Amino acid dipepetide frequency for Desulfohalobium retbaense (strain ATCC 49708 / DSM 5692 / JCM 16813 / HR100)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.096AlaAla: 10.096 ± 0.174	1.42AlaCys: 1.42 ± 0.047	4.369AlaAsp: 4.369 ± 0.079	6.215AlaGlu: 6.215 ± 0.112	3.377AlaPhe: 3.377 ± 0.067	7.715AlaGly: 7.715 ± 0.125	2.063AlaHis: 2.063 ± 0.051	4.303AlaIle: 4.303 ± 0.081	3.708AlaLys: 3.708 ± 0.074	11.43AlaLeu: 11.43 ± 0.141	2.384AlaMet: 2.384 ± 0.056	2.573AlaAsn: 2.573 ± 0.066	4.272AlaPro: 4.272 ± 0.074	4.464AlaGln: 4.464 ± 0.086	6.132AlaArg: 6.132 ± 0.115	5.05AlaSer: 5.05 ± 0.089	4.635AlaThr: 4.635 ± 0.078	7.39AlaVal: 7.39 ± 0.114	1.328AlaTrp: 1.328 ± 0.045	2.34AlaTyr: 2.34 ± 0.056	0.0AlaXaa: 0.0 ± 0.0
Cys	1.215CysAla: 1.215 ± 0.034	0.257CysCys: 0.257 ± 0.021	0.542CysAsp: 0.542 ± 0.029	0.621CysGlu: 0.621 ± 0.026	0.499CysPhe: 0.499 ± 0.024	1.355CysGly: 1.355 ± 0.047	0.495CysHis: 0.495 ± 0.039	0.695CysIle: 0.695 ± 0.029	0.378CysLys: 0.378 ± 0.024	1.543CysLeu: 1.543 ± 0.051	0.26CysMet: 0.26 ± 0.017	0.366CysAsn: 0.366 ± 0.023	1.009CysPro: 1.009 ± 0.043	0.596CysGln: 0.596 ± 0.031	1.027CysArg: 1.027 ± 0.05	0.86CysSer: 0.86 ± 0.033	0.703CysThr: 0.703 ± 0.036	0.911CysVal: 0.911 ± 0.035	0.167CysTrp: 0.167 ± 0.014	0.286CysTyr: 0.286 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	4.279AspAla: 4.279 ± 0.071	0.666AspCys: 0.666 ± 0.03	2.241AspAsp: 2.241 ± 0.052	3.095AspGlu: 3.095 ± 0.079	2.371AspPhe: 2.371 ± 0.051	3.645AspGly: 3.645 ± 0.079	1.251AspHis: 1.251 ± 0.039	3.383AspIle: 3.383 ± 0.065	2.318AspLys: 2.318 ± 0.062	6.122AspLeu: 6.122 ± 0.101	1.363AspMet: 1.363 ± 0.038	1.554AspAsn: 1.554 ± 0.043	3.212AspPro: 3.212 ± 0.064	2.19AspGln: 2.19 ± 0.056	3.351AspArg: 3.351 ± 0.066	2.711AspSer: 2.711 ± 0.061	2.781AspThr: 2.781 ± 0.058	3.437AspVal: 3.437 ± 0.069	0.815AspTrp: 0.815 ± 0.033	1.496AspTyr: 1.496 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	6.885GluAla: 6.885 ± 0.116	0.651GluCys: 0.651 ± 0.03	3.554GluAsp: 3.554 ± 0.077	4.846GluGlu: 4.846 ± 0.103	2.012GluPhe: 2.012 ± 0.045	4.144GluGly: 4.144 ± 0.077	1.778GluHis: 1.778 ± 0.048	3.845GluIle: 3.845 ± 0.091	3.267GluLys: 3.267 ± 0.078	6.664GluLeu: 6.664 ± 0.098	1.84GluMet: 1.84 ± 0.053	2.212GluAsn: 2.212 ± 0.066	2.586GluPro: 2.586 ± 0.067	3.483GluGln: 3.483 ± 0.081	4.43GluArg: 4.43 ± 0.08	3.175GluSer: 3.175 ± 0.076	3.784GluThr: 3.784 ± 0.069	4.717GluVal: 4.717 ± 0.086	0.716GluTrp: 0.716 ± 0.03	1.713GluTyr: 1.713 ± 0.045	0.0GluXaa: 0.0 ± 0.0
Phe	3.638PheAla: 3.638 ± 0.077	0.632PheCys: 0.632 ± 0.026	2.209PheAsp: 2.209 ± 0.054	2.309PheGlu: 2.309 ± 0.055	2.047PhePhe: 2.047 ± 0.069	3.142PheGly: 3.142 ± 0.075	0.828PheHis: 0.828 ± 0.033	1.712PheIle: 1.712 ± 0.055	1.283PheLys: 1.283 ± 0.043	4.345PheLeu: 4.345 ± 0.1	0.829PheMet: 0.829 ± 0.034	1.119PheAsn: 1.119 ± 0.035	1.93PhePro: 1.93 ± 0.052	1.595PheGln: 1.595 ± 0.042	2.119PheArg: 2.119 ± 0.057	2.51PheSer: 2.51 ± 0.064	2.079PheThr: 2.079 ± 0.057	2.887PheVal: 2.887 ± 0.056	0.739PheTrp: 0.739 ± 0.036	1.112PheTyr: 1.112 ± 0.035	0.0PheXaa: 0.0 ± 0.0
Gly	6.474GlyAla: 6.474 ± 0.121	1.248GlyCys: 1.248 ± 0.04	3.584GlyAsp: 3.584 ± 0.079	4.634GlyGlu: 4.634 ± 0.077	3.284GlyPhe: 3.284 ± 0.077	5.96GlyGly: 5.96 ± 0.126	1.93GlyHis: 1.93 ± 0.053	4.277GlyIle: 4.277 ± 0.075	3.422GlyLys: 3.422 ± 0.071	9.038GlyLeu: 9.038 ± 0.135	2.185GlyMet: 2.185 ± 0.059	2.03GlyAsn: 2.03 ± 0.055	3.137GlyPro: 3.137 ± 0.074	3.792GlyGln: 3.792 ± 0.071	5.176GlyArg: 5.176 ± 0.099	4.244GlySer: 4.244 ± 0.075	4.133GlyThr: 4.133 ± 0.081	5.999GlyVal: 5.999 ± 0.09	1.209GlyTrp: 1.209 ± 0.042	2.355GlyTyr: 2.355 ± 0.061	0.0GlyXaa: 0.0 ± 0.0
His	1.901HisAla: 1.901 ± 0.047	0.427HisCys: 0.427 ± 0.022	1.119HisAsp: 1.119 ± 0.036	1.282HisGlu: 1.282 ± 0.04	1.119HisPhe: 1.119 ± 0.038	1.871HisGly: 1.871 ± 0.05	0.639HisHis: 0.639 ± 0.031	1.356HisIle: 1.356 ± 0.042	0.931HisLys: 0.931 ± 0.033	2.729HisLeu: 2.729 ± 0.063	0.544HisMet: 0.544 ± 0.025	0.807HisAsn: 0.807 ± 0.036	1.601HisPro: 1.601 ± 0.048	0.849HisGln: 0.849 ± 0.032	1.605HisArg: 1.605 ± 0.051	1.336HisSer: 1.336 ± 0.041	1.277HisThr: 1.277 ± 0.04	1.464HisVal: 1.464 ± 0.044	0.408HisTrp: 0.408 ± 0.023	0.634HisTyr: 0.634 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	4.649IleAla: 4.649 ± 0.085	0.749IleCys: 0.749 ± 0.034	2.74IleAsp: 2.74 ± 0.058	3.143IleGlu: 3.143 ± 0.069	1.989IlePhe: 1.989 ± 0.05	4.044IleGly: 4.044 ± 0.095	1.15IleHis: 1.15 ± 0.034	2.453IleIle: 2.453 ± 0.078	1.962IleLys: 1.962 ± 0.053	5.343IleLeu: 5.343 ± 0.095	1.012IleMet: 1.012 ± 0.037	1.605IleAsn: 1.605 ± 0.059	2.614IlePro: 2.614 ± 0.063	2.148IleGln: 2.148 ± 0.047	3.103IleArg: 3.103 ± 0.068	2.995IleSer: 2.995 ± 0.065	2.564IleThr: 2.564 ± 0.066	3.595IleVal: 3.595 ± 0.062	0.622IleTrp: 0.622 ± 0.03	1.34IleTyr: 1.34 ± 0.047	0.0IleXaa: 0.0 ± 0.0
Lys	3.89LysAla: 3.89 ± 0.07	0.381LysCys: 0.381 ± 0.024	2.186LysAsp: 2.186 ± 0.058	2.869LysGlu: 2.869 ± 0.076	1.034LysPhe: 1.034 ± 0.037	2.993LysGly: 2.993 ± 0.066	0.881LysHis: 0.881 ± 0.037	2.143LysIle: 2.143 ± 0.06	2.35LysLys: 2.35 ± 0.076	3.31LysLeu: 3.31 ± 0.065	1.02LysMet: 1.02 ± 0.043	1.506LysAsn: 1.506 ± 0.049	1.681LysPro: 1.681 ± 0.047	1.828LysGln: 1.828 ± 0.048	2.953LysArg: 2.953 ± 0.066	2.037LysSer: 2.037 ± 0.054	2.449LysThr: 2.449 ± 0.066	2.66LysVal: 2.66 ± 0.06	0.449LysTrp: 0.449 ± 0.026	1.059LysTyr: 1.059 ± 0.04	0.0LysXaa: 0.0 ± 0.0
Leu	11.452LeuAla: 11.452 ± 0.135	1.472LeuCys: 1.472 ± 0.045	6.452LeuAsp: 6.452 ± 0.085	7.882LeuGlu: 7.882 ± 0.116	4.206LeuPhe: 4.206 ± 0.085	8.841LeuGly: 8.841 ± 0.141	2.532LeuHis: 2.532 ± 0.061	4.324LeuIle: 4.324 ± 0.082	3.968LeuLys: 3.968 ± 0.082	11.092LeuLeu: 11.092 ± 0.169	1.916LeuMet: 1.916 ± 0.05	2.951LeuAsn: 2.951 ± 0.066	5.862LeuPro: 5.862 ± 0.09	5.213LeuGln: 5.213 ± 0.087	7.218LeuArg: 7.218 ± 0.114	6.452LeuSer: 6.452 ± 0.092	5.359LeuThr: 5.359 ± 0.094	7.671LeuVal: 7.671 ± 0.107	1.345LeuTrp: 1.345 ± 0.049	2.586LeuTyr: 2.586 ± 0.065	0.0LeuXaa: 0.0 ± 0.0
Met	2.638MetAla: 2.638 ± 0.061	0.222MetCys: 0.222 ± 0.017	1.436MetAsp: 1.436 ± 0.036	1.422MetGlu: 1.422 ± 0.041	0.601MetPhe: 0.601 ± 0.025	1.839MetGly: 1.839 ± 0.053	0.607MetHis: 0.607 ± 0.028	0.962MetIle: 0.962 ± 0.034	0.717MetLys: 0.717 ± 0.032	2.143MetLeu: 2.143 ± 0.048	0.385MetMet: 0.385 ± 0.027	0.671MetAsn: 0.671 ± 0.031	1.215MetPro: 1.215 ± 0.042	1.142MetGln: 1.142 ± 0.038	1.654MetArg: 1.654 ± 0.044	1.394MetSer: 1.394 ± 0.045	1.288MetThr: 1.288 ± 0.039	1.631MetVal: 1.631 ± 0.047	0.222MetTrp: 0.222 ± 0.018	0.491MetTyr: 0.491 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	2.709AsnAla: 2.709 ± 0.062	0.42AsnCys: 0.42 ± 0.025	1.362AsnAsp: 1.362 ± 0.046	1.587AsnGlu: 1.587 ± 0.047	1.161AsnPhe: 1.161 ± 0.04	2.241AsnGly: 2.241 ± 0.064	0.644AsnHis: 0.644 ± 0.032	1.842AsnIle: 1.842 ± 0.056	1.284AsnLys: 1.284 ± 0.054	2.997AsnLeu: 2.997 ± 0.06	0.74AsnMet: 0.74 ± 0.03	0.874AsnAsn: 0.874 ± 0.04	1.818AsnPro: 1.818 ± 0.052	1.172AsnGln: 1.172 ± 0.038	1.798AsnArg: 1.798 ± 0.045	1.365AsnSer: 1.365 ± 0.052	1.648AsnThr: 1.648 ± 0.047	2.012AsnVal: 2.012 ± 0.053	0.483AsnTrp: 0.483 ± 0.023	0.786AsnTyr: 0.786 ± 0.031	0.0AsnXaa: 0.0 ± 0.0
Pro	4.42ProAla: 4.42 ± 0.084	0.644ProCys: 0.644 ± 0.032	3.085ProAsp: 3.085 ± 0.067	4.773ProGlu: 4.773 ± 0.089	2.006ProPhe: 2.006 ± 0.05	4.323ProGly: 4.323 ± 0.084	1.195ProHis: 1.195 ± 0.036	1.857ProIle: 1.857 ± 0.043	1.898ProLys: 1.898 ± 0.053	5.037ProLeu: 5.037 ± 0.089	0.926ProMet: 0.926 ± 0.032	1.262ProAsn: 1.262 ± 0.036	2.249ProPro: 2.249 ± 0.061	2.534ProGln: 2.534 ± 0.052	2.564ProArg: 2.564 ± 0.059	2.746ProSer: 2.746 ± 0.057	2.063ProThr: 2.063 ± 0.053	3.915ProVal: 3.915 ± 0.076	0.798ProTrp: 0.798 ± 0.034	1.323ProTyr: 1.323 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	5.603GlnAla: 5.603 ± 0.088	0.565GlnCys: 0.565 ± 0.026	2.701GlnAsp: 2.701 ± 0.053	3.729GlnGlu: 3.729 ± 0.094	1.28GlnPhe: 1.28 ± 0.044	3.77GlnGly: 3.77 ± 0.074	0.984GlnHis: 0.984 ± 0.035	2.172GlnIle: 2.172 ± 0.061	1.945GlnLys: 1.945 ± 0.052	3.935GlnLeu: 3.935 ± 0.074	0.99GlnMet: 0.99 ± 0.031	1.362GlnAsn: 1.362 ± 0.047	1.826GlnPro: 1.826 ± 0.053	2.183GlnGln: 2.183 ± 0.069	3.368GlnArg: 3.368 ± 0.071	2.606GlnSer: 2.606 ± 0.056	2.679GlnThr: 2.679 ± 0.066	2.962GlnVal: 2.962 ± 0.054	0.809GlnTrp: 0.809 ± 0.035	0.936GlnTyr: 0.936 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	4.952ArgAla: 4.952 ± 0.097	0.844ArgCys: 0.844 ± 0.039	3.353ArgAsp: 3.353 ± 0.069	4.851ArgGlu: 4.851 ± 0.08	3.036ArgPhe: 3.036 ± 0.073	3.911ArgGly: 3.911 ± 0.082	1.796ArgHis: 1.796 ± 0.044	3.745ArgIle: 3.745 ± 0.063	2.743ArgLys: 2.743 ± 0.059	7.949ArgLeu: 7.949 ± 0.126	1.454ArgMet: 1.454 ± 0.047	1.866ArgAsn: 1.866 ± 0.047	2.926ArgPro: 2.926 ± 0.057	3.538ArgGln: 3.538 ± 0.072	4.549ArgArg: 4.549 ± 0.096	3.509ArgSer: 3.509 ± 0.071	2.958ArgThr: 2.958 ± 0.062	4.393ArgVal: 4.393 ± 0.093	0.911ArgTrp: 0.911 ± 0.038	1.959ArgTyr: 1.959 ± 0.054	0.0ArgXaa: 0.0 ± 0.0
Ser	4.805SerAla: 4.805 ± 0.084	0.815SerCys: 0.815 ± 0.031	2.575SerAsp: 2.575 ± 0.065	3.352SerGlu: 3.352 ± 0.064	2.263SerPhe: 2.263 ± 0.058	5.244SerGly: 5.244 ± 0.083	1.198SerHis: 1.198 ± 0.041	2.708SerIle: 2.708 ± 0.074	2.039SerLys: 2.039 ± 0.051	6.476SerLeu: 6.476 ± 0.098	1.409SerMet: 1.409 ± 0.041	1.433SerAsn: 1.433 ± 0.045	2.816SerPro: 2.816 ± 0.064	2.516SerGln: 2.516 ± 0.057	3.791SerArg: 3.791 ± 0.073	3.484SerSer: 3.484 ± 0.078	2.736SerThr: 2.736 ± 0.06	3.709SerVal: 3.709 ± 0.07	0.841SerTrp: 0.841 ± 0.03	1.403SerTyr: 1.403 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	5.255ThrAla: 5.255 ± 0.098	0.615ThrCys: 0.615 ± 0.026	2.513ThrAsp: 2.513 ± 0.059	2.895ThrGlu: 2.895 ± 0.054	1.908ThrPhe: 1.908 ± 0.051	4.683ThrGly: 4.683 ± 0.076	1.172ThrHis: 1.172 ± 0.039	2.861ThrIle: 2.861 ± 0.073	1.771ThrLys: 1.771 ± 0.044	5.839ThrLeu: 5.839 ± 0.101	1.1ThrMet: 1.1 ± 0.035	1.447ThrAsn: 1.447 ± 0.047	3.204ThrPro: 3.204 ± 0.073	1.893ThrGln: 1.893 ± 0.049	2.767ThrArg: 2.767 ± 0.056	2.962ThrSer: 2.962 ± 0.067	2.898ThrThr: 2.898 ± 0.065	4.053ThrVal: 4.053 ± 0.071	0.741ThrTrp: 0.741 ± 0.033	1.426ThrTyr: 1.426 ± 0.045	0.0ThrXaa: 0.0 ± 0.0
Val	6.855ValAla: 6.855 ± 0.095	1.175ValCys: 1.175 ± 0.04	4.081ValAsp: 4.081 ± 0.079	4.281ValGlu: 4.281 ± 0.07	3.116ValPhe: 3.116 ± 0.071	5.08ValGly: 5.08 ± 0.091	1.798ValHis: 1.798 ± 0.051	3.243ValIle: 3.243 ± 0.071	2.185ValLys: 2.185 ± 0.058	8.347ValLeu: 8.347 ± 0.113	1.484ValMet: 1.484 ± 0.048	2.047ValAsn: 2.047 ± 0.051	3.558ValPro: 3.558 ± 0.059	3.408ValGln: 3.408 ± 0.062	4.777ValArg: 4.777 ± 0.09	4.007ValSer: 4.007 ± 0.074	3.634ValThr: 3.634 ± 0.066	5.935ValVal: 5.935 ± 0.104	0.951ValTrp: 0.951 ± 0.036	1.884ValTyr: 1.884 ± 0.047	0.0ValXaa: 0.0 ± 0.0
Trp	1.186TrpAla: 1.186 ± 0.048	0.164TrpCys: 0.164 ± 0.016	0.75TrpAsp: 0.75 ± 0.028	0.968TrpGlu: 0.968 ± 0.035	0.496TrpPhe: 0.496 ± 0.028	1.113TrpGly: 1.113 ± 0.043	0.394TrpHis: 0.394 ± 0.024	0.732TrpIle: 0.732 ± 0.033	0.507TrpLys: 0.507 ± 0.024	1.547TrpLeu: 1.547 ± 0.048	0.337TrpMet: 0.337 ± 0.022	0.42TrpAsn: 0.42 ± 0.022	0.831TrpPro: 0.831 ± 0.033	0.813TrpGln: 0.813 ± 0.036	1.085TrpArg: 1.085 ± 0.041	0.724TrpSer: 0.724 ± 0.029	0.74TrpThr: 0.74 ± 0.033	0.869TrpVal: 0.869 ± 0.033	0.26TrpTrp: 0.26 ± 0.018	0.357TrpTyr: 0.357 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.362TyrAla: 2.362 ± 0.052	0.419TyrCys: 0.419 ± 0.024	1.427TyrAsp: 1.427 ± 0.042	1.547TyrGlu: 1.547 ± 0.047	1.257TyrPhe: 1.257 ± 0.042	2.196TyrGly: 2.196 ± 0.061	0.565TyrHis: 0.565 ± 0.028	1.209TyrIle: 1.209 ± 0.044	1.004TyrLys: 1.004 ± 0.038	2.906TyrLeu: 2.906 ± 0.065	0.499TyrMet: 0.499 ± 0.028	0.841TyrAsn: 0.841 ± 0.031	1.27TyrPro: 1.27 ± 0.042	1.049TyrGln: 1.049 ± 0.04	1.776TyrArg: 1.776 ± 0.047	1.451TyrSer: 1.451 ± 0.046	1.594TyrThr: 1.594 ± 0.049	1.634TyrVal: 1.634 ± 0.051	0.48TyrTrp: 0.48 ± 0.025	0.879TyrTyr: 0.879 ± 0.037	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2500 proteins (812020 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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