Amino acid dipepetide frequency for Acidaminococcus sp. CAG:917

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.358AlaAla: 5.358 ± 0.167	1.068AlaCys: 1.068 ± 0.059	4.823AlaAsp: 4.823 ± 0.121	5.201AlaGlu: 5.201 ± 0.132	3.529AlaPhe: 3.529 ± 0.12	4.604AlaGly: 4.604 ± 0.128	0.995AlaHis: 0.995 ± 0.058	5.594AlaIle: 5.594 ± 0.129	6.411AlaLys: 6.411 ± 0.172	7.474AlaLeu: 7.474 ± 0.178	1.964AlaMet: 1.964 ± 0.069	3.09AlaAsn: 3.09 ± 0.106	2.068AlaPro: 2.068 ± 0.086	2.131AlaGln: 2.131 ± 0.084	2.468AlaArg: 2.468 ± 0.086	4.486AlaSer: 4.486 ± 0.129	3.912AlaThr: 3.912 ± 0.129	6.811AlaVal: 6.811 ± 0.133	0.333AlaTrp: 0.333 ± 0.032	2.714AlaTyr: 2.714 ± 0.076	0.01AlaXaa: 0.01 ± 0.005
Cys	1.196CysAla: 1.196 ± 0.069	0.304CysCys: 0.304 ± 0.031	1.369CysAsp: 1.369 ± 0.064	0.981CysGlu: 0.981 ± 0.057	0.771CysPhe: 0.771 ± 0.043	1.526CysGly: 1.526 ± 0.068	0.28CysHis: 0.28 ± 0.027	0.94CysIle: 0.94 ± 0.047	0.894CysLys: 0.894 ± 0.044	1.328CysLeu: 1.328 ± 0.065	0.335CysMet: 0.335 ± 0.029	0.658CysAsn: 0.658 ± 0.046	0.783CysPro: 0.783 ± 0.051	0.313CysGln: 0.313 ± 0.026	0.537CysArg: 0.537 ± 0.038	0.995CysSer: 0.995 ± 0.062	0.665CysThr: 0.665 ± 0.039	1.051CysVal: 1.051 ± 0.065	0.072CysTrp: 0.072 ± 0.013	0.566CysTyr: 0.566 ± 0.042	0.0CysXaa: 0.0 ± 0.0
Asp	3.929AspAla: 3.929 ± 0.11	0.983AspCys: 0.983 ± 0.052	3.531AspAsp: 3.531 ± 0.109	5.245AspGlu: 5.245 ± 0.12	3.625AspPhe: 3.625 ± 0.097	5.218AspGly: 5.218 ± 0.181	0.523AspHis: 0.523 ± 0.04	4.818AspIle: 4.818 ± 0.105	5.505AspLys: 5.505 ± 0.125	4.401AspLeu: 4.401 ± 0.117	1.726AspMet: 1.726 ± 0.062	2.651AspAsn: 2.651 ± 0.085	1.2AspPro: 1.2 ± 0.06	0.721AspGln: 0.721 ± 0.043	2.082AspArg: 2.082 ± 0.075	3.936AspSer: 3.936 ± 0.112	3.196AspThr: 3.196 ± 0.098	4.459AspVal: 4.459 ± 0.11	0.378AspTrp: 0.378 ± 0.032	3.032AspTyr: 3.032 ± 0.101	0.0AspXaa: 0.0 ± 0.0
Glu	5.045GluAla: 5.045 ± 0.121	0.94GluCys: 0.94 ± 0.055	3.384GluAsp: 3.384 ± 0.109	5.216GluGlu: 5.216 ± 0.163	3.01GluPhe: 3.01 ± 0.083	4.404GluGly: 4.404 ± 0.117	0.87GluHis: 0.87 ± 0.044	5.862GluIle: 5.862 ± 0.118	7.187GluLys: 7.187 ± 0.176	5.751GluLeu: 5.751 ± 0.128	1.933GluMet: 1.933 ± 0.08	4.37GluAsn: 4.37 ± 0.101	1.543GluPro: 1.543 ± 0.071	2.169GluGln: 2.169 ± 0.082	3.02GluArg: 3.02 ± 0.103	3.497GluSer: 3.497 ± 0.094	3.524GluThr: 3.524 ± 0.104	4.548GluVal: 4.548 ± 0.099	0.494GluTrp: 0.494 ± 0.04	2.832GluTyr: 2.832 ± 0.08	0.0GluXaa: 0.0 ± 0.0
Phe	3.601PheAla: 3.601 ± 0.093	0.921PheCys: 0.921 ± 0.046	3.664PheAsp: 3.664 ± 0.092	3.249PheGlu: 3.249 ± 0.081	2.082PhePhe: 2.082 ± 0.079	3.415PheGly: 3.415 ± 0.095	0.494PheHis: 0.494 ± 0.036	3.326PheIle: 3.326 ± 0.097	3.919PheLys: 3.919 ± 0.104	3.673PheLeu: 3.673 ± 0.116	1.085PheMet: 1.085 ± 0.051	2.309PheAsn: 2.309 ± 0.076	1.239PhePro: 1.239 ± 0.058	0.682PheGln: 0.682 ± 0.038	1.302PheArg: 1.302 ± 0.06	3.584PheSer: 3.584 ± 0.088	2.497PheThr: 2.497 ± 0.094	3.507PheVal: 3.507 ± 0.097	0.335PheTrp: 0.335 ± 0.028	1.945PheTyr: 1.945 ± 0.081	0.005PheXaa: 0.005 ± 0.003
Gly	5.054GlyAla: 5.054 ± 0.145	1.082GlyCys: 1.082 ± 0.069	4.249GlyAsp: 4.249 ± 0.115	5.088GlyGlu: 5.088 ± 0.121	3.182GlyPhe: 3.182 ± 0.087	5.177GlyGly: 5.177 ± 0.152	0.918GlyHis: 0.918 ± 0.055	5.462GlyIle: 5.462 ± 0.13	6.057GlyLys: 6.057 ± 0.124	5.418GlyLeu: 5.418 ± 0.121	1.764GlyMet: 1.764 ± 0.076	2.912GlyAsn: 2.912 ± 0.132	0.974GlyPro: 0.974 ± 0.049	1.837GlyGln: 1.837 ± 0.074	2.601GlyArg: 2.601 ± 0.084	3.753GlySer: 3.753 ± 0.107	3.688GlyThr: 3.688 ± 0.127	5.611GlyVal: 5.611 ± 0.125	0.501GlyTrp: 0.501 ± 0.039	3.317GlyTyr: 3.317 ± 0.092	0.0GlyXaa: 0.0 ± 0.0
His	0.851HisAla: 0.851 ± 0.047	0.251HisCys: 0.251 ± 0.03	0.764HisAsp: 0.764 ± 0.042	0.653HisGlu: 0.653 ± 0.043	0.668HisPhe: 0.668 ± 0.044	0.993HisGly: 0.993 ± 0.055	0.258HisHis: 0.258 ± 0.026	1.094HisIle: 1.094 ± 0.055	0.836HisLys: 0.836 ± 0.049	1.101HisLeu: 1.101 ± 0.065	0.26HisMet: 0.26 ± 0.023	0.651HisAsn: 0.651 ± 0.046	0.653HisPro: 0.653 ± 0.041	0.294HisGln: 0.294 ± 0.025	0.559HisArg: 0.559 ± 0.039	0.901HisSer: 0.901 ± 0.044	0.766HisThr: 0.766 ± 0.043	0.699HisVal: 0.699 ± 0.042	0.072HisTrp: 0.072 ± 0.011	0.523HisTyr: 0.523 ± 0.043	0.0HisXaa: 0.0 ± 0.0
Ile	6.356IleAla: 6.356 ± 0.148	1.333IleCys: 1.333 ± 0.055	4.958IleAsp: 4.958 ± 0.124	5.428IleGlu: 5.428 ± 0.107	3.17IlePhe: 3.17 ± 0.096	4.895IleGly: 4.895 ± 0.123	0.728IleHis: 0.728 ± 0.045	5.293IleIle: 5.293 ± 0.136	6.006IleLys: 6.006 ± 0.123	6.267IleLeu: 6.267 ± 0.134	1.74IleMet: 1.74 ± 0.074	3.476IleAsn: 3.476 ± 0.102	2.577IlePro: 2.577 ± 0.089	1.222IleGln: 1.222 ± 0.056	2.374IleArg: 2.374 ± 0.069	5.5IleSer: 5.5 ± 0.136	3.866IleThr: 3.866 ± 0.105	5.688IleVal: 5.688 ± 0.134	0.448IleTrp: 0.448 ± 0.033	2.75IleTyr: 2.75 ± 0.085	0.002IleXaa: 0.002 ± 0.002
Lys	6.508LysAla: 6.508 ± 0.146	1.13LysCys: 1.13 ± 0.07	4.642LysAsp: 4.642 ± 0.117	6.585LysGlu: 6.585 ± 0.147	3.145LysPhe: 3.145 ± 0.1	5.115LysGly: 5.115 ± 0.132	0.967LysHis: 0.967 ± 0.044	6.766LysIle: 6.766 ± 0.159	8.118LysLys: 8.118 ± 0.215	6.681LysLeu: 6.681 ± 0.16	2.456LysMet: 2.456 ± 0.088	4.888LysAsn: 4.888 ± 0.119	2.307LysPro: 2.307 ± 0.086	2.512LysGln: 2.512 ± 0.09	3.439LysArg: 3.439 ± 0.111	4.917LysSer: 4.917 ± 0.111	4.924LysThr: 4.924 ± 0.121	5.245LysVal: 5.245 ± 0.129	0.521LysTrp: 0.521 ± 0.032	3.29LysTyr: 3.29 ± 0.084	0.0LysXaa: 0.0 ± 0.0
Leu	6.409LeuAla: 6.409 ± 0.132	1.634LeuCys: 1.634 ± 0.08	5.387LeuAsp: 5.387 ± 0.146	5.201LeuGlu: 5.201 ± 0.137	3.873LeuPhe: 3.873 ± 0.124	5.585LeuGly: 5.585 ± 0.131	1.138LeuHis: 1.138 ± 0.06	6.262LeuIle: 6.262 ± 0.154	8.595LeuLys: 8.595 ± 0.187	7.496LeuLeu: 7.496 ± 0.184	1.894LeuMet: 1.894 ± 0.066	4.517LeuAsn: 4.517 ± 0.113	3.329LeuPro: 3.329 ± 0.09	1.699LeuGln: 1.699 ± 0.064	2.977LeuArg: 2.977 ± 0.092	7.568LeuSer: 7.568 ± 0.146	5.307LeuThr: 5.307 ± 0.131	5.529LeuVal: 5.529 ± 0.123	0.55LeuTrp: 0.55 ± 0.036	3.232LeuTyr: 3.232 ± 0.1	0.005LeuXaa: 0.005 ± 0.003
Met	1.894MetAla: 1.894 ± 0.089	0.325MetCys: 0.325 ± 0.027	1.232MetAsp: 1.232 ± 0.06	1.408MetGlu: 1.408 ± 0.061	1.085MetPhe: 1.085 ± 0.055	1.692MetGly: 1.692 ± 0.079	0.33MetHis: 0.33 ± 0.027	1.697MetIle: 1.697 ± 0.069	1.967MetLys: 1.967 ± 0.072	2.442MetLeu: 2.442 ± 0.086	0.513MetMet: 0.513 ± 0.04	1.155MetAsn: 1.155 ± 0.051	1.2MetPro: 1.2 ± 0.054	0.87MetGln: 0.87 ± 0.044	1.065MetArg: 1.065 ± 0.049	1.788MetSer: 1.788 ± 0.066	1.653MetThr: 1.653 ± 0.059	1.306MetVal: 1.306 ± 0.052	0.159MetTrp: 0.159 ± 0.02	0.672MetTyr: 0.672 ± 0.041	0.002MetXaa: 0.002 ± 0.002
Asn	3.777AsnAla: 3.777 ± 0.107	0.747AsnCys: 0.747 ± 0.046	2.449AsnAsp: 2.449 ± 0.093	2.955AsnGlu: 2.955 ± 0.088	2.152AsnPhe: 2.152 ± 0.078	3.755AsnGly: 3.755 ± 0.125	0.636AsnHis: 0.636 ± 0.043	3.502AsnIle: 3.502 ± 0.104	3.374AsnLys: 3.374 ± 0.1	4.527AsnLeu: 4.527 ± 0.113	1.282AsnMet: 1.282 ± 0.05	2.051AsnAsn: 2.051 ± 0.086	2.104AsnPro: 2.104 ± 0.074	1.027AsnGln: 1.027 ± 0.051	1.579AsnArg: 1.579 ± 0.063	3.037AsnSer: 3.037 ± 0.108	2.379AsnThr: 2.379 ± 0.087	3.427AsnVal: 3.427 ± 0.108	0.352AsnTrp: 0.352 ± 0.03	2.123AsnTyr: 2.123 ± 0.12	0.005AsnXaa: 0.005 ± 0.003
Pro	1.909ProAla: 1.909 ± 0.067	0.48ProCys: 0.48 ± 0.042	2.136ProAsp: 2.136 ± 0.078	2.34ProGlu: 2.34 ± 0.081	1.738ProPhe: 1.738 ± 0.077	1.208ProGly: 1.208 ± 0.057	0.525ProHis: 0.525 ± 0.04	2.037ProIle: 2.037 ± 0.071	2.439ProLys: 2.439 ± 0.08	2.849ProLeu: 2.849 ± 0.086	0.721ProMet: 0.721 ± 0.046	1.246ProAsn: 1.246 ± 0.067	0.844ProPro: 0.844 ± 0.047	1.007ProGln: 1.007 ± 0.048	0.841ProArg: 0.841 ± 0.048	2.357ProSer: 2.357 ± 0.077	1.909ProThr: 1.909 ± 0.07	2.473ProVal: 2.473 ± 0.089	0.234ProTrp: 0.234 ± 0.024	1.528ProTyr: 1.528 ± 0.062	0.0ProXaa: 0.0 ± 0.0
Gln	1.658GlnAla: 1.658 ± 0.075	0.268GlnCys: 0.268 ± 0.026	0.993GlnAsp: 0.993 ± 0.053	1.244GlnGlu: 1.244 ± 0.065	1.082GlnPhe: 1.082 ± 0.055	1.574GlnGly: 1.574 ± 0.065	0.27GlnHis: 0.27 ± 0.029	2.184GlnIle: 2.184 ± 0.076	2.567GlnLys: 2.567 ± 0.09	1.998GlnLeu: 1.998 ± 0.07	0.67GlnMet: 0.67 ± 0.04	1.711GlnAsn: 1.711 ± 0.07	0.74GlnPro: 0.74 ± 0.043	0.677GlnGln: 0.677 ± 0.05	1.106GlnArg: 1.106 ± 0.055	1.661GlnSer: 1.661 ± 0.07	1.591GlnThr: 1.591 ± 0.065	1.302GlnVal: 1.302 ± 0.055	0.161GlnTrp: 0.161 ± 0.022	0.926GlnTyr: 0.926 ± 0.048	0.005GlnXaa: 0.005 ± 0.004
Arg	2.569ArgAla: 2.569 ± 0.088	0.523ArgCys: 0.523 ± 0.039	1.772ArgAsp: 1.772 ± 0.073	2.579ArgGlu: 2.579 ± 0.088	1.817ArgPhe: 1.817 ± 0.068	2.23ArgGly: 2.23 ± 0.089	0.709ArgHis: 0.709 ± 0.041	2.728ArgIle: 2.728 ± 0.085	2.646ArgLys: 2.646 ± 0.085	3.652ArgLeu: 3.652 ± 0.107	0.827ArgMet: 0.827 ± 0.041	1.417ArgAsn: 1.417 ± 0.059	1.077ArgPro: 1.077 ± 0.057	1.371ArgGln: 1.371 ± 0.067	1.651ArgArg: 1.651 ± 0.08	1.846ArgSer: 1.846 ± 0.066	1.752ArgThr: 1.752 ± 0.065	2.463ArgVal: 2.463 ± 0.075	0.246ArgTrp: 0.246 ± 0.025	1.697ArgTyr: 1.697 ± 0.064	0.0ArgXaa: 0.0 ± 0.0
Ser	5.05SerAla: 5.05 ± 0.121	0.839SerCys: 0.839 ± 0.051	4.987SerAsp: 4.987 ± 0.113	4.71SerGlu: 4.71 ± 0.117	3.237SerPhe: 3.237 ± 0.108	5.091SerGly: 5.091 ± 0.144	0.892SerHis: 0.892 ± 0.052	4.298SerIle: 4.298 ± 0.103	4.567SerLys: 4.567 ± 0.109	6.522SerLeu: 6.522 ± 0.144	1.403SerMet: 1.403 ± 0.057	2.625SerAsn: 2.625 ± 0.102	2.029SerPro: 2.029 ± 0.084	1.731SerGln: 1.731 ± 0.067	2.15SerArg: 2.15 ± 0.08	4.37SerSer: 4.37 ± 0.135	3.085SerThr: 3.085 ± 0.101	5.541SerVal: 5.541 ± 0.136	0.359SerTrp: 0.359 ± 0.031	2.577SerTyr: 2.577 ± 0.09	0.002SerXaa: 0.002 ± 0.002
Thr	4.705ThrAla: 4.705 ± 0.111	0.559ThrCys: 0.559 ± 0.032	3.358ThrAsp: 3.358 ± 0.103	3.439ThrGlu: 3.439 ± 0.099	2.499ThrPhe: 2.499 ± 0.102	4.03ThrGly: 4.03 ± 0.12	0.827ThrHis: 0.827 ± 0.045	3.637ThrIle: 3.637 ± 0.112	3.615ThrLys: 3.615 ± 0.101	5.317ThrLeu: 5.317 ± 0.126	1.147ThrMet: 1.147 ± 0.049	2.099ThrAsn: 2.099 ± 0.091	2.217ThrPro: 2.217 ± 0.085	1.376ThrGln: 1.376 ± 0.064	1.692ThrArg: 1.692 ± 0.057	3.439ThrSer: 3.439 ± 0.131	2.794ThrThr: 2.794 ± 0.119	5.344ThrVal: 5.344 ± 0.122	0.248ThrTrp: 0.248 ± 0.029	2.049ThrTyr: 2.049 ± 0.118	0.0ThrXaa: 0.0 ± 0.0
Val	5.662ValAla: 5.662 ± 0.146	1.398ValCys: 1.398 ± 0.075	4.213ValAsp: 4.213 ± 0.105	5.076ValGlu: 5.076 ± 0.112	3.794ValPhe: 3.794 ± 0.104	4.633ValGly: 4.633 ± 0.114	0.848ValHis: 0.848 ± 0.048	5.122ValIle: 5.122 ± 0.121	6.153ValLys: 6.153 ± 0.13	7.171ValLeu: 7.171 ± 0.12	1.752ValMet: 1.752 ± 0.067	3.186ValAsn: 3.186 ± 0.087	2.398ValPro: 2.398 ± 0.071	1.504ValGln: 1.504 ± 0.052	2.381ValArg: 2.381 ± 0.083	5.175ValSer: 5.175 ± 0.145	4.245ValThr: 4.245 ± 0.121	5.488ValVal: 5.488 ± 0.136	0.46ValTrp: 0.46 ± 0.036	3.015ValTyr: 3.015 ± 0.11	0.002ValXaa: 0.002 ± 0.002
Trp	0.513TrpAla: 0.513 ± 0.04	0.116TrpCys: 0.116 ± 0.018	0.403TrpAsp: 0.403 ± 0.03	0.403TrpGlu: 0.403 ± 0.033	0.304TrpPhe: 0.304 ± 0.025	0.547TrpGly: 0.547 ± 0.036	0.128TrpHis: 0.128 ± 0.016	0.374TrpIle: 0.374 ± 0.025	0.436TrpLys: 0.436 ± 0.04	0.55TrpLeu: 0.55 ± 0.035	0.135TrpMet: 0.135 ± 0.019	0.357TrpAsn: 0.357 ± 0.029	0.087TrpPro: 0.087 ± 0.017	0.251TrpGln: 0.251 ± 0.024	0.239TrpArg: 0.239 ± 0.026	0.364TrpSer: 0.364 ± 0.028	0.335TrpThr: 0.335 ± 0.027	0.349TrpVal: 0.349 ± 0.032	0.101TrpTrp: 0.101 ± 0.017	0.284TrpTyr: 0.284 ± 0.032	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.998TyrAla: 2.998 ± 0.094	0.665TyrCys: 0.665 ± 0.045	2.849TyrAsp: 2.849 ± 0.098	2.593TyrGlu: 2.593 ± 0.077	2.07TyrPhe: 2.07 ± 0.068	2.948TyrGly: 2.948 ± 0.085	0.513TyrHis: 0.513 ± 0.032	3.08TyrIle: 3.08 ± 0.096	2.859TyrLys: 2.859 ± 0.08	3.567TyrLeu: 3.567 ± 0.087	0.846TyrMet: 0.846 ± 0.044	1.873TyrAsn: 1.873 ± 0.086	1.451TyrPro: 1.451 ± 0.069	0.991TyrGln: 0.991 ± 0.049	1.502TyrArg: 1.502 ± 0.063	2.888TyrSer: 2.888 ± 0.1	2.304TyrThr: 2.304 ± 0.121	2.827TyrVal: 2.827 ± 0.153	0.248TyrTrp: 0.248 ± 0.027	1.825TyrTyr: 1.825 ± 0.11	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.002XaaAla: 0.002 ± 0.002	0.0XaaCys: 0.0 ± 0.0	0.002XaaAsp: 0.002 ± 0.002	0.005XaaGlu: 0.005 ± 0.003	0.0XaaPhe: 0.0 ± 0.0	0.007XaaGly: 0.007 ± 0.004	0.0XaaHis: 0.0 ± 0.0	0.002XaaIle: 0.002 ± 0.002	0.0XaaLys: 0.0 ± 0.0	0.002XaaLeu: 0.002 ± 0.002	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.002XaaGln: 0.002 ± 0.003	0.007XaaArg: 0.007 ± 0.004	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.007XaaVal: 0.007 ± 0.003	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.058XaaXaa: 0.058 ± 0.016

Statistics based on 1276 proteins (414890 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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