Human cyclovirus

Taxonomy: Viruses; Monodnaviria; Shotokuvirae; Cressdnaviricota; Arfiviricetes; Cirlivirales; Circoviridae; Cyclovirus; unclassified Cyclovirus

Average proteome isoelectric point is 8.7

Get precalculated fractions of proteins

Acidic
pI < 6.8
6.8-7.4
pI > 7.4
Basic
    
All



Virtual 2D-PAGE plot for 2 proteins (isoelectric point calculated using IPC2_protein)

Get csv file with sequences according to given criteria:
        -     Method 

     -  kDa    
                                                                                      

* You can choose from 21 different methods for calculating isoelectric point

Summary statistics related to proteome-wise predictions


    
Protein with the lowest isoelectric point:
>tr|W5ZU54|W5ZU54_9CIRC Capsid protein OS=Human cyclovirus OX=1455626 PE=4 SV=1
MM1 pKa = 7.18NSVVRR6 pKa = 11.84RR7 pKa = 11.84FCFTWHH13 pKa = 7.63DD14 pKa = 3.96YY15 pKa = 11.15DD16 pKa = 5.87CEE18 pKa = 4.16DD19 pKa = 3.19VAKK22 pKa = 9.79TEE24 pKa = 4.25RR25 pKa = 11.84FINTHH30 pKa = 5.5CKK32 pKa = 9.81YY33 pKa = 10.69GIFGKK38 pKa = 8.63EE39 pKa = 3.59VCPDD43 pKa = 2.94TRR45 pKa = 11.84RR46 pKa = 11.84IHH48 pKa = 6.34LQGFCSLAKK57 pKa = 9.8PKK59 pKa = 10.13RR60 pKa = 11.84FKK62 pKa = 9.89WIKK65 pKa = 8.43EE66 pKa = 3.76QLSNRR71 pKa = 11.84IHH73 pKa = 6.64IEE75 pKa = 3.52KK76 pKa = 10.88AMGSDD81 pKa = 4.36KK82 pKa = 11.06EE83 pKa = 4.14NQQYY87 pKa = 10.51CSKK90 pKa = 10.48SGKK93 pKa = 9.76FFEE96 pKa = 5.1KK97 pKa = 10.55GSPSEE102 pKa = 4.23GSGQRR107 pKa = 11.84TDD109 pKa = 3.0IQSLLEE115 pKa = 4.25TIQGGEE121 pKa = 3.45HH122 pKa = 7.43DD123 pKa = 3.79IRR125 pKa = 11.84RR126 pKa = 11.84IAEE129 pKa = 4.05KK130 pKa = 10.64HH131 pKa = 4.9PACYY135 pKa = 9.3IRR137 pKa = 11.84YY138 pKa = 8.05YY139 pKa = 10.56RR140 pKa = 11.84GIRR143 pKa = 11.84SYY145 pKa = 11.49LNLVAPVSPRR155 pKa = 11.84NFKK158 pKa = 10.36TEE160 pKa = 3.23VRR162 pKa = 11.84YY163 pKa = 9.96YY164 pKa = 9.6WGPPGSGKK172 pKa = 8.77SRR174 pKa = 11.84RR175 pKa = 11.84SLEE178 pKa = 4.08EE179 pKa = 3.49SSGLLDD185 pKa = 3.07GTVYY189 pKa = 10.54YY190 pKa = 10.39KK191 pKa = 10.64PRR193 pKa = 11.84GEE195 pKa = 3.68WWDD198 pKa = 3.98GYY200 pKa = 7.75MQQTSVIIDD209 pKa = 4.09DD210 pKa = 4.39FYY212 pKa = 11.87GWIKK216 pKa = 10.75YY217 pKa = 10.28DD218 pKa = 4.1EE219 pKa = 4.44LLKK222 pKa = 10.69ICDD225 pKa = 4.0RR226 pKa = 11.84YY227 pKa = 8.51PHH229 pKa = 6.56KK230 pKa = 11.23VPIKK234 pKa = 10.44GGFEE238 pKa = 4.18EE239 pKa = 4.92FTSKK243 pKa = 11.17YY244 pKa = 10.6IFITSNVDD252 pKa = 2.89VCDD255 pKa = 4.02LYY257 pKa = 11.53KK258 pKa = 11.06FNGYY262 pKa = 5.83TTAAIDD268 pKa = 3.36RR269 pKa = 11.84RR270 pKa = 11.84ITIKK274 pKa = 10.81EE275 pKa = 3.92NIII278 pKa = 3.67

Molecular weight: 32.54 kDa
Isoelectric point according different methods:





Protein with the highest isoelectric point:
>tr|W5ZU54|W5ZU54_9CIRC Capsid protein OS=Human cyclovirus OX=1455626 PE=4 SV=1
MM1 pKa = 7.67ALRR4 pKa = 11.84RR5 pKa = 11.84RR6 pKa = 11.84FKK8 pKa = 10.33ARR10 pKa = 11.84RR11 pKa = 11.84PVRR14 pKa = 11.84RR15 pKa = 11.84YY16 pKa = 8.62KK17 pKa = 10.49RR18 pKa = 11.84RR19 pKa = 11.84FMRR22 pKa = 11.84YY23 pKa = 6.66RR24 pKa = 11.84RR25 pKa = 11.84RR26 pKa = 11.84RR27 pKa = 11.84KK28 pKa = 8.04YY29 pKa = 7.41QQRR32 pKa = 11.84VKK34 pKa = 9.76PGDD37 pKa = 3.54MIIQLKK43 pKa = 10.19RR44 pKa = 11.84IRR46 pKa = 11.84TVKK49 pKa = 10.47VNSQVNEE56 pKa = 4.08YY57 pKa = 10.4IGLNFTAKK65 pKa = 10.32DD66 pKa = 3.97FPEE69 pKa = 4.44LQPFLTQFEE78 pKa = 4.37AFQFQRR84 pKa = 11.84YY85 pKa = 6.89AVKK88 pKa = 10.56VIPSMNVSNNSTSRR102 pKa = 11.84IGTYY106 pKa = 10.59CLVPWHH112 pKa = 6.89KK113 pKa = 10.2KK114 pKa = 4.05TTKK117 pKa = 7.32PTNYY121 pKa = 10.33SSMLSIDD128 pKa = 3.08KK129 pKa = 10.74SRR131 pKa = 11.84VYY133 pKa = 10.59RR134 pKa = 11.84GTQTAYY140 pKa = 10.54RR141 pKa = 11.84SFVPAVHH148 pKa = 5.76VQAEE152 pKa = 4.48TTGTGDD158 pKa = 3.11AAAVIKK164 pKa = 8.99WKK166 pKa = 10.01PRR168 pKa = 11.84IDD170 pKa = 3.76IVNLYY175 pKa = 10.51NDD177 pKa = 3.35VEE179 pKa = 5.23FYY181 pKa = 11.09CGMIGIQGIPDD192 pKa = 3.04ATEE195 pKa = 3.64NVNYY199 pKa = 9.14YY200 pKa = 10.45HH201 pKa = 6.11VVEE204 pKa = 4.39YY205 pKa = 7.72VTCKK209 pKa = 10.69LINQNYY215 pKa = 9.48LNDD218 pKa = 3.77KK219 pKa = 10.1AVQARR224 pKa = 11.84ALEE227 pKa = 4.33EE228 pKa = 4.24SFSEE232 pKa = 4.18AFEE235 pKa = 4.84AII237 pKa = 3.73

Molecular weight: 27.79 kDa
Isoelectric point according different methods:





Peptides (in silico digests for buttom-up proteomics)

Below you can find in silico digests of the whole proteome with Trypsin, Chymotrypsin, Trypsin+LysC, LysN, ArgC proteases suitable for different mass spec machines.

Try
ESI
ChTry
ESI
ArgC
ESI
LysN
ESI
TryLysC
ESI

Try
MALDI
ChTry
MALDI
ArgC
MALDI
LysN
MALDI
TryLysC
MALDI

Try
LTQ
ChTry
LTQ
ArgC
LTQ
LysN
LTQ
TryLysC
LTQ

Try
MSlow
ChTry
MSlow
ArgC
MSlow
LysN
MSlow
TryLysC
MSlow

Try
MShigh
ChTry
MShigh
ArgC
MShigh
LysN
MShigh
TryLysC
MShigh

General Statistics

Number of major isoforms

Number of additional isoforms

Number of all proteins

Number of amino acids

Min. Seq. Length

Max. Seq. Length

Avg. Seq. Length

Avg. Mol. Weight

2

0

2

515

237

278

257.5

30.17

Amino acid frequency

Ala

Cys

Asp

Glu

Phe

Gly

His

Ile

Lys

Leu

4.854 ± 1.397

2.33 ± 0.641

4.66 ± 0.774

5.825 ± 0.713

5.049 ± 0.009

6.019 ± 1.339

1.942 ± 0.407

7.573 ± 0.749

7.573 ± 0.495

4.66 ± 0.011

Met

Asn

Gln

Pro

Arg

Ser

Thr

Val

Trp

Tyr

1.748 ± 0.472

4.466 ± 0.868

4.078 ± 0.085

4.272 ± 0.731

8.738 ± 0.837

6.214 ± 0.693

5.631 ± 0.421

6.408 ± 1.478

1.553 ± 0.427

6.408 ± 0.047
Note: For amino acid frequency statistics the error has been estimated with the bootstraping (x100) at the protein level

Most of the basic statistics you can see at this page can be downloaded from this CSV file

For dipeptide frequency statistics click here
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski