 ± 0.017
0.624TrpIle: 0.624 ± 0.034
0.506TrpLys: 0.506 ± 0.03
0.727TrpLeu: 0.727 ± 0.039
0.287TrpMet: 0.287 ± 0.02
0.427TrpAsn: 0.427 ± 0.027
0.25TrpPro: 0.25 ± 0.023
0.338TrpGln: 0.338 ± 0.024
0.311TrpArg: 0.311 ± 0.025
0.412TrpSer: 0.412 ± 0.027
0.354TrpThr: 0.354 ± 0.025
0.44TrpVal: 0.44 ± 0.027
0.068TrpTrp: 0.068 ± 0.01
0.316TrpTyr: 0.316 ± 0.023
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.606TyrAla: 2.606 ± 0.063
0.613TyrCys: 0.613 ± 0.034
2.702TyrAsp: 2.702 ± 0.066
2.742TyrGlu: 2.742 ± 0.075
1.713TyrPhe: 1.713 ± 0.06
3.119TyrGly: 3.119 ± 0.066
0.557TyrHis: 0.557 ± 0.029
3.006TyrIle: 3.006 ± 0.069
2.4TyrLys: 2.4 ± 0.066
3.141TyrLeu: 3.141 ± 0.087
1.104TyrMet: 1.104 ± 0.041
1.539TyrAsn: 1.539 ± 0.049
1.303TyrPro: 1.303 ± 0.049
0.932TyrGln: 0.932 ± 0.037
1.811TyrArg: 1.811 ± 0.058
2.278TyrSer: 2.278 ± 0.06
1.91TyrThr: 1.91 ± 0.058
2.413TyrVal: 2.413 ± 0.067
0.305TyrTrp: 0.305 ± 0.022
1.57TyrTyr: 1.57 ± 0.056
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.002XaaAla: 0.002 ± 0.002
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.002XaaGly: 0.002 ± 0.002
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.002XaaVal: 0.002 ± 0.002
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.007XaaXaa: 0.007 ± 0.004
Statistics based on 1960 proteins (592543 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski