Amino acid dipepetide frequency for Paracoccus alcaliphilus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.789AlaAla: 17.789 ± 0.19	1.015AlaCys: 1.015 ± 0.031	7.491AlaAsp: 7.491 ± 0.096	8.313AlaGlu: 8.313 ± 0.103	3.997AlaPhe: 3.997 ± 0.061	11.54AlaGly: 11.54 ± 0.12	2.4AlaHis: 2.4 ± 0.046	6.403AlaIle: 6.403 ± 0.069	2.833AlaLys: 2.833 ± 0.06	13.938AlaLeu: 13.938 ± 0.139	4.0AlaMet: 4.0 ± 0.061	2.549AlaAsn: 2.549 ± 0.049	6.025AlaPro: 6.025 ± 0.091	4.76AlaGln: 4.76 ± 0.062	10.062AlaArg: 10.062 ± 0.106	5.81AlaSer: 5.81 ± 0.07	6.097AlaThr: 6.097 ± 0.083	8.133AlaVal: 8.133 ± 0.077	1.485AlaTrp: 1.485 ± 0.036	2.139AlaTyr: 2.139 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	0.986CysAla: 0.986 ± 0.029	0.117CysCys: 0.117 ± 0.008	0.606CysAsp: 0.606 ± 0.021	0.39CysGlu: 0.39 ± 0.019	0.298CysPhe: 0.298 ± 0.013	0.905CysGly: 0.905 ± 0.027	0.283CysHis: 0.283 ± 0.014	0.373CysIle: 0.373 ± 0.018	0.175CysLys: 0.175 ± 0.014	0.829CysLeu: 0.829 ± 0.024	0.153CysMet: 0.153 ± 0.011	0.197CysAsn: 0.197 ± 0.011	0.576CysPro: 0.576 ± 0.021	0.242CysGln: 0.242 ± 0.013	0.64CysArg: 0.64 ± 0.023	0.422CysSer: 0.422 ± 0.02	0.363CysThr: 0.363 ± 0.015	0.552CysVal: 0.552 ± 0.021	0.142CysTrp: 0.142 ± 0.01	0.194CysTyr: 0.194 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	7.391AspAla: 7.391 ± 0.086	0.525AspCys: 0.525 ± 0.021	3.61AspAsp: 3.61 ± 0.056	3.568AspGlu: 3.568 ± 0.057	2.309AspPhe: 2.309 ± 0.049	5.665AspGly: 5.665 ± 0.09	1.527AspHis: 1.527 ± 0.032	2.993AspIle: 2.993 ± 0.055	1.365AspLys: 1.365 ± 0.036	6.766AspLeu: 6.766 ± 0.083	1.602AspMet: 1.602 ± 0.034	1.348AspAsn: 1.348 ± 0.032	4.082AspPro: 4.082 ± 0.059	2.265AspGln: 2.265 ± 0.039	4.985AspArg: 4.985 ± 0.063	2.513AspSer: 2.513 ± 0.041	2.581AspThr: 2.581 ± 0.047	3.488AspVal: 3.488 ± 0.058	1.241AspTrp: 1.241 ± 0.034	1.551AspTyr: 1.551 ± 0.034	0.0AspXaa: 0.0 ± 0.0
Glu	7.692GluAla: 7.692 ± 0.086	0.346GluCys: 0.346 ± 0.018	3.01GluAsp: 3.01 ± 0.052	2.86GluGlu: 2.86 ± 0.053	1.691GluPhe: 1.691 ± 0.036	4.782GluGly: 4.782 ± 0.06	1.067GluHis: 1.067 ± 0.026	3.423GluIle: 3.423 ± 0.049	1.663GluLys: 1.663 ± 0.046	5.124GluLeu: 5.124 ± 0.069	1.669GluMet: 1.669 ± 0.03	1.588GluAsn: 1.588 ± 0.036	2.532GluPro: 2.532 ± 0.048	2.001GluGln: 2.001 ± 0.044	4.44GluArg: 4.44 ± 0.063	2.225GluSer: 2.225 ± 0.04	3.397GluThr: 3.397 ± 0.057	3.939GluVal: 3.939 ± 0.048	0.854GluTrp: 0.854 ± 0.029	1.032GluTyr: 1.032 ± 0.027	0.0GluXaa: 0.0 ± 0.0
Phe	4.384PheAla: 4.384 ± 0.059	0.395PheCys: 0.395 ± 0.018	2.667PheAsp: 2.667 ± 0.045	1.812PheGlu: 1.812 ± 0.039	1.288PhePhe: 1.288 ± 0.038	3.518PheGly: 3.518 ± 0.058	0.784PheHis: 0.784 ± 0.024	1.609PheIle: 1.609 ± 0.04	0.69PheLys: 0.69 ± 0.026	3.259PheLeu: 3.259 ± 0.061	0.822PheMet: 0.822 ± 0.023	0.91PheAsn: 0.91 ± 0.024	1.523PhePro: 1.523 ± 0.032	1.069PheGln: 1.069 ± 0.03	2.415PheArg: 2.415 ± 0.047	1.982PheSer: 1.982 ± 0.039	1.936PheThr: 1.936 ± 0.041	2.47PheVal: 2.47 ± 0.046	0.608PheTrp: 0.608 ± 0.025	0.8PheTyr: 0.8 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	10.09GlyAla: 10.09 ± 0.108	0.835GlyCys: 0.835 ± 0.027	4.933GlyAsp: 4.933 ± 0.078	4.38GlyGlu: 4.38 ± 0.07	3.762GlyPhe: 3.762 ± 0.047	7.705GlyGly: 7.705 ± 0.126	2.084GlyHis: 2.084 ± 0.046	4.766GlyIle: 4.766 ± 0.064	2.664GlyLys: 2.664 ± 0.048	9.481GlyLeu: 9.481 ± 0.086	2.785GlyMet: 2.785 ± 0.059	2.289GlyAsn: 2.289 ± 0.062	3.939GlyPro: 3.939 ± 0.055	3.723GlyGln: 3.723 ± 0.06	6.889GlyArg: 6.889 ± 0.088	4.383GlySer: 4.383 ± 0.071	4.424GlyThr: 4.424 ± 0.066	5.972GlyVal: 5.972 ± 0.073	1.662GlyTrp: 1.662 ± 0.038	2.118GlyTyr: 2.118 ± 0.039	0.001GlyXaa: 0.001 ± 0.001
His	2.471HisAla: 2.471 ± 0.045	0.241HisCys: 0.241 ± 0.014	1.453HisAsp: 1.453 ± 0.033	1.08HisGlu: 1.08 ± 0.03	0.822HisPhe: 0.822 ± 0.023	1.986HisGly: 1.986 ± 0.034	0.644HisHis: 0.644 ± 0.022	1.017HisIle: 1.017 ± 0.029	0.441HisLys: 0.441 ± 0.018	2.31HisLeu: 2.31 ± 0.048	0.543HisMet: 0.543 ± 0.021	0.451HisAsn: 0.451 ± 0.017	1.489HisPro: 1.489 ± 0.037	0.671HisGln: 0.671 ± 0.024	1.634HisArg: 1.634 ± 0.037	0.981HisSer: 0.981 ± 0.029	0.662HisThr: 0.662 ± 0.023	1.526HisVal: 1.526 ± 0.031	0.367HisTrp: 0.367 ± 0.016	0.558HisTyr: 0.558 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	7.509IleAla: 7.509 ± 0.088	0.618IleCys: 0.618 ± 0.02	3.444IleAsp: 3.444 ± 0.054	3.525IleGlu: 3.525 ± 0.054	1.697IlePhe: 1.697 ± 0.036	5.16IleGly: 5.16 ± 0.058	1.037IleHis: 1.037 ± 0.025	2.29IleIle: 2.29 ± 0.049	1.02IleLys: 1.02 ± 0.03	4.823IleLeu: 4.823 ± 0.072	1.154IleMet: 1.154 ± 0.034	1.254IleAsn: 1.254 ± 0.029	2.492IlePro: 2.492 ± 0.038	1.181IleGln: 1.181 ± 0.034	3.983IleArg: 3.983 ± 0.056	3.007IleSer: 3.007 ± 0.054	2.882IleThr: 2.882 ± 0.044	3.686IleVal: 3.686 ± 0.053	0.862IleTrp: 0.862 ± 0.025	1.098IleTyr: 1.098 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	3.151LysAla: 3.151 ± 0.059	0.141LysCys: 0.141 ± 0.011	1.397LysAsp: 1.397 ± 0.039	1.139LysGlu: 1.139 ± 0.035	0.719LysPhe: 0.719 ± 0.026	2.227LysGly: 2.227 ± 0.045	0.482LysHis: 0.482 ± 0.019	1.264LysIle: 1.264 ± 0.034	0.833LysLys: 0.833 ± 0.032	2.442LysLeu: 2.442 ± 0.051	0.675LysMet: 0.675 ± 0.029	0.601LysAsn: 0.601 ± 0.023	1.578LysPro: 1.578 ± 0.043	0.802LysGln: 0.802 ± 0.024	1.885LysArg: 1.885 ± 0.044	1.4LysSer: 1.4 ± 0.039	1.536LysThr: 1.536 ± 0.041	1.782LysVal: 1.782 ± 0.041	0.346LysTrp: 0.346 ± 0.016	0.484LysTyr: 0.484 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	13.906LeuAla: 13.906 ± 0.143	0.92LeuCys: 0.92 ± 0.028	6.226LeuAsp: 6.226 ± 0.079	4.922LeuGlu: 4.922 ± 0.061	3.301LeuPhe: 3.301 ± 0.06	8.303LeuGly: 8.303 ± 0.096	2.012LeuHis: 2.012 ± 0.044	5.708LeuIle: 5.708 ± 0.075	2.68LeuLys: 2.68 ± 0.058	9.409LeuLeu: 9.409 ± 0.121	2.679LeuMet: 2.679 ± 0.042	2.574LeuAsn: 2.574 ± 0.042	6.235LeuPro: 6.235 ± 0.09	2.876LeuGln: 2.876 ± 0.056	8.096LeuArg: 8.096 ± 0.079	6.339LeuSer: 6.339 ± 0.067	6.324LeuThr: 6.324 ± 0.071	6.683LeuVal: 6.683 ± 0.084	1.343LeuTrp: 1.343 ± 0.033	1.89LeuTyr: 1.89 ± 0.039	0.0LeuXaa: 0.0 ± 0.0
Met	3.76MetAla: 3.76 ± 0.055	0.146MetCys: 0.146 ± 0.009	1.364MetAsp: 1.364 ± 0.03	1.248MetGlu: 1.248 ± 0.034	0.774MetPhe: 0.774 ± 0.024	2.238MetGly: 2.238 ± 0.04	0.417MetHis: 0.417 ± 0.014	1.58MetIle: 1.58 ± 0.037	0.863MetLys: 0.863 ± 0.025	2.809MetLeu: 2.809 ± 0.049	0.73MetMet: 0.73 ± 0.026	0.864MetAsn: 0.864 ± 0.026	1.628MetPro: 1.628 ± 0.033	1.029MetGln: 1.029 ± 0.029	2.195MetArg: 2.195 ± 0.041	1.698MetSer: 1.698 ± 0.036	1.986MetThr: 1.986 ± 0.037	1.848MetVal: 1.848 ± 0.041	0.231MetTrp: 0.231 ± 0.015	0.293MetTyr: 0.293 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	2.908AsnAla: 2.908 ± 0.049	0.239AsnCys: 0.239 ± 0.015	1.485AsnAsp: 1.485 ± 0.051	1.123AsnGlu: 1.123 ± 0.031	0.859AsnPhe: 0.859 ± 0.025	2.229AsnGly: 2.229 ± 0.053	0.53AsnHis: 0.53 ± 0.019	1.376AsnIle: 1.376 ± 0.034	0.518AsnLys: 0.518 ± 0.019	2.462AsnLeu: 2.462 ± 0.042	0.638AsnMet: 0.638 ± 0.019	0.589AsnAsn: 0.589 ± 0.024	1.879AsnPro: 1.879 ± 0.038	0.737AsnGln: 0.737 ± 0.024	1.943AsnArg: 1.943 ± 0.041	1.175AsnSer: 1.175 ± 0.033	1.163AsnThr: 1.163 ± 0.03	1.587AsnVal: 1.587 ± 0.033	0.465AsnTrp: 0.465 ± 0.019	0.545AsnTyr: 0.545 ± 0.02	0.0AsnXaa: 0.0 ± 0.0
Pro	6.896ProAla: 6.896 ± 0.109	0.368ProCys: 0.368 ± 0.017	4.459ProAsp: 4.459 ± 0.068	4.124ProGlu: 4.124 ± 0.056	1.914ProPhe: 1.914 ± 0.038	5.097ProGly: 5.097 ± 0.075	1.123ProHis: 1.123 ± 0.026	2.198ProIle: 2.198 ± 0.04	1.319ProLys: 1.319 ± 0.032	4.974ProLeu: 4.974 ± 0.071	1.31ProMet: 1.31 ± 0.034	1.195ProAsn: 1.195 ± 0.03	2.643ProPro: 2.643 ± 0.066	1.993ProGln: 1.993 ± 0.039	3.349ProArg: 3.349 ± 0.056	2.56ProSer: 2.56 ± 0.041	2.281ProThr: 2.281 ± 0.043	4.57ProVal: 4.57 ± 0.06	0.7ProTrp: 0.7 ± 0.024	1.014ProTyr: 1.014 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	4.587GlnAla: 4.587 ± 0.063	0.214GlnCys: 0.214 ± 0.013	1.85GlnAsp: 1.85 ± 0.035	1.535GlnGlu: 1.535 ± 0.031	1.029GlnPhe: 1.029 ± 0.026	2.988GlnGly: 2.988 ± 0.046	0.654GlnHis: 0.654 ± 0.022	2.212GlnIle: 2.212 ± 0.042	0.972GlnLys: 0.972 ± 0.031	3.067GlnLeu: 3.067 ± 0.052	1.182GlnMet: 1.182 ± 0.029	0.899GlnAsn: 0.899 ± 0.028	2.268GlnPro: 2.268 ± 0.043	1.466GlnGln: 1.466 ± 0.042	2.676GlnArg: 2.676 ± 0.049	1.772GlnSer: 1.772 ± 0.041	1.821GlnThr: 1.821 ± 0.037	2.575GlnVal: 2.575 ± 0.044	0.403GlnTrp: 0.403 ± 0.016	0.587GlnTyr: 0.587 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	9.066ArgAla: 9.066 ± 0.099	0.543ArgCys: 0.543 ± 0.022	5.017ArgAsp: 5.017 ± 0.065	4.08ArgGlu: 4.08 ± 0.063	2.877ArgPhe: 2.877 ± 0.051	5.257ArgGly: 5.257 ± 0.07	2.019ArgHis: 2.019 ± 0.038	4.711ArgIle: 4.711 ± 0.067	2.2ArgLys: 2.2 ± 0.051	8.713ArgLeu: 8.713 ± 0.099	2.338ArgMet: 2.338 ± 0.042	2.011ArgAsn: 2.011 ± 0.037	4.078ArgPro: 4.078 ± 0.058	3.091ArgGln: 3.091 ± 0.059	6.362ArgArg: 6.362 ± 0.085	3.566ArgSer: 3.566 ± 0.051	3.064ArgThr: 3.064 ± 0.055	4.819ArgVal: 4.819 ± 0.059	1.099ArgTrp: 1.099 ± 0.032	1.553ArgTyr: 1.553 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	5.842SerAla: 5.842 ± 0.074	0.433SerCys: 0.433 ± 0.02	3.324SerAsp: 3.324 ± 0.049	2.55SerGlu: 2.55 ± 0.049	2.128SerPhe: 2.128 ± 0.039	5.598SerGly: 5.598 ± 0.082	1.122SerHis: 1.122 ± 0.03	2.393SerIle: 2.393 ± 0.042	1.12SerLys: 1.12 ± 0.03	5.048SerLeu: 5.048 ± 0.071	1.285SerMet: 1.285 ± 0.031	1.193SerAsn: 1.193 ± 0.031	2.665SerPro: 2.665 ± 0.054	1.656SerGln: 1.656 ± 0.039	3.751SerArg: 3.751 ± 0.058	2.408SerSer: 2.408 ± 0.054	2.377SerThr: 2.377 ± 0.044	3.565SerVal: 3.565 ± 0.052	0.764SerTrp: 0.764 ± 0.025	1.147SerTyr: 1.147 ± 0.03	0.0SerXaa: 0.0 ± 0.0
Thr	6.031ThrAla: 6.031 ± 0.08	0.463ThrCys: 0.463 ± 0.02	3.139ThrAsp: 3.139 ± 0.05	2.924ThrGlu: 2.924 ± 0.048	1.607ThrPhe: 1.607 ± 0.037	5.487ThrGly: 5.487 ± 0.071	1.097ThrHis: 1.097 ± 0.033	2.725ThrIle: 2.725 ± 0.044	1.032ThrLys: 1.032 ± 0.029	5.543ThrLeu: 5.543 ± 0.075	1.184ThrMet: 1.184 ± 0.034	1.16ThrAsn: 1.16 ± 0.032	3.287ThrPro: 3.287 ± 0.059	1.534ThrGln: 1.534 ± 0.033	3.912ThrArg: 3.912 ± 0.059	2.475ThrSer: 2.475 ± 0.041	2.765ThrThr: 2.765 ± 0.054	3.881ThrVal: 3.881 ± 0.049	0.605ThrTrp: 0.605 ± 0.022	1.019ThrTyr: 1.019 ± 0.029	0.0ThrXaa: 0.0 ± 0.0
Val	8.692ValAla: 8.692 ± 0.091	0.544ValCys: 0.544 ± 0.019	3.612ValAsp: 3.612 ± 0.058	4.073ValGlu: 4.073 ± 0.059	2.521ValPhe: 2.521 ± 0.043	5.157ValGly: 5.157 ± 0.067	1.213ValHis: 1.213 ± 0.029	4.114ValIle: 4.114 ± 0.062	1.688ValLys: 1.688 ± 0.041	7.423ValLeu: 7.423 ± 0.084	2.116ValMet: 2.116 ± 0.041	1.806ValAsn: 1.806 ± 0.044	3.392ValPro: 3.392 ± 0.048	2.166ValGln: 2.166 ± 0.039	4.267ValArg: 4.267 ± 0.059	3.84ValSer: 3.84 ± 0.057	4.459ValThr: 4.459 ± 0.069	5.133ValVal: 5.133 ± 0.066	0.975ValTrp: 0.975 ± 0.026	1.233ValTyr: 1.233 ± 0.031	0.0ValXaa: 0.0 ± 0.0
Trp	1.419TrpAla: 1.419 ± 0.035	0.131TrpCys: 0.131 ± 0.01	0.762TrpAsp: 0.762 ± 0.028	0.583TrpGlu: 0.583 ± 0.022	0.565TrpPhe: 0.565 ± 0.018	1.068TrpGly: 1.068 ± 0.028	0.362TrpHis: 0.362 ± 0.017	0.746TrpIle: 0.746 ± 0.025	0.418TrpLys: 0.418 ± 0.017	1.885TrpLeu: 1.885 ± 0.043	0.414TrpMet: 0.414 ± 0.017	0.428TrpAsn: 0.428 ± 0.017	0.76TrpPro: 0.76 ± 0.026	0.805TrpGln: 0.805 ± 0.025	1.361TrpArg: 1.361 ± 0.039	0.808TrpSer: 0.808 ± 0.029	0.815TrpThr: 0.815 ± 0.027	0.87TrpVal: 0.87 ± 0.028	0.249TrpTrp: 0.249 ± 0.014	0.26TrpTyr: 0.26 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.207TyrAla: 2.207 ± 0.044	0.211TyrCys: 0.211 ± 0.013	1.524TyrAsp: 1.524 ± 0.038	1.107TyrGlu: 1.107 ± 0.031	0.779TyrPhe: 0.779 ± 0.025	1.977TyrGly: 1.977 ± 0.041	0.491TyrHis: 0.491 ± 0.018	0.823TyrIle: 0.823 ± 0.028	0.389TyrLys: 0.389 ± 0.02	2.119TyrLeu: 2.119 ± 0.041	0.422TyrMet: 0.422 ± 0.019	0.544TyrAsn: 0.544 ± 0.021	1.016TyrPro: 1.016 ± 0.03	0.692TyrGln: 0.692 ± 0.02	1.62TyrArg: 1.62 ± 0.034	1.003TyrSer: 1.003 ± 0.03	0.939TyrThr: 0.939 ± 0.027	1.344TyrVal: 1.344 ± 0.032	0.309TyrTrp: 0.309 ± 0.014	0.503TyrTyr: 0.503 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.001	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.004XaaXaa: 0.004 ± 0.004

Statistics based on 4561 proteins (1370639 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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