Human T-cell leukemia virus 1 (isolate Caribbea HS-35 subtype A) (HTLV-1)

Taxonomy: Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes; Ortervirales; Retroviridae; Orthoretrovirinae; Deltaretrovirus; Primate T-lymphotropic virus 1; Human T-cell leukemia virus type I; HTLV-1 subtype A

Average proteome isoelectric point is 7.83

Get precalculated fractions of proteins

Acidic
pI < 6.8
6.8-7.4
pI > 7.4
Basic
    
All



Virtual 2D-PAGE plot for 13 proteins (isoelectric point calculated using IPC2_protein)

Get csv file with sequences according to given criteria:
        -     Method 

     -  kDa    
                                                                                      

* You can choose from 21 different methods for calculating isoelectric point

Summary statistics related to proteome-wise predictions


    
Protein with the lowest isoelectric point:
>sp|P0C745-2|HBZ-2_HTL1C Isoform of P0C745 Isoform HBZ-SI of HTLV-1 basic zipper factor OS=Human T-cell leukemia virus 1 (isolate Caribbea HS-35 subtype A) OX=11927 GN=HBZ PE=1 SV=1
MM1 pKa = 8.02DD2 pKa = 5.6ALSAQLYY9 pKa = 10.43SSLSLDD15 pKa = 4.19SPPSPPRR22 pKa = 11.84EE23 pKa = 3.79PLRR26 pKa = 11.84PLRR29 pKa = 11.84SLPRR33 pKa = 11.84QSLIQPPTFHH43 pKa = 7.19PPSSRR48 pKa = 11.84PCANTPPSEE57 pKa = 4.03MDD59 pKa = 2.87TWNPPLGSTSQPCLFQTPDD78 pKa = 3.97SGPKK82 pKa = 8.26TCTPSGEE89 pKa = 4.42APLSACTSTSFPPPSPGPSCPMM111 pKa = 4.14

Molecular weight: 11.7 kDa
Isoelectric point according different methods:





Protein with the highest isoelectric point:
>sp|P0CK17-2|P30II-2_HTL1C Isoform of P0CK17 Isoform p13II of Accessory protein p30II OS=Human T-cell leukemia virus 1 (isolate Caribbea HS-35 subtype A) OX=11927 PE=3 SV=1
MM1 pKa = 7.78PKK3 pKa = 8.91TRR5 pKa = 11.84RR6 pKa = 11.84RR7 pKa = 11.84PRR9 pKa = 11.84RR10 pKa = 11.84SQRR13 pKa = 11.84KK14 pKa = 8.69RR15 pKa = 11.84PPTPWQPPPFSLQGLHH31 pKa = 6.98LAFQLSSIAINPQLLHH47 pKa = 6.47FFFPSTLFRR56 pKa = 11.84LLSPLSPLALTALLLFLLSPGEE78 pKa = 4.09VSGLLLRR85 pKa = 11.84PLPAPCLLLFLPFQILSNLLFLLFLPLFFSLPLLLSPSLPITMRR129 pKa = 11.84FPARR133 pKa = 11.84WRR135 pKa = 11.84FPPWRR140 pKa = 11.84APSQPAAAFLFF151 pKa = 4.4

Molecular weight: 17.24 kDa
Isoelectric point according different methods:





Peptides (in silico digests for buttom-up proteomics)

Below you can find in silico digests of the whole proteome with Trypsin, Chymotrypsin, Trypsin+LysC, LysN, ArgC proteases suitable for different mass spec machines.

Try
ESI
ChTry
ESI
ArgC
ESI
LysN
ESI
TryLysC
ESI

Try
MALDI
ChTry
MALDI
ArgC
MALDI
LysN
MALDI
TryLysC
MALDI

Try
LTQ
ChTry
LTQ
ArgC
LTQ
LysN
LTQ
TryLysC
LTQ

Try
MSlow
ChTry
MSlow
ArgC
MSlow
LysN
MSlow
TryLysC
MSlow

Try
MShigh
ChTry
MShigh
ArgC
MShigh
LysN
MShigh
TryLysC
MShigh

General Statistics

Number of major isoforms

Number of additional isoforms

Number of all proteins

Number of amino acids

Min. Seq. Length

Max. Seq. Length

Avg. Seq. Length

Avg. Mol. Weight

9

4

13

4676

87

1462

359.7

40.17

Amino acid frequency

Ala

Cys

Asp

Glu

Phe

Gly

His

Ile

Lys

Leu

6.63 ± 0.505

2.224 ± 0.278

3.464 ± 0.319

4.32 ± 1.508

3.486 ± 0.647

5.026 ± 0.249

3.208 ± 0.506

4.085 ± 0.633

4.063 ± 0.542

13.238 ± 0.772

Met

Asn

Gln

Pro

Arg

Ser

Thr

Val

Trp

Tyr

1.24 ± 0.174

2.93 ± 0.449

11.869 ± 1.03

6.009 ± 0.739

6.202 ± 1.164

8.618 ± 1.223

5.689 ± 0.694

3.55 ± 0.329

1.882 ± 0.12

2.267 ± 0.297
Note: For amino acid frequency statistics the error has been estimated with the bootstraping (x100) at the protein level

Most of the basic statistics you can see at this page can be downloaded from this CSV file

For dipeptide frequency statistics click here
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski