Amino acid dipepetide frequency for Haliea sp. SAOS-164

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.45AlaAla: 15.45 ± 0.15	1.408AlaCys: 1.408 ± 0.032	6.693AlaAsp: 6.693 ± 0.075	7.239AlaGlu: 7.239 ± 0.087	3.605AlaPhe: 3.605 ± 0.052	10.383AlaGly: 10.383 ± 0.093	2.172AlaHis: 2.172 ± 0.037	5.025AlaIle: 5.025 ± 0.061	2.517AlaLys: 2.517 ± 0.052	13.513AlaLeu: 13.513 ± 0.143	3.049AlaMet: 3.049 ± 0.052	2.84AlaAsn: 2.84 ± 0.049	5.274AlaPro: 5.274 ± 0.086	5.193AlaGln: 5.193 ± 0.072	8.072AlaArg: 8.072 ± 0.096	6.319AlaSer: 6.319 ± 0.074	5.228AlaThr: 5.228 ± 0.066	8.067AlaVal: 8.067 ± 0.093	1.636AlaTrp: 1.636 ± 0.038	2.708AlaTyr: 2.708 ± 0.044	0.0AlaXaa: 0.0 ± 0.0
Cys	1.32CysAla: 1.32 ± 0.031	0.166CysCys: 0.166 ± 0.012	0.646CysAsp: 0.646 ± 0.02	0.66CysGlu: 0.66 ± 0.021	0.391CysPhe: 0.391 ± 0.015	1.087CysGly: 1.087 ± 0.03	0.395CysHis: 0.395 ± 0.039	0.48CysIle: 0.48 ± 0.018	0.235CysLys: 0.235 ± 0.013	1.197CysLeu: 1.197 ± 0.032	0.21CysMet: 0.21 ± 0.012	0.266CysAsn: 0.266 ± 0.015	0.575CysPro: 0.575 ± 0.021	0.328CysGln: 0.328 ± 0.016	0.778CysArg: 0.778 ± 0.025	0.705CysSer: 0.705 ± 0.022	0.566CysThr: 0.566 ± 0.022	0.715CysVal: 0.715 ± 0.021	0.141CysTrp: 0.141 ± 0.011	0.292CysTyr: 0.292 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	6.854AspAla: 6.854 ± 0.079	0.73AspCys: 0.73 ± 0.024	3.617AspAsp: 3.617 ± 0.065	3.842AspGlu: 3.842 ± 0.055	2.503AspPhe: 2.503 ± 0.049	4.922AspGly: 4.922 ± 0.073	1.213AspHis: 1.213 ± 0.03	3.264AspIle: 3.264 ± 0.05	1.715AspLys: 1.715 ± 0.037	5.953AspLeu: 5.953 ± 0.066	1.438AspMet: 1.438 ± 0.031	1.944AspAsn: 1.944 ± 0.04	3.511AspPro: 3.511 ± 0.054	1.759AspGln: 1.759 ± 0.04	3.263AspArg: 3.263 ± 0.045	3.345AspSer: 3.345 ± 0.053	3.194AspThr: 3.194 ± 0.045	3.907AspVal: 3.907 ± 0.061	1.146AspTrp: 1.146 ± 0.03	2.223AspTyr: 2.223 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	7.046GluAla: 7.046 ± 0.08	0.559GluCys: 0.559 ± 0.023	3.392GluAsp: 3.392 ± 0.051	4.128GluGlu: 4.128 ± 0.068	2.319GluPhe: 2.319 ± 0.045	4.24GluGly: 4.24 ± 0.062	1.658GluHis: 1.658 ± 0.036	3.289GluIle: 3.289 ± 0.044	2.056GluLys: 2.056 ± 0.049	7.237GluLeu: 7.237 ± 0.075	1.486GluMet: 1.486 ± 0.035	1.786GluAsn: 1.786 ± 0.033	2.794GluPro: 2.794 ± 0.049	3.305GluGln: 3.305 ± 0.064	5.108GluArg: 5.108 ± 0.064	3.156GluSer: 3.156 ± 0.046	2.936GluThr: 2.936 ± 0.048	4.683GluVal: 4.683 ± 0.064	0.733GluTrp: 0.733 ± 0.023	1.691GluTyr: 1.691 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	4.069PheAla: 4.069 ± 0.057	0.458PheCys: 0.458 ± 0.02	2.676PheAsp: 2.676 ± 0.045	2.235PheGlu: 2.235 ± 0.041	1.364PhePhe: 1.364 ± 0.035	3.358PheGly: 3.358 ± 0.052	0.793PheHis: 0.793 ± 0.021	1.724PheIle: 1.724 ± 0.038	0.813PheLys: 0.813 ± 0.023	3.339PheLeu: 3.339 ± 0.05	0.799PheMet: 0.799 ± 0.02	1.212PheAsn: 1.212 ± 0.027	1.579PhePro: 1.579 ± 0.032	1.078PheGln: 1.078 ± 0.023	2.09PheArg: 2.09 ± 0.037	2.439PheSer: 2.439 ± 0.043	2.07PheThr: 2.07 ± 0.04	2.419PheVal: 2.419 ± 0.051	0.482PheTrp: 0.482 ± 0.02	1.121PheTyr: 1.121 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	8.347GlyAla: 8.347 ± 0.079	0.987GlyCys: 0.987 ± 0.03	5.023GlyAsp: 5.023 ± 0.073	6.006GlyGlu: 6.006 ± 0.076	3.282GlyPhe: 3.282 ± 0.056	6.885GlyGly: 6.885 ± 0.09	1.748GlyHis: 1.748 ± 0.04	4.285GlyIle: 4.285 ± 0.061	2.807GlyLys: 2.807 ± 0.046	8.292GlyLeu: 8.292 ± 0.083	2.333GlyMet: 2.333 ± 0.046	2.409GlyAsn: 2.409 ± 0.045	2.872GlyPro: 2.872 ± 0.047	2.931GlyGln: 2.931 ± 0.051	5.346GlyArg: 5.346 ± 0.064	4.821GlySer: 4.821 ± 0.06	3.907GlyThr: 3.907 ± 0.064	6.214GlyVal: 6.214 ± 0.07	1.305GlyTrp: 1.305 ± 0.03	2.621GlyTyr: 2.621 ± 0.042	0.0GlyXaa: 0.0 ± 0.0
His	2.209HisAla: 2.209 ± 0.048	0.357HisCys: 0.357 ± 0.018	1.086HisAsp: 1.086 ± 0.028	1.092HisGlu: 1.092 ± 0.027	0.905HisPhe: 0.905 ± 0.026	1.933HisGly: 1.933 ± 0.04	0.604HisHis: 0.604 ± 0.024	1.017HisIle: 1.017 ± 0.026	0.539HisLys: 0.539 ± 0.021	2.322HisLeu: 2.322 ± 0.045	0.5HisMet: 0.5 ± 0.018	0.667HisAsn: 0.667 ± 0.023	1.416HisPro: 1.416 ± 0.035	0.725HisGln: 0.725 ± 0.023	1.638HisArg: 1.638 ± 0.042	1.334HisSer: 1.334 ± 0.033	1.021HisThr: 1.021 ± 0.031	1.232HisVal: 1.232 ± 0.028	0.431HisTrp: 0.431 ± 0.017	0.817HisTyr: 0.817 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	5.777IleAla: 5.777 ± 0.073	0.515IleCys: 0.515 ± 0.017	3.51IleAsp: 3.51 ± 0.052	3.273IleGlu: 3.273 ± 0.053	1.488IlePhe: 1.488 ± 0.036	3.878IleGly: 3.878 ± 0.056	1.0IleHis: 1.0 ± 0.031	1.893IleIle: 1.893 ± 0.041	1.203IleLys: 1.203 ± 0.031	3.88IleLeu: 3.88 ± 0.059	0.834IleMet: 0.834 ± 0.029	1.559IleAsn: 1.559 ± 0.037	2.342IlePro: 2.342 ± 0.039	1.282IleGln: 1.282 ± 0.03	2.642IleArg: 2.642 ± 0.043	2.733IleSer: 2.733 ± 0.049	2.56IleThr: 2.56 ± 0.044	3.18IleVal: 3.18 ± 0.052	0.471IleTrp: 0.471 ± 0.021	1.267IleTyr: 1.267 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	2.809LysAla: 2.809 ± 0.059	0.187LysCys: 0.187 ± 0.012	1.272LysAsp: 1.272 ± 0.034	1.303LysGlu: 1.303 ± 0.035	0.842LysPhe: 0.842 ± 0.028	1.831LysGly: 1.831 ± 0.038	0.569LysHis: 0.569 ± 0.021	1.3LysIle: 1.3 ± 0.035	1.022LysLys: 1.022 ± 0.043	3.043LysLeu: 3.043 ± 0.055	0.63LysMet: 0.63 ± 0.024	0.782LysAsn: 0.782 ± 0.025	1.524LysPro: 1.524 ± 0.038	1.145LysGln: 1.145 ± 0.027	1.888LysArg: 1.888 ± 0.038	1.53LysSer: 1.53 ± 0.037	1.399LysThr: 1.399 ± 0.034	2.062LysVal: 2.062 ± 0.041	0.291LysTrp: 0.291 ± 0.017	0.737LysTyr: 0.737 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	14.145LeuAla: 14.145 ± 0.138	1.274LeuCys: 1.274 ± 0.03	6.936LeuAsp: 6.936 ± 0.073	6.848LeuGlu: 6.848 ± 0.075	3.667LeuPhe: 3.667 ± 0.053	8.838LeuGly: 8.838 ± 0.095	2.391LeuHis: 2.391 ± 0.044	3.815LeuIle: 3.815 ± 0.055	2.756LeuLys: 2.756 ± 0.055	12.06LeuLeu: 12.06 ± 0.158	2.217LeuMet: 2.217 ± 0.046	2.709LeuAsn: 2.709 ± 0.045	5.845LeuPro: 5.845 ± 0.066	4.435LeuGln: 4.435 ± 0.064	7.919LeuArg: 7.919 ± 0.093	6.12LeuSer: 6.12 ± 0.072	4.681LeuThr: 4.681 ± 0.051	8.01LeuVal: 8.01 ± 0.099	1.413LeuTrp: 1.413 ± 0.037	2.616LeuTyr: 2.616 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	2.571MetAla: 2.571 ± 0.042	0.179MetCys: 0.179 ± 0.012	1.286MetAsp: 1.286 ± 0.029	1.242MetGlu: 1.242 ± 0.034	0.708MetPhe: 0.708 ± 0.021	1.804MetGly: 1.804 ± 0.036	0.541MetHis: 0.541 ± 0.019	1.022MetIle: 1.022 ± 0.03	0.737MetLys: 0.737 ± 0.021	2.575MetLeu: 2.575 ± 0.05	0.475MetMet: 0.475 ± 0.02	0.729MetAsn: 0.729 ± 0.024	1.335MetPro: 1.335 ± 0.035	1.048MetGln: 1.048 ± 0.028	1.648MetArg: 1.648 ± 0.037	1.624MetSer: 1.624 ± 0.036	1.314MetThr: 1.314 ± 0.026	1.521MetVal: 1.521 ± 0.033	0.207MetTrp: 0.207 ± 0.013	0.451MetTyr: 0.451 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.006AsnAla: 3.006 ± 0.05	0.37AsnCys: 0.37 ± 0.017	1.43AsnAsp: 1.43 ± 0.035	1.362AsnGlu: 1.362 ± 0.036	1.125AsnPhe: 1.125 ± 0.027	2.169AsnGly: 2.169 ± 0.044	0.604AsnHis: 0.604 ± 0.019	1.494AsnIle: 1.494 ± 0.033	0.719AsnLys: 0.719 ± 0.029	3.023AsnLeu: 3.023 ± 0.047	0.617AsnMet: 0.617 ± 0.021	0.889AsnAsn: 0.889 ± 0.029	1.985AsnPro: 1.985 ± 0.041	0.972AsnGln: 0.972 ± 0.028	1.926AsnArg: 1.926 ± 0.034	1.518AsnSer: 1.518 ± 0.032	1.569AsnThr: 1.569 ± 0.04	1.836AsnVal: 1.836 ± 0.039	0.469AsnTrp: 0.469 ± 0.016	0.914AsnTyr: 0.914 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	6.574ProAla: 6.574 ± 0.095	0.388ProCys: 0.388 ± 0.018	3.337ProAsp: 3.337 ± 0.046	3.996ProGlu: 3.996 ± 0.055	1.677ProPhe: 1.677 ± 0.035	4.998ProGly: 4.998 ± 0.067	0.978ProHis: 0.978 ± 0.028	1.73ProIle: 1.73 ± 0.033	1.013ProLys: 1.013 ± 0.03	5.268ProLeu: 5.268 ± 0.064	1.07ProMet: 1.07 ± 0.028	1.211ProAsn: 1.211 ± 0.03	2.544ProPro: 2.544 ± 0.059	2.028ProGln: 2.028 ± 0.036	3.027ProArg: 3.027 ± 0.05	2.253ProSer: 2.253 ± 0.038	2.173ProThr: 2.173 ± 0.037	4.085ProVal: 4.085 ± 0.06	0.788ProTrp: 0.788 ± 0.021	1.181ProTyr: 1.181 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	4.874GlnAla: 4.874 ± 0.074	0.395GlnCys: 0.395 ± 0.019	1.898GlnAsp: 1.898 ± 0.038	1.907GlnGlu: 1.907 ± 0.044	1.353GlnPhe: 1.353 ± 0.036	2.695GlnGly: 2.695 ± 0.045	0.889GlnHis: 0.889 ± 0.025	1.546GlnIle: 1.546 ± 0.033	0.907GlnLys: 0.907 ± 0.027	4.762GlnLeu: 4.762 ± 0.066	0.932GlnMet: 0.932 ± 0.026	0.775GlnAsn: 0.775 ± 0.028	2.124GlnPro: 2.124 ± 0.043	1.978GlnGln: 1.978 ± 0.048	3.581GlnArg: 3.581 ± 0.061	1.93GlnSer: 1.93 ± 0.038	1.494GlnThr: 1.494 ± 0.031	3.223GlnVal: 3.223 ± 0.047	0.666GlnTrp: 0.666 ± 0.022	0.943GlnTyr: 0.943 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	7.209ArgAla: 7.209 ± 0.084	0.748ArgCys: 0.748 ± 0.021	4.375ArgAsp: 4.375 ± 0.057	5.681ArgGlu: 5.681 ± 0.064	2.772ArgPhe: 2.772 ± 0.046	5.011ArgGly: 5.011 ± 0.055	1.641ArgHis: 1.641 ± 0.036	3.281ArgIle: 3.281 ± 0.048	1.972ArgLys: 1.972 ± 0.043	7.495ArgLeu: 7.495 ± 0.09	1.631ArgMet: 1.631 ± 0.028	1.983ArgAsn: 1.983 ± 0.038	2.931ArgPro: 2.931 ± 0.053	2.919ArgGln: 2.919 ± 0.048	5.186ArgArg: 5.186 ± 0.069	3.561ArgSer: 3.561 ± 0.053	2.69ArgThr: 2.69 ± 0.04	4.813ArgVal: 4.813 ± 0.059	1.157ArgTrp: 1.157 ± 0.032	2.194ArgTyr: 2.194 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	6.525SerAla: 6.525 ± 0.069	0.543SerCys: 0.543 ± 0.019	3.202SerAsp: 3.202 ± 0.045	3.228SerGlu: 3.228 ± 0.047	2.072SerPhe: 2.072 ± 0.044	5.462SerGly: 5.462 ± 0.061	1.203SerHis: 1.203 ± 0.028	2.681SerIle: 2.681 ± 0.044	1.371SerLys: 1.371 ± 0.033	6.167SerLeu: 6.167 ± 0.072	1.325SerMet: 1.325 ± 0.03	1.566SerAsn: 1.566 ± 0.034	2.843SerPro: 2.843 ± 0.048	1.84SerGln: 1.84 ± 0.034	3.757SerArg: 3.757 ± 0.046	3.23SerSer: 3.23 ± 0.054	2.66SerThr: 2.66 ± 0.047	4.118SerVal: 4.118 ± 0.057	0.748SerTrp: 0.748 ± 0.024	1.534SerTyr: 1.534 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	5.378ThrAla: 5.378 ± 0.073	0.536ThrCys: 0.536 ± 0.023	2.704ThrAsp: 2.704 ± 0.05	2.535ThrGlu: 2.535 ± 0.044	1.615ThrPhe: 1.615 ± 0.035	4.694ThrGly: 4.694 ± 0.058	0.969ThrHis: 0.969 ± 0.028	2.065ThrIle: 2.065 ± 0.038	0.884ThrLys: 0.884 ± 0.03	5.886ThrLeu: 5.886 ± 0.063	0.917ThrMet: 0.917 ± 0.028	1.173ThrAsn: 1.173 ± 0.036	3.132ThrPro: 3.132 ± 0.047	1.592ThrGln: 1.592 ± 0.031	3.269ThrArg: 3.269 ± 0.049	2.576ThrSer: 2.576 ± 0.047	2.56ThrThr: 2.56 ± 0.048	3.561ThrVal: 3.561 ± 0.058	0.73ThrTrp: 0.73 ± 0.025	1.289ThrTyr: 1.289 ± 0.029	0.0ThrXaa: 0.0 ± 0.0
Val	8.339ValAla: 8.339 ± 0.098	0.794ValCys: 0.794 ± 0.027	4.806ValAsp: 4.806 ± 0.075	4.817ValGlu: 4.817 ± 0.063	2.769ValPhe: 2.769 ± 0.047	5.162ValGly: 5.162 ± 0.071	1.48ValHis: 1.48 ± 0.036	3.646ValIle: 3.646 ± 0.055	1.865ValLys: 1.865 ± 0.039	7.536ValLeu: 7.536 ± 0.076	1.625ValMet: 1.625 ± 0.031	2.236ValAsn: 2.236 ± 0.046	3.581ValPro: 3.581 ± 0.053	2.351ValGln: 2.351 ± 0.041	4.402ValArg: 4.402 ± 0.059	4.278ValSer: 4.278 ± 0.063	3.907ValThr: 3.907 ± 0.055	5.798ValVal: 5.798 ± 0.076	0.831ValTrp: 0.831 ± 0.027	1.934ValTyr: 1.934 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	1.108TrpAla: 1.108 ± 0.025	0.179TrpCys: 0.179 ± 0.013	0.801TrpAsp: 0.801 ± 0.027	0.757TrpGlu: 0.757 ± 0.023	0.514TrpPhe: 0.514 ± 0.02	0.928TrpGly: 0.928 ± 0.028	0.363TrpHis: 0.363 ± 0.017	0.575TrpIle: 0.575 ± 0.02	0.375TrpLys: 0.375 ± 0.017	1.959TrpLeu: 1.959 ± 0.045	0.368TrpMet: 0.368 ± 0.014	0.473TrpAsn: 0.473 ± 0.019	0.658TrpPro: 0.658 ± 0.021	0.828TrpGln: 0.828 ± 0.023	1.249TrpArg: 1.249 ± 0.031	0.907TrpSer: 0.907 ± 0.026	0.65TrpThr: 0.65 ± 0.022	0.993TrpVal: 0.993 ± 0.029	0.222TrpTrp: 0.222 ± 0.013	0.425TrpTyr: 0.425 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.783TyrAla: 2.783 ± 0.047	0.378TyrCys: 0.378 ± 0.017	1.652TyrAsp: 1.652 ± 0.038	1.451TyrGlu: 1.451 ± 0.037	1.146TyrPhe: 1.146 ± 0.03	2.146TyrGly: 2.146 ± 0.041	0.637TyrHis: 0.637 ± 0.023	1.156TyrIle: 1.156 ± 0.03	0.658TyrLys: 0.658 ± 0.024	3.19TyrLeu: 3.19 ± 0.049	0.558TyrMet: 0.558 ± 0.016	0.788TyrAsn: 0.788 ± 0.026	1.452TyrPro: 1.452 ± 0.031	1.134TyrGln: 1.134 ± 0.027	2.461TyrArg: 2.461 ± 0.043	1.695TyrSer: 1.695 ± 0.033	1.487TyrThr: 1.487 ± 0.039	1.718TyrVal: 1.718 ± 0.037	0.467TyrTrp: 0.467 ± 0.019	0.934TyrTyr: 0.934 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4187 proteins (1444718 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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