Amino acid dipepetide frequency for Curtobacterium sp. MCBD17_030

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.754AlaAla: 20.754 ± 0.209	0.586AlaCys: 0.586 ± 0.025	8.82AlaAsp: 8.82 ± 0.104	7.195AlaGlu: 7.195 ± 0.098	3.862AlaPhe: 3.862 ± 0.056	12.428AlaGly: 12.428 ± 0.123	2.38AlaHis: 2.38 ± 0.048	4.694AlaIle: 4.694 ± 0.076	2.551AlaLys: 2.551 ± 0.067	13.301AlaLeu: 13.301 ± 0.145	2.59AlaMet: 2.59 ± 0.054	2.188AlaAsn: 2.188 ± 0.048	6.508AlaPro: 6.508 ± 0.101	3.503AlaGln: 3.503 ± 0.072	9.08AlaArg: 9.08 ± 0.11	7.283AlaSer: 7.283 ± 0.082	8.346AlaThr: 8.346 ± 0.13	13.566AlaVal: 13.566 ± 0.15	1.835AlaTrp: 1.835 ± 0.047	2.166AlaTyr: 2.166 ± 0.04	0.0AlaXaa: 0.0 ± 0.0
Cys	0.573CysAla: 0.573 ± 0.029	0.057CysCys: 0.057 ± 0.006	0.26CysAsp: 0.26 ± 0.016	0.206CysGlu: 0.206 ± 0.016	0.148CysPhe: 0.148 ± 0.012	0.511CysGly: 0.511 ± 0.026	0.103CysHis: 0.103 ± 0.011	0.183CysIle: 0.183 ± 0.012	0.055CysLys: 0.055 ± 0.008	0.392CysLeu: 0.392 ± 0.02	0.087CysMet: 0.087 ± 0.009	0.1CysAsn: 0.1 ± 0.01	0.255CysPro: 0.255 ± 0.018	0.099CysGln: 0.099 ± 0.01	0.324CysArg: 0.324 ± 0.017	0.362CysSer: 0.362 ± 0.018	0.342CysThr: 0.342 ± 0.021	0.431CysVal: 0.431 ± 0.019	0.072CysTrp: 0.072 ± 0.008	0.089CysTyr: 0.089 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	9.19AspAla: 9.19 ± 0.114	0.248AspCys: 0.248 ± 0.016	5.071AspAsp: 5.071 ± 0.096	4.377AspGlu: 4.377 ± 0.082	1.596AspPhe: 1.596 ± 0.041	6.852AspGly: 6.852 ± 0.099	1.452AspHis: 1.452 ± 0.038	1.926AspIle: 1.926 ± 0.046	0.92AspLys: 0.92 ± 0.036	6.526AspLeu: 6.526 ± 0.086	0.844AspMet: 0.844 ± 0.03	0.861AspAsn: 0.861 ± 0.036	4.381AspPro: 4.381 ± 0.073	1.939AspGln: 1.939 ± 0.048	5.559AspArg: 5.559 ± 0.103	2.627AspSer: 2.627 ± 0.054	3.6AspThr: 3.6 ± 0.06	6.608AspVal: 6.608 ± 0.085	0.951AspTrp: 0.951 ± 0.031	1.052AspTyr: 1.052 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	5.803GluAla: 5.803 ± 0.083	0.192GluCys: 0.192 ± 0.015	3.072GluAsp: 3.072 ± 0.062	2.311GluGlu: 2.311 ± 0.058	1.493GluPhe: 1.493 ± 0.041	3.31GluGly: 3.31 ± 0.065	1.709GluHis: 1.709 ± 0.044	1.975GluIle: 1.975 ± 0.048	1.029GluLys: 1.029 ± 0.038	5.619GluLeu: 5.619 ± 0.086	0.772GluMet: 0.772 ± 0.027	0.981GluAsn: 0.981 ± 0.029	2.967GluPro: 2.967 ± 0.064	2.507GluGln: 2.507 ± 0.057	5.234GluArg: 5.234 ± 0.096	2.647GluSer: 2.647 ± 0.052	2.844GluThr: 2.844 ± 0.058	4.426GluVal: 4.426 ± 0.08	0.727GluTrp: 0.727 ± 0.029	1.07GluTyr: 1.07 ± 0.041	0.0GluXaa: 0.0 ± 0.0
Phe	3.946PheAla: 3.946 ± 0.066	0.153PheCys: 0.153 ± 0.011	2.298PheAsp: 2.298 ± 0.054	1.434PheGlu: 1.434 ± 0.039	0.917PhePhe: 0.917 ± 0.037	3.216PheGly: 3.216 ± 0.055	0.572PheHis: 0.572 ± 0.022	0.996PheIle: 0.996 ± 0.036	0.412PheLys: 0.412 ± 0.023	2.731PheLeu: 2.731 ± 0.057	0.38PheMet: 0.38 ± 0.02	0.529PheAsn: 0.529 ± 0.024	1.399PhePro: 1.399 ± 0.037	0.743PheGln: 0.743 ± 0.026	2.043PheArg: 2.043 ± 0.044	1.632PheSer: 1.632 ± 0.042	2.116PheThr: 2.116 ± 0.048	2.949PheVal: 2.949 ± 0.049	0.45PheTrp: 0.45 ± 0.022	0.517PheTyr: 0.517 ± 0.021	0.0PheXaa: 0.0 ± 0.0
Gly	10.912GlyAla: 10.912 ± 0.136	0.535GlyCys: 0.535 ± 0.027	5.339GlyAsp: 5.339 ± 0.088	4.012GlyGlu: 4.012 ± 0.069	3.144GlyPhe: 3.144 ± 0.056	7.904GlyGly: 7.904 ± 0.109	2.054GlyHis: 2.054 ± 0.05	4.2GlyIle: 4.2 ± 0.066	2.191GlyLys: 2.191 ± 0.057	8.61GlyLeu: 8.61 ± 0.112	1.767GlyMet: 1.767 ± 0.049	1.795GlyAsn: 1.795 ± 0.053	4.24GlyPro: 4.24 ± 0.068	2.688GlyGln: 2.688 ± 0.052	6.991GlyArg: 6.991 ± 0.102	6.165GlySer: 6.165 ± 0.092	6.799GlyThr: 6.799 ± 0.135	8.439GlyVal: 8.439 ± 0.097	1.639GlyTrp: 1.639 ± 0.045	2.05GlyTyr: 2.05 ± 0.042	0.0GlyXaa: 0.0 ± 0.0
His	2.438HisAla: 2.438 ± 0.049	0.125HisCys: 0.125 ± 0.011	1.603HisAsp: 1.603 ± 0.036	1.248HisGlu: 1.248 ± 0.039	0.54HisPhe: 0.54 ± 0.024	2.252HisGly: 2.252 ± 0.064	0.602HisHis: 0.602 ± 0.024	0.603HisIle: 0.603 ± 0.025	0.231HisLys: 0.231 ± 0.014	2.03HisLeu: 2.03 ± 0.047	0.342HisMet: 0.342 ± 0.018	0.322HisAsn: 0.322 ± 0.015	1.436HisPro: 1.436 ± 0.038	0.568HisGln: 0.568 ± 0.024	1.907HisArg: 1.907 ± 0.048	0.827HisSer: 0.827 ± 0.03	1.105HisThr: 1.105 ± 0.033	1.971HisVal: 1.971 ± 0.047	0.316HisTrp: 0.316 ± 0.019	0.349HisTyr: 0.349 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	6.133IleAla: 6.133 ± 0.076	0.174IleCys: 0.174 ± 0.013	2.975IleAsp: 2.975 ± 0.064	2.275IleGlu: 2.275 ± 0.055	0.603IlePhe: 0.603 ± 0.031	4.429IleGly: 4.429 ± 0.082	0.555IleHis: 0.555 ± 0.025	1.248IleIle: 1.248 ± 0.045	0.68IleLys: 0.68 ± 0.03	2.507IleLeu: 2.507 ± 0.067	0.477IleMet: 0.477 ± 0.022	0.716IleAsn: 0.716 ± 0.025	1.905IlePro: 1.905 ± 0.045	0.79IleGln: 0.79 ± 0.029	2.548IleArg: 2.548 ± 0.05	1.852IleSer: 1.852 ± 0.041	2.626IleThr: 2.626 ± 0.057	3.989IleVal: 3.989 ± 0.074	0.414IleTrp: 0.414 ± 0.025	0.447IleTyr: 0.447 ± 0.022	0.0IleXaa: 0.0 ± 0.0
Lys	2.258LysAla: 2.258 ± 0.056	0.056LysCys: 0.056 ± 0.008	1.143LysAsp: 1.143 ± 0.04	0.823LysGlu: 0.823 ± 0.029	0.449LysPhe: 0.449 ± 0.022	1.499LysGly: 1.499 ± 0.047	0.455LysHis: 0.455 ± 0.021	0.756LysIle: 0.756 ± 0.029	0.686LysLys: 0.686 ± 0.035	1.592LysLeu: 1.592 ± 0.048	0.315LysMet: 0.315 ± 0.018	0.465LysAsn: 0.465 ± 0.024	1.126LysPro: 1.126 ± 0.034	0.766LysGln: 0.766 ± 0.026	1.424LysArg: 1.424 ± 0.044	1.102LysSer: 1.102 ± 0.04	1.34LysThr: 1.34 ± 0.04	1.605LysVal: 1.605 ± 0.049	0.249LysTrp: 0.249 ± 0.015	0.43LysTyr: 0.43 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	13.394LeuAla: 13.394 ± 0.131	0.399LeuCys: 0.399 ± 0.019	6.771LeuAsp: 6.771 ± 0.098	4.735LeuGlu: 4.735 ± 0.07	2.692LeuPhe: 2.692 ± 0.059	9.001LeuGly: 9.001 ± 0.114	2.005LeuHis: 2.005 ± 0.045	3.053LeuIle: 3.053 ± 0.072	1.427LeuLys: 1.427 ± 0.047	9.46LeuLeu: 9.46 ± 0.126	1.325LeuMet: 1.325 ± 0.041	1.448LeuAsn: 1.448 ± 0.037	5.519LeuPro: 5.519 ± 0.078	2.715LeuGln: 2.715 ± 0.054	7.475LeuArg: 7.475 ± 0.104	4.964LeuSer: 4.964 ± 0.072	6.226LeuThr: 6.226 ± 0.084	10.469LeuVal: 10.469 ± 0.127	1.17LeuTrp: 1.17 ± 0.038	1.406LeuTyr: 1.406 ± 0.041	0.0LeuXaa: 0.0 ± 0.0
Met	1.932MetAla: 1.932 ± 0.048	0.077MetCys: 0.077 ± 0.008	0.81MetAsp: 0.81 ± 0.03	0.569MetGlu: 0.569 ± 0.023	0.432MetPhe: 0.432 ± 0.023	1.196MetGly: 1.196 ± 0.036	0.414MetHis: 0.414 ± 0.022	0.661MetIle: 0.661 ± 0.026	0.314MetLys: 0.314 ± 0.016	1.645MetLeu: 1.645 ± 0.041	0.258MetMet: 0.258 ± 0.015	0.418MetAsn: 0.418 ± 0.02	1.158MetPro: 1.158 ± 0.033	0.586MetGln: 0.586 ± 0.026	1.325MetArg: 1.325 ± 0.04	1.374MetSer: 1.374 ± 0.036	1.783MetThr: 1.783 ± 0.038	1.318MetVal: 1.318 ± 0.031	0.186MetTrp: 0.186 ± 0.014	0.271MetTyr: 0.271 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	2.38AsnAla: 2.38 ± 0.055	0.093AsnCys: 0.093 ± 0.009	1.222AsnAsp: 1.222 ± 0.046	0.846AsnGlu: 0.846 ± 0.028	0.479AsnPhe: 0.479 ± 0.022	1.949AsnGly: 1.949 ± 0.049	0.367AsnHis: 0.367 ± 0.021	0.621AsnIle: 0.621 ± 0.025	0.361AsnLys: 0.361 ± 0.021	1.545AsnLeu: 1.545 ± 0.041	0.305AsnMet: 0.305 ± 0.018	0.361AsnAsn: 0.361 ± 0.021	1.344AsnPro: 1.344 ± 0.04	0.537AsnGln: 0.537 ± 0.023	1.271AsnArg: 1.271 ± 0.038	0.896AsnSer: 0.896 ± 0.037	1.178AsnThr: 1.178 ± 0.037	1.625AsnVal: 1.625 ± 0.043	0.304AsnTrp: 0.304 ± 0.02	0.378AsnTyr: 0.378 ± 0.02	0.0AsnXaa: 0.0 ± 0.0
Pro	7.225ProAla: 7.225 ± 0.109	0.203ProCys: 0.203 ± 0.015	4.257ProAsp: 4.257 ± 0.062	3.594ProGlu: 3.594 ± 0.072	1.677ProPhe: 1.677 ± 0.038	5.282ProGly: 5.282 ± 0.08	1.054ProHis: 1.054 ± 0.033	1.87ProIle: 1.87 ± 0.049	1.047ProLys: 1.047 ± 0.038	4.563ProLeu: 4.563 ± 0.068	0.902ProMet: 0.902 ± 0.03	0.991ProAsn: 0.991 ± 0.033	2.122ProPro: 2.122 ± 0.056	1.385ProGln: 1.385 ± 0.041	3.36ProArg: 3.36 ± 0.067	3.414ProSer: 3.414 ± 0.067	4.061ProThr: 4.061 ± 0.071	5.705ProVal: 5.705 ± 0.09	0.863ProTrp: 0.863 ± 0.026	1.012ProTyr: 1.012 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	3.732GlnAla: 3.732 ± 0.068	0.116GlnCys: 0.116 ± 0.011	1.667GlnAsp: 1.667 ± 0.043	1.35GlnGlu: 1.35 ± 0.038	0.84GlnPhe: 0.84 ± 0.026	2.153GlnGly: 2.153 ± 0.044	0.779GlnHis: 0.779 ± 0.024	1.222GlnIle: 1.222 ± 0.036	0.587GlnLys: 0.587 ± 0.024	3.01GlnLeu: 3.01 ± 0.055	0.457GlnMet: 0.457 ± 0.023	0.571GlnAsn: 0.571 ± 0.025	1.595GlnPro: 1.595 ± 0.041	1.513GlnGln: 1.513 ± 0.049	2.59GlnArg: 2.59 ± 0.05	1.53GlnSer: 1.53 ± 0.038	1.653GlnThr: 1.653 ± 0.043	2.781GlnVal: 2.781 ± 0.057	0.474GlnTrp: 0.474 ± 0.02	0.744GlnTyr: 0.744 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	9.483ArgAla: 9.483 ± 0.131	0.335ArgCys: 0.335 ± 0.019	4.644ArgAsp: 4.644 ± 0.089	3.656ArgGlu: 3.656 ± 0.074	2.494ArgPhe: 2.494 ± 0.051	5.64ArgGly: 5.64 ± 0.084	1.637ArgHis: 1.637 ± 0.04	3.379ArgIle: 3.379 ± 0.05	1.411ArgLys: 1.411 ± 0.044	7.001ArgLeu: 7.001 ± 0.104	1.696ArgMet: 1.696 ± 0.042	1.424ArgAsn: 1.424 ± 0.039	4.201ArgPro: 4.201 ± 0.074	2.296ArgGln: 2.296 ± 0.048	7.155ArgArg: 7.155 ± 0.126	4.889ArgSer: 4.889 ± 0.067	5.249ArgThr: 5.249 ± 0.075	6.53ArgVal: 6.53 ± 0.096	1.353ArgTrp: 1.353 ± 0.034	1.577ArgTyr: 1.577 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	7.586SerAla: 7.586 ± 0.103	0.293SerCys: 0.293 ± 0.018	3.464SerAsp: 3.464 ± 0.068	2.436SerGlu: 2.436 ± 0.048	1.833SerPhe: 1.833 ± 0.04	6.217SerGly: 6.217 ± 0.104	0.962SerHis: 0.962 ± 0.03	2.246SerIle: 2.246 ± 0.045	1.116SerLys: 1.116 ± 0.033	4.905SerLeu: 4.905 ± 0.071	1.168SerMet: 1.168 ± 0.029	1.082SerAsn: 1.082 ± 0.038	2.866SerPro: 2.866 ± 0.055	1.358SerGln: 1.358 ± 0.036	3.828SerArg: 3.828 ± 0.062	3.705SerSer: 3.705 ± 0.078	4.161SerThr: 4.161 ± 0.079	5.29SerVal: 5.29 ± 0.074	0.955SerTrp: 0.955 ± 0.028	1.062SerTyr: 1.062 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	9.34ThrAla: 9.34 ± 0.121	0.313ThrCys: 0.313 ± 0.019	4.307ThrAsp: 4.307 ± 0.079	3.107ThrGlu: 3.107 ± 0.06	1.92ThrPhe: 1.92 ± 0.04	6.723ThrGly: 6.723 ± 0.108	1.093ThrHis: 1.093 ± 0.034	2.862ThrIle: 2.862 ± 0.061	1.359ThrLys: 1.359 ± 0.045	5.997ThrLeu: 5.997 ± 0.08	1.071ThrMet: 1.071 ± 0.032	1.388ThrAsn: 1.388 ± 0.041	4.281ThrPro: 4.281 ± 0.072	1.5ThrGln: 1.5 ± 0.042	4.072ThrArg: 4.072 ± 0.063	3.921ThrSer: 3.921 ± 0.077	5.262ThrThr: 5.262 ± 0.093	7.107ThrVal: 7.107 ± 0.129	1.024ThrTrp: 1.024 ± 0.035	1.212ThrTyr: 1.212 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	12.725ValAla: 12.725 ± 0.139	0.479ValCys: 0.479 ± 0.024	6.7ValAsp: 6.7 ± 0.086	4.876ValGlu: 4.876 ± 0.09	3.144ValPhe: 3.144 ± 0.058	8.044ValGly: 8.044 ± 0.103	2.002ValHis: 2.002 ± 0.042	3.736ValIle: 3.736 ± 0.072	1.51ValLys: 1.51 ± 0.044	10.866ValLeu: 10.866 ± 0.141	1.441ValMet: 1.441 ± 0.039	1.68ValAsn: 1.68 ± 0.048	5.607ValPro: 5.607 ± 0.078	2.721ValGln: 2.721 ± 0.045	7.094ValArg: 7.094 ± 0.108	5.274ValSer: 5.274 ± 0.085	7.009ValThr: 7.009 ± 0.113	11.619ValVal: 11.619 ± 0.161	1.128ValTrp: 1.128 ± 0.035	1.542ValTyr: 1.542 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	1.67TrpAla: 1.67 ± 0.037	0.101TrpCys: 0.101 ± 0.009	0.815TrpAsp: 0.815 ± 0.03	0.605TrpGlu: 0.605 ± 0.025	0.585TrpPhe: 0.585 ± 0.027	1.038TrpGly: 1.038 ± 0.036	0.345TrpHis: 0.345 ± 0.017	0.595TrpIle: 0.595 ± 0.023	0.32TrpLys: 0.32 ± 0.018	1.549TrpLeu: 1.549 ± 0.045	0.299TrpMet: 0.299 ± 0.017	0.368TrpAsn: 0.368 ± 0.019	0.714TrpPro: 0.714 ± 0.026	0.568TrpGln: 0.568 ± 0.025	1.208TrpArg: 1.208 ± 0.035	1.04TrpSer: 1.04 ± 0.031	1.055TrpThr: 1.055 ± 0.032	1.211TrpVal: 1.211 ± 0.036	0.351TrpTrp: 0.351 ± 0.017	0.307TrpTyr: 0.307 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.161TyrAla: 2.161 ± 0.046	0.111TyrCys: 0.111 ± 0.01	1.339TyrAsp: 1.339 ± 0.044	1.029TyrGlu: 1.029 ± 0.032	0.587TyrPhe: 0.587 ± 0.027	1.831TyrGly: 1.831 ± 0.041	0.277TyrHis: 0.277 ± 0.016	0.518TyrIle: 0.518 ± 0.026	0.334TyrLys: 0.334 ± 0.019	1.807TyrLeu: 1.807 ± 0.044	0.232TyrMet: 0.232 ± 0.015	0.375TyrAsn: 0.375 ± 0.02	0.962TyrPro: 0.962 ± 0.031	0.58TyrGln: 0.58 ± 0.024	1.562TyrArg: 1.562 ± 0.042	1.029TyrSer: 1.029 ± 0.035	1.105TyrThr: 1.105 ± 0.047	1.559TyrVal: 1.559 ± 0.033	0.281TyrTrp: 0.281 ± 0.016	0.387TyrTyr: 0.387 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3329 proteins (1050386 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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