Amino acid dipepetide frequency for Grapevine virus E

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.252AlaAla: 3.252 ± 2.977
0.813AlaCys: 0.813 ± 0.441
5.285AlaAsp: 5.285 ± 1.729
4.472AlaGlu: 4.472 ± 1.094
4.065AlaPhe: 4.065 ± 1.418
4.472AlaGly: 4.472 ± 1.057
1.22AlaHis: 1.22 ± 0.475
3.659AlaIle: 3.659 ± 2.317
6.504AlaLys: 6.504 ± 3.057
5.691AlaLeu: 5.691 ± 0.617
1.626AlaMet: 1.626 ± 0.999
3.252AlaAsn: 3.252 ± 1.346
2.439AlaPro: 2.439 ± 1.177
2.439AlaGln: 2.439 ± 1.121
3.659AlaArg: 3.659 ± 0.936
4.878AlaSer: 4.878 ± 1.627
3.252AlaThr: 3.252 ± 1.005
5.285AlaVal: 5.285 ± 0.944
0.0AlaTrp: 0.0 ± 0.0
1.22AlaTyr: 1.22 ± 0.561
0.0AlaXaa: 0.0 ± 0.0
Cys
1.626CysAla: 1.626 ± 1.087
0.813CysCys: 0.813 ± 0.868
0.407CysAsp: 0.407 ± 0.221
1.626CysGlu: 1.626 ± 0.552
1.626CysPhe: 1.626 ± 0.883
1.626CysGly: 1.626 ± 0.826
0.0CysHis: 0.0 ± 0.0
2.033CysIle: 2.033 ± 1.296
0.813CysLys: 0.813 ± 0.441
1.626CysLeu: 1.626 ± 0.883
0.0CysMet: 0.0 ± 0.0
1.626CysAsn: 1.626 ± 0.968
0.813CysPro: 0.813 ± 0.441
0.407CysGln: 0.407 ± 0.221
1.22CysArg: 1.22 ± 0.514
0.813CysSer: 0.813 ± 0.543
2.439CysThr: 2.439 ± 0.486
0.407CysVal: 0.407 ± 0.221
0.0CysTrp: 0.0 ± 0.0
1.22CysTyr: 1.22 ± 1.709
0.0CysXaa: 0.0 ± 0.0
Asp
4.065AspAla: 4.065 ± 0.9
2.033AspCys: 2.033 ± 1.104
3.252AspAsp: 3.252 ± 1.005
5.285AspGlu: 5.285 ± 2.21
4.878AspPhe: 4.878 ± 0.677
3.659AspGly: 3.659 ± 0.836
3.659AspHis: 3.659 ± 1.987
1.22AspIle: 1.22 ± 0.662
4.065AspLys: 4.065 ± 1.992
4.472AspLeu: 4.472 ± 1.781
1.22AspMet: 1.22 ± 0.818
2.846AspAsn: 2.846 ± 1.183
3.252AspPro: 3.252 ± 1.005
2.033AspGln: 2.033 ± 1.463
2.033AspArg: 2.033 ± 0.614
3.252AspSer: 3.252 ± 0.695
1.22AspThr: 1.22 ± 0.475
2.033AspVal: 2.033 ± 0.89
0.407AspTrp: 0.407 ± 0.221
1.626AspTyr: 1.626 ± 0.503
0.0AspXaa: 0.0 ± 0.0
Glu
7.724GluAla: 7.724 ± 1.445
0.407GluCys: 0.407 ± 0.967
3.659GluAsp: 3.659 ± 1.101
7.317GluGlu: 7.317 ± 0.77
2.439GluPhe: 2.439 ± 0.775
4.472GluGly: 4.472 ± 1.283
2.846GluHis: 2.846 ± 1.083
3.252GluIle: 3.252 ± 1.156
2.033GluLys: 2.033 ± 1.104
7.724GluLeu: 7.724 ± 2.386
1.626GluMet: 1.626 ± 0.503
3.252GluAsn: 3.252 ± 0.835
3.252GluPro: 3.252 ± 2.508
0.813GluGln: 0.813 ± 0.566
2.846GluArg: 2.846 ± 0.952
4.065GluSer: 4.065 ± 2.207
4.065GluThr: 4.065 ± 1.089
6.504GluVal: 6.504 ± 1.104
0.407GluTrp: 0.407 ± 0.221
2.439GluTyr: 2.439 ± 1.635
0.0GluXaa: 0.0 ± 0.0
Phe
5.285PheAla: 5.285 ± 1.01
0.407PheCys: 0.407 ± 0.221
4.065PheAsp: 4.065 ± 1.34
3.659PheGlu: 3.659 ± 0.862
1.626PhePhe: 1.626 ± 0.883
2.439PheGly: 2.439 ± 0.949
0.813PheHis: 0.813 ± 0.566
3.252PheIle: 3.252 ± 1.156
2.846PheLys: 2.846 ± 0.896
5.285PheLeu: 5.285 ± 0.927
2.033PheMet: 2.033 ± 1.332
2.033PheAsn: 2.033 ± 0.865
0.813PhePro: 0.813 ± 0.543
1.22PheGln: 1.22 ± 0.475
2.439PheArg: 2.439 ± 0.486
5.691PheSer: 5.691 ± 1.798
4.065PheThr: 4.065 ± 1.57
0.813PheVal: 0.813 ± 0.543
0.0PheTrp: 0.0 ± 0.0
0.407PheTyr: 0.407 ± 0.221
0.0PheXaa: 0.0 ± 0.0
Gly
2.846GlyAla: 2.846 ± 0.655
1.22GlyCys: 1.22 ± 0.933
5.691GlyAsp: 5.691 ± 2.484
3.659GlyGlu: 3.659 ± 1.382
2.439GlyPhe: 2.439 ± 0.949
2.439GlyGly: 2.439 ± 0.775
1.22GlyHis: 1.22 ± 0.662
1.626GlyIle: 1.626 ± 1.132
6.098GlyLys: 6.098 ± 1.863
8.13GlyLeu: 8.13 ± 1.8
1.22GlyMet: 1.22 ± 1.04
2.033GlyAsn: 2.033 ± 1.71
2.439GlyPro: 2.439 ± 0.825
2.846GlyGln: 2.846 ± 1.007
4.472GlyArg: 4.472 ± 2.513
4.472GlySer: 4.472 ± 1.483
3.252GlyThr: 3.252 ± 0.855
5.691GlyVal: 5.691 ± 3.022
0.813GlyTrp: 0.813 ± 0.441
2.846GlyTyr: 2.846 ± 1.545
0.0GlyXaa: 0.0 ± 0.0
His
2.439HisAla: 2.439 ± 1.324
0.407HisCys: 0.407 ± 0.221
1.22HisAsp: 1.22 ± 0.475
1.22HisGlu: 1.22 ± 0.561
2.033HisPhe: 2.033 ± 1.104
1.22HisGly: 1.22 ± 0.475
1.22HisHis: 1.22 ± 0.662
0.813HisIle: 0.813 ± 0.441
3.659HisLys: 3.659 ± 1.424
3.659HisLeu: 3.659 ± 1.405
0.407HisMet: 0.407 ± 0.68
0.0HisAsn: 0.0 ± 0.0
1.626HisPro: 1.626 ± 0.503
0.813HisGln: 0.813 ± 0.627
0.813HisArg: 0.813 ± 0.441
1.626HisSer: 1.626 ± 0.883
0.813HisThr: 0.813 ± 0.566
0.813HisVal: 0.813 ± 0.543
0.0HisTrp: 0.0 ± 0.0
0.813HisTyr: 0.813 ± 0.441
0.0HisXaa: 0.0 ± 0.0
Ile
5.285IleAla: 5.285 ± 1.153
2.439IleCys: 2.439 ± 0.949
2.846IleAsp: 2.846 ± 0.952
4.472IleGlu: 4.472 ± 2.435
3.659IlePhe: 3.659 ± 1.405
3.659IleGly: 3.659 ± 1.052
1.22IleHis: 1.22 ± 0.662
2.439IleIle: 2.439 ± 0.775
4.472IleLys: 4.472 ± 1.192
6.504IleLeu: 6.504 ± 1.095
1.22IleMet: 1.22 ± 0.475
2.439IleAsn: 2.439 ± 0.949
2.439IlePro: 2.439 ± 0.814
2.439IleGln: 2.439 ± 0.486
2.439IleArg: 2.439 ± 1.888
2.439IleSer: 2.439 ± 0.588
1.22IleThr: 1.22 ± 0.662
2.846IleVal: 2.846 ± 0.714
0.0IleTrp: 0.0 ± 0.0
2.439IleTyr: 2.439 ± 0.814
0.0IleXaa: 0.0 ± 0.0
Lys
5.691LysAla: 5.691 ± 1.056
0.813LysCys: 0.813 ± 0.441
4.065LysAsp: 4.065 ± 1.57
3.659LysGlu: 3.659 ± 0.721
1.22LysPhe: 1.22 ± 0.933
6.911LysGly: 6.911 ± 2.238
2.033LysHis: 2.033 ± 0.996
4.472LysIle: 4.472 ± 0.953
3.659LysLys: 3.659 ± 1.987
8.537LysLeu: 8.537 ± 2.375
2.033LysMet: 2.033 ± 0.58
4.065LysAsn: 4.065 ± 0.937
1.626LysPro: 1.626 ± 0.883
1.626LysGln: 1.626 ± 0.968
4.065LysArg: 4.065 ± 1.78
5.691LysSer: 5.691 ± 3.379
3.252LysThr: 3.252 ± 1.156
4.878LysVal: 4.878 ± 3.46
2.033LysTrp: 2.033 ± 0.666
2.033LysTyr: 2.033 ± 1.866
0.0LysXaa: 0.0 ± 0.0
Leu
5.691LeuAla: 5.691 ± 2.342
2.846LeuCys: 2.846 ± 1.044
6.504LeuAsp: 6.504 ± 1.977
6.098LeuGlu: 6.098 ± 1.264
6.098LeuPhe: 6.098 ± 1.71
6.504LeuGly: 6.504 ± 1.75
2.033LeuHis: 2.033 ± 1.104
5.691LeuIle: 5.691 ± 1.918
9.35LeuLys: 9.35 ± 1.191
7.724LeuLeu: 7.724 ± 2.53
2.846LeuMet: 2.846 ± 1.111
3.252LeuAsn: 3.252 ± 0.733
2.846LeuPro: 2.846 ± 1.155
2.439LeuGln: 2.439 ± 1.027
5.691LeuArg: 5.691 ± 1.973
7.724LeuSer: 7.724 ± 1.615
7.317LeuThr: 7.317 ± 2.137
5.691LeuVal: 5.691 ± 1.591
0.813LeuTrp: 0.813 ± 0.441
3.252LeuTyr: 3.252 ± 1.564
0.0LeuXaa: 0.0 ± 0.0
Met
1.22MetAla: 1.22 ± 0.662
1.626MetCys: 1.626 ± 0.577
0.813MetAsp: 0.813 ± 0.868
2.846MetGlu: 2.846 ± 0.483
0.813MetPhe: 0.813 ± 0.566
2.439MetGly: 2.439 ± 0.486
1.626MetHis: 1.626 ± 0.731
1.626MetIle: 1.626 ± 0.577
1.626MetLys: 1.626 ± 0.503
2.846MetLeu: 2.846 ± 0.952
0.407MetMet: 0.407 ± 0.221
1.626MetAsn: 1.626 ± 0.971
1.626MetPro: 1.626 ± 0.883
0.0MetGln: 0.0 ± 0.0
1.626MetArg: 1.626 ± 0.968
1.626MetSer: 1.626 ± 0.503
0.813MetThr: 0.813 ± 1.509
2.846MetVal: 2.846 ± 0.814
0.0MetTrp: 0.0 ± 0.0
1.22MetTyr: 1.22 ± 0.911
0.0MetXaa: 0.0 ± 0.0
Asn
2.033AsnAla: 2.033 ± 1.231
2.033AsnCys: 2.033 ± 1.104
1.626AsnAsp: 1.626 ± 0.883
2.033AsnGlu: 2.033 ± 0.89
2.033AsnPhe: 2.033 ± 0.86
2.033AsnGly: 2.033 ± 0.86
1.22AsnHis: 1.22 ± 0.475
3.252AsnIle: 3.252 ± 1.236
2.846AsnLys: 2.846 ± 1.795
5.691AsnLeu: 5.691 ± 1.714
0.813AsnMet: 0.813 ± 0.441
2.439AsnAsn: 2.439 ± 1.274
2.846AsnPro: 2.846 ± 0.714
2.033AsnGln: 2.033 ± 0.71
1.22AsnArg: 1.22 ± 0.662
2.439AsnSer: 2.439 ± 2.226
1.22AsnThr: 1.22 ± 0.662
1.22AsnVal: 1.22 ± 0.475
0.407AsnTrp: 0.407 ± 0.967
2.846AsnTyr: 2.846 ± 1.034
0.0AsnXaa: 0.0 ± 0.0
Pro
2.033ProAla: 2.033 ± 0.89
0.813ProCys: 0.813 ± 0.627
1.626ProAsp: 1.626 ± 0.503
4.472ProGlu: 4.472 ± 1.592
2.439ProPhe: 2.439 ± 2.598
4.878ProGly: 4.878 ± 1.997
1.22ProHis: 1.22 ± 0.561
2.846ProIle: 2.846 ± 1.545
0.813ProLys: 0.813 ± 0.441
6.504ProLeu: 6.504 ± 2.131
0.407ProMet: 0.407 ± 0.221
2.439ProAsn: 2.439 ± 0.775
2.846ProPro: 2.846 ± 0.655
1.22ProGln: 1.22 ± 0.561
0.813ProArg: 0.813 ± 0.543
2.846ProSer: 2.846 ± 1.044
1.22ProThr: 1.22 ± 0.911
2.033ProVal: 2.033 ± 0.67
0.407ProTrp: 0.407 ± 0.221
2.439ProTyr: 2.439 ± 1.027
0.0ProXaa: 0.0 ± 0.0
Gln
2.033GlnAla: 2.033 ± 0.89
0.0GlnCys: 0.0 ± 0.0
1.626GlnAsp: 1.626 ± 0.971
1.626GlnGlu: 1.626 ± 0.577
1.22GlnPhe: 1.22 ± 0.662
1.626GlnGly: 1.626 ± 0.883
0.0GlnHis: 0.0 ± 0.0
2.439GlnIle: 2.439 ± 1.027
2.846GlnLys: 2.846 ± 1.007
4.472GlnLeu: 4.472 ± 1.074
1.626GlnMet: 1.626 ± 0.577
0.813GlnAsn: 0.813 ± 0.441
1.626GlnPro: 1.626 ± 0.883
0.407GlnGln: 0.407 ± 0.688
2.846GlnArg: 2.846 ± 0.483
1.626GlnSer: 1.626 ± 1.308
1.626GlnThr: 1.626 ± 0.774
3.252GlnVal: 3.252 ± 3.737
0.0GlnTrp: 0.0 ± 0.0
0.0GlnTyr: 0.0 ± 0.0
0.0GlnXaa: 0.0 ± 0.0
Arg
4.878ArgAla: 4.878 ± 1.119
0.407ArgCys: 0.407 ± 0.967
1.626ArgAsp: 1.626 ± 0.883
2.439ArgGlu: 2.439 ± 1.242
1.626ArgPhe: 1.626 ± 0.826
2.846ArgGly: 2.846 ± 0.959
0.407ArgHis: 0.407 ± 0.221
3.252ArgIle: 3.252 ± 1.374
5.691ArgLys: 5.691 ± 1.21
5.285ArgLeu: 5.285 ± 0.798
1.626ArgMet: 1.626 ± 0.883
1.22ArgAsn: 1.22 ± 1.37
1.626ArgPro: 1.626 ± 0.552
2.033ArgGln: 2.033 ± 0.67
1.626ArgArg: 1.626 ± 0.968
3.252ArgSer: 3.252 ± 2.481
2.846ArgThr: 2.846 ± 2.34
1.626ArgVal: 1.626 ± 0.883
0.0ArgTrp: 0.0 ± 0.0
3.252ArgTyr: 3.252 ± 0.875
0.0ArgXaa: 0.0 ± 0.0
Ser
3.659SerAla: 3.659 ± 2.223
1.626SerCys: 1.626 ± 0.83
6.098SerAsp: 6.098 ± 1.527
4.878SerGlu: 4.878 ± 3.14
3.252SerPhe: 3.252 ± 1.105
5.691SerGly: 5.691 ± 1.351
1.22SerHis: 1.22 ± 0.662
4.878SerIle: 4.878 ± 1.297
4.065SerLys: 4.065 ± 1.026
4.065SerLeu: 4.065 ± 0.937
2.439SerMet: 2.439 ± 1.324
1.22SerAsn: 1.22 ± 0.662
2.846SerPro: 2.846 ± 1.212
2.033SerGln: 2.033 ± 1.007
2.439SerArg: 2.439 ± 1.0
4.878SerSer: 4.878 ± 1.474
4.065SerThr: 4.065 ± 1.645
4.472SerVal: 4.472 ± 2.865
0.0SerTrp: 0.0 ± 0.0
3.252SerTyr: 3.252 ± 1.766
0.0SerXaa: 0.0 ± 0.0
Thr
1.626ThrAla: 1.626 ± 1.308
0.407ThrCys: 0.407 ± 0.221
2.439ThrAsp: 2.439 ± 0.796
4.878ThrGlu: 4.878 ± 1.335
2.846ThrPhe: 2.846 ± 0.959
1.22ThrGly: 1.22 ± 0.662
1.22ThrHis: 1.22 ± 0.475
3.252ThrIle: 3.252 ± 1.156
2.439ThrLys: 2.439 ± 1.737
4.065ThrLeu: 4.065 ± 1.34
1.626ThrMet: 1.626 ± 0.883
2.439ThrAsn: 2.439 ± 0.647
3.659ThrPro: 3.659 ± 2.042
2.033ThrGln: 2.033 ± 0.67
2.033ThrArg: 2.033 ± 1.169
2.846ThrSer: 2.846 ± 0.483
1.626ThrThr: 1.626 ± 1.108
4.472ThrVal: 4.472 ± 1.094
0.813ThrTrp: 0.813 ± 0.441
1.22ThrTyr: 1.22 ± 0.475
0.0ThrXaa: 0.0 ± 0.0
Val
4.065ValAla: 4.065 ± 1.541
1.22ValCys: 1.22 ± 1.211
2.033ValAsp: 2.033 ± 0.614
5.285ValGlu: 5.285 ± 2.207
2.846ValPhe: 2.846 ± 2.469
5.691ValGly: 5.691 ± 2.295
1.626ValHis: 1.626 ± 0.883
4.065ValIle: 4.065 ± 2.302
3.659ValLys: 3.659 ± 2.388
3.252ValLeu: 3.252 ± 0.989
2.439ValMet: 2.439 ± 1.753
2.846ValAsn: 2.846 ± 1.007
2.033ValPro: 2.033 ± 0.67
2.439ValGln: 2.439 ± 0.825
3.659ValArg: 3.659 ± 1.941
4.878ValSer: 4.878 ± 1.163
1.22ValThr: 1.22 ± 0.475
4.878ValVal: 4.878 ± 1.172
0.0ValTrp: 0.0 ± 0.0
3.252ValTyr: 3.252 ± 0.989
0.0ValXaa: 0.0 ± 0.0
Trp
0.407TrpAla: 0.407 ± 0.221
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
0.0TrpGlu: 0.0 ± 0.0
0.407TrpPhe: 0.407 ± 0.221
0.0TrpGly: 0.0 ± 0.0
0.0TrpHis: 0.0 ± 0.0
0.0TrpIle: 0.0 ± 0.0
0.407TrpLys: 0.407 ± 0.221
0.407TrpLeu: 0.407 ± 0.221
0.813TrpMet: 0.813 ± 0.722
0.407TrpAsn: 0.407 ± 0.221
0.813TrpPro: 0.813 ± 0.441
0.407TrpGln: 0.407 ± 0.688
0.407TrpArg: 0.407 ± 0.221
0.407TrpSer: 0.407 ± 0.221
0.407TrpThr: 0.407 ± 0.221
0.407TrpVal: 0.407 ± 0.221
0.0TrpTrp: 0.0 ± 0.0
0.407TrpTyr: 0.407 ± 0.221
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.626TyrAla: 1.626 ± 0.883
0.813TyrCys: 0.813 ± 1.281
1.626TyrAsp: 1.626 ± 0.503
1.22TyrGlu: 1.22 ± 0.662
1.626TyrPhe: 1.626 ± 0.883
1.626TyrGly: 1.626 ± 0.826
0.813TyrHis: 0.813 ± 0.441
2.846TyrIle: 2.846 ± 0.814
4.472TyrLys: 4.472 ± 1.221
4.472TyrLeu: 4.472 ± 0.881
2.439TyrMet: 2.439 ± 1.274
2.033TyrAsn: 2.033 ± 2.002
2.846TyrPro: 2.846 ± 0.94
2.033TyrGln: 2.033 ± 0.614
1.22TyrArg: 1.22 ± 0.662
1.626TyrSer: 1.626 ± 1.132
1.22TyrThr: 1.22 ± 0.561
1.22TyrVal: 1.22 ± 1.241
0.407TyrTrp: 0.407 ± 0.221
0.813TyrTyr: 0.813 ± 0.868
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5 proteins (2461 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski