Amino acid dipepetide frequency for Prevotella sp. CAG:485

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.896AlaAla: 8.896 ± 0.153	1.027AlaCys: 1.027 ± 0.04	6.21AlaAsp: 6.21 ± 0.125	5.761AlaGlu: 5.761 ± 0.109	3.412AlaPhe: 3.412 ± 0.088	6.445AlaGly: 6.445 ± 0.146	1.367AlaHis: 1.367 ± 0.045	4.897AlaIle: 4.897 ± 0.106	4.398AlaLys: 4.398 ± 0.095	8.625AlaLeu: 8.625 ± 0.12	2.54AlaMet: 2.54 ± 0.064	3.644AlaAsn: 3.644 ± 0.073	3.69AlaPro: 3.69 ± 0.093	3.286AlaGln: 3.286 ± 0.07	4.277AlaArg: 4.277 ± 0.101	4.96AlaSer: 4.96 ± 0.086	4.954AlaThr: 4.954 ± 0.104	6.001AlaVal: 6.001 ± 0.113	0.958AlaTrp: 0.958 ± 0.036	2.818AlaTyr: 2.818 ± 0.058	0.006AlaXaa: 0.006 ± 0.003
Cys	1.007CysAla: 1.007 ± 0.043	0.196CysCys: 0.196 ± 0.017	0.644CysAsp: 0.644 ± 0.031	0.604CysGlu: 0.604 ± 0.028	0.587CysPhe: 0.587 ± 0.031	1.203CysGly: 1.203 ± 0.048	0.311CysHis: 0.311 ± 0.021	0.708CysIle: 0.708 ± 0.035	0.514CysLys: 0.514 ± 0.03	1.108CysLeu: 1.108 ± 0.044	0.348CysMet: 0.348 ± 0.023	0.584CysAsn: 0.584 ± 0.028	0.567CysPro: 0.567 ± 0.031	0.354CysGln: 0.354 ± 0.02	0.866CysArg: 0.866 ± 0.035	0.901CysSer: 0.901 ± 0.039	0.623CysThr: 0.623 ± 0.032	0.892CysVal: 0.892 ± 0.037	0.129CysTrp: 0.129 ± 0.013	0.594CysTyr: 0.594 ± 0.039	0.0CysXaa: 0.0 ± 0.0
Asp	4.855AspAla: 4.855 ± 0.091	0.762AspCys: 0.762 ± 0.034	2.827AspAsp: 2.827 ± 0.081	3.294AspGlu: 3.294 ± 0.081	2.835AspPhe: 2.835 ± 0.071	4.192AspGly: 4.192 ± 0.103	0.849AspHis: 0.849 ± 0.036	3.583AspIle: 3.583 ± 0.078	3.145AspLys: 3.145 ± 0.076	4.628AspLeu: 4.628 ± 0.099	1.723AspMet: 1.723 ± 0.046	2.765AspAsn: 2.765 ± 0.067	2.3AspPro: 2.3 ± 0.059	1.205AspGln: 1.205 ± 0.042	2.837AspArg: 2.837 ± 0.073	3.519AspSer: 3.519 ± 0.084	3.162AspThr: 3.162 ± 0.078	3.874AspVal: 3.874 ± 0.094	0.761AspTrp: 0.761 ± 0.029	2.578AspTyr: 2.578 ± 0.068	0.001AspXaa: 0.001 ± 0.002
Glu	5.728GluAla: 5.728 ± 0.114	0.573GluCys: 0.573 ± 0.026	2.535GluAsp: 2.535 ± 0.063	4.121GluGlu: 4.121 ± 0.115	2.099GluPhe: 2.099 ± 0.063	4.034GluGly: 4.034 ± 0.079	1.092GluHis: 1.092 ± 0.038	3.744GluIle: 3.744 ± 0.083	3.652GluLys: 3.652 ± 0.083	5.373GluLeu: 5.373 ± 0.101	1.813GluMet: 1.813 ± 0.059	2.85GluAsn: 2.85 ± 0.073	2.208GluPro: 2.208 ± 0.056	2.296GluGln: 2.296 ± 0.065	3.053GluArg: 3.053 ± 0.084	2.92GluSer: 2.92 ± 0.069	2.867GluThr: 2.867 ± 0.076	3.877GluVal: 3.877 ± 0.091	0.696GluTrp: 0.696 ± 0.033	2.27GluTyr: 2.27 ± 0.06	0.0GluXaa: 0.0 ± 0.0
Phe	3.439PheAla: 3.439 ± 0.076	0.624PheCys: 0.624 ± 0.031	2.585PheAsp: 2.585 ± 0.062	1.969PheGlu: 1.969 ± 0.054	1.768PhePhe: 1.768 ± 0.054	3.232PheGly: 3.232 ± 0.072	0.784PheHis: 0.784 ± 0.033	2.517PheIle: 2.517 ± 0.069	1.9PheLys: 1.9 ± 0.056	3.427PheLeu: 3.427 ± 0.092	1.221PheMet: 1.221 ± 0.045	2.316PheAsn: 2.316 ± 0.061	1.571PhePro: 1.571 ± 0.047	0.993PheGln: 0.993 ± 0.033	2.3PheArg: 2.3 ± 0.054	2.985PheSer: 2.985 ± 0.074	2.703PheThr: 2.703 ± 0.065	2.539PheVal: 2.539 ± 0.076	0.512PheTrp: 0.512 ± 0.027	1.626PheTyr: 1.626 ± 0.052	0.0PheXaa: 0.0 ± 0.0
Gly	5.779GlyAla: 5.779 ± 0.099	1.066GlyCys: 1.066 ± 0.04	3.798GlyAsp: 3.798 ± 0.079	3.995GlyGlu: 3.995 ± 0.082	3.204GlyPhe: 3.204 ± 0.073	5.318GlyGly: 5.318 ± 0.134	1.528GlyHis: 1.528 ± 0.052	5.232GlyIle: 5.232 ± 0.119	4.786GlyLys: 4.786 ± 0.094	6.164GlyLeu: 6.164 ± 0.108	2.162GlyMet: 2.162 ± 0.059	3.785GlyAsn: 3.785 ± 0.104	1.735GlyPro: 1.735 ± 0.057	2.336GlyGln: 2.336 ± 0.07	3.931GlyArg: 3.931 ± 0.078	4.72GlySer: 4.72 ± 0.112	4.616GlyThr: 4.616 ± 0.128	5.321GlyVal: 5.321 ± 0.107	0.961GlyTrp: 0.961 ± 0.037	3.139GlyTyr: 3.139 ± 0.08	0.007GlyXaa: 0.007 ± 0.003
His	1.436HisAla: 1.436 ± 0.042	0.315HisCys: 0.315 ± 0.022	1.008HisAsp: 1.008 ± 0.041	0.948HisGlu: 0.948 ± 0.038	0.954HisPhe: 0.954 ± 0.04	1.371HisGly: 1.371 ± 0.045	0.542HisHis: 0.542 ± 0.038	1.308HisIle: 1.308 ± 0.043	0.906HisLys: 0.906 ± 0.037	1.828HisLeu: 1.828 ± 0.054	0.289HisMet: 0.289 ± 0.02	0.998HisAsn: 0.998 ± 0.033	1.096HisPro: 1.096 ± 0.045	0.587HisGln: 0.587 ± 0.03	1.121HisArg: 1.121 ± 0.05	1.2HisSer: 1.2 ± 0.044	1.121HisThr: 1.121 ± 0.039	0.957HisVal: 0.957 ± 0.043	0.255HisTrp: 0.255 ± 0.017	0.791HisTyr: 0.791 ± 0.031	0.001HisXaa: 0.001 ± 0.001
Ile	5.511IleAla: 5.511 ± 0.099	0.872IleCys: 0.872 ± 0.032	4.141IleAsp: 4.141 ± 0.078	3.655IleGlu: 3.655 ± 0.084	2.584IlePhe: 2.584 ± 0.068	4.472IleGly: 4.472 ± 0.102	1.021IleHis: 1.021 ± 0.041	3.732IleIle: 3.732 ± 0.099	3.047IleLys: 3.047 ± 0.067	5.019IleLeu: 5.019 ± 0.1	1.548IleMet: 1.548 ± 0.052	2.897IleAsn: 2.897 ± 0.07	2.858IlePro: 2.858 ± 0.071	1.479IleGln: 1.479 ± 0.05	2.93IleArg: 2.93 ± 0.064	4.081IleSer: 4.081 ± 0.08	4.183IleThr: 4.183 ± 0.094	3.819IleVal: 3.819 ± 0.093	0.584IleTrp: 0.584 ± 0.031	2.352IleTyr: 2.352 ± 0.062	0.0IleXaa: 0.0 ± 0.0
Lys	5.21LysAla: 5.21 ± 0.093	0.469LysCys: 0.469 ± 0.028	2.653LysAsp: 2.653 ± 0.062	3.734LysGlu: 3.734 ± 0.079	1.677LysPhe: 1.677 ± 0.049	4.062LysGly: 4.062 ± 0.084	0.98LysHis: 0.98 ± 0.038	3.438LysIle: 3.438 ± 0.081	3.376LysLys: 3.376 ± 0.091	4.422LysLeu: 4.422 ± 0.087	1.823LysMet: 1.823 ± 0.052	2.421LysAsn: 2.421 ± 0.065	2.571LysPro: 2.571 ± 0.072	1.749LysGln: 1.749 ± 0.051	2.886LysArg: 2.886 ± 0.072	2.785LysSer: 2.785 ± 0.077	2.914LysThr: 2.914 ± 0.071	3.975LysVal: 3.975 ± 0.081	0.624LysTrp: 0.624 ± 0.036	2.025LysTyr: 2.025 ± 0.058	0.0LysXaa: 0.0 ± 0.0
Leu	7.473LeuAla: 7.473 ± 0.12	1.382LeuCys: 1.382 ± 0.052	4.805LeuAsp: 4.805 ± 0.093	4.57LeuGlu: 4.57 ± 0.089	3.483LeuPhe: 3.483 ± 0.089	6.282LeuGly: 6.282 ± 0.1	1.975LeuHis: 1.975 ± 0.06	4.927LeuIle: 4.927 ± 0.11	5.123LeuLys: 5.123 ± 0.088	9.166LeuLeu: 9.166 ± 0.16	2.515LeuMet: 2.515 ± 0.06	4.213LeuAsn: 4.213 ± 0.087	4.865LeuPro: 4.865 ± 0.094	3.69LeuGln: 3.69 ± 0.088	5.835LeuArg: 5.835 ± 0.106	6.245LeuSer: 6.245 ± 0.093	6.098LeuThr: 6.098 ± 0.117	5.174LeuVal: 5.174 ± 0.09	1.083LeuTrp: 1.083 ± 0.042	3.195LeuTyr: 3.195 ± 0.075	0.006LeuXaa: 0.006 ± 0.003
Met	2.904MetAla: 2.904 ± 0.073	0.26MetCys: 0.26 ± 0.019	1.286MetAsp: 1.286 ± 0.05	1.7MetGlu: 1.7 ± 0.054	0.883MetPhe: 0.883 ± 0.038	1.89MetGly: 1.89 ± 0.047	0.468MetHis: 0.468 ± 0.026	1.44MetIle: 1.44 ± 0.05	1.883MetLys: 1.883 ± 0.051	2.863MetLeu: 2.863 ± 0.071	0.791MetMet: 0.791 ± 0.034	1.239MetAsn: 1.239 ± 0.045	1.509MetPro: 1.509 ± 0.051	1.132MetGln: 1.132 ± 0.045	1.866MetArg: 1.866 ± 0.048	1.627MetSer: 1.627 ± 0.049	1.738MetThr: 1.738 ± 0.051	1.752MetVal: 1.752 ± 0.052	0.252MetTrp: 0.252 ± 0.019	0.711MetTyr: 0.711 ± 0.031	0.0MetXaa: 0.0 ± 0.0
Asn	4.015AsnAla: 4.015 ± 0.081	0.731AsnCys: 0.731 ± 0.058	2.535AsnAsp: 2.535 ± 0.073	2.263AsnGlu: 2.263 ± 0.058	2.113AsnPhe: 2.113 ± 0.066	3.946AsnGly: 3.946 ± 0.108	0.925AsnHis: 0.925 ± 0.041	3.3AsnIle: 3.3 ± 0.065	2.349AsnLys: 2.349 ± 0.058	4.213AsnLeu: 4.213 ± 0.086	1.295AsnMet: 1.295 ± 0.039	2.44AsnAsn: 2.44 ± 0.066	2.666AsnPro: 2.666 ± 0.06	1.365AsnGln: 1.365 ± 0.046	2.33AsnArg: 2.33 ± 0.054	2.697AsnSer: 2.697 ± 0.074	2.694AsnThr: 2.694 ± 0.078	3.194AsnVal: 3.194 ± 0.069	0.591AsnTrp: 0.591 ± 0.03	2.018AsnTyr: 2.018 ± 0.061	0.001AsnXaa: 0.001 ± 0.001
Pro	4.259ProAla: 4.259 ± 0.095	0.374ProCys: 0.374 ± 0.025	3.194ProAsp: 3.194 ± 0.072	3.732ProGlu: 3.732 ± 0.082	1.797ProPhe: 1.797 ± 0.059	3.327ProGly: 3.327 ± 0.078	0.762ProHis: 0.762 ± 0.038	1.833ProIle: 1.833 ± 0.06	2.106ProLys: 2.106 ± 0.063	3.92ProLeu: 3.92 ± 0.077	1.154ProMet: 1.154 ± 0.043	1.674ProAsn: 1.674 ± 0.058	1.18ProPro: 1.18 ± 0.045	1.955ProGln: 1.955 ± 0.055	1.882ProArg: 1.882 ± 0.052	2.52ProSer: 2.52 ± 0.061	2.21ProThr: 2.21 ± 0.062	3.55ProVal: 3.55 ± 0.077	0.528ProTrp: 0.528 ± 0.032	1.751ProTyr: 1.751 ± 0.058	0.004ProXaa: 0.004 ± 0.002
Gln	2.94GlnAla: 2.94 ± 0.071	0.354GlnCys: 0.354 ± 0.025	1.346GlnAsp: 1.346 ± 0.041	1.761GlnGlu: 1.761 ± 0.053	1.211GlnPhe: 1.211 ± 0.043	2.476GlnGly: 2.476 ± 0.066	0.701GlnHis: 0.701 ± 0.032	2.136GlnIle: 2.136 ± 0.052	1.961GlnLys: 1.961 ± 0.06	3.278GlnLeu: 3.278 ± 0.089	1.079GlnMet: 1.079 ± 0.041	1.536GlnAsn: 1.536 ± 0.052	1.696GlnPro: 1.696 ± 0.048	1.834GlnGln: 1.834 ± 0.067	2.162GlnArg: 2.162 ± 0.069	1.788GlnSer: 1.788 ± 0.058	1.988GlnThr: 1.988 ± 0.057	1.918GlnVal: 1.918 ± 0.053	0.503GlnTrp: 0.503 ± 0.032	1.331GlnTyr: 1.331 ± 0.046	0.001GlnXaa: 0.001 ± 0.001
Arg	3.65ArgAla: 3.65 ± 0.075	0.696ArgCys: 0.696 ± 0.032	2.512ArgAsp: 2.512 ± 0.063	3.087ArgGlu: 3.087 ± 0.071	2.471ArgPhe: 2.471 ± 0.063	3.311ArgGly: 3.311 ± 0.068	1.428ArgHis: 1.428 ± 0.048	3.66ArgIle: 3.66 ± 0.076	3.178ArgLys: 3.178 ± 0.083	5.573ArgLeu: 5.573 ± 0.114	1.713ArgMet: 1.713 ± 0.049	2.752ArgAsn: 2.752 ± 0.054	2.158ArgPro: 2.158 ± 0.058	2.437ArgGln: 2.437 ± 0.072	4.006ArgArg: 4.006 ± 0.105	2.814ArgSer: 2.814 ± 0.07	2.635ArgThr: 2.635 ± 0.058	3.379ArgVal: 3.379 ± 0.071	0.695ArgTrp: 0.695 ± 0.031	2.379ArgTyr: 2.379 ± 0.061	0.004ArgXaa: 0.004 ± 0.002
Ser	5.448SerAla: 5.448 ± 0.099	0.819SerCys: 0.819 ± 0.036	3.357SerAsp: 3.357 ± 0.074	3.032SerGlu: 3.032 ± 0.074	2.72SerPhe: 2.72 ± 0.066	5.032SerGly: 5.032 ± 0.105	1.213SerHis: 1.213 ± 0.049	3.465SerIle: 3.465 ± 0.076	2.753SerLys: 2.753 ± 0.068	5.968SerLeu: 5.968 ± 0.101	1.651SerMet: 1.651 ± 0.05	2.771SerAsn: 2.771 ± 0.062	2.548SerPro: 2.548 ± 0.066	1.918SerGln: 1.918 ± 0.053	3.172SerArg: 3.172 ± 0.066	3.71SerSer: 3.71 ± 0.083	3.494SerThr: 3.494 ± 0.093	4.364SerVal: 4.364 ± 0.095	0.752SerTrp: 0.752 ± 0.035	2.464SerTyr: 2.464 ± 0.067	0.001SerXaa: 0.001 ± 0.001
Thr	5.548ThrAla: 5.548 ± 0.11	0.56ThrCys: 0.56 ± 0.027	3.691ThrAsp: 3.691 ± 0.088	2.989ThrGlu: 2.989 ± 0.062	2.477ThrPhe: 2.477 ± 0.06	4.856ThrGly: 4.856 ± 0.118	1.036ThrHis: 1.036 ± 0.04	3.425ThrIle: 3.425 ± 0.082	2.142ThrLys: 2.142 ± 0.057	6.118ThrLeu: 6.118 ± 0.087	1.244ThrMet: 1.244 ± 0.039	2.365ThrAsn: 2.365 ± 0.069	3.412ThrPro: 3.412 ± 0.074	1.761ThrGln: 1.761 ± 0.057	2.574ThrArg: 2.574 ± 0.062	3.245ThrSer: 3.245 ± 0.082	3.427ThrThr: 3.427 ± 0.089	4.703ThrVal: 4.703 ± 0.107	0.613ThrTrp: 0.613 ± 0.03	2.162ThrTyr: 2.162 ± 0.063	0.0ThrXaa: 0.0 ± 0.0
Val	6.088ValAla: 6.088 ± 0.122	0.947ValCys: 0.947 ± 0.043	3.703ValAsp: 3.703 ± 0.085	4.147ValGlu: 4.147 ± 0.086	2.533ValPhe: 2.533 ± 0.06	4.295ValGly: 4.295 ± 0.107	1.017ValHis: 1.017 ± 0.039	4.455ValIle: 4.455 ± 0.102	4.061ValLys: 4.061 ± 0.091	5.705ValLeu: 5.705 ± 0.101	1.969ValMet: 1.969 ± 0.062	3.444ValAsn: 3.444 ± 0.078	2.939ValPro: 2.939 ± 0.066	1.887ValGln: 1.887 ± 0.051	3.5ValArg: 3.5 ± 0.08	4.567ValSer: 4.567 ± 0.093	3.858ValThr: 3.858 ± 0.088	4.695ValVal: 4.695 ± 0.089	0.836ValTrp: 0.836 ± 0.032	2.523ValTyr: 2.523 ± 0.057	0.003ValXaa: 0.003 ± 0.002
Trp	0.808TrpAla: 0.808 ± 0.039	0.187TrpCys: 0.187 ± 0.019	0.614TrpAsp: 0.614 ± 0.032	0.591TrpGlu: 0.591 ± 0.034	0.489TrpPhe: 0.489 ± 0.03	0.958TrpGly: 0.958 ± 0.042	0.268TrpHis: 0.268 ± 0.018	0.69TrpIle: 0.69 ± 0.034	0.646TrpLys: 0.646 ± 0.032	1.3TrpLeu: 1.3 ± 0.052	0.364TrpMet: 0.364 ± 0.026	0.603TrpAsn: 0.603 ± 0.03	0.43TrpPro: 0.43 ± 0.026	0.594TrpGln: 0.594 ± 0.026	0.722TrpArg: 0.722 ± 0.034	0.69TrpSer: 0.69 ± 0.032	0.699TrpThr: 0.699 ± 0.032	0.709TrpVal: 0.709 ± 0.035	0.186TrpTrp: 0.186 ± 0.017	0.413TrpTyr: 0.413 ± 0.024	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.169TyrAla: 3.169 ± 0.075	0.524TyrCys: 0.524 ± 0.027	2.25TyrAsp: 2.25 ± 0.059	1.846TyrGlu: 1.846 ± 0.057	1.715TyrPhe: 1.715 ± 0.048	2.873TyrGly: 2.873 ± 0.071	0.767TyrHis: 0.767 ± 0.03	2.296TyrIle: 2.296 ± 0.061	1.869TyrLys: 1.869 ± 0.055	3.402TyrLeu: 3.402 ± 0.075	0.949TyrMet: 0.949 ± 0.038	2.385TyrAsn: 2.385 ± 0.07	1.709TyrPro: 1.709 ± 0.055	1.144TyrGln: 1.144 ± 0.052	2.287TyrArg: 2.287 ± 0.063	2.676TyrSer: 2.676 ± 0.062	2.358TyrThr: 2.358 ± 0.067	2.48TyrVal: 2.48 ± 0.065	0.443TyrTrp: 0.443 ± 0.025	1.808TyrTyr: 1.808 ± 0.063	0.001TyrXaa: 0.001 ± 0.001
Xaa	0.007XaaAla: 0.007 ± 0.003	0.001XaaCys: 0.001 ± 0.001	0.001XaaAsp: 0.001 ± 0.001	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.006XaaGly: 0.006 ± 0.002	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.001XaaLys: 0.001 ± 0.001	0.003XaaLeu: 0.003 ± 0.002	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.004XaaPro: 0.004 ± 0.002	0.0XaaGln: 0.0 ± 0.0	0.003XaaArg: 0.003 ± 0.002	0.004XaaSer: 0.004 ± 0.003	0.006XaaThr: 0.006 ± 0.003	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.001	0.039XaaXaa: 0.039 ± 0.01

Statistics based on 1956 proteins (695163 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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