Amino acid dipepetide frequency for Moorella thermoacetica (strain ATCC 39073 / JCM 9320)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.935AlaAla: 13.935 ± 0.185	1.26AlaCys: 1.26 ± 0.049	4.259AlaAsp: 4.259 ± 0.092	5.884AlaGlu: 5.884 ± 0.093	3.203AlaPhe: 3.203 ± 0.071	11.369AlaGly: 11.369 ± 0.141	1.49AlaHis: 1.49 ± 0.049	6.169AlaIle: 6.169 ± 0.099	3.063AlaLys: 3.063 ± 0.079	11.562AlaLeu: 11.562 ± 0.131	2.572AlaMet: 2.572 ± 0.067	2.5AlaAsn: 2.5 ± 0.067	3.784AlaPro: 3.784 ± 0.081	2.378AlaGln: 2.378 ± 0.057	8.913AlaArg: 8.913 ± 0.121	4.495AlaSer: 4.495 ± 0.086	5.239AlaThr: 5.239 ± 0.092	8.176AlaVal: 8.176 ± 0.104	1.181AlaTrp: 1.181 ± 0.036	2.719AlaTyr: 2.719 ± 0.053	0.0AlaXaa: 0.0 ± 0.0
Cys	0.77CysAla: 0.77 ± 0.037	0.192CysCys: 0.192 ± 0.018	0.414CysAsp: 0.414 ± 0.025	0.422CysGlu: 0.422 ± 0.024	0.343CysPhe: 0.343 ± 0.025	1.265CysGly: 1.265 ± 0.05	0.313CysHis: 0.313 ± 0.019	0.515CysIle: 0.515 ± 0.025	0.289CysLys: 0.289 ± 0.02	1.145CysLeu: 1.145 ± 0.038	0.194CysMet: 0.194 ± 0.017	0.329CysAsn: 0.329 ± 0.023	0.862CysPro: 0.862 ± 0.041	0.456CysGln: 0.456 ± 0.028	1.087CysArg: 1.087 ± 0.046	0.531CysSer: 0.531 ± 0.031	0.48CysThr: 0.48 ± 0.025	0.519CysVal: 0.519 ± 0.029	0.121CysTrp: 0.121 ± 0.013	0.344CysTyr: 0.344 ± 0.022	0.0CysXaa: 0.0 ± 0.0
Asp	3.784AspAla: 3.784 ± 0.072	0.475AspCys: 0.475 ± 0.026	1.788AspAsp: 1.788 ± 0.054	2.676AspGlu: 2.676 ± 0.065	2.01AspPhe: 2.01 ± 0.051	3.599AspGly: 3.599 ± 0.081	0.771AspHis: 0.771 ± 0.034	3.144AspIle: 3.144 ± 0.065	2.027AspLys: 2.027 ± 0.061	5.977AspLeu: 5.977 ± 0.1	0.974AspMet: 0.974 ± 0.038	1.423AspAsn: 1.423 ± 0.051	2.866AspPro: 2.866 ± 0.066	1.451AspGln: 1.451 ± 0.044	3.047AspArg: 3.047 ± 0.068	1.714AspSer: 1.714 ± 0.045	2.152AspThr: 2.152 ± 0.06	3.079AspVal: 3.079 ± 0.066	0.638AspTrp: 0.638 ± 0.029	1.722AspTyr: 1.722 ± 0.046	0.0AspXaa: 0.0 ± 0.0
Glu	7.43GluAla: 7.43 ± 0.11	0.496GluCys: 0.496 ± 0.027	2.88GluAsp: 2.88 ± 0.067	5.855GluGlu: 5.855 ± 0.127	1.952GluPhe: 1.952 ± 0.049	5.109GluGly: 5.109 ± 0.088	1.125GluHis: 1.125 ± 0.036	4.788GluIle: 4.788 ± 0.089	4.095GluLys: 4.095 ± 0.089	7.378GluLeu: 7.378 ± 0.121	1.817GluMet: 1.817 ± 0.051	2.088GluAsn: 2.088 ± 0.059	2.511GluPro: 2.511 ± 0.061	2.422GluGln: 2.422 ± 0.067	4.517GluArg: 4.517 ± 0.092	1.996GluSer: 1.996 ± 0.051	3.022GluThr: 3.022 ± 0.064	5.897GluVal: 5.897 ± 0.09	0.584GluTrp: 0.584 ± 0.029	1.68GluTyr: 1.68 ± 0.054	0.0GluXaa: 0.0 ± 0.0
Phe	2.887PheAla: 2.887 ± 0.063	0.435PheCys: 0.435 ± 0.025	1.536PheAsp: 1.536 ± 0.056	1.46PheGlu: 1.46 ± 0.052	1.664PhePhe: 1.664 ± 0.057	2.671PheGly: 2.671 ± 0.057	0.697PheHis: 0.697 ± 0.029	2.347PheIle: 2.347 ± 0.068	1.491PheLys: 1.491 ± 0.048	4.259PheLeu: 4.259 ± 0.084	0.763PheMet: 0.763 ± 0.038	1.366PheAsn: 1.366 ± 0.04	1.663PhePro: 1.663 ± 0.054	1.185PheGln: 1.185 ± 0.039	1.964PheArg: 1.964 ± 0.044	1.925PheSer: 1.925 ± 0.047	2.117PheThr: 2.117 ± 0.051	2.011PheVal: 2.011 ± 0.056	0.444PheTrp: 0.444 ± 0.024	1.383PheTyr: 1.383 ± 0.045	0.0PheXaa: 0.0 ± 0.0
Gly	7.452GlyAla: 7.452 ± 0.118	1.081GlyCys: 1.081 ± 0.042	3.728GlyAsp: 3.728 ± 0.08	5.589GlyGlu: 5.589 ± 0.085	3.019GlyPhe: 3.019 ± 0.06	6.892GlyGly: 6.892 ± 0.129	1.605GlyHis: 1.605 ± 0.051	5.621GlyIle: 5.621 ± 0.102	4.248GlyLys: 4.248 ± 0.091	9.689GlyLeu: 9.689 ± 0.134	2.133GlyMet: 2.133 ± 0.051	2.663GlyAsn: 2.663 ± 0.065	3.401GlyPro: 3.401 ± 0.074	3.349GlyGln: 3.349 ± 0.078	6.276GlyArg: 6.276 ± 0.101	4.245GlySer: 4.245 ± 0.094	4.34GlyThr: 4.34 ± 0.09	6.389GlyVal: 6.389 ± 0.106	1.16GlyTrp: 1.16 ± 0.042	3.022GlyTyr: 3.022 ± 0.072	0.0GlyXaa: 0.0 ± 0.0
His	1.184HisAla: 1.184 ± 0.045	0.269HisCys: 0.269 ± 0.021	0.773HisAsp: 0.773 ± 0.031	0.879HisGlu: 0.879 ± 0.035	0.762HisPhe: 0.762 ± 0.031	1.491HisGly: 1.491 ± 0.048	0.463HisHis: 0.463 ± 0.026	1.015HisIle: 1.015 ± 0.039	0.548HisLys: 0.548 ± 0.029	2.399HisLeu: 2.399 ± 0.059	0.305HisMet: 0.305 ± 0.021	0.587HisAsn: 0.587 ± 0.027	1.278HisPro: 1.278 ± 0.041	0.753HisGln: 0.753 ± 0.035	1.269HisArg: 1.269 ± 0.046	0.779HisSer: 0.779 ± 0.036	0.861HisThr: 0.861 ± 0.034	0.939HisVal: 0.939 ± 0.036	0.202HisTrp: 0.202 ± 0.017	0.636HisTyr: 0.636 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	5.907IleAla: 5.907 ± 0.082	0.664IleCys: 0.664 ± 0.031	3.027IleAsp: 3.027 ± 0.068	3.313IleGlu: 3.313 ± 0.068	2.34IlePhe: 2.34 ± 0.065	4.38IleGly: 4.38 ± 0.089	0.998IleHis: 0.998 ± 0.039	4.452IleIle: 4.452 ± 0.092	3.248IleLys: 3.248 ± 0.081	6.62IleLeu: 6.62 ± 0.103	1.419IleMet: 1.419 ± 0.045	2.347IleAsn: 2.347 ± 0.052	3.223IlePro: 3.223 ± 0.072	1.788IleGln: 1.788 ± 0.053	3.41IleArg: 3.41 ± 0.062	3.094IleSer: 3.094 ± 0.071	3.775IleThr: 3.775 ± 0.08	3.944IleVal: 3.944 ± 0.077	0.585IleTrp: 0.585 ± 0.029	1.87IleTyr: 1.87 ± 0.049	0.0IleXaa: 0.0 ± 0.0
Lys	4.027LysAla: 4.027 ± 0.079	0.301LysCys: 0.301 ± 0.023	2.155LysAsp: 2.155 ± 0.057	3.918LysGlu: 3.918 ± 0.093	1.113LysPhe: 1.113 ± 0.047	3.509LysGly: 3.509 ± 0.074	0.589LysHis: 0.589 ± 0.028	3.046LysIle: 3.046 ± 0.069	2.629LysLys: 2.629 ± 0.074	3.917LysLeu: 3.917 ± 0.082	1.201LysMet: 1.201 ± 0.042	1.595LysAsn: 1.595 ± 0.049	1.918LysPro: 1.918 ± 0.056	1.309LysGln: 1.309 ± 0.053	2.397LysArg: 2.397 ± 0.068	1.766LysSer: 1.766 ± 0.045	2.076LysThr: 2.076 ± 0.051	3.687LysVal: 3.687 ± 0.079	0.412LysTrp: 0.412 ± 0.023	1.285LysTyr: 1.285 ± 0.038	0.0LysXaa: 0.0 ± 0.0
Leu	14.809LeuAla: 14.809 ± 0.196	0.93LeuCys: 0.93 ± 0.036	5.313LeuAsp: 5.313 ± 0.102	8.237LeuGlu: 8.237 ± 0.125	3.454LeuPhe: 3.454 ± 0.08	8.902LeuGly: 8.902 ± 0.148	1.804LeuHis: 1.804 ± 0.047	5.779LeuIle: 5.779 ± 0.105	5.748LeuLys: 5.748 ± 0.098	11.538LeuLeu: 11.538 ± 0.177	2.236LeuMet: 2.236 ± 0.059	3.286LeuAsn: 3.286 ± 0.064	6.279LeuPro: 6.279 ± 0.097	4.143LeuGln: 4.143 ± 0.073	6.44LeuArg: 6.44 ± 0.112	4.877LeuSer: 4.877 ± 0.083	5.857LeuThr: 5.857 ± 0.091	8.83LeuVal: 8.83 ± 0.117	1.025LeuTrp: 1.025 ± 0.041	2.852LeuTyr: 2.852 ± 0.073	0.0LeuXaa: 0.0 ± 0.0
Met	3.059MetAla: 3.059 ± 0.071	0.16MetCys: 0.16 ± 0.013	1.081MetAsp: 1.081 ± 0.036	1.619MetGlu: 1.619 ± 0.055	0.642MetPhe: 0.642 ± 0.03	1.967MetGly: 1.967 ± 0.051	0.367MetHis: 0.367 ± 0.024	1.148MetIle: 1.148 ± 0.043	0.996MetLys: 0.996 ± 0.042	2.246MetLeu: 2.246 ± 0.058	0.477MetMet: 0.477 ± 0.027	0.66MetAsn: 0.66 ± 0.027	1.205MetPro: 1.205 ± 0.039	0.787MetGln: 0.787 ± 0.031	1.123MetArg: 1.123 ± 0.04	0.922MetSer: 0.922 ± 0.035	1.229MetThr: 1.229 ± 0.046	2.101MetVal: 2.101 ± 0.054	0.173MetTrp: 0.173 ± 0.016	0.455MetTyr: 0.455 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	2.262AsnAla: 2.262 ± 0.055	0.406AsnCys: 0.406 ± 0.025	1.252AsnAsp: 1.252 ± 0.041	1.567AsnGlu: 1.567 ± 0.055	1.229AsnPhe: 1.229 ± 0.039	2.33AsnGly: 2.33 ± 0.065	0.548AsnHis: 0.548 ± 0.03	2.167AsnIle: 2.167 ± 0.055	1.268AsnLys: 1.268 ± 0.042	3.981AsnLeu: 3.981 ± 0.073	0.656AsnMet: 0.656 ± 0.029	1.144AsnAsn: 1.144 ± 0.042	2.217AsnPro: 2.217 ± 0.05	1.051AsnGln: 1.051 ± 0.036	2.038AsnArg: 2.038 ± 0.052	1.446AsnSer: 1.446 ± 0.046	1.438AsnThr: 1.438 ± 0.042	1.811AsnVal: 1.811 ± 0.053	0.427AsnTrp: 0.427 ± 0.028	1.16AsnTyr: 1.16 ± 0.042	0.0AsnXaa: 0.0 ± 0.0
Pro	5.839ProAla: 5.839 ± 0.097	0.481ProCys: 0.481 ± 0.022	2.707ProAsp: 2.707 ± 0.062	4.539ProGlu: 4.539 ± 0.082	1.737ProPhe: 1.737 ± 0.046	5.885ProGly: 5.885 ± 0.106	0.831ProHis: 0.831 ± 0.038	1.931ProIle: 1.931 ± 0.048	1.236ProLys: 1.236 ± 0.044	5.085ProLeu: 5.085 ± 0.086	0.843ProMet: 0.843 ± 0.037	1.103ProAsn: 1.103 ± 0.038	2.596ProPro: 2.596 ± 0.069	1.468ProGln: 1.468 ± 0.047	3.179ProArg: 3.179 ± 0.071	1.996ProSer: 1.996 ± 0.055	1.859ProThr: 1.859 ± 0.052	4.75ProVal: 4.75 ± 0.087	0.629ProTrp: 0.629 ± 0.028	1.591ProTyr: 1.591 ± 0.053	0.0ProXaa: 0.0 ± 0.0
Gln	4.22GlnAla: 4.22 ± 0.089	0.297GlnCys: 0.297 ± 0.02	1.53GlnAsp: 1.53 ± 0.041	3.372GlnGlu: 3.372 ± 0.074	0.879GlnPhe: 0.879 ± 0.037	3.036GlnGly: 3.036 ± 0.063	0.572GlnHis: 0.572 ± 0.03	1.744GlnIle: 1.744 ± 0.056	1.68GlnLys: 1.68 ± 0.053	3.39GlnLeu: 3.39 ± 0.077	0.857GlnMet: 0.857 ± 0.034	0.835GlnAsn: 0.835 ± 0.027	1.734GlnPro: 1.734 ± 0.052	1.736GlnGln: 1.736 ± 0.064	2.209GlnArg: 2.209 ± 0.059	1.162GlnSer: 1.162 ± 0.037	1.275GlnThr: 1.275 ± 0.04	3.776GlnVal: 3.776 ± 0.077	0.305GlnTrp: 0.305 ± 0.019	0.869GlnTyr: 0.869 ± 0.039	0.0GlnXaa: 0.0 ± 0.0
Arg	6.04ArgAla: 6.04 ± 0.092	0.765ArgCys: 0.765 ± 0.037	3.087ArgAsp: 3.087 ± 0.066	6.388ArgGlu: 6.388 ± 0.102	2.002ArgPhe: 2.002 ± 0.048	5.049ArgGly: 5.049 ± 0.08	1.357ArgHis: 1.357 ± 0.044	3.37ArgIle: 3.37 ± 0.07	2.415ArgLys: 2.415 ± 0.07	8.282ArgLeu: 8.282 ± 0.12	1.399ArgMet: 1.399 ± 0.041	1.756ArgAsn: 1.756 ± 0.052	3.406ArgPro: 3.406 ± 0.064	3.739ArgGln: 3.739 ± 0.092	5.774ArgArg: 5.774 ± 0.102	2.526ArgSer: 2.526 ± 0.06	2.523ArgThr: 2.523 ± 0.056	5.74ArgVal: 5.74 ± 0.09	0.838ArgTrp: 0.838 ± 0.034	2.22ArgTyr: 2.22 ± 0.05	0.0ArgXaa: 0.0 ± 0.0
Ser	3.123SerAla: 3.123 ± 0.073	0.555SerCys: 0.555 ± 0.027	1.793SerAsp: 1.793 ± 0.056	2.052SerGlu: 2.052 ± 0.051	1.885SerPhe: 1.885 ± 0.042	4.305SerGly: 4.305 ± 0.096	0.878SerHis: 0.878 ± 0.036	2.596SerIle: 2.596 ± 0.062	1.499SerLys: 1.499 ± 0.045	5.756SerLeu: 5.756 ± 0.099	1.057SerMet: 1.057 ± 0.038	1.258SerAsn: 1.258 ± 0.047	2.417SerPro: 2.417 ± 0.065	1.623SerGln: 1.623 ± 0.045	3.578SerArg: 3.578 ± 0.067	2.245SerSer: 2.245 ± 0.072	2.296SerThr: 2.296 ± 0.057	2.59SerVal: 2.59 ± 0.069	0.686SerTrp: 0.686 ± 0.031	1.405SerTyr: 1.405 ± 0.043	0.0SerXaa: 0.0 ± 0.0
Thr	5.448ThrAla: 5.448 ± 0.093	0.584ThrCys: 0.584 ± 0.027	1.987ThrAsp: 1.987 ± 0.058	2.385ThrGlu: 2.385 ± 0.056	1.869ThrPhe: 1.869 ± 0.057	5.465ThrGly: 5.465 ± 0.088	0.83ThrHis: 0.83 ± 0.033	3.349ThrIle: 3.349 ± 0.062	1.399ThrLys: 1.399 ± 0.04	5.473ThrLeu: 5.473 ± 0.099	1.072ThrMet: 1.072 ± 0.037	1.311ThrAsn: 1.311 ± 0.05	2.977ThrPro: 2.977 ± 0.069	1.083ThrGln: 1.083 ± 0.038	3.382ThrArg: 3.382 ± 0.063	2.54ThrSer: 2.54 ± 0.06	2.873ThrThr: 2.873 ± 0.065	3.958ThrVal: 3.958 ± 0.079	0.646ThrTrp: 0.646 ± 0.031	1.436ThrTyr: 1.436 ± 0.041	0.0ThrXaa: 0.0 ± 0.0
Val	8.754ValAla: 8.754 ± 0.117	0.69ValCys: 0.69 ± 0.029	3.998ValAsp: 3.998 ± 0.073	5.135ValGlu: 5.135 ± 0.093	2.546ValPhe: 2.546 ± 0.066	5.224ValGly: 5.224 ± 0.09	1.161ValHis: 1.161 ± 0.043	5.086ValIle: 5.086 ± 0.097	3.695ValLys: 3.695 ± 0.076	8.154ValLeu: 8.154 ± 0.121	1.737ValMet: 1.737 ± 0.052	2.685ValAsn: 2.685 ± 0.062	3.759ValPro: 3.759 ± 0.07	2.365ValGln: 2.365 ± 0.052	4.619ValArg: 4.619 ± 0.083	3.439ValSer: 3.439 ± 0.07	4.675ValThr: 4.675 ± 0.083	6.155ValVal: 6.155 ± 0.106	0.634ValTrp: 0.634 ± 0.033	2.149ValTyr: 2.149 ± 0.049	0.0ValXaa: 0.0 ± 0.0
Trp	0.867TrpAla: 0.867 ± 0.038	0.1TrpCys: 0.1 ± 0.011	0.509TrpAsp: 0.509 ± 0.026	0.849TrpGlu: 0.849 ± 0.035	0.334TrpPhe: 0.334 ± 0.024	0.872TrpGly: 0.872 ± 0.035	0.246TrpHis: 0.246 ± 0.017	0.439TrpIle: 0.439 ± 0.025	0.358TrpLys: 0.358 ± 0.025	1.503TrpLeu: 1.503 ± 0.046	0.25TrpMet: 0.25 ± 0.018	0.315TrpAsn: 0.315 ± 0.02	0.617TrpPro: 0.617 ± 0.029	0.923TrpGln: 0.923 ± 0.038	0.946TrpArg: 0.946 ± 0.039	0.537TrpSer: 0.537 ± 0.024	0.455TrpThr: 0.455 ± 0.029	0.644TrpVal: 0.644 ± 0.031	0.215TrpTrp: 0.215 ± 0.018	0.322TrpTyr: 0.322 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.354TyrAla: 2.354 ± 0.053	0.451TyrCys: 0.451 ± 0.028	1.503TyrAsp: 1.503 ± 0.047	1.503TyrGlu: 1.503 ± 0.048	1.287TyrPhe: 1.287 ± 0.038	2.583TyrGly: 2.583 ± 0.063	0.746TyrHis: 0.746 ± 0.035	1.696TyrIle: 1.696 ± 0.045	0.918TyrLys: 0.918 ± 0.037	3.985TyrLeu: 3.985 ± 0.085	0.454TyrMet: 0.454 ± 0.027	1.144TyrAsn: 1.144 ± 0.039	1.573TyrPro: 1.573 ± 0.045	1.47TyrGln: 1.47 ± 0.047	2.508TyrArg: 2.508 ± 0.068	1.358TyrSer: 1.358 ± 0.046	1.526TyrThr: 1.526 ± 0.052	1.667TyrVal: 1.667 ± 0.043	0.394TyrTrp: 0.394 ± 0.026	1.156TyrTyr: 1.156 ± 0.045	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2451 proteins (751866 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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