Amino acid dipepetide frequency for Bacteroides sp. CAG:462

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.879AlaAla: 6.879 ± 0.104	1.283AlaCys: 1.283 ± 0.041	5.358AlaAsp: 5.358 ± 0.081	5.136AlaGlu: 5.136 ± 0.081	3.308AlaPhe: 3.308 ± 0.059	5.723AlaGly: 5.723 ± 0.081	1.497AlaHis: 1.497 ± 0.047	4.25AlaIle: 4.25 ± 0.081	3.634AlaLys: 3.634 ± 0.074	7.582AlaLeu: 7.582 ± 0.096	1.86AlaMet: 1.86 ± 0.047	3.101AlaAsn: 3.101 ± 0.061	2.734AlaPro: 2.734 ± 0.048	2.865AlaGln: 2.865 ± 0.062	4.192AlaArg: 4.192 ± 0.077	4.513AlaSer: 4.513 ± 0.075	4.187AlaThr: 4.187 ± 0.072	5.321AlaVal: 5.321 ± 0.077	0.998AlaTrp: 0.998 ± 0.035	3.342AlaTyr: 3.342 ± 0.06	0.001AlaXaa: 0.001 ± 0.001
Cys	0.924CysAla: 0.924 ± 0.032	0.235CysCys: 0.235 ± 0.017	0.673CysAsp: 0.673 ± 0.025	0.695CysGlu: 0.695 ± 0.027	0.603CysPhe: 0.603 ± 0.026	1.097CysGly: 1.097 ± 0.033	0.361CysHis: 0.361 ± 0.02	0.821CysIle: 0.821 ± 0.031	0.57CysLys: 0.57 ± 0.024	1.402CysLeu: 1.402 ± 0.04	0.349CysMet: 0.349 ± 0.018	0.493CysAsn: 0.493 ± 0.023	0.6CysPro: 0.6 ± 0.027	0.364CysGln: 0.364 ± 0.018	0.914CysArg: 0.914 ± 0.03	0.804CysSer: 0.804 ± 0.028	0.762CysThr: 0.762 ± 0.029	0.802CysVal: 0.802 ± 0.031	0.158CysTrp: 0.158 ± 0.012	0.543CysTyr: 0.543 ± 0.024	0.0CysXaa: 0.0 ± 0.0
Asp	4.827AspAla: 4.827 ± 0.074	0.718AspCys: 0.718 ± 0.026	3.081AspAsp: 3.081 ± 0.063	4.327AspGlu: 4.327 ± 0.078	3.056AspPhe: 3.056 ± 0.056	4.96AspGly: 4.96 ± 0.093	0.977AspHis: 0.977 ± 0.035	3.744AspIle: 3.744 ± 0.067	3.244AspLys: 3.244 ± 0.057	4.979AspLeu: 4.979 ± 0.069	1.545AspMet: 1.545 ± 0.039	2.69AspAsn: 2.69 ± 0.048	2.214AspPro: 2.214 ± 0.053	1.186AspGln: 1.186 ± 0.034	3.275AspArg: 3.275 ± 0.059	3.136AspSer: 3.136 ± 0.068	3.098AspThr: 3.098 ± 0.053	3.929AspVal: 3.929 ± 0.067	0.952AspTrp: 0.952 ± 0.032	3.083AspTyr: 3.083 ± 0.059	0.0AspXaa: 0.0 ± 0.0
Glu	5.472GluAla: 5.472 ± 0.097	0.662GluCys: 0.662 ± 0.026	3.326GluAsp: 3.326 ± 0.064	4.924GluGlu: 4.924 ± 0.085	2.261GluPhe: 2.261 ± 0.052	4.688GluGly: 4.688 ± 0.074	1.464GluHis: 1.464 ± 0.039	3.42GluIle: 3.42 ± 0.07	4.024GluLys: 4.024 ± 0.076	6.176GluLeu: 6.176 ± 0.086	1.914GluMet: 1.914 ± 0.045	2.878GluAsn: 2.878 ± 0.059	2.003GluPro: 2.003 ± 0.044	2.881GluGln: 2.881 ± 0.053	4.054GluArg: 4.054 ± 0.08	2.965GluSer: 2.965 ± 0.054	3.244GluThr: 3.244 ± 0.057	4.538GluVal: 4.538 ± 0.073	0.849GluTrp: 0.849 ± 0.033	2.396GluTyr: 2.396 ± 0.054	0.0GluXaa: 0.0 ± 0.0
Phe	3.078PheAla: 3.078 ± 0.057	0.645PheCys: 0.645 ± 0.026	2.853PheAsp: 2.853 ± 0.053	2.267PheGlu: 2.267 ± 0.045	1.956PhePhe: 1.956 ± 0.055	3.202PheGly: 3.202 ± 0.053	0.947PheHis: 0.947 ± 0.033	2.627PheIle: 2.627 ± 0.06	1.944PheLys: 1.944 ± 0.052	3.927PheLeu: 3.927 ± 0.079	1.178PheMet: 1.178 ± 0.035	2.044PheAsn: 2.044 ± 0.044	1.698PhePro: 1.698 ± 0.04	1.211PheGln: 1.211 ± 0.032	2.722PheArg: 2.722 ± 0.054	2.969PheSer: 2.969 ± 0.063	2.786PheThr: 2.786 ± 0.051	2.738PheVal: 2.738 ± 0.051	0.543PheTrp: 0.543 ± 0.026	1.904PheTyr: 1.904 ± 0.043	0.0PheXaa: 0.0 ± 0.0
Gly	4.862GlyAla: 4.862 ± 0.087	1.054GlyCys: 1.054 ± 0.031	3.84GlyAsp: 3.84 ± 0.067	4.343GlyGlu: 4.343 ± 0.062	3.034GlyPhe: 3.034 ± 0.065	5.086GlyGly: 5.086 ± 0.099	1.515GlyHis: 1.515 ± 0.045	4.948GlyIle: 4.948 ± 0.086	4.65GlyLys: 4.65 ± 0.072	6.101GlyLeu: 6.101 ± 0.084	2.252GlyMet: 2.252 ± 0.046	3.41GlyAsn: 3.41 ± 0.071	1.458GlyPro: 1.458 ± 0.038	2.301GlyGln: 2.301 ± 0.046	3.996GlyArg: 3.996 ± 0.074	4.212GlySer: 4.212 ± 0.079	4.572GlyThr: 4.572 ± 0.074	5.273GlyVal: 5.273 ± 0.08	1.104GlyTrp: 1.104 ± 0.039	3.392GlyTyr: 3.392 ± 0.066	0.002GlyXaa: 0.002 ± 0.002
His	1.526HisAla: 1.526 ± 0.039	0.359HisCys: 0.359 ± 0.022	1.109HisAsp: 1.109 ± 0.032	1.135HisGlu: 1.135 ± 0.033	1.115HisPhe: 1.115 ± 0.037	1.416HisGly: 1.416 ± 0.036	0.565HisHis: 0.565 ± 0.025	1.469HisIle: 1.469 ± 0.042	0.886HisLys: 0.886 ± 0.028	2.089HisLeu: 2.089 ± 0.05	0.37HisMet: 0.37 ± 0.023	0.86HisAsn: 0.86 ± 0.031	1.306HisPro: 1.306 ± 0.04	0.607HisGln: 0.607 ± 0.027	1.265HisArg: 1.265 ± 0.04	1.115HisSer: 1.115 ± 0.032	1.261HisThr: 1.261 ± 0.035	1.3HisVal: 1.3 ± 0.037	0.288HisTrp: 0.288 ± 0.019	1.005HisTyr: 1.005 ± 0.034	0.0HisXaa: 0.0 ± 0.0
Ile	4.608IleAla: 4.608 ± 0.084	0.816IleCys: 0.816 ± 0.027	3.938IleAsp: 3.938 ± 0.071	3.603IleGlu: 3.603 ± 0.074	2.169IlePhe: 2.169 ± 0.065	4.051IleGly: 4.051 ± 0.079	1.301IleHis: 1.301 ± 0.033	3.456IleIle: 3.456 ± 0.083	2.768IleLys: 2.768 ± 0.06	5.021IleLeu: 5.021 ± 0.088	1.183IleMet: 1.183 ± 0.035	2.622IleAsn: 2.622 ± 0.053	2.795IlePro: 2.795 ± 0.056	1.778IleGln: 1.778 ± 0.041	3.737IleArg: 3.737 ± 0.058	3.436IleSer: 3.436 ± 0.072	3.369IleThr: 3.369 ± 0.069	3.949IleVal: 3.949 ± 0.073	0.569IleTrp: 0.569 ± 0.027	2.353IleTyr: 2.353 ± 0.047	0.001IleXaa: 0.001 ± 0.001
Lys	4.418LysAla: 4.418 ± 0.077	0.445LysCys: 0.445 ± 0.023	3.433LysAsp: 3.433 ± 0.071	4.404LysGlu: 4.404 ± 0.086	1.718LysPhe: 1.718 ± 0.044	4.002LysGly: 4.002 ± 0.065	1.117LysHis: 1.117 ± 0.036	2.618LysIle: 2.618 ± 0.057	3.4LysLys: 3.4 ± 0.071	4.537LysLeu: 4.537 ± 0.074	1.619LysMet: 1.619 ± 0.043	2.445LysAsn: 2.445 ± 0.049	1.93LysPro: 1.93 ± 0.046	2.135LysGln: 2.135 ± 0.056	2.965LysArg: 2.965 ± 0.062	2.707LysSer: 2.707 ± 0.058	2.854LysThr: 2.854 ± 0.054	3.657LysVal: 3.657 ± 0.062	0.596LysTrp: 0.596 ± 0.028	2.25LysTyr: 2.25 ± 0.052	0.0LysXaa: 0.0 ± 0.0
Leu	7.294LeuAla: 7.294 ± 0.096	1.474LeuCys: 1.474 ± 0.038	5.232LeuAsp: 5.232 ± 0.084	5.176LeuGlu: 5.176 ± 0.072	4.203LeuPhe: 4.203 ± 0.072	5.991LeuGly: 5.991 ± 0.083	2.234LeuHis: 2.234 ± 0.055	4.79LeuIle: 4.79 ± 0.086	5.4LeuLys: 5.4 ± 0.077	9.576LeuLeu: 9.576 ± 0.147	2.433LeuMet: 2.433 ± 0.049	4.116LeuAsn: 4.116 ± 0.075	4.571LeuPro: 4.571 ± 0.077	3.469LeuGln: 3.469 ± 0.056	5.484LeuArg: 5.484 ± 0.09	6.595LeuSer: 6.595 ± 0.092	6.097LeuThr: 6.097 ± 0.093	5.828LeuVal: 5.828 ± 0.09	1.087LeuTrp: 1.087 ± 0.035	3.807LeuTyr: 3.807 ± 0.067	0.002LeuXaa: 0.002 ± 0.001
Met	2.007MetAla: 2.007 ± 0.054	0.239MetCys: 0.239 ± 0.015	1.587MetAsp: 1.587 ± 0.04	1.825MetGlu: 1.825 ± 0.044	0.93MetPhe: 0.93 ± 0.03	1.837MetGly: 1.837 ± 0.043	0.461MetHis: 0.461 ± 0.023	1.254MetIle: 1.254 ± 0.033	2.199MetLys: 2.199 ± 0.044	2.453MetLeu: 2.453 ± 0.053	0.725MetMet: 0.725 ± 0.027	1.466MetAsn: 1.466 ± 0.04	1.208MetPro: 1.208 ± 0.035	1.088MetGln: 1.088 ± 0.035	1.482MetArg: 1.482 ± 0.041	1.401MetSer: 1.401 ± 0.034	1.527MetThr: 1.527 ± 0.038	1.528MetVal: 1.528 ± 0.041	0.22MetTrp: 0.22 ± 0.015	0.829MetTyr: 0.829 ± 0.028	0.0MetXaa: 0.0 ± 0.0
Asn	3.311AsnAla: 3.311 ± 0.065	0.48AsnCys: 0.48 ± 0.026	2.349AsnAsp: 2.349 ± 0.053	2.701AsnGlu: 2.701 ± 0.056	1.905AsnPhe: 1.905 ± 0.051	3.433AsnGly: 3.433 ± 0.075	0.91AsnHis: 0.91 ± 0.031	2.994AsnIle: 2.994 ± 0.067	2.243AsnLys: 2.243 ± 0.059	4.155AsnLeu: 4.155 ± 0.071	1.155AsnMet: 1.155 ± 0.032	2.102AsnAsn: 2.102 ± 0.054	2.375AsnPro: 2.375 ± 0.052	1.367AsnGln: 1.367 ± 0.038	2.627AsnArg: 2.627 ± 0.051	2.293AsnSer: 2.293 ± 0.048	2.444AsnThr: 2.444 ± 0.054	3.027AsnVal: 3.027 ± 0.058	0.588AsnTrp: 0.588 ± 0.022	2.211AsnTyr: 2.211 ± 0.053	0.0AsnXaa: 0.0 ± 0.0
Pro	3.355ProAla: 3.355 ± 0.058	0.444ProCys: 0.444 ± 0.022	3.016ProAsp: 3.016 ± 0.056	3.345ProGlu: 3.345 ± 0.07	1.84ProPhe: 1.84 ± 0.047	2.911ProGly: 2.911 ± 0.064	0.824ProHis: 0.824 ± 0.032	2.005ProIle: 2.005 ± 0.048	1.741ProLys: 1.741 ± 0.041	3.695ProLeu: 3.695 ± 0.071	0.977ProMet: 0.977 ± 0.032	1.555ProAsn: 1.555 ± 0.044	0.967ProPro: 0.967 ± 0.038	1.56ProGln: 1.56 ± 0.037	1.735ProArg: 1.735 ± 0.043	2.517ProSer: 2.517 ± 0.056	2.226ProThr: 2.226 ± 0.043	3.351ProVal: 3.351 ± 0.061	0.492ProTrp: 0.492 ± 0.021	1.864ProTyr: 1.864 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	2.944GlnAla: 2.944 ± 0.059	0.356GlnCys: 0.356 ± 0.019	1.694GlnAsp: 1.694 ± 0.043	2.277GlnGlu: 2.277 ± 0.052	1.279GlnPhe: 1.279 ± 0.041	2.258GlnGly: 2.258 ± 0.047	0.747GlnHis: 0.747 ± 0.029	1.772GlnIle: 1.772 ± 0.046	1.803GlnLys: 1.803 ± 0.048	3.433GlnLeu: 3.433 ± 0.057	1.04GlnMet: 1.04 ± 0.033	1.48GlnAsn: 1.48 ± 0.042	1.521GlnPro: 1.521 ± 0.041	1.659GlnGln: 1.659 ± 0.048	1.972GlnArg: 1.972 ± 0.047	1.835GlnSer: 1.835 ± 0.044	2.247GlnThr: 2.247 ± 0.043	2.445GlnVal: 2.445 ± 0.05	0.513GlnTrp: 0.513 ± 0.025	1.329GlnTyr: 1.329 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	3.828ArgAla: 3.828 ± 0.073	0.637ArgCys: 0.637 ± 0.023	2.763ArgAsp: 2.763 ± 0.06	3.809ArgGlu: 3.809 ± 0.066	2.724ArgPhe: 2.724 ± 0.057	3.155ArgGly: 3.155 ± 0.057	1.392ArgHis: 1.392 ± 0.043	3.735ArgIle: 3.735 ± 0.059	3.191ArgLys: 3.191 ± 0.065	6.085ArgLeu: 6.085 ± 0.09	1.875ArgMet: 1.875 ± 0.046	2.549ArgAsn: 2.549 ± 0.048	2.424ArgPro: 2.424 ± 0.056	2.507ArgGln: 2.507 ± 0.058	3.884ArgArg: 3.884 ± 0.081	2.894ArgSer: 2.894 ± 0.053	3.266ArgThr: 3.266 ± 0.06	3.608ArgVal: 3.608 ± 0.063	0.914ArgTrp: 0.914 ± 0.03	2.557ArgTyr: 2.557 ± 0.054	0.003ArgXaa: 0.003 ± 0.002
Ser	4.38SerAla: 4.38 ± 0.074	0.841SerCys: 0.841 ± 0.027	3.149SerAsp: 3.149 ± 0.056	3.205SerGlu: 3.205 ± 0.062	3.034SerPhe: 3.034 ± 0.07	4.311SerGly: 4.311 ± 0.074	1.106SerHis: 1.106 ± 0.035	3.566SerIle: 3.566 ± 0.068	2.546SerLys: 2.546 ± 0.048	6.163SerLeu: 6.163 ± 0.096	1.383SerMet: 1.383 ± 0.035	2.426SerAsn: 2.426 ± 0.051	2.432SerPro: 2.432 ± 0.054	1.777SerGln: 1.777 ± 0.043	3.089SerArg: 3.089 ± 0.063	3.564SerSer: 3.564 ± 0.063	3.291SerThr: 3.291 ± 0.066	4.151SerVal: 4.151 ± 0.065	0.776SerTrp: 0.776 ± 0.028	2.654SerTyr: 2.654 ± 0.062	0.002SerXaa: 0.002 ± 0.002
Thr	4.585ThrAla: 4.585 ± 0.079	0.636ThrCys: 0.636 ± 0.026	4.091ThrAsp: 4.091 ± 0.069	3.26ThrGlu: 3.26 ± 0.066	2.781ThrPhe: 2.781 ± 0.054	4.634ThrGly: 4.634 ± 0.074	1.167ThrHis: 1.167 ± 0.035	3.232ThrIle: 3.232 ± 0.055	2.193ThrLys: 2.193 ± 0.051	6.143ThrLeu: 6.143 ± 0.078	1.175ThrMet: 1.175 ± 0.038	2.297ThrAsn: 2.297 ± 0.055	3.051ThrPro: 3.051 ± 0.057	1.772ThrGln: 1.772 ± 0.041	2.891ThrArg: 2.891 ± 0.062	3.245ThrSer: 3.245 ± 0.056	3.32ThrThr: 3.32 ± 0.066	4.429ThrVal: 4.429 ± 0.07	0.689ThrTrp: 0.689 ± 0.027	2.599ThrTyr: 2.599 ± 0.063	0.0ThrXaa: 0.0 ± 0.0
Val	5.167ValAla: 5.167 ± 0.077	1.12ValCys: 1.12 ± 0.032	4.029ValAsp: 4.029 ± 0.065	4.389ValGlu: 4.389 ± 0.073	2.798ValPhe: 2.798 ± 0.059	4.609ValGly: 4.609 ± 0.091	1.292ValHis: 1.292 ± 0.038	3.869ValIle: 3.869 ± 0.068	3.902ValLys: 3.902 ± 0.069	6.128ValLeu: 6.128 ± 0.087	1.675ValMet: 1.675 ± 0.041	3.15ValAsn: 3.15 ± 0.063	2.935ValPro: 2.935 ± 0.057	2.012ValGln: 2.012 ± 0.043	4.12ValArg: 4.12 ± 0.076	4.522ValSer: 4.522 ± 0.075	4.177ValThr: 4.177 ± 0.069	4.94ValVal: 4.94 ± 0.089	0.804ValTrp: 0.804 ± 0.031	2.708ValTyr: 2.708 ± 0.055	0.0ValXaa: 0.0 ± 0.0
Trp	0.874TrpAla: 0.874 ± 0.029	0.207TrpCys: 0.207 ± 0.016	0.777TrpAsp: 0.777 ± 0.03	0.803TrpGlu: 0.803 ± 0.029	0.564TrpPhe: 0.564 ± 0.027	0.979TrpGly: 0.979 ± 0.037	0.31TrpHis: 0.31 ± 0.017	0.611TrpIle: 0.611 ± 0.026	0.807TrpLys: 0.807 ± 0.025	1.245TrpLeu: 1.245 ± 0.035	0.485TrpMet: 0.485 ± 0.02	0.762TrpAsn: 0.762 ± 0.028	0.242TrpPro: 0.242 ± 0.015	0.606TrpGln: 0.606 ± 0.025	0.678TrpArg: 0.678 ± 0.029	0.712TrpSer: 0.712 ± 0.029	0.761TrpThr: 0.761 ± 0.027	0.804TrpVal: 0.804 ± 0.031	0.208TrpTrp: 0.208 ± 0.015	0.527TrpTyr: 0.527 ± 0.024	0.001TrpXaa: 0.001 ± 0.001
Tyr	3.423TyrAla: 3.423 ± 0.068	0.517TyrCys: 0.517 ± 0.023	2.723TyrAsp: 2.723 ± 0.058	2.516TyrGlu: 2.516 ± 0.047	1.961TyrPhe: 1.961 ± 0.042	3.059TyrGly: 3.059 ± 0.059	0.861TyrHis: 0.861 ± 0.028	2.343TyrIle: 2.343 ± 0.048	2.103TyrLys: 2.103 ± 0.046	3.967TyrLeu: 3.967 ± 0.062	1.071TyrMet: 1.071 ± 0.034	2.223TyrAsn: 2.223 ± 0.058	1.953TyrPro: 1.953 ± 0.042	1.458TyrGln: 1.458 ± 0.041	2.718TyrArg: 2.718 ± 0.059	2.41TyrSer: 2.41 ± 0.053	2.703TyrThr: 2.703 ± 0.067	2.729TyrVal: 2.729 ± 0.05	0.615TyrTrp: 0.615 ± 0.025	2.105TyrTyr: 2.105 ± 0.052	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.002XaaAla: 0.002 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.001XaaGlu: 0.001 ± 0.001	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.001XaaLys: 0.001 ± 0.001	0.003XaaLeu: 0.003 ± 0.002	0.001XaaMet: 0.001 ± 0.001	0.0XaaAsn: 0.0 ± 0.0	0.002XaaPro: 0.002 ± 0.001	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.001	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.014XaaXaa: 0.014 ± 0.005

Statistics based on 2834 proteins (1012360 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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