Amino acid dipepetide frequency for Pseudomonas mangrovi

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.601AlaAla: 13.601 ± 0.159	1.401AlaCys: 1.401 ± 0.034	6.037AlaAsp: 6.037 ± 0.088	8.066AlaGlu: 8.066 ± 0.099	3.714AlaPhe: 3.714 ± 0.061	9.728AlaGly: 9.728 ± 0.119	2.221AlaHis: 2.221 ± 0.047	4.809AlaIle: 4.809 ± 0.072	2.922AlaLys: 2.922 ± 0.067	14.81AlaLeu: 14.81 ± 0.137	2.649AlaMet: 2.649 ± 0.052	2.681AlaAsn: 2.681 ± 0.052	4.775AlaPro: 4.775 ± 0.068	5.45AlaGln: 5.45 ± 0.089	8.7AlaArg: 8.7 ± 0.1	6.421AlaSer: 6.421 ± 0.072	4.433AlaThr: 4.433 ± 0.069	7.261AlaVal: 7.261 ± 0.082	1.628AlaTrp: 1.628 ± 0.042	2.39AlaTyr: 2.39 ± 0.049	0.001AlaXaa: 0.001 ± 0.001
Cys	1.246CysAla: 1.246 ± 0.039	0.158CysCys: 0.158 ± 0.012	0.568CysAsp: 0.568 ± 0.019	0.613CysGlu: 0.613 ± 0.024	0.335CysPhe: 0.335 ± 0.019	1.044CysGly: 1.044 ± 0.033	0.295CysHis: 0.295 ± 0.019	0.454CysIle: 0.454 ± 0.019	0.234CysLys: 0.234 ± 0.016	1.251CysLeu: 1.251 ± 0.037	0.211CysMet: 0.211 ± 0.014	0.282CysAsn: 0.282 ± 0.015	0.532CysPro: 0.532 ± 0.026	0.405CysGln: 0.405 ± 0.019	0.75CysArg: 0.75 ± 0.026	0.723CysSer: 0.723 ± 0.028	0.41CysThr: 0.41 ± 0.02	0.686CysVal: 0.686 ± 0.027	0.163CysTrp: 0.163 ± 0.01	0.26CysTyr: 0.26 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	6.237AspAla: 6.237 ± 0.079	0.597AspCys: 0.597 ± 0.024	2.894AspAsp: 2.894 ± 0.069	3.886AspGlu: 3.886 ± 0.061	2.09AspPhe: 2.09 ± 0.044	4.86AspGly: 4.86 ± 0.089	1.05AspHis: 1.05 ± 0.029	2.473AspIle: 2.473 ± 0.051	1.636AspLys: 1.636 ± 0.042	6.152AspLeu: 6.152 ± 0.074	1.162AspMet: 1.162 ± 0.029	1.455AspAsn: 1.455 ± 0.033	2.988AspPro: 2.988 ± 0.054	2.075AspGln: 2.075 ± 0.046	3.218AspArg: 3.218 ± 0.049	3.096AspSer: 3.096 ± 0.056	2.081AspThr: 2.081 ± 0.051	3.277AspVal: 3.277 ± 0.059	1.08AspTrp: 1.08 ± 0.028	1.704AspTyr: 1.704 ± 0.043	0.0AspXaa: 0.0 ± 0.0
Glu	7.042GluAla: 7.042 ± 0.084	0.47GluCys: 0.47 ± 0.02	2.811GluAsp: 2.811 ± 0.056	3.655GluGlu: 3.655 ± 0.06	1.884GluPhe: 1.884 ± 0.04	4.305GluGly: 4.305 ± 0.068	1.623GluHis: 1.623 ± 0.039	2.858GluIle: 2.858 ± 0.052	2.048GluLys: 2.048 ± 0.05	7.959GluLeu: 7.959 ± 0.098	1.419GluMet: 1.419 ± 0.037	1.506GluAsn: 1.506 ± 0.036	2.802GluPro: 2.802 ± 0.053	4.42GluGln: 4.42 ± 0.07	5.689GluArg: 5.689 ± 0.089	2.935GluSer: 2.935 ± 0.05	2.427GluThr: 2.427 ± 0.047	4.561GluVal: 4.561 ± 0.066	0.743GluTrp: 0.743 ± 0.025	1.239GluTyr: 1.239 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	4.246PheAla: 4.246 ± 0.073	0.458PheCys: 0.458 ± 0.021	2.485PheAsp: 2.485 ± 0.049	2.163PheGlu: 2.163 ± 0.044	1.404PhePhe: 1.404 ± 0.039	3.07PheGly: 3.07 ± 0.057	0.756PheHis: 0.756 ± 0.026	1.667PheIle: 1.667 ± 0.04	1.031PheLys: 1.031 ± 0.031	3.402PheLeu: 3.402 ± 0.047	0.761PheMet: 0.761 ± 0.026	1.15PheAsn: 1.15 ± 0.034	1.349PhePro: 1.349 ± 0.033	1.175PheGln: 1.175 ± 0.03	2.03PheArg: 2.03 ± 0.04	2.454PheSer: 2.454 ± 0.053	1.612PheThr: 1.612 ± 0.04	2.453PheVal: 2.453 ± 0.05	0.533PheTrp: 0.533 ± 0.025	0.974PheTyr: 0.974 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	7.615GlyAla: 7.615 ± 0.095	1.052GlyCys: 1.052 ± 0.03	4.078GlyAsp: 4.078 ± 0.08	5.568GlyGlu: 5.568 ± 0.079	3.285GlyPhe: 3.285 ± 0.058	6.245GlyGly: 6.245 ± 0.127	1.857GlyHis: 1.857 ± 0.042	3.867GlyIle: 3.867 ± 0.064	2.989GlyLys: 2.989 ± 0.063	9.419GlyLeu: 9.419 ± 0.107	2.291GlyMet: 2.291 ± 0.048	2.33GlyAsn: 2.33 ± 0.058	2.591GlyPro: 2.591 ± 0.046	3.458GlyGln: 3.458 ± 0.056	5.614GlyArg: 5.614 ± 0.077	4.895GlySer: 4.895 ± 0.082	3.42GlyThr: 3.42 ± 0.065	6.014GlyVal: 6.014 ± 0.088	1.346GlyTrp: 1.346 ± 0.035	2.349GlyTyr: 2.349 ± 0.043	0.0GlyXaa: 0.0 ± 0.0
His	2.452HisAla: 2.452 ± 0.053	0.343HisCys: 0.343 ± 0.019	1.17HisAsp: 1.17 ± 0.033	1.175HisGlu: 1.175 ± 0.037	0.979HisPhe: 0.979 ± 0.029	1.997HisGly: 1.997 ± 0.044	0.538HisHis: 0.538 ± 0.022	0.884HisIle: 0.884 ± 0.031	0.545HisLys: 0.545 ± 0.021	2.69HisLeu: 2.69 ± 0.053	0.484HisMet: 0.484 ± 0.021	0.574HisAsn: 0.574 ± 0.024	1.522HisPro: 1.522 ± 0.038	0.941HisGln: 0.941 ± 0.03	1.461HisArg: 1.461 ± 0.039	1.191HisSer: 1.191 ± 0.036	0.815HisThr: 0.815 ± 0.027	1.205HisVal: 1.205 ± 0.033	0.464HisTrp: 0.464 ± 0.021	0.724HisTyr: 0.724 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	5.513IleAla: 5.513 ± 0.079	0.498IleCys: 0.498 ± 0.023	3.248IleAsp: 3.248 ± 0.05	3.534IleGlu: 3.534 ± 0.057	1.417IlePhe: 1.417 ± 0.036	4.244IleGly: 4.244 ± 0.064	0.969IleHis: 0.969 ± 0.027	1.831IleIle: 1.831 ± 0.043	1.379IleLys: 1.379 ± 0.036	4.088IleLeu: 4.088 ± 0.07	0.729IleMet: 0.729 ± 0.031	1.498IleAsn: 1.498 ± 0.038	2.095IlePro: 2.095 ± 0.046	1.578IleGln: 1.578 ± 0.042	3.078IleArg: 3.078 ± 0.052	2.757IleSer: 2.757 ± 0.052	2.141IleThr: 2.141 ± 0.054	2.753IleVal: 2.753 ± 0.05	0.494IleTrp: 0.494 ± 0.022	1.07IleTyr: 1.07 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	3.386LysAla: 3.386 ± 0.075	0.179LysCys: 0.179 ± 0.014	1.432LysAsp: 1.432 ± 0.041	1.434LysGlu: 1.434 ± 0.04	0.731LysPhe: 0.731 ± 0.024	2.292LysGly: 2.292 ± 0.054	0.597LysHis: 0.597 ± 0.022	1.341LysIle: 1.341 ± 0.04	1.115LysLys: 1.115 ± 0.04	3.145LysLeu: 3.145 ± 0.063	0.643LysMet: 0.643 ± 0.022	0.812LysAsn: 0.812 ± 0.029	1.841LysPro: 1.841 ± 0.048	1.285LysGln: 1.285 ± 0.039	2.17LysArg: 2.17 ± 0.045	1.643LysSer: 1.643 ± 0.045	1.486LysThr: 1.486 ± 0.037	2.434LysVal: 2.434 ± 0.051	0.295LysTrp: 0.295 ± 0.018	0.591LysTyr: 0.591 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	15.881LeuAla: 15.881 ± 0.162	1.37LeuCys: 1.37 ± 0.038	7.376LeuAsp: 7.376 ± 0.082	7.261LeuGlu: 7.261 ± 0.087	4.186LeuPhe: 4.186 ± 0.068	9.748LeuGly: 9.748 ± 0.1	2.561LeuHis: 2.561 ± 0.052	5.497LeuIle: 5.497 ± 0.082	3.718LeuLys: 3.718 ± 0.059	15.751LeuLeu: 15.751 ± 0.201	2.401LeuMet: 2.401 ± 0.048	3.17LeuAsn: 3.17 ± 0.055	6.66LeuPro: 6.66 ± 0.081	5.461LeuGln: 5.461 ± 0.085	8.955LeuArg: 8.955 ± 0.119	7.045LeuSer: 7.045 ± 0.086	5.174LeuThr: 5.174 ± 0.074	8.147LeuVal: 8.147 ± 0.091	1.515LeuTrp: 1.515 ± 0.038	2.633LeuTyr: 2.633 ± 0.047	0.0LeuXaa: 0.0 ± 0.0
Met	2.401MetAla: 2.401 ± 0.048	0.15MetCys: 0.15 ± 0.01	1.043MetAsp: 1.043 ± 0.034	0.963MetGlu: 0.963 ± 0.029	0.621MetPhe: 0.621 ± 0.028	1.55MetGly: 1.55 ± 0.036	0.539MetHis: 0.539 ± 0.022	1.034MetIle: 1.034 ± 0.03	0.811MetLys: 0.811 ± 0.025	2.851MetLeu: 2.851 ± 0.057	0.431MetMet: 0.431 ± 0.023	0.752MetAsn: 0.752 ± 0.027	1.339MetPro: 1.339 ± 0.035	1.125MetGln: 1.125 ± 0.028	1.663MetArg: 1.663 ± 0.034	1.577MetSer: 1.577 ± 0.038	1.238MetThr: 1.238 ± 0.034	1.419MetVal: 1.419 ± 0.032	0.157MetTrp: 0.157 ± 0.011	0.355MetTyr: 0.355 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	2.812AsnAla: 2.812 ± 0.05	0.296AsnCys: 0.296 ± 0.015	1.403AsnAsp: 1.403 ± 0.045	1.356AsnGlu: 1.356 ± 0.036	0.953AsnPhe: 0.953 ± 0.029	2.247AsnGly: 2.247 ± 0.052	0.584AsnHis: 0.584 ± 0.022	1.265AsnIle: 1.265 ± 0.035	0.712AsnLys: 0.712 ± 0.028	3.315AsnLeu: 3.315 ± 0.061	0.525AsnMet: 0.525 ± 0.019	0.776AsnAsn: 0.776 ± 0.037	1.842AsnPro: 1.842 ± 0.048	1.202AsnGln: 1.202 ± 0.034	1.924AsnArg: 1.924 ± 0.039	1.451AsnSer: 1.451 ± 0.042	1.151AsnThr: 1.151 ± 0.033	1.67AsnVal: 1.67 ± 0.05	0.406AsnTrp: 0.406 ± 0.022	0.724AsnTyr: 0.724 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	6.073ProAla: 6.073 ± 0.08	0.426ProCys: 0.426 ± 0.021	2.834ProAsp: 2.834 ± 0.051	3.378ProGlu: 3.378 ± 0.052	1.72ProPhe: 1.72 ± 0.04	4.106ProGly: 4.106 ± 0.067	0.97ProHis: 0.97 ± 0.027	1.861ProIle: 1.861 ± 0.043	1.213ProLys: 1.213 ± 0.033	6.196ProLeu: 6.196 ± 0.086	1.113ProMet: 1.113 ± 0.032	1.184ProAsn: 1.184 ± 0.034	2.084ProPro: 2.084 ± 0.046	2.457ProGln: 2.457 ± 0.051	2.995ProArg: 2.995 ± 0.057	2.643ProSer: 2.643 ± 0.052	2.071ProThr: 2.071 ± 0.046	3.563ProVal: 3.563 ± 0.058	0.757ProTrp: 0.757 ± 0.026	1.142ProTyr: 1.142 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	6.123GlnAla: 6.123 ± 0.085	0.328GlnCys: 0.328 ± 0.018	1.883GlnAsp: 1.883 ± 0.042	2.186GlnGlu: 2.186 ± 0.046	1.295GlnPhe: 1.295 ± 0.036	3.432GlnGly: 3.432 ± 0.056	1.122GlnHis: 1.122 ± 0.03	2.066GlnIle: 2.066 ± 0.042	1.093GlnLys: 1.093 ± 0.034	6.119GlnLeu: 6.119 ± 0.085	1.068GlnMet: 1.068 ± 0.032	1.011GlnAsn: 1.011 ± 0.028	2.626GlnPro: 2.626 ± 0.045	2.848GlnGln: 2.848 ± 0.056	4.308GlnArg: 4.308 ± 0.076	2.317GlnSer: 2.317 ± 0.048	1.918GlnThr: 1.918 ± 0.04	3.584GlnVal: 3.584 ± 0.053	0.629GlnTrp: 0.629 ± 0.02	0.89GlnTyr: 0.89 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	7.094ArgAla: 7.094 ± 0.09	0.717ArgCys: 0.717 ± 0.028	3.959ArgAsp: 3.959 ± 0.062	5.146ArgGlu: 5.146 ± 0.084	3.025ArgPhe: 3.025 ± 0.051	4.696ArgGly: 4.696 ± 0.064	1.952ArgHis: 1.952 ± 0.046	3.682ArgIle: 3.682 ± 0.054	2.032ArgLys: 2.032 ± 0.047	10.093ArgLeu: 10.093 ± 0.13	1.768ArgMet: 1.768 ± 0.038	1.981ArgAsn: 1.981 ± 0.038	3.127ArgPro: 3.127 ± 0.06	4.019ArgGln: 4.019 ± 0.066	5.323ArgArg: 5.323 ± 0.093	3.988ArgSer: 3.988 ± 0.055	2.71ArgThr: 2.71 ± 0.056	4.797ArgVal: 4.797 ± 0.076	1.186ArgTrp: 1.186 ± 0.033	2.184ArgTyr: 2.184 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	6.299SerAla: 6.299 ± 0.077	0.571SerCys: 0.571 ± 0.025	2.929SerAsp: 2.929 ± 0.057	3.456SerGlu: 3.456 ± 0.056	2.128SerPhe: 2.128 ± 0.043	5.229SerGly: 5.229 ± 0.088	1.251SerHis: 1.251 ± 0.035	2.624SerIle: 2.624 ± 0.058	1.493SerLys: 1.493 ± 0.035	7.309SerLeu: 7.309 ± 0.087	1.332SerMet: 1.332 ± 0.035	1.62SerAsn: 1.62 ± 0.038	2.629SerPro: 2.629 ± 0.052	2.4SerGln: 2.4 ± 0.047	4.108SerArg: 4.108 ± 0.063	3.427SerSer: 3.427 ± 0.064	2.439SerThr: 2.439 ± 0.05	3.727SerVal: 3.727 ± 0.066	0.844SerTrp: 0.844 ± 0.029	1.445SerTyr: 1.445 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	4.436ThrAla: 4.436 ± 0.065	0.427ThrCys: 0.427 ± 0.018	2.112ThrAsp: 2.112 ± 0.043	2.117ThrGlu: 2.117 ± 0.049	1.56ThrPhe: 1.56 ± 0.038	3.713ThrGly: 3.713 ± 0.072	0.895ThrHis: 0.895 ± 0.027	1.661ThrIle: 1.661 ± 0.045	0.872ThrLys: 0.872 ± 0.033	6.284ThrLeu: 6.284 ± 0.082	0.654ThrMet: 0.654 ± 0.026	0.933ThrAsn: 0.933 ± 0.033	2.801ThrPro: 2.801 ± 0.054	1.716ThrGln: 1.716 ± 0.04	3.143ThrArg: 3.143 ± 0.05	2.393ThrSer: 2.393 ± 0.049	1.964ThrThr: 1.964 ± 0.044	2.753ThrVal: 2.753 ± 0.052	0.602ThrTrp: 0.602 ± 0.025	1.041ThrTyr: 1.041 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	7.68ValAla: 7.68 ± 0.087	0.719ValCys: 0.719 ± 0.026	3.873ValAsp: 3.873 ± 0.059	4.656ValGlu: 4.656 ± 0.073	2.363ValPhe: 2.363 ± 0.045	5.0ValGly: 5.0 ± 0.081	1.419ValHis: 1.419 ± 0.035	3.525ValIle: 3.525 ± 0.061	1.969ValLys: 1.969 ± 0.051	8.118ValLeu: 8.118 ± 0.097	1.569ValMet: 1.569 ± 0.039	1.843ValAsn: 1.843 ± 0.045	3.196ValPro: 3.196 ± 0.057	2.558ValGln: 2.558 ± 0.048	4.854ValArg: 4.854 ± 0.069	3.964ValSer: 3.964 ± 0.061	3.096ValThr: 3.096 ± 0.058	5.086ValVal: 5.086 ± 0.076	0.832ValTrp: 0.832 ± 0.027	1.451ValTyr: 1.451 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	1.137TrpAla: 1.137 ± 0.031	0.161TrpCys: 0.161 ± 0.011	0.638TrpAsp: 0.638 ± 0.028	0.57TrpGlu: 0.57 ± 0.022	0.548TrpPhe: 0.548 ± 0.019	0.844TrpGly: 0.844 ± 0.028	0.393TrpHis: 0.393 ± 0.019	0.629TrpIle: 0.629 ± 0.025	0.387TrpLys: 0.387 ± 0.018	2.433TrpLeu: 2.433 ± 0.06	0.364TrpMet: 0.364 ± 0.02	0.417TrpAsn: 0.417 ± 0.019	0.713TrpPro: 0.713 ± 0.029	1.024TrpGln: 1.024 ± 0.03	1.218TrpArg: 1.218 ± 0.039	0.857TrpSer: 0.857 ± 0.028	0.555TrpThr: 0.555 ± 0.022	0.858TrpVal: 0.858 ± 0.028	0.255TrpTrp: 0.255 ± 0.016	0.34TrpTyr: 0.34 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.422TyrAla: 2.422 ± 0.049	0.3TyrCys: 0.3 ± 0.018	1.239TyrAsp: 1.239 ± 0.035	1.215TyrGlu: 1.215 ± 0.032	0.937TyrPhe: 0.937 ± 0.029	1.93TyrGly: 1.93 ± 0.042	0.563TyrHis: 0.563 ± 0.023	0.882TyrIle: 0.882 ± 0.026	0.654TyrLys: 0.654 ± 0.023	3.123TyrLeu: 3.123 ± 0.056	0.446TyrMet: 0.446 ± 0.018	0.636TyrAsn: 0.636 ± 0.025	1.274TyrPro: 1.274 ± 0.031	1.249TyrGln: 1.249 ± 0.033	2.281TyrArg: 2.281 ± 0.042	1.484TyrSer: 1.484 ± 0.04	0.934TyrThr: 0.934 ± 0.032	1.526TyrVal: 1.526 ± 0.037	0.412TyrTrp: 0.412 ± 0.02	0.693TyrTyr: 0.693 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.001	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3682 proteins (1184299 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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