Amino acid dipepetide frequency for Helicobacter sp. 10-6591

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.279AlaAla: 3.279 ± 0.087
1.064AlaCys: 1.064 ± 0.055
2.753AlaAsp: 2.753 ± 0.072
2.504AlaGlu: 2.504 ± 0.085
3.622AlaPhe: 3.622 ± 0.099
3.734AlaGly: 3.734 ± 0.095
1.754AlaHis: 1.754 ± 0.058
5.596AlaIle: 5.596 ± 0.108
6.057AlaLys: 6.057 ± 0.12
9.253AlaLeu: 9.253 ± 0.138
1.584AlaMet: 1.584 ± 0.065
3.907AlaAsn: 3.907 ± 0.102
2.051AlaPro: 2.051 ± 0.061
3.773AlaGln: 3.773 ± 0.087
3.419AlaArg: 3.419 ± 0.083
4.4AlaSer: 4.4 ± 0.097
3.19AlaThr: 3.19 ± 0.097
3.007AlaVal: 3.007 ± 0.089
0.416AlaTrp: 0.416 ± 0.027
2.78AlaTyr: 2.78 ± 0.076
0.0AlaXaa: 0.0 ± 0.0
Cys
1.192CysAla: 1.192 ± 0.051
0.166CysCys: 0.166 ± 0.019
0.796CysAsp: 0.796 ± 0.044
0.861CysGlu: 0.861 ± 0.048
0.804CysPhe: 0.804 ± 0.036
1.098CysGly: 1.098 ± 0.052
0.25CysHis: 0.25 ± 0.025
1.218CysIle: 1.218 ± 0.051
1.036CysLys: 1.036 ± 0.051
1.216CysLeu: 1.216 ± 0.054
0.416CysMet: 0.416 ± 0.031
0.599CysAsn: 0.599 ± 0.035
0.38CysPro: 0.38 ± 0.034
0.333CysGln: 0.333 ± 0.027
0.349CysArg: 0.349 ± 0.026
0.735CysSer: 0.735 ± 0.043
0.516CysThr: 0.516 ± 0.032
1.277CysVal: 1.277 ± 0.059
0.079CysTrp: 0.079 ± 0.014
0.38CysTyr: 0.38 ± 0.03
0.0CysXaa: 0.0 ± 0.0
Asp
2.621AspAla: 2.621 ± 0.073
0.883AspCys: 0.883 ± 0.049
2.118AspAsp: 2.118 ± 0.08
3.377AspGlu: 3.377 ± 0.099
3.643AspPhe: 3.643 ± 0.091
2.991AspGly: 2.991 ± 0.088
0.55AspHis: 0.55 ± 0.037
4.56AspIle: 4.56 ± 0.099
3.986AspLys: 3.986 ± 0.098
4.964AspLeu: 4.964 ± 0.097
1.265AspMet: 1.265 ± 0.049
2.37AspAsn: 2.37 ± 0.081
1.218AspPro: 1.218 ± 0.054
0.721AspGln: 0.721 ± 0.035
1.781AspArg: 1.781 ± 0.063
5.789AspSer: 5.789 ± 0.098
2.828AspThr: 2.828 ± 0.082
2.749AspVal: 2.749 ± 0.08
0.39AspTrp: 0.39 ± 0.024
2.028AspTyr: 2.028 ± 0.065
0.0AspXaa: 0.0 ± 0.0
Glu
3.639GluAla: 3.639 ± 0.096
0.918GluCys: 0.918 ± 0.048
2.345GluAsp: 2.345 ± 0.066
3.33GluGlu: 3.33 ± 0.1
3.815GluPhe: 3.815 ± 0.094
2.987GluGly: 2.987 ± 0.091
1.269GluHis: 1.269 ± 0.05
6.363GluIle: 6.363 ± 0.117
4.221GluLys: 4.221 ± 0.118
6.516GluLeu: 6.516 ± 0.125
1.251GluMet: 1.251 ± 0.057
4.091GluAsn: 4.091 ± 0.088
1.247GluPro: 1.247 ± 0.055
2.603GluGln: 2.603 ± 0.082
2.538GluArg: 2.538 ± 0.075
5.304GluSer: 5.304 ± 0.104
1.945GluThr: 1.945 ± 0.06
4.069GluVal: 4.069 ± 0.107
0.461GluTrp: 0.461 ± 0.031
2.335GluTyr: 2.335 ± 0.072
0.0GluXaa: 0.0 ± 0.0
Phe
3.758PheAla: 3.758 ± 0.083
1.033PheCys: 1.033 ± 0.044
2.897PheAsp: 2.897 ± 0.09
3.35PheGlu: 3.35 ± 0.091
3.001PhePhe: 3.001 ± 0.098
4.177PheGly: 4.177 ± 0.101
0.948PheHis: 0.948 ± 0.049
3.892PheIle: 3.892 ± 0.098
3.261PheLys: 3.261 ± 0.083
6.043PheLeu: 6.043 ± 0.137
1.186PheMet: 1.186 ± 0.047
2.11PheAsn: 2.11 ± 0.064
1.255PhePro: 1.255 ± 0.053
1.399PheGln: 1.399 ± 0.058
1.663PheArg: 1.663 ± 0.056
4.349PheSer: 4.349 ± 0.1
2.193PheThr: 2.193 ± 0.069
3.925PheVal: 3.925 ± 0.104
0.504PheTrp: 0.504 ± 0.037
2.248PheTyr: 2.248 ± 0.079
0.0PheXaa: 0.0 ± 0.0
Gly
4.325GlyAla: 4.325 ± 0.109
0.82GlyCys: 0.82 ± 0.043
2.962GlyAsp: 2.962 ± 0.089
3.543GlyGlu: 3.543 ± 0.088
4.071GlyPhe: 4.071 ± 0.091
4.41GlyGly: 4.41 ± 0.108
1.062GlyHis: 1.062 ± 0.055
6.12GlyIle: 6.12 ± 0.129
4.191GlyLys: 4.191 ± 0.103
5.791GlyLeu: 5.791 ± 0.112
1.523GlyMet: 1.523 ± 0.061
2.849GlyAsn: 2.849 ± 0.117
0.759GlyPro: 0.759 ± 0.04
1.716GlyGln: 1.716 ± 0.071
2.201GlyArg: 2.201 ± 0.064
4.14GlySer: 4.14 ± 0.133
2.69GlyThr: 2.69 ± 0.105
4.956GlyVal: 4.956 ± 0.117
0.4GlyTrp: 0.4 ± 0.036
2.629GlyTyr: 2.629 ± 0.073
0.0GlyXaa: 0.0 ± 0.0
His
1.302HisAla: 1.302 ± 0.052
0.28HisCys: 0.28 ± 0.024
0.701HisAsp: 0.701 ± 0.037
0.832HisGlu: 0.832 ± 0.04
1.249HisPhe: 1.249 ± 0.051
1.027HisGly: 1.027 ± 0.051
0.459HisHis: 0.459 ± 0.033
2.075HisIle: 2.075 ± 0.074
1.915HisLys: 1.915 ± 0.068
2.071HisLeu: 2.071 ± 0.063
0.392HisMet: 0.392 ± 0.03
1.228HisAsn: 1.228 ± 0.053
0.796HisPro: 0.796 ± 0.041
0.646HisGln: 0.646 ± 0.036
0.786HisArg: 0.786 ± 0.04
1.521HisSer: 1.521 ± 0.057
1.582HisThr: 1.582 ± 0.06
0.603HisVal: 0.603 ± 0.036
0.144HisTrp: 0.144 ± 0.021
0.739HisTyr: 0.739 ± 0.042
0.0HisXaa: 0.0 ± 0.0
Ile
6.999IleAla: 6.999 ± 0.128
1.198IleCys: 1.198 ± 0.051
4.589IleAsp: 4.589 ± 0.104
5.681IleGlu: 5.681 ± 0.115
4.057IlePhe: 4.057 ± 0.116
5.222IleGly: 5.222 ± 0.122
1.442IleHis: 1.442 ± 0.058
5.523IleIle: 5.523 ± 0.121
5.809IleLys: 5.809 ± 0.105
8.757IleLeu: 8.757 ± 0.149
1.48IleMet: 1.48 ± 0.053
3.898IleAsn: 3.898 ± 0.092
2.985IlePro: 2.985 ± 0.089
3.137IleGln: 3.137 ± 0.088
2.662IleArg: 2.662 ± 0.073
5.527IleSer: 5.527 ± 0.108
4.875IleThr: 4.875 ± 0.11
4.845IleVal: 4.845 ± 0.11
0.546IleTrp: 0.546 ± 0.038
2.853IleTyr: 2.853 ± 0.073
0.0IleXaa: 0.0 ± 0.0
Lys
5.281LysAla: 5.281 ± 0.115
0.64LysCys: 0.64 ± 0.039
5.023LysAsp: 5.023 ± 0.092
6.061LysGlu: 6.061 ± 0.121
2.516LysPhe: 2.516 ± 0.071
3.866LysGly: 3.866 ± 0.101
1.543LysHis: 1.543 ± 0.054
6.875LysIle: 6.875 ± 0.133
5.531LysLys: 5.531 ± 0.112
6.78LysLeu: 6.78 ± 0.134
1.586LysMet: 1.586 ± 0.058
5.58LysAsn: 5.58 ± 0.132
2.477LysPro: 2.477 ± 0.08
3.206LysGln: 3.206 ± 0.079
3.011LysArg: 3.011 ± 0.078
5.027LysSer: 5.027 ± 0.102
3.86LysThr: 3.86 ± 0.084
3.693LysVal: 3.693 ± 0.096
0.491LysTrp: 0.491 ± 0.031
2.349LysTyr: 2.349 ± 0.066
0.0LysXaa: 0.0 ± 0.0
Leu
7.377LeuAla: 7.377 ± 0.129
1.838LeuCys: 1.838 ± 0.066
6.455LeuAsp: 6.455 ± 0.125
8.063LeuGlu: 8.063 ± 0.15
4.794LeuPhe: 4.794 ± 0.133
6.989LeuGly: 6.989 ± 0.132
2.581LeuHis: 2.581 ± 0.08
6.487LeuIle: 6.487 ± 0.134
8.396LeuLys: 8.396 ± 0.151
10.899LeuLeu: 10.899 ± 0.224
1.89LeuMet: 1.89 ± 0.064
5.017LeuAsn: 5.017 ± 0.104
3.815LeuPro: 3.815 ± 0.098
5.306LeuGln: 5.306 ± 0.114
4.593LeuArg: 4.593 ± 0.088
8.566LeuSer: 8.566 ± 0.137
4.152LeuThr: 4.152 ± 0.097
5.419LeuVal: 5.419 ± 0.112
0.796LeuTrp: 0.796 ± 0.041
3.655LeuTyr: 3.655 ± 0.1
0.0LeuXaa: 0.0 ± 0.0
Met
1.411MetAla: 1.411 ± 0.059
0.254MetCys: 0.254 ± 0.026
1.019MetAsp: 1.019 ± 0.047
1.145MetGlu: 1.145 ± 0.054
0.881MetPhe: 0.881 ± 0.043
1.373MetGly: 1.373 ± 0.051
0.439MetHis: 0.439 ± 0.027
1.509MetIle: 1.509 ± 0.058
1.458MetLys: 1.458 ± 0.051
2.68MetLeu: 2.68 ± 0.074
0.404MetMet: 0.404 ± 0.031
0.918MetAsn: 0.918 ± 0.043
1.027MetPro: 1.027 ± 0.048
1.429MetGln: 1.429 ± 0.056
1.277MetArg: 1.277 ± 0.047
1.318MetSer: 1.318 ± 0.053
0.733MetThr: 0.733 ± 0.039
1.247MetVal: 1.247 ± 0.053
0.166MetTrp: 0.166 ± 0.019
0.554MetTyr: 0.554 ± 0.031
0.0MetXaa: 0.0 ± 0.0
Asn
4.609AsnAla: 4.609 ± 0.111
0.473AsnCys: 0.473 ± 0.041
2.307AsnAsp: 2.307 ± 0.081
2.832AsnGlu: 2.832 ± 0.072
2.607AsnPhe: 2.607 ± 0.078
3.431AsnGly: 3.431 ± 0.123
0.926AsnHis: 0.926 ± 0.043
4.67AsnIle: 4.67 ± 0.106
3.817AsnLys: 3.817 ± 0.098
6.156AsnLeu: 6.156 ± 0.117
1.149AsnMet: 1.149 ± 0.047
2.847AsnAsn: 2.847 ± 0.125
2.751AsnPro: 2.751 ± 0.083
1.864AsnGln: 1.864 ± 0.075
1.785AsnArg: 1.785 ± 0.062
3.178AsnSer: 3.178 ± 0.094
3.488AsnThr: 3.488 ± 0.099
2.719AsnVal: 2.719 ± 0.08
0.303AsnTrp: 0.303 ± 0.026
1.6AsnTyr: 1.6 ± 0.066
0.0AsnXaa: 0.0 ± 0.0
Pro
1.616ProAla: 1.616 ± 0.055
0.365ProCys: 0.365 ± 0.028
1.342ProAsp: 1.342 ± 0.052
1.547ProGlu: 1.547 ± 0.06
1.693ProPhe: 1.693 ± 0.056
1.117ProGly: 1.117 ± 0.046
0.918ProHis: 0.918 ± 0.044
2.55ProIle: 2.55 ± 0.081
3.033ProLys: 3.033 ± 0.082
3.567ProLeu: 3.567 ± 0.074
0.676ProMet: 0.676 ± 0.037
1.937ProAsn: 1.937 ± 0.066
1.005ProPro: 1.005 ± 0.063
1.773ProGln: 1.773 ± 0.065
1.149ProArg: 1.149 ± 0.053
2.38ProSer: 2.38 ± 0.072
1.838ProThr: 1.838 ± 0.063
1.464ProVal: 1.464 ± 0.068
0.197ProTrp: 0.197 ± 0.021
1.308ProTyr: 1.308 ± 0.055
0.0ProXaa: 0.0 ± 0.0
Gln
3.194GlnAla: 3.194 ± 0.085
0.39GlnCys: 0.39 ± 0.031
2.745GlnAsp: 2.745 ± 0.076
3.825GlnGlu: 3.825 ± 0.093
1.127GlnPhe: 1.127 ± 0.046
2.258GlnGly: 2.258 ± 0.072
0.66GlnHis: 0.66 ± 0.039
3.438GlnIle: 3.438 ± 0.09
3.957GlnLys: 3.957 ± 0.091
2.573GlnLeu: 2.573 ± 0.076
0.881GlnMet: 0.881 ± 0.043
3.318GlnAsn: 3.318 ± 0.089
0.893GlnPro: 0.893 ± 0.045
1.45GlnGln: 1.45 ± 0.063
1.547GlnArg: 1.547 ± 0.051
3.377GlnSer: 3.377 ± 0.076
2.333GlnThr: 2.333 ± 0.075
1.872GlnVal: 1.872 ± 0.061
0.292GlnTrp: 0.292 ± 0.027
1.239GlnTyr: 1.239 ± 0.048
0.0GlnXaa: 0.0 ± 0.0
Arg
2.747ArgAla: 2.747 ± 0.083
0.325ArgCys: 0.325 ± 0.025
2.343ArgAsp: 2.343 ± 0.069
3.031ArgGlu: 3.031 ± 0.08
2.524ArgPhe: 2.524 ± 0.073
2.195ArgGly: 2.195 ± 0.063
0.759ArgHis: 0.759 ± 0.042
3.73ArgIle: 3.73 ± 0.087
2.534ArgLys: 2.534 ± 0.074
4.041ArgLeu: 4.041 ± 0.086
0.883ArgMet: 0.883 ± 0.041
2.01ArgAsn: 2.01 ± 0.059
0.979ArgPro: 0.979 ± 0.05
1.31ArgGln: 1.31 ± 0.048
1.358ArgArg: 1.358 ± 0.054
2.124ArgSer: 2.124 ± 0.062
1.594ArgThr: 1.594 ± 0.058
2.581ArgVal: 2.581 ± 0.072
0.258ArgTrp: 0.258 ± 0.022
1.673ArgTyr: 1.673 ± 0.062
0.0ArgXaa: 0.0 ± 0.0
Ser
5.141SerAla: 5.141 ± 0.097
0.875SerCys: 0.875 ± 0.045
3.113SerAsp: 3.113 ± 0.086
3.364SerGlu: 3.364 ± 0.085
4.148SerPhe: 4.148 ± 0.091
4.859SerGly: 4.859 ± 0.112
1.669SerHis: 1.669 ± 0.06
5.704SerIle: 5.704 ± 0.104
5.531SerLys: 5.531 ± 0.111
8.497SerLeu: 8.497 ± 0.153
1.72SerMet: 1.72 ± 0.059
3.45SerAsn: 3.45 ± 0.12
2.073SerPro: 2.073 ± 0.064
3.535SerGln: 3.535 ± 0.083
2.613SerArg: 2.613 ± 0.072
4.895SerSer: 4.895 ± 0.111
3.389SerThr: 3.389 ± 0.087
4.42SerVal: 4.42 ± 0.084
0.497SerTrp: 0.497 ± 0.031
2.859SerTyr: 2.859 ± 0.092
0.0SerXaa: 0.0 ± 0.0
Thr
2.445ThrAla: 2.445 ± 0.067
0.473ThrCys: 0.473 ± 0.036
2.193ThrAsp: 2.193 ± 0.065
1.913ThrGlu: 1.913 ± 0.059
2.179ThrPhe: 2.179 ± 0.073
2.451ThrGly: 2.451 ± 0.084
1.413ThrHis: 1.413 ± 0.049
4.006ThrIle: 4.006 ± 0.146
3.886ThrLys: 3.886 ± 0.087
6.154ThrLeu: 6.154 ± 0.118
0.843ThrMet: 0.843 ± 0.045
2.966ThrAsn: 2.966 ± 0.094
2.546ThrPro: 2.546 ± 0.086
3.539ThrGln: 3.539 ± 0.092
1.886ThrArg: 1.886 ± 0.071
3.153ThrSer: 3.153 ± 0.082
2.696ThrThr: 2.696 ± 0.088
1.019ThrVal: 1.019 ± 0.061
0.309ThrTrp: 0.309 ± 0.026
1.764ThrTyr: 1.764 ± 0.062
0.0ThrXaa: 0.0 ± 0.0
Val
3.982ValAla: 3.982 ± 0.092
1.092ValCys: 1.092 ± 0.048
2.818ValAsp: 2.818 ± 0.076
3.06ValGlu: 3.06 ± 0.088
3.811ValPhe: 3.811 ± 0.102
4.097ValGly: 4.097 ± 0.105
0.794ValHis: 0.794 ± 0.045
4.497ValIle: 4.497 ± 0.103
3.214ValLys: 3.214 ± 0.1
6.749ValLeu: 6.749 ± 0.142
1.283ValMet: 1.283 ± 0.051
2.126ValAsn: 2.126 ± 0.057
1.651ValPro: 1.651 ± 0.068
1.947ValGln: 1.947 ± 0.067
2.556ValArg: 2.556 ± 0.076
4.169ValSer: 4.169 ± 0.089
1.756ValThr: 1.756 ± 0.065
4.185ValVal: 4.185 ± 0.11
0.473ValTrp: 0.473 ± 0.036
2.061ValTyr: 2.061 ± 0.065
0.0ValXaa: 0.0 ± 0.0
Trp
0.422TrpAla: 0.422 ± 0.037
0.14TrpCys: 0.14 ± 0.018
0.351TrpAsp: 0.351 ± 0.028
0.473TrpGlu: 0.473 ± 0.033
0.343TrpPhe: 0.343 ± 0.032
0.554TrpGly: 0.554 ± 0.037
0.213TrpHis: 0.213 ± 0.021
0.631TrpIle: 0.631 ± 0.044
0.355TrpLys: 0.355 ± 0.029
0.855TrpLeu: 0.855 ± 0.043
0.134TrpMet: 0.134 ± 0.015
0.416TrpAsn: 0.416 ± 0.03
0.087TrpPro: 0.087 ± 0.014
0.351TrpGln: 0.351 ± 0.025
0.363TrpArg: 0.363 ± 0.028
0.386TrpSer: 0.386 ± 0.029
0.187TrpThr: 0.187 ± 0.021
0.465TrpVal: 0.465 ± 0.038
0.097TrpTrp: 0.097 ± 0.016
0.258TrpTyr: 0.258 ± 0.025
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.802TyrAla: 2.802 ± 0.081
0.473TyrCys: 0.473 ± 0.035
1.961TyrAsp: 1.961 ± 0.059
2.453TyrGlu: 2.453 ± 0.058
2.307TyrPhe: 2.307 ± 0.098
2.323TyrGly: 2.323 ± 0.081
0.698TyrHis: 0.698 ± 0.035
2.64TyrIle: 2.64 ± 0.075
3.208TyrLys: 3.208 ± 0.089
3.525TyrLeu: 3.525 ± 0.084
0.694TyrMet: 0.694 ± 0.034
1.878TyrAsn: 1.878 ± 0.064
1.48TyrPro: 1.48 ± 0.06
1.332TyrGln: 1.332 ± 0.049
1.46TyrArg: 1.46 ± 0.047
2.016TyrSer: 2.016 ± 0.069
1.99TyrThr: 1.99 ± 0.074
1.807TyrVal: 1.807 ± 0.063
0.264TyrTrp: 0.264 ± 0.024
1.308TyrTyr: 1.308 ± 0.059
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1547 proteins (492504 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski