Amino acid dipepetide frequency for Blautia sp. CAG:257

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.941AlaAla: 7.941 ± 0.144
1.196AlaCys: 1.196 ± 0.038
4.464AlaAsp: 4.464 ± 0.074
6.16AlaGlu: 6.16 ± 0.106
2.97AlaPhe: 2.97 ± 0.061
6.671AlaGly: 6.671 ± 0.111
1.103AlaHis: 1.103 ± 0.044
4.334AlaIle: 4.334 ± 0.086
4.335AlaLys: 4.335 ± 0.083
6.933AlaLeu: 6.933 ± 0.097
2.38AlaMet: 2.38 ± 0.056
2.143AlaAsn: 2.143 ± 0.052
2.173AlaPro: 2.173 ± 0.054
2.432AlaGln: 2.432 ± 0.068
3.11AlaArg: 3.11 ± 0.068
4.018AlaSer: 4.018 ± 0.086
2.842AlaThr: 2.842 ± 0.067
7.338AlaVal: 7.338 ± 0.117
0.587AlaTrp: 0.587 ± 0.029
2.63AlaTyr: 2.63 ± 0.062
0.0AlaXaa: 0.0 ± 0.0
Cys
1.207CysAla: 1.207 ± 0.042
0.316CysCys: 0.316 ± 0.021
0.806CysAsp: 0.806 ± 0.033
0.908CysGlu: 0.908 ± 0.037
0.677CysPhe: 0.677 ± 0.034
1.621CysGly: 1.621 ± 0.05
0.353CysHis: 0.353 ± 0.02
1.155CysIle: 1.155 ± 0.044
0.745CysLys: 0.745 ± 0.035
1.266CysLeu: 1.266 ± 0.039
0.543CysMet: 0.543 ± 0.026
0.493CysAsn: 0.493 ± 0.026
0.688CysPro: 0.688 ± 0.033
0.516CysGln: 0.516 ± 0.025
0.964CysArg: 0.964 ± 0.044
1.059CysSer: 1.059 ± 0.034
0.848CysThr: 0.848 ± 0.035
1.061CysVal: 1.061 ± 0.038
0.123CysTrp: 0.123 ± 0.013
0.486CysTyr: 0.486 ± 0.027
0.0CysXaa: 0.0 ± 0.0
Asp
3.855AspAla: 3.855 ± 0.087
0.806AspCys: 0.806 ± 0.036
2.35AspAsp: 2.35 ± 0.067
4.229AspGlu: 4.229 ± 0.069
2.63AspPhe: 2.63 ± 0.067
4.123AspGly: 4.123 ± 0.086
1.011AspHis: 1.011 ± 0.04
4.208AspIle: 4.208 ± 0.071
3.246AspLys: 3.246 ± 0.072
4.406AspLeu: 4.406 ± 0.074
1.878AspMet: 1.878 ± 0.047
1.924AspAsn: 1.924 ± 0.051
1.947AspPro: 1.947 ± 0.046
1.74AspGln: 1.74 ± 0.051
2.62AspArg: 2.62 ± 0.06
3.224AspSer: 3.224 ± 0.068
3.056AspThr: 3.056 ± 0.073
3.516AspVal: 3.516 ± 0.064
0.536AspTrp: 0.536 ± 0.034
2.567AspTyr: 2.567 ± 0.063
0.0AspXaa: 0.0 ± 0.0
Glu
6.049GluAla: 6.049 ± 0.102
0.799GluCys: 0.799 ± 0.035
4.422GluAsp: 4.422 ± 0.093
7.946GluGlu: 7.946 ± 0.155
2.785GluPhe: 2.785 ± 0.066
4.815GluGly: 4.815 ± 0.083
1.343GluHis: 1.343 ± 0.042
6.151GluIle: 6.151 ± 0.092
7.39GluLys: 7.39 ± 0.121
7.039GluLeu: 7.039 ± 0.105
2.559GluMet: 2.559 ± 0.056
4.383GluAsn: 4.383 ± 0.073
2.06GluPro: 2.06 ± 0.055
2.97GluGln: 2.97 ± 0.067
3.199GluArg: 3.199 ± 0.074
3.202GluSer: 3.202 ± 0.065
4.137GluThr: 4.137 ± 0.088
4.378GluVal: 4.378 ± 0.076
0.584GluTrp: 0.584 ± 0.027
3.159GluTyr: 3.159 ± 0.062
0.0GluXaa: 0.0 ± 0.0
Phe
2.849PheAla: 2.849 ± 0.059
0.91PheCys: 0.91 ± 0.04
2.311PheAsp: 2.311 ± 0.053
2.39PheGlu: 2.39 ± 0.058
2.002PhePhe: 2.002 ± 0.059
3.092PheGly: 3.092 ± 0.07
0.922PheHis: 0.922 ± 0.035
2.595PheIle: 2.595 ± 0.066
1.692PheLys: 1.692 ± 0.049
4.159PheLeu: 4.159 ± 0.087
1.305PheMet: 1.305 ± 0.043
1.379PheAsn: 1.379 ± 0.044
1.5PhePro: 1.5 ± 0.05
1.49PheGln: 1.49 ± 0.045
1.971PheArg: 1.971 ± 0.056
2.961PheSer: 2.961 ± 0.066
2.252PheThr: 2.252 ± 0.05
2.816PheVal: 2.816 ± 0.057
0.459PheTrp: 0.459 ± 0.026
1.74PheTyr: 1.74 ± 0.049
0.0PheXaa: 0.0 ± 0.0
Gly
5.402GlyAla: 5.402 ± 0.105
1.394GlyCys: 1.394 ± 0.042
3.586GlyAsp: 3.586 ± 0.08
5.185GlyGlu: 5.185 ± 0.1
3.342GlyPhe: 3.342 ± 0.079
5.105GlyGly: 5.105 ± 0.103
1.262GlyHis: 1.262 ± 0.041
6.735GlyIle: 6.735 ± 0.106
5.717GlyLys: 5.717 ± 0.079
6.004GlyLeu: 6.004 ± 0.103
2.65GlyMet: 2.65 ± 0.067
3.226GlyAsn: 3.226 ± 0.059
1.442GlyPro: 1.442 ± 0.047
2.272GlyGln: 2.272 ± 0.056
3.135GlyArg: 3.135 ± 0.065
4.244GlySer: 4.244 ± 0.094
4.457GlyThr: 4.457 ± 0.079
5.031GlyVal: 5.031 ± 0.097
0.66GlyTrp: 0.66 ± 0.03
3.229GlyTyr: 3.229 ± 0.067
0.0GlyXaa: 0.0 ± 0.0
His
1.105HisAla: 1.105 ± 0.037
0.322HisCys: 0.322 ± 0.017
0.861HisAsp: 0.861 ± 0.034
1.105HisGlu: 1.105 ± 0.048
0.774HisPhe: 0.774 ± 0.033
1.371HisGly: 1.371 ± 0.046
0.438HisHis: 0.438 ± 0.031
1.393HisIle: 1.393 ± 0.046
1.041HisLys: 1.041 ± 0.034
1.47HisLeu: 1.47 ± 0.044
0.62HisMet: 0.62 ± 0.027
0.742HisAsn: 0.742 ± 0.033
0.881HisPro: 0.881 ± 0.037
0.595HisGln: 0.595 ± 0.025
0.846HisArg: 0.846 ± 0.035
1.013HisSer: 1.013 ± 0.036
1.034HisThr: 1.034 ± 0.042
1.207HisVal: 1.207 ± 0.038
0.163HisTrp: 0.163 ± 0.013
0.691HisTyr: 0.691 ± 0.034
0.0HisXaa: 0.0 ± 0.0
Ile
5.243IleAla: 5.243 ± 0.092
1.423IleCys: 1.423 ± 0.046
3.52IleAsp: 3.52 ± 0.062
4.141IleGlu: 4.141 ± 0.075
2.936IlePhe: 2.936 ± 0.063
4.769IleGly: 4.769 ± 0.089
1.468IleHis: 1.468 ± 0.042
4.643IleIle: 4.643 ± 0.098
3.533IleLys: 3.533 ± 0.067
7.638IleLeu: 7.638 ± 0.126
2.03IleMet: 2.03 ± 0.06
2.471IleAsn: 2.471 ± 0.055
3.336IlePro: 3.336 ± 0.063
2.55IleGln: 2.55 ± 0.058
4.101IleArg: 4.101 ± 0.069
4.905IleSer: 4.905 ± 0.081
4.002IleThr: 4.002 ± 0.074
4.598IleVal: 4.598 ± 0.085
0.595IleTrp: 0.595 ± 0.03
2.731IleTyr: 2.731 ± 0.061
0.0IleXaa: 0.0 ± 0.0
Lys
5.016LysAla: 5.016 ± 0.083
0.698LysCys: 0.698 ± 0.033
3.688LysAsp: 3.688 ± 0.064
6.605LysGlu: 6.605 ± 0.103
1.865LysPhe: 1.865 ± 0.045
4.131LysGly: 4.131 ± 0.08
0.996LysHis: 0.996 ± 0.038
4.787LysIle: 4.787 ± 0.089
6.726LysLys: 6.726 ± 0.106
5.286LysLeu: 5.286 ± 0.086
2.237LysMet: 2.237 ± 0.058
3.617LysAsn: 3.617 ± 0.064
1.953LysPro: 1.953 ± 0.052
2.211LysGln: 2.211 ± 0.057
3.014LysArg: 3.014 ± 0.062
3.144LysSer: 3.144 ± 0.071
3.956LysThr: 3.956 ± 0.075
4.033LysVal: 4.033 ± 0.077
0.587LysTrp: 0.587 ± 0.024
2.63LysTyr: 2.63 ± 0.056
0.0LysXaa: 0.0 ± 0.0
Leu
6.957LeuAla: 6.957 ± 0.104
1.654LeuCys: 1.654 ± 0.043
5.106LeuAsp: 5.106 ± 0.081
6.676LeuGlu: 6.676 ± 0.105
3.68LeuPhe: 3.68 ± 0.078
6.251LeuGly: 6.251 ± 0.096
1.66LeuHis: 1.66 ± 0.043
6.029LeuIle: 6.029 ± 0.113
6.363LeuLys: 6.363 ± 0.098
8.707LeuLeu: 8.707 ± 0.167
2.764LeuMet: 2.764 ± 0.067
3.604LeuAsn: 3.604 ± 0.056
3.552LeuPro: 3.552 ± 0.063
2.786LeuGln: 2.786 ± 0.059
3.752LeuArg: 3.752 ± 0.072
6.009LeuSer: 6.009 ± 0.092
5.197LeuThr: 5.197 ± 0.082
5.574LeuVal: 5.574 ± 0.098
0.731LeuTrp: 0.731 ± 0.031
3.255LeuTyr: 3.255 ± 0.069
0.0LeuXaa: 0.0 ± 0.0
Met
2.637MetAla: 2.637 ± 0.063
0.374MetCys: 0.374 ± 0.023
1.916MetAsp: 1.916 ± 0.05
2.968MetGlu: 2.968 ± 0.065
1.03MetPhe: 1.03 ± 0.039
2.428MetGly: 2.428 ± 0.053
0.446MetHis: 0.446 ± 0.027
2.259MetIle: 2.259 ± 0.062
2.772MetLys: 2.772 ± 0.053
2.627MetLeu: 2.627 ± 0.071
0.993MetMet: 0.993 ± 0.038
1.569MetAsn: 1.569 ± 0.045
1.15MetPro: 1.15 ± 0.041
1.029MetGln: 1.029 ± 0.038
1.19MetArg: 1.19 ± 0.041
1.749MetSer: 1.749 ± 0.042
1.797MetThr: 1.797 ± 0.05
2.009MetVal: 2.009 ± 0.053
0.206MetTrp: 0.206 ± 0.017
0.922MetTyr: 0.922 ± 0.034
0.0MetXaa: 0.0 ± 0.0
Asn
2.755AsnAla: 2.755 ± 0.06
0.575AsnCys: 0.575 ± 0.025
1.842AsnAsp: 1.842 ± 0.053
2.463AsnGlu: 2.463 ± 0.058
1.455AsnPhe: 1.455 ± 0.045
3.424AsnGly: 3.424 ± 0.072
0.763AsnHis: 0.763 ± 0.034
3.194AsnIle: 3.194 ± 0.074
2.267AsnLys: 2.267 ± 0.054
3.646AsnLeu: 3.646 ± 0.073
1.408AsnMet: 1.408 ± 0.04
1.49AsnAsn: 1.49 ± 0.048
2.045AsnPro: 2.045 ± 0.057
1.412AsnGln: 1.412 ± 0.036
2.15AsnArg: 2.15 ± 0.064
2.294AsnSer: 2.294 ± 0.053
2.437AsnThr: 2.437 ± 0.061
2.58AsnVal: 2.58 ± 0.055
0.41AsnTrp: 0.41 ± 0.026
1.614AsnTyr: 1.614 ± 0.045
0.0AsnXaa: 0.0 ± 0.0
Pro
2.689ProAla: 2.689 ± 0.066
0.541ProCys: 0.541 ± 0.029
2.377ProAsp: 2.377 ± 0.054
3.952ProGlu: 3.952 ± 0.084
1.517ProPhe: 1.517 ± 0.045
2.781ProGly: 2.781 ± 0.059
0.581ProHis: 0.581 ± 0.022
1.61ProIle: 1.61 ± 0.045
1.72ProLys: 1.72 ± 0.047
2.782ProLeu: 2.782 ± 0.061
0.888ProMet: 0.888 ± 0.034
1.09ProAsn: 1.09 ± 0.035
0.682ProPro: 0.682 ± 0.028
1.136ProGln: 1.136 ± 0.037
1.142ProArg: 1.142 ± 0.04
1.886ProSer: 1.886 ± 0.048
1.477ProThr: 1.477 ± 0.046
3.591ProVal: 3.591 ± 0.067
0.358ProTrp: 0.358 ± 0.026
1.422ProTyr: 1.422 ± 0.043
0.0ProXaa: 0.0 ± 0.0
Gln
2.597GlnAla: 2.597 ± 0.064
0.397GlnCys: 0.397 ± 0.021
1.682GlnAsp: 1.682 ± 0.053
3.457GlnGlu: 3.457 ± 0.079
1.157GlnPhe: 1.157 ± 0.04
2.271GlnGly: 2.271 ± 0.053
0.423GlnHis: 0.423 ± 0.022
2.517GlnIle: 2.517 ± 0.049
3.094GlnLys: 3.094 ± 0.06
2.772GlnLeu: 2.772 ± 0.059
1.199GlnMet: 1.199 ± 0.038
1.639GlnAsn: 1.639 ± 0.049
1.05GlnPro: 1.05 ± 0.036
1.23GlnGln: 1.23 ± 0.047
1.396GlnArg: 1.396 ± 0.041
1.545GlnSer: 1.545 ± 0.045
1.682GlnThr: 1.682 ± 0.041
2.224GlnVal: 2.224 ± 0.058
0.355GlnTrp: 0.355 ± 0.019
1.281GlnTyr: 1.281 ± 0.042
0.0GlnXaa: 0.0 ± 0.0
Arg
2.76ArgAla: 2.76 ± 0.067
0.663ArgCys: 0.663 ± 0.03
2.275ArgAsp: 2.275 ± 0.056
4.334ArgGlu: 4.334 ± 0.082
1.84ArgPhe: 1.84 ± 0.054
2.729ArgGly: 2.729 ± 0.067
0.798ArgHis: 0.798 ± 0.033
3.643ArgIle: 3.643 ± 0.077
3.73ArgLys: 3.73 ± 0.067
4.075ArgLeu: 4.075 ± 0.082
1.571ArgMet: 1.571 ± 0.05
2.145ArgAsn: 2.145 ± 0.05
1.378ArgPro: 1.378 ± 0.045
1.835ArgGln: 1.835 ± 0.047
2.436ArgArg: 2.436 ± 0.058
2.194ArgSer: 2.194 ± 0.057
2.37ArgThr: 2.37 ± 0.055
2.658ArgVal: 2.658 ± 0.061
0.337ArgTrp: 0.337 ± 0.019
1.805ArgTyr: 1.805 ± 0.052
0.0ArgXaa: 0.0 ± 0.0
Ser
4.395SerAla: 4.395 ± 0.083
0.999SerCys: 0.999 ± 0.043
2.994SerAsp: 2.994 ± 0.066
3.993SerGlu: 3.993 ± 0.075
2.73SerPhe: 2.73 ± 0.051
5.276SerGly: 5.276 ± 0.088
1.114SerHis: 1.114 ± 0.039
3.581SerIle: 3.581 ± 0.079
2.614SerLys: 2.614 ± 0.053
5.15SerLeu: 5.15 ± 0.081
1.853SerMet: 1.853 ± 0.047
1.786SerAsn: 1.786 ± 0.048
1.911SerPro: 1.911 ± 0.053
1.998SerGln: 1.998 ± 0.049
3.096SerArg: 3.096 ± 0.064
3.558SerSer: 3.558 ± 0.09
2.522SerThr: 2.522 ± 0.059
4.751SerVal: 4.751 ± 0.081
0.647SerTrp: 0.647 ± 0.031
2.29SerTyr: 2.29 ± 0.055
0.0SerXaa: 0.0 ± 0.0
Thr
4.568ThrAla: 4.568 ± 0.103
0.74ThrCys: 0.74 ± 0.031
3.216ThrAsp: 3.216 ± 0.066
4.577ThrGlu: 4.577 ± 0.088
2.087ThrPhe: 2.087 ± 0.053
5.165ThrGly: 5.165 ± 0.099
0.833ThrHis: 0.833 ± 0.032
3.265ThrIle: 3.265 ± 0.072
2.744ThrLys: 2.744 ± 0.057
4.678ThrLeu: 4.678 ± 0.084
1.52ThrMet: 1.52 ± 0.041
1.73ThrAsn: 1.73 ± 0.047
2.146ThrPro: 2.146 ± 0.06
1.47ThrGln: 1.47 ± 0.049
1.992ThrArg: 1.992 ± 0.054
2.933ThrSer: 2.933 ± 0.06
2.563ThrThr: 2.563 ± 0.068
4.792ThrVal: 4.792 ± 0.089
0.47ThrTrp: 0.47 ± 0.027
1.919ThrTyr: 1.919 ± 0.048
0.0ThrXaa: 0.0 ± 0.0
Val
4.656ValAla: 4.656 ± 0.086
1.303ValCys: 1.303 ± 0.042
3.653ValAsp: 3.653 ± 0.079
4.516ValGlu: 4.516 ± 0.083
3.241ValPhe: 3.241 ± 0.064
4.404ValGly: 4.404 ± 0.104
1.167ValHis: 1.167 ± 0.032
5.368ValIle: 5.368 ± 0.1
4.57ValLys: 4.57 ± 0.082
7.04ValLeu: 7.04 ± 0.105
2.184ValMet: 2.184 ± 0.051
2.807ValAsn: 2.807 ± 0.065
2.68ValPro: 2.68 ± 0.059
2.291ValGln: 2.291 ± 0.061
3.029ValArg: 3.029 ± 0.068
4.722ValSer: 4.722 ± 0.086
4.191ValThr: 4.191 ± 0.086
4.706ValVal: 4.706 ± 0.094
0.624ValTrp: 0.624 ± 0.026
2.645ValTyr: 2.645 ± 0.057
0.0ValXaa: 0.0 ± 0.0
Trp
0.549TrpAla: 0.549 ± 0.028
0.138TrpCys: 0.138 ± 0.013
0.508TrpAsp: 0.508 ± 0.025
0.72TrpGlu: 0.72 ± 0.033
0.368TrpPhe: 0.368 ± 0.026
0.626TrpGly: 0.626 ± 0.025
0.152TrpHis: 0.152 ± 0.013
0.606TrpIle: 0.606 ± 0.029
0.876TrpLys: 0.876 ± 0.034
0.847TrpLeu: 0.847 ± 0.034
0.349TrpMet: 0.349 ± 0.021
0.489TrpAsn: 0.489 ± 0.028
0.195TrpPro: 0.195 ± 0.016
0.335TrpGln: 0.335 ± 0.02
0.319TrpArg: 0.319 ± 0.021
0.435TrpSer: 0.435 ± 0.024
0.433TrpThr: 0.433 ± 0.026
0.473TrpVal: 0.473 ± 0.023
0.109TrpTrp: 0.109 ± 0.013
0.345TrpTyr: 0.345 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.532TyrAla: 2.532 ± 0.057
0.586TyrCys: 0.586 ± 0.03
2.297TyrAsp: 2.297 ± 0.058
3.044TyrGlu: 3.044 ± 0.061
1.709TyrPhe: 1.709 ± 0.051
3.028TyrGly: 3.028 ± 0.057
0.837TyrHis: 0.837 ± 0.041
2.562TyrIle: 2.562 ± 0.063
2.005TyrLys: 2.005 ± 0.055
3.781TyrLeu: 3.781 ± 0.073
1.137TyrMet: 1.137 ± 0.041
1.498TyrAsn: 1.498 ± 0.05
1.453TyrPro: 1.453 ± 0.047
1.669TyrGln: 1.669 ± 0.051
2.113TyrArg: 2.113 ± 0.06
2.163TyrSer: 2.163 ± 0.055
2.156TyrThr: 2.156 ± 0.061
2.462TyrVal: 2.462 ± 0.058
0.329TyrTrp: 0.329 ± 0.023
1.739TyrTyr: 1.739 ± 0.06
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2516 proteins (801810 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski