Amino acid dipepetide frequency for Lysobacter spongiicola DSM 21749

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.464AlaAla: 17.464 ± 0.185	1.145AlaCys: 1.145 ± 0.034	7.184AlaAsp: 7.184 ± 0.098	7.733AlaGlu: 7.733 ± 0.11	3.891AlaPhe: 3.891 ± 0.068	11.883AlaGly: 11.883 ± 0.132	2.44AlaHis: 2.44 ± 0.046	5.328AlaIle: 5.328 ± 0.079	2.882AlaLys: 2.882 ± 0.073	14.423AlaLeu: 14.423 ± 0.173	3.513AlaMet: 3.513 ± 0.061	2.654AlaAsn: 2.654 ± 0.052	6.346AlaPro: 6.346 ± 0.096	4.154AlaGln: 4.154 ± 0.07	9.9AlaArg: 9.9 ± 0.12	6.588AlaSer: 6.588 ± 0.09	6.368AlaThr: 6.368 ± 0.098	8.77AlaVal: 8.77 ± 0.111	1.916AlaTrp: 1.916 ± 0.051	2.23AlaTyr: 2.23 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	0.939CysAla: 0.939 ± 0.035	0.111CysCys: 0.111 ± 0.011	0.485CysAsp: 0.485 ± 0.023	0.487CysGlu: 0.487 ± 0.023	0.254CysPhe: 0.254 ± 0.016	0.86CysGly: 0.86 ± 0.033	0.248CysHis: 0.248 ± 0.016	0.307CysIle: 0.307 ± 0.02	0.157CysLys: 0.157 ± 0.014	0.705CysLeu: 0.705 ± 0.028	0.129CysMet: 0.129 ± 0.012	0.202CysAsn: 0.202 ± 0.015	0.454CysPro: 0.454 ± 0.025	0.228CysGln: 0.228 ± 0.015	0.606CysArg: 0.606 ± 0.026	0.491CysSer: 0.491 ± 0.022	0.42CysThr: 0.42 ± 0.021	0.612CysVal: 0.612 ± 0.025	0.115CysTrp: 0.115 ± 0.011	0.18CysTyr: 0.18 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	8.163AspAla: 8.163 ± 0.092	0.416AspCys: 0.416 ± 0.022	3.634AspAsp: 3.634 ± 0.075	3.741AspGlu: 3.741 ± 0.068	2.024AspPhe: 2.024 ± 0.048	6.081AspGly: 6.081 ± 0.099	1.337AspHis: 1.337 ± 0.041	2.458AspIle: 2.458 ± 0.057	1.331AspLys: 1.331 ± 0.039	5.721AspLeu: 5.721 ± 0.087	1.196AspMet: 1.196 ± 0.034	1.342AspAsn: 1.342 ± 0.041	4.031AspPro: 4.031 ± 0.072	1.828AspGln: 1.828 ± 0.048	4.597AspArg: 4.597 ± 0.067	2.676AspSer: 2.676 ± 0.06	2.861AspThr: 2.861 ± 0.053	4.247AspVal: 4.247 ± 0.071	1.057AspTrp: 1.057 ± 0.039	1.546AspTyr: 1.546 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	8.0GluAla: 8.0 ± 0.119	0.383GluCys: 0.383 ± 0.02	3.037GluAsp: 3.037 ± 0.062	3.106GluGlu: 3.106 ± 0.062	1.913GluPhe: 1.913 ± 0.047	4.915GluGly: 4.915 ± 0.078	1.56GluHis: 1.56 ± 0.039	2.598GluIle: 2.598 ± 0.053	1.499GluLys: 1.499 ± 0.048	6.684GluLeu: 6.684 ± 0.079	1.339GluMet: 1.339 ± 0.039	1.249GluAsn: 1.249 ± 0.038	3.099GluPro: 3.099 ± 0.058	2.817GluGln: 2.817 ± 0.06	5.851GluArg: 5.851 ± 0.088	2.892GluSer: 2.892 ± 0.061	2.716GluThr: 2.716 ± 0.057	4.892GluVal: 4.892 ± 0.073	0.898GluTrp: 0.898 ± 0.033	1.202GluTyr: 1.202 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	3.89PheAla: 3.89 ± 0.081	0.299PheCys: 0.299 ± 0.019	2.66PheAsp: 2.66 ± 0.061	2.206PheGlu: 2.206 ± 0.047	1.145PhePhe: 1.145 ± 0.045	3.3PheGly: 3.3 ± 0.068	0.767PheHis: 0.767 ± 0.031	1.24PheIle: 1.24 ± 0.038	0.789PheLys: 0.789 ± 0.028	2.899PheLeu: 2.899 ± 0.066	0.68PheMet: 0.68 ± 0.025	0.995PheAsn: 0.995 ± 0.035	1.358PhePro: 1.358 ± 0.04	0.919PheGln: 0.919 ± 0.033	2.136PheArg: 2.136 ± 0.048	1.932PheSer: 1.932 ± 0.041	1.623PheThr: 1.623 ± 0.044	2.494PheVal: 2.494 ± 0.049	0.485PheTrp: 0.485 ± 0.028	0.737PheTyr: 0.737 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	9.515GlyAla: 9.515 ± 0.13	0.841GlyCys: 0.841 ± 0.033	5.386GlyAsp: 5.386 ± 0.091	5.733GlyGlu: 5.733 ± 0.093	3.493GlyPhe: 3.493 ± 0.065	7.895GlyGly: 7.895 ± 0.137	2.258GlyHis: 2.258 ± 0.051	4.076GlyIle: 4.076 ± 0.083	2.772GlyLys: 2.772 ± 0.07	8.92GlyLeu: 8.92 ± 0.107	2.498GlyMet: 2.498 ± 0.055	2.373GlyAsn: 2.373 ± 0.057	3.498GlyPro: 3.498 ± 0.061	3.123GlyGln: 3.123 ± 0.062	6.831GlyArg: 6.831 ± 0.115	5.209GlySer: 5.209 ± 0.091	4.621GlyThr: 4.621 ± 0.074	6.441GlyVal: 6.441 ± 0.08	1.726GlyTrp: 1.726 ± 0.05	2.317GlyTyr: 2.317 ± 0.058	0.0GlyXaa: 0.0 ± 0.0
His	2.984HisAla: 2.984 ± 0.053	0.284HisCys: 0.284 ± 0.016	1.373HisAsp: 1.373 ± 0.041	1.229HisGlu: 1.229 ± 0.033	0.796HisPhe: 0.796 ± 0.024	2.43HisGly: 2.43 ± 0.054	0.663HisHis: 0.663 ± 0.028	0.708HisIle: 0.708 ± 0.029	0.456HisLys: 0.456 ± 0.023	2.278HisLeu: 2.278 ± 0.053	0.44HisMet: 0.44 ± 0.023	0.448HisAsn: 0.448 ± 0.02	1.581HisPro: 1.581 ± 0.045	0.697HisGln: 0.697 ± 0.026	1.783HisArg: 1.783 ± 0.043	1.026HisSer: 1.026 ± 0.032	0.971HisThr: 0.971 ± 0.031	1.731HisVal: 1.731 ± 0.042	0.435HisTrp: 0.435 ± 0.024	0.586HisTyr: 0.586 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	5.719IleAla: 5.719 ± 0.082	0.306IleCys: 0.306 ± 0.018	3.213IleAsp: 3.213 ± 0.053	3.153IleGlu: 3.153 ± 0.062	1.041IlePhe: 1.041 ± 0.044	4.212IleGly: 4.212 ± 0.081	0.836IleHis: 0.836 ± 0.03	1.402IleIle: 1.402 ± 0.045	1.106IleLys: 1.106 ± 0.04	2.924IleLeu: 2.924 ± 0.058	0.571IleMet: 0.571 ± 0.026	1.218IleAsn: 1.218 ± 0.036	2.029IlePro: 2.029 ± 0.05	1.104IleGln: 1.104 ± 0.037	2.772IleArg: 2.772 ± 0.05	2.09IleSer: 2.09 ± 0.045	2.025IleThr: 2.025 ± 0.044	3.034IleVal: 3.034 ± 0.063	0.394IleTrp: 0.394 ± 0.021	0.756IleTyr: 0.756 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	2.98LysAla: 2.98 ± 0.076	0.145LysCys: 0.145 ± 0.013	1.298LysAsp: 1.298 ± 0.045	1.196LysGlu: 1.196 ± 0.042	0.641LysPhe: 0.641 ± 0.029	1.84LysGly: 1.84 ± 0.048	0.586LysHis: 0.586 ± 0.022	0.976LysIle: 0.976 ± 0.031	0.917LysLys: 0.917 ± 0.066	2.731LysLeu: 2.731 ± 0.055	0.556LysMet: 0.556 ± 0.027	0.546LysAsn: 0.546 ± 0.029	1.68LysPro: 1.68 ± 0.052	1.015LysGln: 1.015 ± 0.031	1.998LysArg: 1.998 ± 0.05	1.282LysSer: 1.282 ± 0.041	1.253LysThr: 1.253 ± 0.039	2.029LysVal: 2.029 ± 0.061	0.284LysTrp: 0.284 ± 0.018	0.507LysTyr: 0.507 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	14.733LeuAla: 14.733 ± 0.177	0.807LeuCys: 0.807 ± 0.024	6.831LeuAsp: 6.831 ± 0.086	6.362LeuGlu: 6.362 ± 0.092	3.205LeuPhe: 3.205 ± 0.064	8.867LeuGly: 8.867 ± 0.105	2.449LeuHis: 2.449 ± 0.062	3.29LeuIle: 3.29 ± 0.068	2.64LeuLys: 2.64 ± 0.055	11.861LeuLeu: 11.861 ± 0.169	2.271LeuMet: 2.271 ± 0.046	2.105LeuAsn: 2.105 ± 0.052	6.377LeuPro: 6.377 ± 0.083	3.857LeuGln: 3.857 ± 0.065	8.51LeuArg: 8.51 ± 0.115	5.747LeuSer: 5.747 ± 0.075	4.445LeuThr: 4.445 ± 0.078	8.74LeuVal: 8.74 ± 0.105	1.322LeuTrp: 1.322 ± 0.042	2.011LeuTyr: 2.011 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	2.941MetAla: 2.941 ± 0.059	0.154MetCys: 0.154 ± 0.012	1.236MetAsp: 1.236 ± 0.039	1.197MetGlu: 1.197 ± 0.036	0.655MetPhe: 0.655 ± 0.028	1.71MetGly: 1.71 ± 0.051	0.506MetHis: 0.506 ± 0.02	0.847MetIle: 0.847 ± 0.027	0.845MetLys: 0.845 ± 0.032	2.567MetLeu: 2.567 ± 0.059	0.492MetMet: 0.492 ± 0.026	0.658MetAsn: 0.658 ± 0.027	1.474MetPro: 1.474 ± 0.039	0.962MetGln: 0.962 ± 0.035	1.799MetArg: 1.799 ± 0.047	1.52MetSer: 1.52 ± 0.038	1.326MetThr: 1.326 ± 0.041	1.684MetVal: 1.684 ± 0.042	0.219MetTrp: 0.219 ± 0.015	0.416MetTyr: 0.416 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	2.945AsnAla: 2.945 ± 0.064	0.219AsnCys: 0.219 ± 0.015	1.274AsnAsp: 1.274 ± 0.034	1.21AsnGlu: 1.21 ± 0.034	0.745AsnPhe: 0.745 ± 0.031	2.175AsnGly: 2.175 ± 0.051	0.484AsnHis: 0.484 ± 0.025	1.016AsnIle: 1.016 ± 0.032	0.549AsnLys: 0.549 ± 0.025	2.27AsnLeu: 2.27 ± 0.059	0.436AsnMet: 0.436 ± 0.022	0.601AsnAsn: 0.601 ± 0.028	1.761AsnPro: 1.761 ± 0.046	0.735AsnGln: 0.735 ± 0.027	1.766AsnArg: 1.766 ± 0.045	1.049AsnSer: 1.049 ± 0.036	1.15AsnThr: 1.15 ± 0.039	1.706AsnVal: 1.706 ± 0.048	0.354AsnTrp: 0.354 ± 0.019	0.534AsnTyr: 0.534 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	7.528ProAla: 7.528 ± 0.11	0.321ProCys: 0.321 ± 0.023	3.961ProAsp: 3.961 ± 0.07	3.85ProGlu: 3.85 ± 0.07	1.585ProPhe: 1.585 ± 0.042	5.459ProGly: 5.459 ± 0.075	1.093ProHis: 1.093 ± 0.031	1.826ProIle: 1.826 ± 0.046	1.149ProLys: 1.149 ± 0.042	5.324ProLeu: 5.324 ± 0.087	1.399ProMet: 1.399 ± 0.04	1.009ProAsn: 1.009 ± 0.033	3.184ProPro: 3.184 ± 0.082	1.625ProGln: 1.625 ± 0.048	3.887ProArg: 3.887 ± 0.072	2.729ProSer: 2.729 ± 0.059	2.577ProThr: 2.577 ± 0.055	4.686ProVal: 4.686 ± 0.093	0.829ProTrp: 0.829 ± 0.031	1.107ProTyr: 1.107 ± 0.041	0.0ProXaa: 0.0 ± 0.0
Gln	4.853GlnAla: 4.853 ± 0.085	0.236GlnCys: 0.236 ± 0.018	1.565GlnAsp: 1.565 ± 0.038	1.563GlnGlu: 1.563 ± 0.04	1.042GlnPhe: 1.042 ± 0.033	2.717GlnGly: 2.717 ± 0.056	0.747GlnHis: 0.747 ± 0.027	1.232GlnIle: 1.232 ± 0.037	0.764GlnLys: 0.764 ± 0.031	3.874GlnLeu: 3.874 ± 0.063	0.827GlnMet: 0.827 ± 0.028	0.621GlnAsn: 0.621 ± 0.029	2.169GlnPro: 2.169 ± 0.058	1.63GlnGln: 1.63 ± 0.046	3.24GlnArg: 3.24 ± 0.07	1.676GlnSer: 1.676 ± 0.046	1.382GlnThr: 1.382 ± 0.04	3.161GlnVal: 3.161 ± 0.07	0.591GlnTrp: 0.591 ± 0.025	0.713GlnTyr: 0.713 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	8.373ArgAla: 8.373 ± 0.107	0.579ArgCys: 0.579 ± 0.026	4.672ArgAsp: 4.672 ± 0.071	5.455ArgGlu: 5.455 ± 0.076	3.038ArgPhe: 3.038 ± 0.064	5.798ArgGly: 5.798 ± 0.088	2.115ArgHis: 2.115 ± 0.053	3.88ArgIle: 3.88 ± 0.069	2.049ArgLys: 2.049 ± 0.05	8.954ArgLeu: 8.954 ± 0.124	2.134ArgMet: 2.134 ± 0.051	1.937ArgAsn: 1.937 ± 0.044	3.877ArgPro: 3.877 ± 0.074	3.018ArgGln: 3.018 ± 0.057	6.39ArgArg: 6.39 ± 0.103	3.965ArgSer: 3.965 ± 0.058	3.457ArgThr: 3.457 ± 0.069	5.628ArgVal: 5.628 ± 0.096	1.437ArgTrp: 1.437 ± 0.039	2.094ArgTyr: 2.094 ± 0.047	0.0ArgXaa: 0.0 ± 0.0
Ser	6.085SerAla: 6.085 ± 0.083	0.401SerCys: 0.401 ± 0.024	2.974SerAsp: 2.974 ± 0.062	2.852SerGlu: 2.852 ± 0.056	1.709SerPhe: 1.709 ± 0.041	5.542SerGly: 5.542 ± 0.08	1.211SerHis: 1.211 ± 0.038	2.271SerIle: 2.271 ± 0.054	1.203SerLys: 1.203 ± 0.042	5.372SerLeu: 5.372 ± 0.075	1.215SerMet: 1.215 ± 0.039	1.339SerAsn: 1.339 ± 0.039	2.907SerPro: 2.907 ± 0.064	1.663SerGln: 1.663 ± 0.043	4.068SerArg: 4.068 ± 0.068	2.986SerSer: 2.986 ± 0.079	2.791SerThr: 2.791 ± 0.06	3.812SerVal: 3.812 ± 0.068	0.764SerTrp: 0.764 ± 0.026	1.202SerTyr: 1.202 ± 0.04	0.0SerXaa: 0.0 ± 0.0
Thr	5.85ThrAla: 5.85 ± 0.103	0.427ThrCys: 0.427 ± 0.023	2.596ThrAsp: 2.596 ± 0.052	2.412ThrGlu: 2.412 ± 0.053	1.452ThrPhe: 1.452 ± 0.032	4.864ThrGly: 4.864 ± 0.073	1.053ThrHis: 1.053 ± 0.04	1.999ThrIle: 1.999 ± 0.045	0.854ThrLys: 0.854 ± 0.032	5.706ThrLeu: 5.706 ± 0.083	0.966ThrMet: 0.966 ± 0.031	0.953ThrAsn: 0.953 ± 0.04	3.237ThrPro: 3.237 ± 0.054	1.295ThrGln: 1.295 ± 0.04	3.663ThrArg: 3.663 ± 0.064	2.446ThrSer: 2.446 ± 0.055	2.668ThrThr: 2.668 ± 0.058	3.819ThrVal: 3.819 ± 0.074	0.651ThrTrp: 0.651 ± 0.027	1.014ThrTyr: 1.014 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	10.04ValAla: 10.04 ± 0.109	0.579ValCys: 0.579 ± 0.022	4.964ValAsp: 4.964 ± 0.078	5.393ValGlu: 5.393 ± 0.084	2.535ValPhe: 2.535 ± 0.054	6.133ValGly: 6.133 ± 0.095	1.692ValHis: 1.692 ± 0.041	3.045ValIle: 3.045 ± 0.062	1.656ValLys: 1.656 ± 0.052	8.586ValLeu: 8.586 ± 0.121	1.654ValMet: 1.654 ± 0.046	1.766ValAsn: 1.766 ± 0.05	4.227ValPro: 4.227 ± 0.073	2.451ValGln: 2.451 ± 0.06	5.653ValArg: 5.653 ± 0.081	3.974ValSer: 3.974 ± 0.069	3.504ValThr: 3.504 ± 0.075	6.949ValVal: 6.949 ± 0.098	0.828ValTrp: 0.828 ± 0.03	1.39ValTyr: 1.39 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	1.311TrpAla: 1.311 ± 0.037	0.146TrpCys: 0.146 ± 0.012	0.698TrpAsp: 0.698 ± 0.03	0.601TrpGlu: 0.601 ± 0.026	0.583TrpPhe: 0.583 ± 0.027	0.904TrpGly: 0.904 ± 0.034	0.367TrpHis: 0.367 ± 0.02	0.704TrpIle: 0.704 ± 0.029	0.387TrpLys: 0.387 ± 0.02	2.298TrpLeu: 2.298 ± 0.056	0.461TrpMet: 0.461 ± 0.022	0.418TrpAsn: 0.418 ± 0.021	0.786TrpPro: 0.786 ± 0.035	0.692TrpGln: 0.692 ± 0.024	1.392TrpArg: 1.392 ± 0.045	0.915TrpSer: 0.915 ± 0.036	0.701TrpThr: 0.701 ± 0.029	0.997TrpVal: 0.997 ± 0.042	0.32TrpTrp: 0.32 ± 0.021	0.313TrpTyr: 0.313 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.5TyrAla: 2.5 ± 0.057	0.186TyrCys: 0.186 ± 0.015	1.248TyrAsp: 1.248 ± 0.04	1.173TyrGlu: 1.173 ± 0.033	0.81TyrPhe: 0.81 ± 0.029	1.942TyrGly: 1.942 ± 0.048	0.486TyrHis: 0.486 ± 0.025	0.697TyrIle: 0.697 ± 0.029	0.458TyrLys: 0.458 ± 0.025	2.332TyrLeu: 2.332 ± 0.05	0.432TyrMet: 0.432 ± 0.021	0.543TyrAsn: 0.543 ± 0.025	1.052TyrPro: 1.052 ± 0.04	0.788TyrGln: 0.788 ± 0.027	2.008TyrArg: 2.008 ± 0.041	1.173TyrSer: 1.173 ± 0.042	1.067TyrThr: 1.067 ± 0.033	1.588TyrVal: 1.588 ± 0.044	0.371TyrTrp: 0.371 ± 0.017	0.565TyrTyr: 0.565 ± 0.03	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2864 proteins (938805 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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