Amino acid dipepetide frequency for Sporomusa acidovorans DSM 3132

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.005AlaAla: 11.005 ± 0.133	1.231AlaCys: 1.231 ± 0.03	4.616AlaAsp: 4.616 ± 0.064	5.84AlaGlu: 5.84 ± 0.071	3.268AlaPhe: 3.268 ± 0.054	8.007AlaGly: 8.007 ± 0.093	1.419AlaHis: 1.419 ± 0.031	6.631AlaIle: 6.631 ± 0.072	5.717AlaLys: 5.717 ± 0.058	8.406AlaLeu: 8.406 ± 0.075	2.714AlaMet: 2.714 ± 0.041	3.433AlaAsn: 3.433 ± 0.047	2.579AlaPro: 2.579 ± 0.045	3.314AlaGln: 3.314 ± 0.037	3.888AlaArg: 3.888 ± 0.053	4.391AlaSer: 4.391 ± 0.048	4.433AlaThr: 4.433 ± 0.059	7.789AlaVal: 7.789 ± 0.088	0.807AlaTrp: 0.807 ± 0.024	2.685AlaTyr: 2.685 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	0.973CysAla: 0.973 ± 0.026	0.276CysCys: 0.276 ± 0.014	0.597CysAsp: 0.597 ± 0.021	0.634CysGlu: 0.634 ± 0.019	0.536CysPhe: 0.536 ± 0.02	1.353CysGly: 1.353 ± 0.03	0.348CysHis: 0.348 ± 0.018	0.862CysIle: 0.862 ± 0.024	0.712CysLys: 0.712 ± 0.035	1.266CysLeu: 1.266 ± 0.03	0.351CysMet: 0.351 ± 0.013	0.516CysAsn: 0.516 ± 0.016	0.757CysPro: 0.757 ± 0.026	0.556CysGln: 0.556 ± 0.019	0.738CysArg: 0.738 ± 0.017	0.81CysSer: 0.81 ± 0.025	0.673CysThr: 0.673 ± 0.021	0.775CysVal: 0.775 ± 0.022	0.126CysTrp: 0.126 ± 0.01	0.443CysTyr: 0.443 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	3.779AspAla: 3.779 ± 0.052	0.699AspCys: 0.699 ± 0.027	2.236AspAsp: 2.236 ± 0.048	3.147AspGlu: 3.147 ± 0.051	2.12AspPhe: 2.12 ± 0.037	3.38AspGly: 3.38 ± 0.054	0.851AspHis: 0.851 ± 0.023	4.213AspIle: 4.213 ± 0.054	3.356AspLys: 3.356 ± 0.049	4.363AspLeu: 4.363 ± 0.057	1.44AspMet: 1.44 ± 0.033	2.15AspAsn: 2.15 ± 0.041	1.814AspPro: 1.814 ± 0.036	1.58AspGln: 1.58 ± 0.031	2.249AspArg: 2.249 ± 0.037	2.58AspSer: 2.58 ± 0.043	2.548AspThr: 2.548 ± 0.041	3.429AspVal: 3.429 ± 0.054	0.595AspTrp: 0.595 ± 0.02	2.005AspTyr: 2.005 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	5.322GluAla: 5.322 ± 0.058	0.678GluCys: 0.678 ± 0.023	2.605GluAsp: 2.605 ± 0.038	4.124GluGlu: 4.124 ± 0.06	2.271GluPhe: 2.271 ± 0.041	3.289GluGly: 3.289 ± 0.049	1.21GluHis: 1.21 ± 0.028	4.841GluIle: 4.841 ± 0.062	4.703GluLys: 4.703 ± 0.06	6.48GluLeu: 6.48 ± 0.076	1.819GluMet: 1.819 ± 0.036	2.783GluAsn: 2.783 ± 0.04	1.792GluPro: 1.792 ± 0.037	3.118GluGln: 3.118 ± 0.048	3.26GluArg: 3.26 ± 0.051	2.614GluSer: 2.614 ± 0.041	3.165GluThr: 3.165 ± 0.046	4.169GluVal: 4.169 ± 0.054	0.605GluTrp: 0.605 ± 0.02	2.189GluTyr: 2.189 ± 0.034	0.0GluXaa: 0.0 ± 0.0
Phe	3.451PheAla: 3.451 ± 0.046	0.647PheCys: 0.647 ± 0.019	2.073PheAsp: 2.073 ± 0.039	1.895PheGlu: 1.895 ± 0.036	1.768PhePhe: 1.768 ± 0.04	3.109PheGly: 3.109 ± 0.045	0.715PheHis: 0.715 ± 0.023	2.982PheIle: 2.982 ± 0.047	1.915PheLys: 1.915 ± 0.033	3.728PheLeu: 3.728 ± 0.061	1.081PheMet: 1.081 ± 0.027	1.589PheAsn: 1.589 ± 0.032	1.463PhePro: 1.463 ± 0.026	1.127PheGln: 1.127 ± 0.025	1.687PheArg: 1.687 ± 0.032	2.758PheSer: 2.758 ± 0.043	2.286PheThr: 2.286 ± 0.038	2.747PheVal: 2.747 ± 0.045	0.482PheTrp: 0.482 ± 0.02	1.366PheTyr: 1.366 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	5.924GlyAla: 5.924 ± 0.069	1.239GlyCys: 1.239 ± 0.031	3.254GlyAsp: 3.254 ± 0.05	4.043GlyGlu: 4.043 ± 0.053	3.176GlyPhe: 3.176 ± 0.051	5.497GlyGly: 5.497 ± 0.065	1.409GlyHis: 1.409 ± 0.026	6.281GlyIle: 6.281 ± 0.059	5.125GlyLys: 5.125 ± 0.053	7.173GlyLeu: 7.173 ± 0.081	2.451GlyMet: 2.451 ± 0.042	2.969GlyAsn: 2.969 ± 0.049	1.908GlyPro: 1.908 ± 0.035	2.909GlyGln: 2.909 ± 0.044	3.453GlyArg: 3.453 ± 0.052	4.06GlySer: 4.06 ± 0.057	4.304GlyThr: 4.304 ± 0.059	5.406GlyVal: 5.406 ± 0.065	0.855GlyTrp: 0.855 ± 0.025	2.918GlyTyr: 2.918 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	1.397HisAla: 1.397 ± 0.033	0.322HisCys: 0.322 ± 0.016	0.928HisAsp: 0.928 ± 0.026	0.993HisGlu: 0.993 ± 0.025	0.742HisPhe: 0.742 ± 0.022	1.345HisGly: 1.345 ± 0.03	0.486HisHis: 0.486 ± 0.026	1.436HisIle: 1.436 ± 0.027	1.0HisLys: 1.0 ± 0.025	1.737HisLeu: 1.737 ± 0.031	0.485HisMet: 0.485 ± 0.015	0.865HisAsn: 0.865 ± 0.026	0.971HisPro: 0.971 ± 0.026	0.652HisGln: 0.652 ± 0.021	0.851HisArg: 0.851 ± 0.024	1.087HisSer: 1.087 ± 0.026	1.05HisThr: 1.05 ± 0.025	1.242HisVal: 1.242 ± 0.027	0.227HisTrp: 0.227 ± 0.011	0.755HisTyr: 0.755 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	7.266IleAla: 7.266 ± 0.075	0.984IleCys: 0.984 ± 0.025	4.011IleAsp: 4.011 ± 0.053	4.349IleGlu: 4.349 ± 0.051	2.669IlePhe: 2.669 ± 0.045	5.741IleGly: 5.741 ± 0.063	1.369IleHis: 1.369 ± 0.028	5.591IleIle: 5.591 ± 0.071	4.325IleLys: 4.325 ± 0.068	6.68IleLeu: 6.68 ± 0.076	1.899IleMet: 1.899 ± 0.033	3.302IleAsn: 3.302 ± 0.043	3.368IlePro: 3.368 ± 0.045	2.211IleGln: 2.211 ± 0.043	3.308IleArg: 3.308 ± 0.048	4.54IleSer: 4.54 ± 0.056	4.483IleThr: 4.483 ± 0.059	5.471IleVal: 5.471 ± 0.069	0.624IleTrp: 0.624 ± 0.022	2.141IleTyr: 2.141 ± 0.038	0.0IleXaa: 0.0 ± 0.0
Lys	5.162LysAla: 5.162 ± 0.066	0.6LysCys: 0.6 ± 0.021	2.875LysAsp: 2.875 ± 0.049	4.18LysGlu: 4.18 ± 0.056	1.854LysPhe: 1.854 ± 0.031	3.521LysGly: 3.521 ± 0.048	1.009LysHis: 1.009 ± 0.029	4.72LysIle: 4.72 ± 0.064	4.093LysLys: 4.093 ± 0.063	5.89LysLeu: 5.89 ± 0.059	1.879LysMet: 1.879 ± 0.037	3.014LysAsn: 3.014 ± 0.045	2.461LysPro: 2.461 ± 0.046	2.701LysGln: 2.701 ± 0.039	2.722LysArg: 2.722 ± 0.047	2.862LysSer: 2.862 ± 0.039	3.456LysThr: 3.456 ± 0.053	4.428LysVal: 4.428 ± 0.051	0.578LysTrp: 0.578 ± 0.018	2.117LysTyr: 2.117 ± 0.044	0.0LysXaa: 0.0 ± 0.0
Leu	10.402LeuAla: 10.402 ± 0.087	1.234LeuCys: 1.234 ± 0.027	4.517LeuAsp: 4.517 ± 0.049	5.631LeuGlu: 5.631 ± 0.066	3.904LeuPhe: 3.904 ± 0.056	7.153LeuGly: 7.153 ± 0.071	1.739LeuHis: 1.739 ± 0.034	6.297LeuIle: 6.297 ± 0.063	5.545LeuLys: 5.545 ± 0.057	9.878LeuLeu: 9.878 ± 0.1	2.35LeuMet: 2.35 ± 0.039	3.834LeuAsn: 3.834 ± 0.053	4.551LeuPro: 4.551 ± 0.05	3.492LeuGln: 3.492 ± 0.055	4.316LeuArg: 4.316 ± 0.055	6.11LeuSer: 6.11 ± 0.067	6.154LeuThr: 6.154 ± 0.067	6.764LeuVal: 6.764 ± 0.068	0.9LeuTrp: 0.9 ± 0.023	2.789LeuTyr: 2.789 ± 0.042	0.0LeuXaa: 0.0 ± 0.0
Met	2.866MetAla: 2.866 ± 0.038	0.264MetCys: 0.264 ± 0.014	1.376MetAsp: 1.376 ± 0.026	1.707MetGlu: 1.707 ± 0.033	0.907MetPhe: 0.907 ± 0.026	1.993MetGly: 1.993 ± 0.042	0.442MetHis: 0.442 ± 0.014	1.809MetIle: 1.809 ± 0.032	1.745MetLys: 1.745 ± 0.033	2.812MetLeu: 2.812 ± 0.039	0.793MetMet: 0.793 ± 0.024	1.307MetAsn: 1.307 ± 0.026	1.294MetPro: 1.294 ± 0.028	1.081MetGln: 1.081 ± 0.026	1.288MetArg: 1.288 ± 0.028	1.653MetSer: 1.653 ± 0.034	1.556MetThr: 1.556 ± 0.03	1.963MetVal: 1.963 ± 0.034	0.202MetTrp: 0.202 ± 0.011	0.698MetTyr: 0.698 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	3.142AsnAla: 3.142 ± 0.05	0.623AsnCys: 0.623 ± 0.023	1.928AsnAsp: 1.928 ± 0.045	2.267AsnGlu: 2.267 ± 0.042	1.678AsnPhe: 1.678 ± 0.028	2.939AsnGly: 2.939 ± 0.053	0.849AsnHis: 0.849 ± 0.021	3.437AsnIle: 3.437 ± 0.047	2.622AsnLys: 2.622 ± 0.045	4.082AsnLeu: 4.082 ± 0.045	1.224AsnMet: 1.224 ± 0.032	1.943AsnAsn: 1.943 ± 0.047	2.158AsnPro: 2.158 ± 0.036	1.686AsnGln: 1.686 ± 0.034	1.964AsnArg: 1.964 ± 0.035	2.427AsnSer: 2.427 ± 0.044	2.293AsnThr: 2.293 ± 0.045	2.791AsnVal: 2.791 ± 0.039	0.486AsnTrp: 0.486 ± 0.019	1.502AsnTyr: 1.502 ± 0.035	0.0AsnXaa: 0.0 ± 0.0
Pro	3.864ProAla: 3.864 ± 0.06	0.488ProCys: 0.488 ± 0.019	2.372ProAsp: 2.372 ± 0.044	3.136ProGlu: 3.136 ± 0.041	1.633ProPhe: 1.633 ± 0.033	3.278ProGly: 3.278 ± 0.055	0.805ProHis: 0.805 ± 0.023	2.468ProIle: 2.468 ± 0.036	1.85ProLys: 1.85 ± 0.037	3.802ProLeu: 3.802 ± 0.058	0.881ProMet: 0.881 ± 0.024	1.417ProAsn: 1.417 ± 0.027	1.489ProPro: 1.489 ± 0.034	1.511ProGln: 1.511 ± 0.034	1.454ProArg: 1.454 ± 0.029	1.874ProSer: 1.874 ± 0.03	1.913ProThr: 1.913 ± 0.031	3.613ProVal: 3.613 ± 0.052	0.442ProTrp: 0.442 ± 0.018	1.324ProTyr: 1.324 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	4.184GlnAla: 4.184 ± 0.059	0.426GlnCys: 0.426 ± 0.015	1.802GlnAsp: 1.802 ± 0.035	2.823GlnGlu: 2.823 ± 0.046	1.275GlnPhe: 1.275 ± 0.029	2.589GlnGly: 2.589 ± 0.042	0.706GlnHis: 0.706 ± 0.021	2.718GlnIle: 2.718 ± 0.04	2.24GlnLys: 2.24 ± 0.04	3.686GlnLeu: 3.686 ± 0.043	1.059GlnMet: 1.059 ± 0.026	1.613GlnAsn: 1.613 ± 0.031	1.583GlnPro: 1.583 ± 0.029	1.967GlnGln: 1.967 ± 0.042	1.642GlnArg: 1.642 ± 0.035	1.972GlnSer: 1.972 ± 0.034	2.057GlnThr: 2.057 ± 0.037	2.783GlnVal: 2.783 ± 0.054	0.358GlnTrp: 0.358 ± 0.015	1.298GlnTyr: 1.298 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	3.084ArgAla: 3.084 ± 0.042	0.571ArgCys: 0.571 ± 0.022	2.133ArgAsp: 2.133 ± 0.038	3.463ArgGlu: 3.463 ± 0.052	1.769ArgPhe: 1.769 ± 0.034	2.8ArgGly: 2.8 ± 0.037	0.973ArgHis: 0.973 ± 0.026	3.3ArgIle: 3.3 ± 0.039	2.878ArgLys: 2.878 ± 0.041	4.925ArgLeu: 4.925 ± 0.061	1.349ArgMet: 1.349 ± 0.029	1.9ArgAsn: 1.9 ± 0.037	1.752ArgPro: 1.752 ± 0.031	2.534ArgGln: 2.534 ± 0.035	2.475ArgArg: 2.475 ± 0.047	2.242ArgSer: 2.242 ± 0.032	2.266ArgThr: 2.266 ± 0.042	3.048ArgVal: 3.048 ± 0.046	0.479ArgTrp: 0.479 ± 0.018	1.711ArgTyr: 1.711 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	4.526SerAla: 4.526 ± 0.06	0.705SerCys: 0.705 ± 0.02	2.557SerAsp: 2.557 ± 0.04	3.023SerGlu: 3.023 ± 0.041	2.356SerPhe: 2.356 ± 0.044	4.774SerGly: 4.774 ± 0.06	1.079SerHis: 1.079 ± 0.028	3.964SerIle: 3.964 ± 0.052	2.964SerLys: 2.964 ± 0.041	5.716SerLeu: 5.716 ± 0.069	1.562SerMet: 1.562 ± 0.03	2.082SerAsn: 2.082 ± 0.038	2.315SerPro: 2.315 ± 0.04	2.289SerGln: 2.289 ± 0.04	2.674SerArg: 2.674 ± 0.044	3.247SerSer: 3.247 ± 0.055	2.902SerThr: 2.902 ± 0.046	3.799SerVal: 3.799 ± 0.05	0.637SerTrp: 0.637 ± 0.02	1.904SerTyr: 1.904 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	5.609ThrAla: 5.609 ± 0.074	0.654ThrCys: 0.654 ± 0.018	2.688ThrAsp: 2.688 ± 0.04	3.011ThrGlu: 3.011 ± 0.046	2.034ThrPhe: 2.034 ± 0.033	5.208ThrGly: 5.208 ± 0.065	0.918ThrHis: 0.918 ± 0.022	4.228ThrIle: 4.228 ± 0.055	2.797ThrLys: 2.797 ± 0.046	5.239ThrLeu: 5.239 ± 0.062	1.422ThrMet: 1.422 ± 0.032	2.218ThrAsn: 2.218 ± 0.047	2.561ThrPro: 2.561 ± 0.042	1.673ThrGln: 1.673 ± 0.035	2.073ThrArg: 2.073 ± 0.032	2.837ThrSer: 2.837 ± 0.045	3.196ThrThr: 3.196 ± 0.05	4.794ThrVal: 4.794 ± 0.055	0.524ThrTrp: 0.524 ± 0.019	1.72ThrTyr: 1.72 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	6.954ValAla: 6.954 ± 0.083	0.994ValCys: 0.994 ± 0.025	3.745ValAsp: 3.745 ± 0.053	4.269ValGlu: 4.269 ± 0.05	2.954ValPhe: 2.954 ± 0.04	5.011ValGly: 5.011 ± 0.063	1.234ValHis: 1.234 ± 0.027	5.631ValIle: 5.631 ± 0.06	4.3ValLys: 4.3 ± 0.05	7.091ValLeu: 7.091 ± 0.069	2.001ValMet: 2.001 ± 0.037	3.183ValAsn: 3.183 ± 0.051	3.011ValPro: 3.011 ± 0.047	2.325ValGln: 2.325 ± 0.039	3.267ValArg: 3.267 ± 0.046	4.444ValSer: 4.444 ± 0.056	4.425ValThr: 4.425 ± 0.054	5.569ValVal: 5.569 ± 0.072	0.685ValTrp: 0.685 ± 0.021	2.187ValTyr: 2.187 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	0.721TrpAla: 0.721 ± 0.023	0.131TrpCys: 0.131 ± 0.008	0.486TrpAsp: 0.486 ± 0.02	0.592TrpGlu: 0.592 ± 0.021	0.43TrpPhe: 0.43 ± 0.018	0.789TrpGly: 0.789 ± 0.022	0.243TrpHis: 0.243 ± 0.013	0.635TrpIle: 0.635 ± 0.021	0.524TrpLys: 0.524 ± 0.021	1.272TrpLeu: 1.272 ± 0.034	0.263TrpMet: 0.263 ± 0.014	0.448TrpAsn: 0.448 ± 0.019	0.385TrpPro: 0.385 ± 0.012	0.59TrpGln: 0.59 ± 0.02	0.546TrpArg: 0.546 ± 0.02	0.567TrpSer: 0.567 ± 0.021	0.446TrpThr: 0.446 ± 0.018	0.631TrpVal: 0.631 ± 0.02	0.151TrpTrp: 0.151 ± 0.011	0.316TrpTyr: 0.316 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.545TyrAla: 2.545 ± 0.037	0.536TyrCys: 0.536 ± 0.02	1.738TyrAsp: 1.738 ± 0.036	1.91TyrGlu: 1.91 ± 0.035	1.524TyrPhe: 1.524 ± 0.037	2.578TyrGly: 2.578 ± 0.043	0.763TyrHis: 0.763 ± 0.02	2.289TyrIle: 2.289 ± 0.037	1.707TyrLys: 1.707 ± 0.034	3.336TyrLeu: 3.336 ± 0.054	0.732TyrMet: 0.732 ± 0.02	1.475TyrAsn: 1.475 ± 0.038	1.401TyrPro: 1.401 ± 0.03	1.468TyrGln: 1.468 ± 0.025	1.796TyrArg: 1.796 ± 0.033	2.002TyrSer: 2.002 ± 0.033	1.797TyrThr: 1.797 ± 0.033	2.07TyrVal: 2.07 ± 0.04	0.401TyrTrp: 0.401 ± 0.016	1.313TyrTyr: 1.313 ± 0.035	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5767 proteins (1704535 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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