Amino acid dipepetide frequency for Streptomyces spongiicola

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
22.442AlaAla: 22.442 ± 0.215
1.082AlaCys: 1.082 ± 0.027
8.179AlaAsp: 8.179 ± 0.091
9.268AlaGlu: 9.268 ± 0.112
3.476AlaPhe: 3.476 ± 0.052
14.341AlaGly: 14.341 ± 0.112
2.793AlaHis: 2.793 ± 0.04
3.175AlaIle: 3.175 ± 0.047
2.434AlaLys: 2.434 ± 0.053
14.264AlaLeu: 14.264 ± 0.112
2.457AlaMet: 2.457 ± 0.04
1.834AlaAsn: 1.834 ± 0.036
7.637AlaPro: 7.637 ± 0.107
3.454AlaGln: 3.454 ± 0.061
11.263AlaArg: 11.263 ± 0.105
5.918AlaSer: 5.918 ± 0.067
6.469AlaThr: 6.469 ± 0.065
12.923AlaVal: 12.923 ± 0.091
1.8AlaTrp: 1.8 ± 0.032
2.658AlaTyr: 2.658 ± 0.037
0.0AlaXaa: 0.0 ± 0.0
Cys
1.156CysAla: 1.156 ± 0.029
0.102CysCys: 0.102 ± 0.009
0.504CysAsp: 0.504 ± 0.016
0.423CysGlu: 0.423 ± 0.015
0.225CysPhe: 0.225 ± 0.011
1.013CysGly: 1.013 ± 0.029
0.193CysHis: 0.193 ± 0.01
0.173CysIle: 0.173 ± 0.009
0.105CysLys: 0.105 ± 0.008
0.755CysLeu: 0.755 ± 0.02
0.127CysMet: 0.127 ± 0.008
0.135CysAsn: 0.135 ± 0.007
0.547CysPro: 0.547 ± 0.021
0.144CysGln: 0.144 ± 0.008
0.719CysArg: 0.719 ± 0.019
0.428CysSer: 0.428 ± 0.017
0.519CysThr: 0.519 ± 0.018
0.658CysVal: 0.658 ± 0.021
0.123CysTrp: 0.123 ± 0.009
0.141CysTyr: 0.141 ± 0.01
0.0CysXaa: 0.0 ± 0.0
Asp
7.546AspAla: 7.546 ± 0.065
0.446AspCys: 0.446 ± 0.019
3.401AspAsp: 3.401 ± 0.05
3.908AspGlu: 3.908 ± 0.05
1.627AspPhe: 1.627 ± 0.03
6.683AspGly: 6.683 ± 0.084
1.375AspHis: 1.375 ± 0.029
1.78AspIle: 1.78 ± 0.032
0.983AspLys: 0.983 ± 0.031
5.938AspLeu: 5.938 ± 0.069
0.798AspMet: 0.798 ± 0.02
0.856AspAsn: 0.856 ± 0.021
4.522AspPro: 4.522 ± 0.059
1.372AspGln: 1.372 ± 0.029
5.468AspArg: 5.468 ± 0.063
2.508AspSer: 2.508 ± 0.043
3.057AspThr: 3.057 ± 0.047
4.563AspVal: 4.563 ± 0.052
0.959AspTrp: 0.959 ± 0.023
1.043AspTyr: 1.043 ± 0.029
0.0AspXaa: 0.0 ± 0.0
Glu
7.838GluAla: 7.838 ± 0.094
0.426GluCys: 0.426 ± 0.016
2.956GluAsp: 2.956 ± 0.045
3.809GluGlu: 3.809 ± 0.062
1.426GluPhe: 1.426 ± 0.03
4.689GluGly: 4.689 ± 0.056
1.528GluHis: 1.528 ± 0.03
2.262GluIle: 2.262 ± 0.039
1.431GluLys: 1.431 ± 0.031
6.825GluLeu: 6.825 ± 0.07
0.931GluMet: 0.931 ± 0.023
0.996GluAsn: 0.996 ± 0.026
3.637GluPro: 3.637 ± 0.047
2.274GluGln: 2.274 ± 0.041
5.892GluArg: 5.892 ± 0.068
2.735GluSer: 2.735 ± 0.042
2.889GluThr: 2.889 ± 0.047
4.611GluVal: 4.611 ± 0.058
0.787GluTrp: 0.787 ± 0.021
1.116GluTyr: 1.116 ± 0.025
0.0GluXaa: 0.0 ± 0.0
Phe
3.686PheAla: 3.686 ± 0.042
0.276PheCys: 0.276 ± 0.013
1.885PheAsp: 1.885 ± 0.034
1.482PheGlu: 1.482 ± 0.032
0.816PhePhe: 0.816 ± 0.025
2.96PheGly: 2.96 ± 0.045
0.601PheHis: 0.601 ± 0.019
0.662PheIle: 0.662 ± 0.021
0.451PheLys: 0.451 ± 0.017
2.501PheLeu: 2.501 ± 0.044
0.383PheMet: 0.383 ± 0.015
0.499PheAsn: 0.499 ± 0.02
1.383PhePro: 1.383 ± 0.029
0.586PheGln: 0.586 ± 0.019
1.919PheArg: 1.919 ± 0.037
1.427PheSer: 1.427 ± 0.031
1.966PheThr: 1.966 ± 0.035
2.142PheVal: 2.142 ± 0.038
0.385PheTrp: 0.385 ± 0.016
0.515PheTyr: 0.515 ± 0.016
0.0PheXaa: 0.0 ± 0.0
Gly
11.903GlyAla: 11.903 ± 0.122
0.908GlyCys: 0.908 ± 0.027
5.545GlyAsp: 5.545 ± 0.058
5.691GlyGlu: 5.691 ± 0.061
2.9GlyPhe: 2.9 ± 0.044
10.019GlyGly: 10.019 ± 0.112
2.416GlyHis: 2.416 ± 0.041
3.309GlyIle: 3.309 ± 0.049
2.17GlyLys: 2.17 ± 0.043
9.547GlyLeu: 9.547 ± 0.086
2.046GlyMet: 2.046 ± 0.036
1.705GlyAsn: 1.705 ± 0.044
5.984GlyPro: 5.984 ± 0.083
2.543GlyGln: 2.543 ± 0.042
9.136GlyArg: 9.136 ± 0.082
5.652GlySer: 5.652 ± 0.065
6.678GlyThr: 6.678 ± 0.073
7.592GlyVal: 7.592 ± 0.081
1.676GlyTrp: 1.676 ± 0.033
2.215GlyTyr: 2.215 ± 0.042
0.0GlyXaa: 0.0 ± 0.0
His
2.666HisAla: 2.666 ± 0.044
0.209HisCys: 0.209 ± 0.01
1.344HisAsp: 1.344 ± 0.028
1.232HisGlu: 1.232 ± 0.028
0.614HisPhe: 0.614 ± 0.02
2.563HisGly: 2.563 ± 0.04
0.682HisHis: 0.682 ± 0.021
0.669HisIle: 0.669 ± 0.019
0.309HisLys: 0.309 ± 0.014
2.298HisLeu: 2.298 ± 0.037
0.332HisMet: 0.332 ± 0.015
0.354HisAsn: 0.354 ± 0.016
1.868HisPro: 1.868 ± 0.035
0.609HisGln: 0.609 ± 0.021
2.281HisArg: 2.281 ± 0.037
1.007HisSer: 1.007 ± 0.026
1.36HisThr: 1.36 ± 0.031
1.672HisVal: 1.672 ± 0.03
0.356HisTrp: 0.356 ± 0.015
0.449HisTyr: 0.449 ± 0.016
0.0HisXaa: 0.0 ± 0.0
Ile
4.565IleAla: 4.565 ± 0.058
0.285IleCys: 0.285 ± 0.013
2.003IleAsp: 2.003 ± 0.034
1.881IleGlu: 1.881 ± 0.036
0.605IlePhe: 0.605 ± 0.02
3.368IleGly: 3.368 ± 0.057
0.582IleHis: 0.582 ± 0.019
0.724IleIle: 0.724 ± 0.022
0.644IleLys: 0.644 ± 0.022
2.219IleLeu: 2.219 ± 0.042
0.433IleMet: 0.433 ± 0.015
0.605IleAsn: 0.605 ± 0.017
1.693IlePro: 1.693 ± 0.028
0.617IleGln: 0.617 ± 0.02
2.356IleArg: 2.356 ± 0.036
1.526IleSer: 1.526 ± 0.03
2.064IleThr: 2.064 ± 0.034
2.597IleVal: 2.597 ± 0.041
0.303IleTrp: 0.303 ± 0.012
0.435IleTyr: 0.435 ± 0.016
0.0IleXaa: 0.0 ± 0.0
Lys
2.626LysAla: 2.626 ± 0.05
0.106LysCys: 0.106 ± 0.008
1.141LysAsp: 1.141 ± 0.031
1.073LysGlu: 1.073 ± 0.026
0.396LysPhe: 0.396 ± 0.016
1.676LysGly: 1.676 ± 0.038
0.402LysHis: 0.402 ± 0.017
0.769LysIle: 0.769 ± 0.024
0.676LysLys: 0.676 ± 0.032
1.817LysLeu: 1.817 ± 0.037
0.329LysMet: 0.329 ± 0.015
0.44LysAsn: 0.44 ± 0.019
1.221LysPro: 1.221 ± 0.029
0.624LysGln: 0.624 ± 0.022
1.437LysArg: 1.437 ± 0.031
1.032LysSer: 1.032 ± 0.025
1.127LysThr: 1.127 ± 0.033
1.585LysVal: 1.585 ± 0.032
0.224LysTrp: 0.224 ± 0.012
0.397LysTyr: 0.397 ± 0.015
0.0LysXaa: 0.0 ± 0.0
Leu
14.779LeuAla: 14.779 ± 0.115
0.824LeuCys: 0.824 ± 0.02
6.517LeuAsp: 6.517 ± 0.062
4.903LeuGlu: 4.903 ± 0.059
2.525LeuPhe: 2.525 ± 0.047
9.346LeuGly: 9.346 ± 0.095
2.352LeuHis: 2.352 ± 0.038
2.856LeuIle: 2.856 ± 0.048
1.762LeuLys: 1.762 ± 0.037
11.186LeuLeu: 11.186 ± 0.112
1.604LeuMet: 1.604 ± 0.031
1.539LeuAsn: 1.539 ± 0.034
6.486LeuPro: 6.486 ± 0.064
2.01LeuGln: 2.01 ± 0.039
9.051LeuArg: 9.051 ± 0.087
5.235LeuSer: 5.235 ± 0.057
6.289LeuThr: 6.289 ± 0.063
8.858LeuVal: 8.858 ± 0.092
1.253LeuTrp: 1.253 ± 0.024
1.77LeuTyr: 1.77 ± 0.036
0.0LeuXaa: 0.0 ± 0.0
Met
2.248MetAla: 2.248 ± 0.037
0.141MetCys: 0.141 ± 0.009
0.88MetAsp: 0.88 ± 0.02
0.77MetGlu: 0.77 ± 0.019
0.442MetPhe: 0.442 ± 0.019
1.298MetGly: 1.298 ± 0.028
0.35MetHis: 0.35 ± 0.017
0.626MetIle: 0.626 ± 0.021
0.407MetLys: 0.407 ± 0.015
1.695MetLeu: 1.695 ± 0.034
0.275MetMet: 0.275 ± 0.013
0.424MetAsn: 0.424 ± 0.014
1.156MetPro: 1.156 ± 0.025
0.406MetGln: 0.406 ± 0.014
1.488MetArg: 1.488 ± 0.031
1.305MetSer: 1.305 ± 0.027
1.481MetThr: 1.481 ± 0.031
1.285MetVal: 1.285 ± 0.024
0.199MetTrp: 0.199 ± 0.01
0.313MetTyr: 0.313 ± 0.015
0.0MetXaa: 0.0 ± 0.0
Asn
2.104AsnAla: 2.104 ± 0.041
0.153AsnCys: 0.153 ± 0.009
0.893AsnAsp: 0.893 ± 0.022
0.793AsnGlu: 0.793 ± 0.024
0.435AsnPhe: 0.435 ± 0.016
1.78AsnGly: 1.78 ± 0.038
0.36AsnHis: 0.36 ± 0.014
0.566AsnIle: 0.566 ± 0.02
0.355AsnLys: 0.355 ± 0.015
1.53AsnLeu: 1.53 ± 0.03
0.293AsnMet: 0.293 ± 0.013
0.358AsnAsn: 0.358 ± 0.018
1.277AsnPro: 1.277 ± 0.027
0.465AsnGln: 0.465 ± 0.015
1.309AsnArg: 1.309 ± 0.03
0.824AsnSer: 0.824 ± 0.022
0.998AsnThr: 0.998 ± 0.03
1.289AsnVal: 1.289 ± 0.029
0.253AsnTrp: 0.253 ± 0.012
0.342AsnTyr: 0.342 ± 0.015
0.0AsnXaa: 0.0 ± 0.0
Pro
9.333ProAla: 9.333 ± 0.12
0.371ProCys: 0.371 ± 0.016
4.527ProAsp: 4.527 ± 0.061
4.551ProGlu: 4.551 ± 0.055
1.521ProPhe: 1.521 ± 0.029
7.719ProGly: 7.719 ± 0.087
1.406ProHis: 1.406 ± 0.03
1.159ProIle: 1.159 ± 0.023
1.03ProLys: 1.03 ± 0.029
5.311ProLeu: 5.311 ± 0.063
0.985ProMet: 0.985 ± 0.025
0.842ProAsn: 0.842 ± 0.025
4.053ProPro: 4.053 ± 0.074
1.652ProGln: 1.652 ± 0.039
4.543ProArg: 4.543 ± 0.058
3.341ProSer: 3.341 ± 0.056
2.83ProThr: 2.83 ± 0.054
5.819ProVal: 5.819 ± 0.064
0.876ProTrp: 0.876 ± 0.022
1.363ProTyr: 1.363 ± 0.025
0.0ProXaa: 0.0 ± 0.0
Gln
3.502GlnAla: 3.502 ± 0.053
0.165GlnCys: 0.165 ± 0.01
1.318GlnAsp: 1.318 ± 0.03
1.355GlnGlu: 1.355 ± 0.034
0.619GlnPhe: 0.619 ± 0.021
2.259GlnGly: 2.259 ± 0.076
0.624GlnHis: 0.624 ± 0.02
0.997GlnIle: 0.997 ± 0.026
0.553GlnLys: 0.553 ± 0.02
2.801GlnLeu: 2.801 ± 0.048
0.441GlnMet: 0.441 ± 0.015
0.451GlnAsn: 0.451 ± 0.013
1.582GlnPro: 1.582 ± 0.038
1.119GlnGln: 1.119 ± 0.034
2.325GlnArg: 2.325 ± 0.036
1.187GlnSer: 1.187 ± 0.03
1.249GlnThr: 1.249 ± 0.027
2.165GlnVal: 2.165 ± 0.035
0.408GlnTrp: 0.408 ± 0.015
0.529GlnTyr: 0.529 ± 0.02
0.0GlnXaa: 0.0 ± 0.0
Arg
10.659ArgAla: 10.659 ± 0.109
0.705ArgCys: 0.705 ± 0.022
4.707ArgAsp: 4.707 ± 0.051
5.302ArgGlu: 5.302 ± 0.065
2.429ArgPhe: 2.429 ± 0.038
6.757ArgGly: 6.757 ± 0.063
2.3ArgHis: 2.3 ± 0.036
3.373ArgIle: 3.373 ± 0.044
1.683ArgLys: 1.683 ± 0.031
9.409ArgLeu: 9.409 ± 0.081
1.878ArgMet: 1.878 ± 0.031
1.451ArgAsn: 1.451 ± 0.028
5.555ArgPro: 5.555 ± 0.07
2.367ArgGln: 2.367 ± 0.043
8.803ArgArg: 8.803 ± 0.094
4.46ArgSer: 4.46 ± 0.059
5.757ArgThr: 5.757 ± 0.063
6.292ArgVal: 6.292 ± 0.065
1.469ArgTrp: 1.469 ± 0.028
1.88ArgTyr: 1.88 ± 0.031
0.0ArgXaa: 0.0 ± 0.0
Ser
6.94SerAla: 6.94 ± 0.069
0.444SerCys: 0.444 ± 0.017
2.594SerAsp: 2.594 ± 0.044
2.538SerGlu: 2.538 ± 0.045
1.502SerPhe: 1.502 ± 0.031
6.272SerGly: 6.272 ± 0.064
1.005SerHis: 1.005 ± 0.027
1.31SerIle: 1.31 ± 0.034
0.906SerLys: 0.906 ± 0.022
4.641SerLeu: 4.641 ± 0.061
1.023SerMet: 1.023 ± 0.026
0.756SerAsn: 0.756 ± 0.019
3.236SerPro: 3.236 ± 0.051
1.195SerGln: 1.195 ± 0.024
4.088SerArg: 4.088 ± 0.049
2.746SerSer: 2.746 ± 0.052
2.836SerThr: 2.836 ± 0.045
4.301SerVal: 4.301 ± 0.052
0.864SerTrp: 0.864 ± 0.02
1.103SerTyr: 1.103 ± 0.027
0.0SerXaa: 0.0 ± 0.0
Thr
8.975ThrAla: 8.975 ± 0.075
0.393ThrCys: 0.393 ± 0.017
3.367ThrAsp: 3.367 ± 0.058
3.176ThrGlu: 3.176 ± 0.047
1.445ThrPhe: 1.445 ± 0.034
7.054ThrGly: 7.054 ± 0.07
1.09ThrHis: 1.09 ± 0.023
1.536ThrIle: 1.536 ± 0.03
0.927ThrLys: 0.927 ± 0.026
5.188ThrLeu: 5.188 ± 0.06
0.904ThrMet: 0.904 ± 0.022
0.864ThrAsn: 0.864 ± 0.026
3.907ThrPro: 3.907 ± 0.059
1.157ThrGln: 1.157 ± 0.028
4.16ThrArg: 4.16 ± 0.055
2.889ThrSer: 2.889 ± 0.043
3.553ThrThr: 3.553 ± 0.071
5.765ThrVal: 5.765 ± 0.058
0.783ThrTrp: 0.783 ± 0.021
1.211ThrTyr: 1.211 ± 0.034
0.0ThrXaa: 0.0 ± 0.0
Val
10.658ValAla: 10.658 ± 0.087
0.821ValCys: 0.821 ± 0.023
4.925ValAsp: 4.925 ± 0.054
4.9ValGlu: 4.9 ± 0.062
2.41ValPhe: 2.41 ± 0.039
6.549ValGly: 6.549 ± 0.072
2.072ValHis: 2.072 ± 0.04
2.58ValIle: 2.58 ± 0.041
1.595ValLys: 1.595 ± 0.035
9.522ValLeu: 9.522 ± 0.09
1.451ValMet: 1.451 ± 0.033
1.591ValAsn: 1.591 ± 0.034
5.647ValPro: 5.647 ± 0.063
1.954ValGln: 1.954 ± 0.034
7.723ValArg: 7.723 ± 0.076
4.341ValSer: 4.341 ± 0.054
5.172ValThr: 5.172 ± 0.054
8.045ValVal: 8.045 ± 0.082
1.147ValTrp: 1.147 ± 0.026
1.556ValTyr: 1.556 ± 0.032
0.0ValXaa: 0.0 ± 0.0
Trp
1.596TrpAla: 1.596 ± 0.031
0.164TrpCys: 0.164 ± 0.01
0.776TrpAsp: 0.776 ± 0.022
0.729TrpGlu: 0.729 ± 0.021
0.51TrpPhe: 0.51 ± 0.018
1.008TrpGly: 1.008 ± 0.026
0.361TrpHis: 0.361 ± 0.014
0.54TrpIle: 0.54 ± 0.018
0.345TrpLys: 0.345 ± 0.016
1.719TrpLeu: 1.719 ± 0.039
0.278TrpMet: 0.278 ± 0.012
0.348TrpAsn: 0.348 ± 0.015
0.775TrpPro: 0.775 ± 0.021
0.553TrpGln: 0.553 ± 0.016
1.345TrpArg: 1.345 ± 0.03
0.874TrpSer: 0.874 ± 0.024
0.974TrpThr: 0.974 ± 0.024
0.918TrpVal: 0.918 ± 0.021
0.329TrpTrp: 0.329 ± 0.013
0.352TrpTyr: 0.352 ± 0.014
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.644TyrAla: 2.644 ± 0.043
0.173TyrCys: 0.173 ± 0.009
1.372TyrAsp: 1.372 ± 0.03
1.275TyrGlu: 1.275 ± 0.027
0.601TyrPhe: 0.601 ± 0.017
2.28TyrGly: 2.28 ± 0.042
0.385TyrHis: 0.385 ± 0.012
0.437TyrIle: 0.437 ± 0.014
0.333TyrLys: 0.333 ± 0.014
1.977TyrLeu: 1.977 ± 0.033
0.221TyrMet: 0.221 ± 0.012
0.328TyrAsn: 0.328 ± 0.014
1.069TyrPro: 1.069 ± 0.026
0.546TyrGln: 0.546 ± 0.018
1.928TyrArg: 1.928 ± 0.033
0.866TyrSer: 0.866 ± 0.02
1.074TyrThr: 1.074 ± 0.027
1.576TyrVal: 1.576 ± 0.029
0.301TyrTrp: 0.301 ± 0.012
0.41TyrTyr: 0.41 ± 0.016
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5628 proteins (1840555 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski