Amino acid dipepetide frequency for Bifidobacterium castoris

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
15.463AlaAla: 15.463 ± 0.26
1.361AlaCys: 1.361 ± 0.044
8.717AlaAsp: 8.717 ± 0.136
5.804AlaGlu: 5.804 ± 0.099
3.534AlaPhe: 3.534 ± 0.085
8.985AlaGly: 8.985 ± 0.135
2.786AlaHis: 2.786 ± 0.062
5.489AlaIle: 5.489 ± 0.1
4.341AlaLys: 4.341 ± 0.101
10.894AlaLeu: 10.894 ± 0.161
3.385AlaMet: 3.385 ± 0.079
3.367AlaAsn: 3.367 ± 0.081
4.925AlaPro: 4.925 ± 0.097
5.05AlaGln: 5.05 ± 0.11
7.852AlaArg: 7.852 ± 0.148
6.38AlaSer: 6.38 ± 0.12
6.246AlaThr: 6.246 ± 0.103
8.851AlaVal: 8.851 ± 0.126
1.682AlaTrp: 1.682 ± 0.053
2.934AlaTyr: 2.934 ± 0.064
0.0AlaXaa: 0.0 ± 0.0
Cys
1.464CysAla: 1.464 ± 0.051
0.156CysCys: 0.156 ± 0.018
0.666CysAsp: 0.666 ± 0.03
0.56CysGlu: 0.56 ± 0.03
0.327CysPhe: 0.327 ± 0.021
1.175CysGly: 1.175 ± 0.043
0.209CysHis: 0.209 ± 0.017
0.474CysIle: 0.474 ± 0.028
0.243CysLys: 0.243 ± 0.017
0.758CysLeu: 0.758 ± 0.034
0.291CysMet: 0.291 ± 0.025
0.247CysAsn: 0.247 ± 0.02
0.493CysPro: 0.493 ± 0.03
0.182CysGln: 0.182 ± 0.019
0.664CysArg: 0.664 ± 0.032
0.616CysSer: 0.616 ± 0.031
0.651CysThr: 0.651 ± 0.033
0.951CysVal: 0.951 ± 0.042
0.149CysTrp: 0.149 ± 0.015
0.26CysTyr: 0.26 ± 0.02
0.0CysXaa: 0.0 ± 0.0
Asp
9.903AspAla: 9.903 ± 0.164
0.63AspCys: 0.63 ± 0.034
6.223AspAsp: 6.223 ± 0.123
5.477AspGlu: 5.477 ± 0.095
2.205AspPhe: 2.205 ± 0.061
7.743AspGly: 7.743 ± 0.13
1.378AspHis: 1.378 ± 0.044
2.954AspIle: 2.954 ± 0.075
2.096AspLys: 2.096 ± 0.07
5.257AspLeu: 5.257 ± 0.103
2.084AspMet: 2.084 ± 0.058
1.581AspAsn: 1.581 ± 0.055
3.862AspPro: 3.862 ± 0.08
1.547AspGln: 1.547 ± 0.047
3.781AspArg: 3.781 ± 0.079
2.87AspSer: 2.87 ± 0.053
3.529AspThr: 3.529 ± 0.086
6.04AspVal: 6.04 ± 0.12
1.136AspTrp: 1.136 ± 0.047
1.968AspTyr: 1.968 ± 0.054
0.0AspXaa: 0.0 ± 0.0
Glu
6.311GluAla: 6.311 ± 0.111
0.474GluCys: 0.474 ± 0.026
3.497GluAsp: 3.497 ± 0.069
3.438GluGlu: 3.438 ± 0.09
1.667GluPhe: 1.667 ± 0.049
3.92GluGly: 3.92 ± 0.088
1.783GluHis: 1.783 ± 0.052
2.556GluIle: 2.556 ± 0.063
1.717GluLys: 1.717 ± 0.055
5.27GluLeu: 5.27 ± 0.083
1.339GluMet: 1.339 ± 0.049
1.479GluAsn: 1.479 ± 0.05
2.75GluPro: 2.75 ± 0.075
2.787GluGln: 2.787 ± 0.064
5.247GluArg: 5.247 ± 0.109
2.805GluSer: 2.805 ± 0.063
3.342GluThr: 3.342 ± 0.072
3.324GluVal: 3.324 ± 0.078
0.651GluTrp: 0.651 ± 0.029
1.624GluTyr: 1.624 ± 0.052
0.0GluXaa: 0.0 ± 0.0
Phe
3.978PheAla: 3.978 ± 0.089
0.336PheCys: 0.336 ± 0.023
2.698PheAsp: 2.698 ± 0.059
1.721PheGlu: 1.721 ± 0.048
1.062PhePhe: 1.062 ± 0.044
3.048PheGly: 3.048 ± 0.078
0.659PheHis: 0.659 ± 0.028
1.612PheIle: 1.612 ± 0.061
0.872PheLys: 0.872 ± 0.041
2.63PheLeu: 2.63 ± 0.077
0.702PheMet: 0.702 ± 0.036
1.091PheAsn: 1.091 ± 0.038
1.315PhePro: 1.315 ± 0.038
0.794PheGln: 0.794 ± 0.034
1.718PheArg: 1.718 ± 0.048
1.839PheSer: 1.839 ± 0.056
2.207PheThr: 2.207 ± 0.069
2.52PheVal: 2.52 ± 0.07
0.405PheTrp: 0.405 ± 0.025
0.849PheTyr: 0.849 ± 0.03
0.0PheXaa: 0.0 ± 0.0
Gly
9.319GlyAla: 9.319 ± 0.152
0.958GlyCys: 0.958 ± 0.043
5.537GlyAsp: 5.537 ± 0.092
4.682GlyGlu: 4.682 ± 0.09
2.907GlyPhe: 2.907 ± 0.067
6.385GlyGly: 6.385 ± 0.123
1.696GlyHis: 1.696 ± 0.053
4.12GlyIle: 4.12 ± 0.079
3.105GlyLys: 3.105 ± 0.075
6.64GlyLeu: 6.64 ± 0.108
2.472GlyMet: 2.472 ± 0.066
2.344GlyAsn: 2.344 ± 0.07
2.656GlyPro: 2.656 ± 0.068
2.367GlyGln: 2.367 ± 0.055
5.364GlyArg: 5.364 ± 0.113
4.543GlySer: 4.543 ± 0.093
4.967GlyThr: 4.967 ± 0.098
7.024GlyVal: 7.024 ± 0.092
1.336GlyTrp: 1.336 ± 0.037
2.612GlyTyr: 2.612 ± 0.075
0.0GlyXaa: 0.0 ± 0.0
His
2.563HisAla: 2.563 ± 0.067
0.239HisCys: 0.239 ± 0.019
1.896HisAsp: 1.896 ± 0.056
1.301HisGlu: 1.301 ± 0.042
0.517HisPhe: 0.517 ± 0.028
2.213HisGly: 2.213 ± 0.06
0.484HisHis: 0.484 ± 0.031
1.018HisIle: 1.018 ± 0.045
0.548HisLys: 0.548 ± 0.027
1.562HisLeu: 1.562 ± 0.047
0.662HisMet: 0.662 ± 0.034
0.582HisAsn: 0.582 ± 0.029
1.33HisPro: 1.33 ± 0.043
0.545HisGln: 0.545 ± 0.03
1.583HisArg: 1.583 ± 0.053
0.91HisSer: 0.91 ± 0.036
1.266HisThr: 1.266 ± 0.05
2.057HisVal: 2.057 ± 0.052
0.353HisTrp: 0.353 ± 0.02
0.62HisTyr: 0.62 ± 0.029
0.0HisXaa: 0.0 ± 0.0
Ile
6.319IleAla: 6.319 ± 0.094
0.631IleCys: 0.631 ± 0.03
4.242IleAsp: 4.242 ± 0.074
3.098IleGlu: 3.098 ± 0.076
1.244IlePhe: 1.244 ± 0.051
4.557IleGly: 4.557 ± 0.074
0.938IleHis: 0.938 ± 0.039
2.647IleIle: 2.647 ± 0.066
1.35IleLys: 1.35 ± 0.047
3.467IleLeu: 3.467 ± 0.072
1.223IleMet: 1.223 ± 0.046
1.543IleAsn: 1.543 ± 0.052
2.433IlePro: 2.433 ± 0.06
1.106IleGln: 1.106 ± 0.041
3.044IleArg: 3.044 ± 0.064
2.488IleSer: 2.488 ± 0.072
2.883IleThr: 2.883 ± 0.073
4.794IleVal: 4.794 ± 0.094
0.598IleTrp: 0.598 ± 0.026
1.091IleTyr: 1.091 ± 0.038
0.0IleXaa: 0.0 ± 0.0
Lys
3.898LysAla: 3.898 ± 0.09
0.161LysCys: 0.161 ± 0.015
2.483LysAsp: 2.483 ± 0.082
1.963LysGlu: 1.963 ± 0.06
0.742LysPhe: 0.742 ± 0.033
2.323LysGly: 2.323 ± 0.069
0.681LysHis: 0.681 ± 0.028
1.444LysIle: 1.444 ± 0.053
1.38LysLys: 1.38 ± 0.05
2.633LysLeu: 2.633 ± 0.07
0.701LysMet: 0.701 ± 0.031
1.136LysAsn: 1.136 ± 0.052
2.025LysPro: 2.025 ± 0.051
1.265LysGln: 1.265 ± 0.049
2.249LysArg: 2.249 ± 0.067
1.796LysSer: 1.796 ± 0.057
2.277LysThr: 2.277 ± 0.074
2.294LysVal: 2.294 ± 0.065
0.402LysTrp: 0.402 ± 0.021
0.955LysTyr: 0.955 ± 0.041
0.0LysXaa: 0.0 ± 0.0
Leu
10.363LeuAla: 10.363 ± 0.157
1.054LeuCys: 1.054 ± 0.04
6.529LeuAsp: 6.529 ± 0.125
4.491LeuGlu: 4.491 ± 0.091
2.889LeuPhe: 2.889 ± 0.071
6.863LeuGly: 6.863 ± 0.111
1.96LeuHis: 1.96 ± 0.052
4.299LeuIle: 4.299 ± 0.098
2.841LeuLys: 2.841 ± 0.08
7.561LeuLeu: 7.561 ± 0.138
2.178LeuMet: 2.178 ± 0.057
2.566LeuAsn: 2.566 ± 0.057
4.305LeuPro: 4.305 ± 0.081
2.337LeuGln: 2.337 ± 0.06
5.947LeuArg: 5.947 ± 0.109
4.936LeuSer: 4.936 ± 0.094
5.391LeuThr: 5.391 ± 0.095
6.28LeuVal: 6.28 ± 0.115
1.09LeuTrp: 1.09 ± 0.046
2.041LeuTyr: 2.041 ± 0.054
0.0LeuXaa: 0.0 ± 0.0
Met
2.958MetAla: 2.958 ± 0.067
0.335MetCys: 0.335 ± 0.022
1.574MetAsp: 1.574 ± 0.042
1.184MetGlu: 1.184 ± 0.039
0.902MetPhe: 0.902 ± 0.039
1.842MetGly: 1.842 ± 0.051
0.646MetHis: 0.646 ± 0.029
1.219MetIle: 1.219 ± 0.042
0.86MetLys: 0.86 ± 0.037
2.797MetLeu: 2.797 ± 0.064
0.777MetMet: 0.777 ± 0.037
0.94MetAsn: 0.94 ± 0.032
1.585MetPro: 1.585 ± 0.045
0.898MetGln: 0.898 ± 0.038
2.362MetArg: 2.362 ± 0.062
1.783MetSer: 1.783 ± 0.04
2.155MetThr: 2.155 ± 0.056
1.676MetVal: 1.676 ± 0.053
0.309MetTrp: 0.309 ± 0.019
0.56MetTyr: 0.56 ± 0.028
0.0MetXaa: 0.0 ± 0.0
Asn
3.57AsnAla: 3.57 ± 0.084
0.227AsnCys: 0.227 ± 0.02
1.999AsnAsp: 1.999 ± 0.053
1.682AsnGlu: 1.682 ± 0.047
0.815AsnPhe: 0.815 ± 0.039
3.009AsnGly: 3.009 ± 0.094
0.585AsnHis: 0.585 ± 0.028
1.407AsnIle: 1.407 ± 0.054
0.969AsnLys: 0.969 ± 0.044
2.321AsnLeu: 2.321 ± 0.058
0.767AsnMet: 0.767 ± 0.033
0.905AsnAsn: 0.905 ± 0.052
1.934AsnPro: 1.934 ± 0.052
0.865AsnGln: 0.865 ± 0.04
1.739AsnArg: 1.739 ± 0.049
1.378AsnSer: 1.378 ± 0.048
1.778AsnThr: 1.778 ± 0.069
2.228AsnVal: 2.228 ± 0.057
0.414AsnTrp: 0.414 ± 0.023
0.791AsnTyr: 0.791 ± 0.037
0.0AsnXaa: 0.0 ± 0.0
Pro
5.384ProAla: 5.384 ± 0.101
0.392ProCys: 0.392 ± 0.023
3.917ProAsp: 3.917 ± 0.081
3.208ProGlu: 3.208 ± 0.074
1.593ProPhe: 1.593 ± 0.04
3.592ProGly: 3.592 ± 0.069
1.065ProHis: 1.065 ± 0.043
2.259ProIle: 2.259 ± 0.058
1.708ProLys: 1.708 ± 0.058
3.856ProLeu: 3.856 ± 0.083
1.264ProMet: 1.264 ± 0.044
1.489ProAsn: 1.489 ± 0.047
1.581ProPro: 1.581 ± 0.058
2.064ProGln: 2.064 ± 0.058
2.866ProArg: 2.866 ± 0.079
2.937ProSer: 2.937 ± 0.067
3.085ProThr: 3.085 ± 0.067
3.717ProVal: 3.717 ± 0.075
0.738ProTrp: 0.738 ± 0.033
1.396ProTyr: 1.396 ± 0.046
0.0ProXaa: 0.0 ± 0.0
Gln
3.714GlnAla: 3.714 ± 0.103
0.316GlnCys: 0.316 ± 0.024
1.612GlnAsp: 1.612 ± 0.05
1.667GlnGlu: 1.667 ± 0.046
0.977GlnPhe: 0.977 ± 0.044
2.303GlnGly: 2.303 ± 0.057
0.741GlnHis: 0.741 ± 0.034
1.984GlnIle: 1.984 ± 0.044
0.913GlnLys: 0.913 ± 0.037
3.235GlnLeu: 3.235 ± 0.067
1.001GlnMet: 1.001 ± 0.039
0.812GlnAsn: 0.812 ± 0.036
1.885GlnPro: 1.885 ± 0.067
1.692GlnGln: 1.692 ± 0.072
2.48GlnArg: 2.48 ± 0.066
1.693GlnSer: 1.693 ± 0.061
2.067GlnThr: 2.067 ± 0.068
2.244GlnVal: 2.244 ± 0.058
0.653GlnTrp: 0.653 ± 0.029
1.101GlnTyr: 1.101 ± 0.045
0.0GlnXaa: 0.0 ± 0.0
Arg
6.9ArgAla: 6.9 ± 0.124
0.648ArgCys: 0.648 ± 0.034
4.315ArgAsp: 4.315 ± 0.103
3.835ArgGlu: 3.835 ± 0.087
2.64ArgPhe: 2.64 ± 0.072
4.351ArgGly: 4.351 ± 0.094
1.814ArgHis: 1.814 ± 0.056
4.074ArgIle: 4.074 ± 0.074
2.335ArgLys: 2.335 ± 0.068
6.198ArgLeu: 6.198 ± 0.128
2.262ArgMet: 2.262 ± 0.057
2.02ArgAsn: 2.02 ± 0.061
3.044ArgPro: 3.044 ± 0.091
2.327ArgGln: 2.327 ± 0.071
6.284ArgArg: 6.284 ± 0.176
3.218ArgSer: 3.218 ± 0.071
4.117ArgThr: 4.117 ± 0.081
4.584ArgVal: 4.584 ± 0.091
1.023ArgTrp: 1.023 ± 0.041
2.011ArgTyr: 2.011 ± 0.061
0.0ArgXaa: 0.0 ± 0.0
Ser
5.908SerAla: 5.908 ± 0.105
0.505SerCys: 0.505 ± 0.026
3.535SerAsp: 3.535 ± 0.08
2.547SerGlu: 2.547 ± 0.063
1.802SerPhe: 1.802 ± 0.051
4.862SerGly: 4.862 ± 0.099
1.079SerHis: 1.079 ± 0.035
2.915SerIle: 2.915 ± 0.069
1.746SerLys: 1.746 ± 0.053
4.554SerLeu: 4.554 ± 0.087
1.651SerMet: 1.651 ± 0.05
1.663SerAsn: 1.663 ± 0.055
2.421SerPro: 2.421 ± 0.051
1.771SerGln: 1.771 ± 0.051
3.3SerArg: 3.3 ± 0.074
3.46SerSer: 3.46 ± 0.095
3.39SerThr: 3.39 ± 0.085
4.183SerVal: 4.183 ± 0.091
0.84SerTrp: 0.84 ± 0.036
1.501SerTyr: 1.501 ± 0.046
0.0SerXaa: 0.0 ± 0.0
Thr
6.857ThrAla: 6.857 ± 0.143
0.552ThrCys: 0.552 ± 0.028
3.984ThrAsp: 3.984 ± 0.1
2.565ThrGlu: 2.565 ± 0.077
1.96ThrPhe: 1.96 ± 0.058
4.957ThrGly: 4.957 ± 0.1
1.244ThrHis: 1.244 ± 0.037
3.379ThrIle: 3.379 ± 0.082
2.066ThrLys: 2.066 ± 0.057
5.83ThrLeu: 5.83 ± 0.096
1.668ThrMet: 1.668 ± 0.054
1.859ThrAsn: 1.859 ± 0.062
3.825ThrPro: 3.825 ± 0.06
1.968ThrGln: 1.968 ± 0.059
3.483ThrArg: 3.483 ± 0.082
3.207ThrSer: 3.207 ± 0.066
3.914ThrThr: 3.914 ± 0.094
5.279ThrVal: 5.279 ± 0.122
0.778ThrTrp: 0.778 ± 0.033
1.517ThrTyr: 1.517 ± 0.05
0.0ThrXaa: 0.0 ± 0.0
Val
8.685ValAla: 8.685 ± 0.116
1.04ValCys: 1.04 ± 0.035
5.849ValAsp: 5.849 ± 0.1
4.534ValGlu: 4.534 ± 0.095
2.861ValPhe: 2.861 ± 0.074
5.384ValGly: 5.384 ± 0.109
1.675ValHis: 1.675 ± 0.046
3.946ValIle: 3.946 ± 0.08
2.431ValLys: 2.431 ± 0.073
6.71ValLeu: 6.71 ± 0.118
1.839ValMet: 1.839 ± 0.06
2.36ValAsn: 2.36 ± 0.062
3.87ValPro: 3.87 ± 0.08
2.148ValGln: 2.148 ± 0.054
5.017ValArg: 5.017 ± 0.097
4.541ValSer: 4.541 ± 0.081
5.086ValThr: 5.086 ± 0.107
6.59ValVal: 6.59 ± 0.113
1.115ValTrp: 1.115 ± 0.042
1.899ValTyr: 1.899 ± 0.054
0.0ValXaa: 0.0 ± 0.0
Trp
1.29TrpAla: 1.29 ± 0.05
0.188TrpCys: 0.188 ± 0.016
0.945TrpAsp: 0.945 ± 0.042
0.641TrpGlu: 0.641 ± 0.032
0.555TrpPhe: 0.555 ± 0.031
0.947TrpGly: 0.947 ± 0.036
0.339TrpHis: 0.339 ± 0.024
0.762TrpIle: 0.762 ± 0.036
0.534TrpLys: 0.534 ± 0.03
1.505TrpLeu: 1.505 ± 0.052
0.46TrpMet: 0.46 ± 0.025
0.588TrpAsn: 0.588 ± 0.031
0.599TrpPro: 0.599 ± 0.028
0.552TrpGln: 0.552 ± 0.027
1.094TrpArg: 1.094 ± 0.041
0.847TrpSer: 0.847 ± 0.036
0.913TrpThr: 0.913 ± 0.038
0.902TrpVal: 0.902 ± 0.038
0.346TrpTrp: 0.346 ± 0.022
0.431TrpTyr: 0.431 ± 0.026
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.199TyrAla: 3.199 ± 0.069
0.334TyrCys: 0.334 ± 0.025
2.043TyrAsp: 2.043 ± 0.062
1.583TyrGlu: 1.583 ± 0.048
0.862TyrPhe: 0.862 ± 0.033
2.574TyrGly: 2.574 ± 0.074
0.489TyrHis: 0.489 ± 0.028
1.138TyrIle: 1.138 ± 0.042
0.751TyrLys: 0.751 ± 0.038
2.242TyrLeu: 2.242 ± 0.06
0.637TyrMet: 0.637 ± 0.029
0.812TyrAsn: 0.812 ± 0.038
1.272TyrPro: 1.272 ± 0.044
0.824TyrGln: 0.824 ± 0.031
1.925TyrArg: 1.925 ± 0.053
1.383TyrSer: 1.383 ± 0.044
1.629TyrThr: 1.629 ± 0.059
2.042TyrVal: 2.042 ± 0.055
0.421TyrTrp: 0.421 ± 0.024
0.766TyrTyr: 0.766 ± 0.035
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2051 proteins (719393 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski