Amino acid dipepetide frequency for Mycoplasma sp. CAG:611

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.537AlaAla: 1.537 ± 0.116
0.595AlaCys: 0.595 ± 0.051
1.529AlaAsp: 1.529 ± 0.082
1.623AlaGlu: 1.623 ± 0.092
1.742AlaPhe: 1.742 ± 0.084
2.21AlaGly: 2.21 ± 0.108
0.475AlaHis: 0.475 ± 0.042
4.023AlaIle: 4.023 ± 0.123
3.933AlaLys: 3.933 ± 0.123
4.18AlaLeu: 4.18 ± 0.135
0.826AlaMet: 0.826 ± 0.064
2.498AlaAsn: 2.498 ± 0.105
0.733AlaPro: 0.733 ± 0.055
0.71AlaGln: 0.71 ± 0.066
1.582AlaArg: 1.582 ± 0.09
3.122AlaSer: 3.122 ± 0.122
2.415AlaThr: 2.415 ± 0.095
2.322AlaVal: 2.322 ± 0.1
0.161AlaTrp: 0.161 ± 0.028
1.821AlaTyr: 1.821 ± 0.095
0.0AlaXaa: 0.0 ± 0.0
Cys
0.426CysAla: 0.426 ± 0.041
0.224CysCys: 0.224 ± 0.035
0.748CysAsp: 0.748 ± 0.059
0.744CysGlu: 0.744 ± 0.053
0.598CysPhe: 0.598 ± 0.049
0.838CysGly: 0.838 ± 0.06
0.179CysHis: 0.179 ± 0.026
1.054CysIle: 1.054 ± 0.057
1.114CysLys: 1.114 ± 0.07
1.051CysLeu: 1.051 ± 0.067
0.243CysMet: 0.243 ± 0.032
0.89CysAsn: 0.89 ± 0.06
0.404CysPro: 0.404 ± 0.04
0.161CysGln: 0.161 ± 0.028
0.247CysArg: 0.247 ± 0.032
0.882CysSer: 0.882 ± 0.066
0.565CysThr: 0.565 ± 0.057
0.591CysVal: 0.591 ± 0.052
0.052CysTrp: 0.052 ± 0.014
0.662CysTyr: 0.662 ± 0.047
0.0CysXaa: 0.0 ± 0.0
Asp
2.191AspAla: 2.191 ± 0.111
0.512AspCys: 0.512 ± 0.051
3.53AspAsp: 3.53 ± 0.138
4.719AspGlu: 4.719 ± 0.133
2.808AspPhe: 2.808 ± 0.115
2.587AspGly: 2.587 ± 0.104
0.46AspHis: 0.46 ± 0.043
6.809AspIle: 6.809 ± 0.17
6.831AspLys: 6.831 ± 0.183
5.866AspLeu: 5.866 ± 0.162
1.354AspMet: 1.354 ± 0.072
4.947AspAsn: 4.947 ± 0.16
1.032AspPro: 1.032 ± 0.063
0.535AspGln: 0.535 ± 0.042
1.211AspArg: 1.211 ± 0.061
2.744AspSer: 2.744 ± 0.115
2.894AspThr: 2.894 ± 0.095
3.874AspVal: 3.874 ± 0.122
0.206AspTrp: 0.206 ± 0.027
3.631AspTyr: 3.631 ± 0.117
0.0AspXaa: 0.0 ± 0.0
Glu
2.853GluAla: 2.853 ± 0.12
0.535GluCys: 0.535 ± 0.047
4.36GluAsp: 4.36 ± 0.145
7.777GluGlu: 7.777 ± 0.235
2.617GluPhe: 2.617 ± 0.1
2.808GluGly: 2.808 ± 0.106
0.703GluHis: 0.703 ± 0.052
7.519GluIle: 7.519 ± 0.171
9.407GluLys: 9.407 ± 0.228
6.685GluLeu: 6.685 ± 0.166
1.72GluMet: 1.72 ± 0.083
5.818GluAsn: 5.818 ± 0.157
1.182GluPro: 1.182 ± 0.068
1.787GluGln: 1.787 ± 0.082
2.255GluArg: 2.255 ± 0.108
2.898GluSer: 2.898 ± 0.103
3.459GluThr: 3.459 ± 0.108
5.074GluVal: 5.074 ± 0.15
0.359GluTrp: 0.359 ± 0.037
3.208GluTyr: 3.208 ± 0.118
0.0GluXaa: 0.0 ± 0.0
Phe
1.757PheAla: 1.757 ± 0.095
0.471PheCys: 0.471 ± 0.045
2.752PheAsp: 2.752 ± 0.102
2.602PheGlu: 2.602 ± 0.106
1.817PhePhe: 1.817 ± 0.095
2.397PheGly: 2.397 ± 0.114
0.355PheHis: 0.355 ± 0.04
5.014PheIle: 5.014 ± 0.204
4.244PheLys: 4.244 ± 0.132
4.176PheLeu: 4.176 ± 0.156
0.916PheMet: 0.916 ± 0.055
4.042PheAsn: 4.042 ± 0.115
1.125PhePro: 1.125 ± 0.066
0.512PheGln: 0.512 ± 0.05
0.946PheArg: 0.946 ± 0.05
2.909PheSer: 2.909 ± 0.115
2.419PheThr: 2.419 ± 0.106
2.7PheVal: 2.7 ± 0.096
0.236PheTrp: 0.236 ± 0.029
2.333PheTyr: 2.333 ± 0.103
0.0PheXaa: 0.0 ± 0.0
Gly
2.344GlyAla: 2.344 ± 0.1
0.77GlyCys: 0.77 ± 0.058
2.371GlyAsp: 2.371 ± 0.103
3.062GlyGlu: 3.062 ± 0.127
2.471GlyPhe: 2.471 ± 0.102
3.096GlyGly: 3.096 ± 0.133
0.92GlyHis: 0.92 ± 0.063
5.216GlyIle: 5.216 ± 0.169
5.085GlyLys: 5.085 ± 0.116
4.352GlyLeu: 4.352 ± 0.141
1.077GlyMet: 1.077 ± 0.073
3.432GlyAsn: 3.432 ± 0.118
0.942GlyPro: 0.942 ± 0.071
0.901GlyGln: 0.901 ± 0.065
1.526GlyArg: 1.526 ± 0.092
3.122GlySer: 3.122 ± 0.124
3.23GlyThr: 3.23 ± 0.121
3.589GlyVal: 3.589 ± 0.124
0.277GlyTrp: 0.277 ± 0.035
3.044GlyTyr: 3.044 ± 0.117
0.0GlyXaa: 0.0 ± 0.0
His
0.527HisAla: 0.527 ± 0.048
0.127HisCys: 0.127 ± 0.022
0.527HisAsp: 0.527 ± 0.046
0.785HisGlu: 0.785 ± 0.051
0.501HisPhe: 0.501 ± 0.042
0.658HisGly: 0.658 ± 0.05
0.232HisHis: 0.232 ± 0.036
1.11HisIle: 1.11 ± 0.071
0.811HisLys: 0.811 ± 0.055
1.006HisLeu: 1.006 ± 0.064
0.273HisMet: 0.273 ± 0.032
0.785HisAsn: 0.785 ± 0.063
0.501HisPro: 0.501 ± 0.049
0.247HisGln: 0.247 ± 0.028
0.374HisArg: 0.374 ± 0.04
0.643HisSer: 0.643 ± 0.053
0.568HisThr: 0.568 ± 0.048
0.658HisVal: 0.658 ± 0.051
0.041HisTrp: 0.041 ± 0.012
0.602HisTyr: 0.602 ± 0.04
0.0HisXaa: 0.0 ± 0.0
Ile
4.023IleAla: 4.023 ± 0.139
1.316IleCys: 1.316 ± 0.081
6.611IleAsp: 6.611 ± 0.173
6.753IleGlu: 6.753 ± 0.168
4.67IlePhe: 4.67 ± 0.189
5.25IleGly: 5.25 ± 0.178
0.995IleHis: 0.995 ± 0.069
11.456IleIle: 11.456 ± 0.297
11.744IleLys: 11.744 ± 0.217
9.677IleLeu: 9.677 ± 0.229
1.881IleMet: 1.881 ± 0.081
9.007IleAsn: 9.007 ± 0.216
2.879IlePro: 2.879 ± 0.116
1.238IleGln: 1.238 ± 0.075
2.797IleArg: 2.797 ± 0.098
6.999IleSer: 6.999 ± 0.173
5.844IleThr: 5.844 ± 0.152
6.035IleVal: 6.035 ± 0.163
0.408IleTrp: 0.408 ± 0.043
4.827IleTyr: 4.827 ± 0.147
0.0IleXaa: 0.0 ± 0.0
Lys
3.563LysAla: 3.563 ± 0.119
0.89LysCys: 0.89 ± 0.058
7.972LysAsp: 7.972 ± 0.2
12.204LysGlu: 12.204 ± 0.261
3.242LysPhe: 3.242 ± 0.11
4.363LysGly: 4.363 ± 0.135
1.129LysHis: 1.129 ± 0.064
10.873LysIle: 10.873 ± 0.246
12.047LysLys: 12.047 ± 0.269
9.325LysLeu: 9.325 ± 0.162
2.715LysMet: 2.715 ± 0.109
8.798LysAsn: 8.798 ± 0.207
1.967LysPro: 1.967 ± 0.089
2.7LysGln: 2.7 ± 0.103
2.987LysArg: 2.987 ± 0.121
4.928LysSer: 4.928 ± 0.148
6.024LysThr: 6.024 ± 0.174
6.397LysVal: 6.397 ± 0.18
0.415LysTrp: 0.415 ± 0.04
6.293LysTyr: 6.293 ± 0.196
0.0LysXaa: 0.0 ± 0.0
Leu
3.818LeuAla: 3.818 ± 0.136
0.976LeuCys: 0.976 ± 0.057
5.687LeuAsp: 5.687 ± 0.144
6.876LeuGlu: 6.876 ± 0.175
4.633LeuPhe: 4.633 ± 0.156
5.179LeuGly: 5.179 ± 0.158
0.935LeuHis: 0.935 ± 0.064
9.497LeuIle: 9.497 ± 0.229
10.634LeuLys: 10.634 ± 0.207
8.435LeuLeu: 8.435 ± 0.213
1.929LeuMet: 1.929 ± 0.083
8.129LeuAsn: 8.129 ± 0.217
2.524LeuPro: 2.524 ± 0.107
1.787LeuGln: 1.787 ± 0.087
2.389LeuArg: 2.389 ± 0.101
6.009LeuSer: 6.009 ± 0.163
5.313LeuThr: 5.313 ± 0.158
5.223LeuVal: 5.223 ± 0.15
0.37LeuTrp: 0.37 ± 0.04
4.218LeuTyr: 4.218 ± 0.152
0.0LeuXaa: 0.0 ± 0.0
Met
1.096MetAla: 1.096 ± 0.072
0.265MetCys: 0.265 ± 0.031
1.264MetAsp: 1.264 ± 0.077
1.675MetGlu: 1.675 ± 0.082
1.021MetPhe: 1.021 ± 0.057
1.129MetGly: 1.129 ± 0.072
0.224MetHis: 0.224 ± 0.027
2.012MetIle: 2.012 ± 0.083
2.602MetLys: 2.602 ± 0.088
2.0MetLeu: 2.0 ± 0.083
0.531MetMet: 0.531 ± 0.046
1.612MetAsn: 1.612 ± 0.07
0.651MetPro: 0.651 ± 0.057
0.482MetGln: 0.482 ± 0.043
0.445MetArg: 0.445 ± 0.043
1.114MetSer: 1.114 ± 0.067
0.946MetThr: 0.946 ± 0.059
1.174MetVal: 1.174 ± 0.074
0.217MetTrp: 0.217 ± 0.031
1.058MetTyr: 1.058 ± 0.069
0.0MetXaa: 0.0 ± 0.0
Asn
2.632AsnAla: 2.632 ± 0.122
0.838AsnCys: 0.838 ± 0.055
4.898AsnAsp: 4.898 ± 0.181
5.844AsnGlu: 5.844 ± 0.143
3.126AsnPhe: 3.126 ± 0.134
3.623AsnGly: 3.623 ± 0.126
0.894AsnHis: 0.894 ± 0.064
9.796AsnIle: 9.796 ± 0.227
9.897AsnLys: 9.897 ± 0.237
7.299AsnLeu: 7.299 ± 0.191
1.888AsnMet: 1.888 ± 0.097
8.603AsnAsn: 8.603 ± 0.243
2.154AsnPro: 2.154 ± 0.097
1.096AsnGln: 1.096 ± 0.068
2.0AsnArg: 2.0 ± 0.097
4.251AsnSer: 4.251 ± 0.14
3.818AsnThr: 3.818 ± 0.129
4.412AsnVal: 4.412 ± 0.152
0.381AsnTrp: 0.381 ± 0.042
5.242AsnTyr: 5.242 ± 0.167
0.0AsnXaa: 0.0 ± 0.0
Pro
0.834ProAla: 0.834 ± 0.06
0.303ProCys: 0.303 ± 0.036
1.241ProAsp: 1.241 ± 0.076
1.585ProGlu: 1.585 ± 0.091
1.268ProPhe: 1.268 ± 0.085
1.286ProGly: 1.286 ± 0.077
0.322ProHis: 0.322 ± 0.032
2.24ProIle: 2.24 ± 0.087
2.206ProLys: 2.206 ± 0.085
2.019ProLeu: 2.019 ± 0.088
0.497ProMet: 0.497 ± 0.051
1.922ProAsn: 1.922 ± 0.086
0.359ProPro: 0.359 ± 0.035
0.4ProGln: 0.4 ± 0.043
0.744ProArg: 0.744 ± 0.061
1.694ProSer: 1.694 ± 0.085
1.522ProThr: 1.522 ± 0.074
1.451ProVal: 1.451 ± 0.071
0.172ProTrp: 0.172 ± 0.025
1.413ProTyr: 1.413 ± 0.083
0.0ProXaa: 0.0 ± 0.0
Gln
0.927GlnAla: 0.927 ± 0.067
0.12GlnCys: 0.12 ± 0.023
1.077GlnAsp: 1.077 ± 0.07
1.57GlnGlu: 1.57 ± 0.093
0.583GlnPhe: 0.583 ± 0.047
0.894GlnGly: 0.894 ± 0.067
0.153GlnHis: 0.153 ± 0.023
1.948GlnIle: 1.948 ± 0.078
1.907GlnLys: 1.907 ± 0.088
1.372GlnLeu: 1.372 ± 0.065
0.423GlnMet: 0.423 ± 0.041
1.458GlnAsn: 1.458 ± 0.078
0.363GlnPro: 0.363 ± 0.033
0.34GlnGln: 0.34 ± 0.039
0.557GlnArg: 0.557 ± 0.05
0.826GlnSer: 0.826 ± 0.059
1.062GlnThr: 1.062 ± 0.067
1.118GlnVal: 1.118 ± 0.068
0.064GlnTrp: 0.064 ± 0.018
0.621GlnTyr: 0.621 ± 0.045
0.0GlnXaa: 0.0 ± 0.0
Arg
0.957ArgAla: 0.957 ± 0.064
0.396ArgCys: 0.396 ± 0.037
1.256ArgAsp: 1.256 ± 0.075
1.709ArgGlu: 1.709 ± 0.087
1.241ArgPhe: 1.241 ± 0.069
1.454ArgGly: 1.454 ± 0.084
0.337ArgHis: 0.337 ± 0.04
2.804ArgIle: 2.804 ± 0.117
3.343ArgLys: 3.343 ± 0.104
2.703ArgLeu: 2.703 ± 0.115
0.804ArgMet: 0.804 ± 0.055
2.127ArgAsn: 2.127 ± 0.091
0.804ArgPro: 0.804 ± 0.054
0.733ArgGln: 0.733 ± 0.053
1.159ArgArg: 1.159 ± 0.07
1.488ArgSer: 1.488 ± 0.07
1.469ArgThr: 1.469 ± 0.073
1.615ArgVal: 1.615 ± 0.086
0.116ArgTrp: 0.116 ± 0.02
1.443ArgTyr: 1.443 ± 0.084
0.0ArgXaa: 0.0 ± 0.0
Ser
1.944SerAla: 1.944 ± 0.087
0.957SerCys: 0.957 ± 0.071
2.995SerAsp: 2.995 ± 0.119
2.901SerGlu: 2.901 ± 0.105
3.358SerPhe: 3.358 ± 0.113
3.152SerGly: 3.152 ± 0.12
0.725SerHis: 0.725 ± 0.05
6.02SerIle: 6.02 ± 0.17
6.162SerLys: 6.162 ± 0.171
6.282SerLeu: 6.282 ± 0.166
1.305SerMet: 1.305 ± 0.059
5.107SerAsn: 5.107 ± 0.158
1.264SerPro: 1.264 ± 0.07
0.938SerGln: 0.938 ± 0.063
1.578SerArg: 1.578 ± 0.078
4.648SerSer: 4.648 ± 0.164
2.901SerThr: 2.901 ± 0.117
3.118SerVal: 3.118 ± 0.115
0.348SerTrp: 0.348 ± 0.036
3.907SerTyr: 3.907 ± 0.133
0.0SerXaa: 0.0 ± 0.0
Thr
1.959ThrAla: 1.959 ± 0.102
0.931ThrCys: 0.931 ± 0.077
2.677ThrAsp: 2.677 ± 0.101
2.651ThrGlu: 2.651 ± 0.099
2.565ThrPhe: 2.565 ± 0.107
3.316ThrGly: 3.316 ± 0.125
0.684ThrHis: 0.684 ± 0.055
5.317ThrIle: 5.317 ± 0.157
5.451ThrLys: 5.451 ± 0.141
5.549ThrLeu: 5.549 ± 0.156
0.924ThrMet: 0.924 ± 0.065
4.027ThrAsn: 4.027 ± 0.131
1.784ThrPro: 1.784 ± 0.08
0.879ThrGln: 0.879 ± 0.06
1.754ThrArg: 1.754 ± 0.083
4.352ThrSer: 4.352 ± 0.141
3.825ThrThr: 3.825 ± 0.162
2.909ThrVal: 2.909 ± 0.13
0.385ThrTrp: 0.385 ± 0.039
2.834ThrTyr: 2.834 ± 0.11
0.0ThrXaa: 0.0 ± 0.0
Val
2.341ValAla: 2.341 ± 0.105
0.823ValCys: 0.823 ± 0.054
3.358ValAsp: 3.358 ± 0.113
3.754ValGlu: 3.754 ± 0.138
2.584ValPhe: 2.584 ± 0.107
3.488ValGly: 3.488 ± 0.12
0.639ValHis: 0.639 ± 0.051
6.3ValIle: 6.3 ± 0.173
5.803ValLys: 5.803 ± 0.166
6.207ValLeu: 6.207 ± 0.15
1.17ValMet: 1.17 ± 0.064
4.453ValAsn: 4.453 ± 0.144
1.436ValPro: 1.436 ± 0.08
0.8ValGln: 0.8 ± 0.052
1.862ValArg: 1.862 ± 0.089
4.019ValSer: 4.019 ± 0.121
3.567ValThr: 3.567 ± 0.118
4.274ValVal: 4.274 ± 0.136
0.344ValTrp: 0.344 ± 0.041
2.655ValTyr: 2.655 ± 0.106
0.0ValXaa: 0.0 ± 0.0
Trp
0.228TrpAla: 0.228 ± 0.032
0.086TrpCys: 0.086 ± 0.018
0.303TrpAsp: 0.303 ± 0.035
0.194TrpGlu: 0.194 ± 0.03
0.232TrpPhe: 0.232 ± 0.033
0.292TrpGly: 0.292 ± 0.036
0.045TrpHis: 0.045 ± 0.015
0.505TrpIle: 0.505 ± 0.045
0.307TrpLys: 0.307 ± 0.035
0.509TrpLeu: 0.509 ± 0.051
0.112TrpMet: 0.112 ± 0.019
0.37TrpAsn: 0.37 ± 0.038
0.108TrpPro: 0.108 ± 0.02
0.101TrpGln: 0.101 ± 0.021
0.127TrpArg: 0.127 ± 0.025
0.284TrpSer: 0.284 ± 0.037
0.273TrpThr: 0.273 ± 0.031
0.303TrpVal: 0.303 ± 0.039
0.064TrpTrp: 0.064 ± 0.016
0.337TrpTyr: 0.337 ± 0.042
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.079TyrAla: 2.079 ± 0.099
0.538TyrCys: 0.538 ± 0.046
3.586TyrAsp: 3.586 ± 0.116
3.993TyrGlu: 3.993 ± 0.118
2.647TyrPhe: 2.647 ± 0.105
2.808TyrGly: 2.808 ± 0.126
0.572TyrHis: 0.572 ± 0.039
4.894TyrIle: 4.894 ± 0.137
5.302TyrLys: 5.302 ± 0.149
5.866TyrLeu: 5.866 ± 0.165
0.927TyrMet: 0.927 ± 0.054
4.666TyrAsn: 4.666 ± 0.154
1.268TyrPro: 1.268 ± 0.069
1.036TyrGln: 1.036 ± 0.064
1.421TyrArg: 1.421 ± 0.083
2.677TyrSer: 2.677 ± 0.101
2.658TyrThr: 2.658 ± 0.088
3.044TyrVal: 3.044 ± 0.112
0.165TyrTrp: 0.165 ± 0.027
2.984TyrTyr: 2.984 ± 0.135
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 943 proteins (267452 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski