Amino acid dipepetide frequency for Clostridium sp. CAG:245

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.659AlaAla: 2.659 ± 0.129
0.588AlaCys: 0.588 ± 0.04
3.066AlaAsp: 3.066 ± 0.104
4.296AlaGlu: 4.296 ± 0.118
2.034AlaPhe: 2.034 ± 0.069
3.649AlaGly: 3.649 ± 0.112
0.776AlaHis: 0.776 ± 0.04
5.849AlaIle: 5.849 ± 0.128
5.559AlaLys: 5.559 ± 0.123
4.611AlaLeu: 4.611 ± 0.131
1.583AlaMet: 1.583 ± 0.069
3.498AlaAsn: 3.498 ± 0.102
1.233AlaPro: 1.233 ± 0.059
1.764AlaGln: 1.764 ± 0.058
2.166AlaArg: 2.166 ± 0.084
3.339AlaSer: 3.339 ± 0.092
3.433AlaThr: 3.433 ± 0.104
3.788AlaVal: 3.788 ± 0.118
0.295AlaTrp: 0.295 ± 0.025
2.024AlaTyr: 2.024 ± 0.076
0.0AlaXaa: 0.0 ± 0.0
Cys
0.578CysAla: 0.578 ± 0.04
0.189CysCys: 0.189 ± 0.026
0.583CysAsp: 0.583 ± 0.039
0.749CysGlu: 0.749 ± 0.041
0.409CysPhe: 0.409 ± 0.036
0.861CysGly: 0.861 ± 0.051
0.196CysHis: 0.196 ± 0.02
0.98CysIle: 0.98 ± 0.055
1.032CysLys: 1.032 ± 0.053
0.893CysLeu: 0.893 ± 0.043
0.278CysMet: 0.278 ± 0.027
0.64CysAsn: 0.64 ± 0.043
0.37CysPro: 0.37 ± 0.025
0.228CysGln: 0.228 ± 0.022
0.412CysArg: 0.412 ± 0.029
0.677CysSer: 0.677 ± 0.042
0.665CysThr: 0.665 ± 0.044
0.62CysVal: 0.62 ± 0.04
0.072CysTrp: 0.072 ± 0.015
0.486CysTyr: 0.486 ± 0.035
0.0CysXaa: 0.0 ± 0.0
Asp
3.006AspAla: 3.006 ± 0.097
0.64AspCys: 0.64 ± 0.04
3.098AspAsp: 3.098 ± 0.107
5.44AspGlu: 5.44 ± 0.125
2.446AspPhe: 2.446 ± 0.08
3.614AspGly: 3.614 ± 0.109
0.513AspHis: 0.513 ± 0.037
5.69AspIle: 5.69 ± 0.119
5.286AspLys: 5.286 ± 0.14
4.487AspLeu: 4.487 ± 0.114
1.436AspMet: 1.436 ± 0.056
3.493AspAsn: 3.493 ± 0.111
1.146AspPro: 1.146 ± 0.066
0.938AspGln: 0.938 ± 0.054
1.672AspArg: 1.672 ± 0.066
3.096AspSer: 3.096 ± 0.095
2.835AspThr: 2.835 ± 0.097
4.004AspVal: 4.004 ± 0.099
0.397AspTrp: 0.397 ± 0.035
2.815AspTyr: 2.815 ± 0.091
0.0AspXaa: 0.0 ± 0.0
Glu
4.505GluAla: 4.505 ± 0.112
0.727GluCys: 0.727 ± 0.043
4.485GluAsp: 4.485 ± 0.114
7.558GluGlu: 7.558 ± 0.166
3.009GluPhe: 3.009 ± 0.099
3.522GluGly: 3.522 ± 0.091
1.0GluHis: 1.0 ± 0.056
7.801GluIle: 7.801 ± 0.169
10.131GluLys: 10.131 ± 0.197
6.688GluLeu: 6.688 ± 0.13
2.213GluMet: 2.213 ± 0.079
7.228GluAsn: 7.228 ± 0.145
1.533GluPro: 1.533 ± 0.07
2.716GluGln: 2.716 ± 0.089
2.724GluArg: 2.724 ± 0.101
3.133GluSer: 3.133 ± 0.083
3.857GluThr: 3.857 ± 0.104
4.44GluVal: 4.44 ± 0.128
0.474GluTrp: 0.474 ± 0.031
3.818GluTyr: 3.818 ± 0.114
0.0GluXaa: 0.0 ± 0.0
Phe
2.438PheAla: 2.438 ± 0.084
0.526PheCys: 0.526 ± 0.037
2.436PheAsp: 2.436 ± 0.074
2.959PheGlu: 2.959 ± 0.088
1.563PhePhe: 1.563 ± 0.075
2.376PheGly: 2.376 ± 0.076
0.427PheHis: 0.427 ± 0.033
3.527PheIle: 3.527 ± 0.114
3.259PheLys: 3.259 ± 0.103
3.354PheLeu: 3.354 ± 0.108
1.086PheMet: 1.086 ± 0.052
2.463PheAsn: 2.463 ± 0.072
0.918PhePro: 0.918 ± 0.059
0.779PheGln: 0.779 ± 0.042
1.198PheArg: 1.198 ± 0.055
2.543PheSer: 2.543 ± 0.083
2.19PheThr: 2.19 ± 0.075
2.582PheVal: 2.582 ± 0.088
0.29PheTrp: 0.29 ± 0.025
1.635PheTyr: 1.635 ± 0.071
0.0PheXaa: 0.0 ± 0.0
Gly
3.205GlyAla: 3.205 ± 0.105
0.722GlyCys: 0.722 ± 0.051
2.818GlyAsp: 2.818 ± 0.087
4.081GlyGlu: 4.081 ± 0.109
2.314GlyPhe: 2.314 ± 0.076
3.277GlyGly: 3.277 ± 0.12
0.863GlyHis: 0.863 ± 0.048
5.936GlyIle: 5.936 ± 0.139
5.777GlyLys: 5.777 ± 0.12
4.507GlyLeu: 4.507 ± 0.107
1.476GlyMet: 1.476 ± 0.071
3.508GlyAsn: 3.508 ± 0.103
0.95GlyPro: 0.95 ± 0.045
1.429GlyGln: 1.429 ± 0.065
2.265GlyArg: 2.265 ± 0.089
3.108GlySer: 3.108 ± 0.099
4.001GlyThr: 4.001 ± 0.131
3.922GlyVal: 3.922 ± 0.106
0.434GlyTrp: 0.434 ± 0.04
2.786GlyTyr: 2.786 ± 0.085
0.0GlyXaa: 0.0 ± 0.0
His
0.647HisAla: 0.647 ± 0.041
0.146HisCys: 0.146 ± 0.02
0.585HisAsp: 0.585 ± 0.037
0.779HisGlu: 0.779 ± 0.048
0.558HisPhe: 0.558 ± 0.038
0.831HisGly: 0.831 ± 0.043
0.213HisHis: 0.213 ± 0.026
1.31HisIle: 1.31 ± 0.066
0.915HisLys: 0.915 ± 0.053
0.977HisLeu: 0.977 ± 0.049
0.337HisMet: 0.337 ± 0.033
0.759HisAsn: 0.759 ± 0.041
0.575HisPro: 0.575 ± 0.04
0.36HisGln: 0.36 ± 0.03
0.449HisArg: 0.449 ± 0.034
0.838HisSer: 0.838 ± 0.047
0.645HisThr: 0.645 ± 0.041
0.685HisVal: 0.685 ± 0.045
0.094HisTrp: 0.094 ± 0.014
0.533HisTyr: 0.533 ± 0.035
0.0HisXaa: 0.0 ± 0.0
Ile
6.355IleAla: 6.355 ± 0.145
1.146IleCys: 1.146 ± 0.049
5.832IleAsp: 5.832 ± 0.133
7.7IleGlu: 7.7 ± 0.177
3.651IlePhe: 3.651 ± 0.124
5.47IleGly: 5.47 ± 0.133
1.077IleHis: 1.077 ± 0.058
9.324IleIle: 9.324 ± 0.204
8.436IleLys: 8.436 ± 0.172
8.312IleLeu: 8.312 ± 0.191
2.17IleMet: 2.17 ± 0.064
6.187IleAsn: 6.187 ± 0.145
3.029IlePro: 3.029 ± 0.086
2.451IleGln: 2.451 ± 0.084
3.116IleArg: 3.116 ± 0.102
6.249IleSer: 6.249 ± 0.13
5.569IleThr: 5.569 ± 0.135
6.363IleVal: 6.363 ± 0.139
0.459IleTrp: 0.459 ± 0.038
3.855IleTyr: 3.855 ± 0.103
0.0IleXaa: 0.0 ± 0.0
Lys
4.907LysAla: 4.907 ± 0.109
0.883LysCys: 0.883 ± 0.049
5.718LysAsp: 5.718 ± 0.147
9.362LysGlu: 9.362 ± 0.208
3.351LysPhe: 3.351 ± 0.104
3.942LysGly: 3.942 ± 0.105
1.099LysHis: 1.099 ± 0.057
9.664LysIle: 9.664 ± 0.182
9.295LysLys: 9.295 ± 0.184
7.814LysLeu: 7.814 ± 0.149
2.845LysMet: 2.845 ± 0.083
7.139LysAsn: 7.139 ± 0.162
2.061LysPro: 2.061 ± 0.068
3.413LysGln: 3.413 ± 0.089
3.279LysArg: 3.279 ± 0.11
4.5LysSer: 4.5 ± 0.102
5.4LysThr: 5.4 ± 0.114
5.864LysVal: 5.864 ± 0.123
0.541LysTrp: 0.541 ± 0.038
5.122LysTyr: 5.122 ± 0.128
0.0LysXaa: 0.0 ± 0.0
Leu
4.956LeuAla: 4.956 ± 0.108
0.925LeuCys: 0.925 ± 0.049
4.787LeuAsp: 4.787 ± 0.104
6.673LeuGlu: 6.673 ± 0.133
3.138LeuPhe: 3.138 ± 0.106
4.817LeuGly: 4.817 ± 0.118
1.141LeuHis: 1.141 ± 0.062
7.181LeuIle: 7.181 ± 0.139
7.841LeuLys: 7.841 ± 0.161
6.881LeuLeu: 6.881 ± 0.154
1.888LeuMet: 1.888 ± 0.068
5.368LeuAsn: 5.368 ± 0.137
2.622LeuPro: 2.622 ± 0.083
2.352LeuGln: 2.352 ± 0.082
2.813LeuArg: 2.813 ± 0.092
5.15LeuSer: 5.15 ± 0.117
4.547LeuThr: 4.547 ± 0.104
4.961LeuVal: 4.961 ± 0.115
0.476LeuTrp: 0.476 ± 0.036
3.354LeuTyr: 3.354 ± 0.089
0.0LeuXaa: 0.0 ± 0.0
Met
1.652MetAla: 1.652 ± 0.071
0.305MetCys: 0.305 ± 0.026
1.337MetAsp: 1.337 ± 0.059
1.895MetGlu: 1.895 ± 0.075
1.047MetPhe: 1.047 ± 0.046
1.359MetGly: 1.359 ± 0.067
0.412MetHis: 0.412 ± 0.034
1.955MetIle: 1.955 ± 0.076
2.711MetLys: 2.711 ± 0.088
2.29MetLeu: 2.29 ± 0.081
0.65MetMet: 0.65 ± 0.042
1.652MetAsn: 1.652 ± 0.063
1.027MetPro: 1.027 ± 0.051
1.027MetGln: 1.027 ± 0.046
0.764MetArg: 0.764 ± 0.044
1.602MetSer: 1.602 ± 0.058
1.116MetThr: 1.116 ± 0.052
1.555MetVal: 1.555 ± 0.071
0.154MetTrp: 0.154 ± 0.021
1.005MetTyr: 1.005 ± 0.049
0.0MetXaa: 0.0 ± 0.0
Asn
3.334AsnAla: 3.334 ± 0.094
0.747AsnCys: 0.747 ± 0.048
3.351AsnAsp: 3.351 ± 0.096
5.132AsnGlu: 5.132 ± 0.124
2.528AsnPhe: 2.528 ± 0.098
4.492AsnGly: 4.492 ± 0.129
0.63AsnHis: 0.63 ± 0.049
7.298AsnIle: 7.298 ± 0.176
6.551AsnLys: 6.551 ± 0.151
5.482AsnLeu: 5.482 ± 0.122
1.717AsnMet: 1.717 ± 0.063
5.147AsnAsn: 5.147 ± 0.158
1.987AsnPro: 1.987 ± 0.081
1.841AsnGln: 1.841 ± 0.069
2.337AsnArg: 2.337 ± 0.089
4.319AsnSer: 4.319 ± 0.127
3.994AsnThr: 3.994 ± 0.116
4.48AsnVal: 4.48 ± 0.121
0.422AsnTrp: 0.422 ± 0.032
2.93AsnTyr: 2.93 ± 0.079
0.0AsnXaa: 0.0 ± 0.0
Pro
1.327ProAla: 1.327 ± 0.06
0.337ProCys: 0.337 ± 0.029
1.605ProAsp: 1.605 ± 0.069
2.545ProGlu: 2.545 ± 0.081
1.156ProPhe: 1.156 ± 0.053
1.436ProGly: 1.436 ± 0.068
0.365ProHis: 0.365 ± 0.031
2.386ProIle: 2.386 ± 0.072
2.111ProLys: 2.111 ± 0.061
1.92ProLeu: 1.92 ± 0.069
0.667ProMet: 0.667 ± 0.047
1.615ProAsn: 1.615 ± 0.062
0.481ProPro: 0.481 ± 0.039
0.781ProGln: 0.781 ± 0.047
0.769ProArg: 0.769 ± 0.049
1.516ProSer: 1.516 ± 0.066
1.56ProThr: 1.56 ± 0.068
1.927ProVal: 1.927 ± 0.07
0.196ProTrp: 0.196 ± 0.021
1.191ProTyr: 1.191 ± 0.056
0.0ProXaa: 0.0 ± 0.0
Gln
1.6GlnAla: 1.6 ± 0.067
0.198GlnCys: 0.198 ± 0.022
1.659GlnAsp: 1.659 ± 0.063
2.637GlnGlu: 2.637 ± 0.087
0.933GlnPhe: 0.933 ± 0.05
1.508GlnGly: 1.508 ± 0.064
0.248GlnHis: 0.248 ± 0.032
2.969GlnIle: 2.969 ± 0.081
2.791GlnLys: 2.791 ± 0.102
2.185GlnLeu: 2.185 ± 0.07
0.863GlnMet: 0.863 ± 0.042
2.218GlnAsn: 2.218 ± 0.08
0.563GlnPro: 0.563 ± 0.039
0.811GlnGln: 0.811 ± 0.043
1.067GlnArg: 1.067 ± 0.06
1.347GlnSer: 1.347 ± 0.061
1.575GlnThr: 1.575 ± 0.063
1.714GlnVal: 1.714 ± 0.062
0.193GlnTrp: 0.193 ± 0.022
1.268GlnTyr: 1.268 ± 0.051
0.0GlnXaa: 0.0 ± 0.0
Arg
1.855ArgAla: 1.855 ± 0.069
0.33ArgCys: 0.33 ± 0.027
1.801ArgAsp: 1.801 ± 0.079
3.004ArgGlu: 3.004 ± 0.092
1.32ArgPhe: 1.32 ± 0.049
1.831ArgGly: 1.831 ± 0.071
0.464ArgHis: 0.464 ± 0.037
3.183ArgIle: 3.183 ± 0.083
3.503ArgLys: 3.503 ± 0.107
2.82ArgLeu: 2.82 ± 0.083
0.987ArgMet: 0.987 ± 0.049
2.29ArgAsn: 2.29 ± 0.093
0.903ArgPro: 0.903 ± 0.055
1.039ArgGln: 1.039 ± 0.055
1.449ArgArg: 1.449 ± 0.066
1.459ArgSer: 1.459 ± 0.065
1.793ArgThr: 1.793 ± 0.069
2.237ArgVal: 2.237 ± 0.075
0.241ArgTrp: 0.241 ± 0.024
1.563ArgTyr: 1.563 ± 0.061
0.0ArgXaa: 0.0 ± 0.0
Ser
3.014SerAla: 3.014 ± 0.088
0.499SerCys: 0.499 ± 0.037
3.014SerAsp: 3.014 ± 0.087
4.09SerGlu: 4.09 ± 0.107
2.394SerPhe: 2.394 ± 0.085
3.917SerGly: 3.917 ± 0.127
0.647SerHis: 0.647 ± 0.041
5.447SerIle: 5.447 ± 0.133
5.929SerLys: 5.929 ± 0.132
4.455SerLeu: 4.455 ± 0.111
1.359SerMet: 1.359 ± 0.058
4.219SerAsn: 4.219 ± 0.117
1.258SerPro: 1.258 ± 0.063
1.736SerGln: 1.736 ± 0.067
1.94SerArg: 1.94 ± 0.066
4.031SerSer: 4.031 ± 0.146
3.562SerThr: 3.562 ± 0.112
3.579SerVal: 3.579 ± 0.103
0.392SerTrp: 0.392 ± 0.039
2.495SerTyr: 2.495 ± 0.084
0.0SerXaa: 0.0 ± 0.0
Thr
3.403ThrAla: 3.403 ± 0.1
0.541ThrCys: 0.541 ± 0.037
3.309ThrAsp: 3.309 ± 0.113
3.947ThrGlu: 3.947 ± 0.101
2.21ThrPhe: 2.21 ± 0.073
3.741ThrGly: 3.741 ± 0.112
0.742ThrHis: 0.742 ± 0.039
5.452ThrIle: 5.452 ± 0.136
4.572ThrLys: 4.572 ± 0.116
4.639ThrLeu: 4.639 ± 0.09
1.213ThrMet: 1.213 ± 0.053
3.641ThrAsn: 3.641 ± 0.095
1.808ThrPro: 1.808 ± 0.065
1.605ThrGln: 1.605 ± 0.076
1.811ThrArg: 1.811 ± 0.081
3.676ThrSer: 3.676 ± 0.126
3.498ThrThr: 3.498 ± 0.135
4.272ThrVal: 4.272 ± 0.125
0.38ThrTrp: 0.38 ± 0.034
2.595ThrTyr: 2.595 ± 0.087
0.0ThrXaa: 0.0 ± 0.0
Val
4.095ValAla: 4.095 ± 0.108
0.784ValCys: 0.784 ± 0.043
3.676ValAsp: 3.676 ± 0.104
4.978ValGlu: 4.978 ± 0.12
2.381ValPhe: 2.381 ± 0.07
3.8ValGly: 3.8 ± 0.108
0.784ValHis: 0.784 ± 0.047
6.008ValIle: 6.008 ± 0.136
5.993ValLys: 5.993 ± 0.132
5.457ValLeu: 5.457 ± 0.118
1.411ValMet: 1.411 ± 0.063
3.805ValAsn: 3.805 ± 0.101
2.007ValPro: 2.007 ± 0.065
1.697ValGln: 1.697 ± 0.06
2.081ValArg: 2.081 ± 0.079
4.073ValSer: 4.073 ± 0.102
3.842ValThr: 3.842 ± 0.128
4.408ValVal: 4.408 ± 0.111
0.365ValTrp: 0.365 ± 0.03
2.572ValTyr: 2.572 ± 0.075
0.0ValXaa: 0.0 ± 0.0
Trp
0.357TrpAla: 0.357 ± 0.03
0.087TrpCys: 0.087 ± 0.015
0.318TrpAsp: 0.318 ± 0.03
0.407TrpGlu: 0.407 ± 0.033
0.253TrpPhe: 0.253 ± 0.026
0.387TrpGly: 0.387 ± 0.031
0.124TrpHis: 0.124 ± 0.017
0.598TrpIle: 0.598 ± 0.039
0.595TrpLys: 0.595 ± 0.044
0.573TrpLeu: 0.573 ± 0.044
0.164TrpMet: 0.164 ± 0.021
0.521TrpAsn: 0.521 ± 0.044
0.131TrpPro: 0.131 ± 0.021
0.243TrpGln: 0.243 ± 0.025
0.193TrpArg: 0.193 ± 0.021
0.345TrpSer: 0.345 ± 0.027
0.29TrpThr: 0.29 ± 0.028
0.28TrpVal: 0.28 ± 0.024
0.067TrpTrp: 0.067 ± 0.013
0.325TrpTyr: 0.325 ± 0.03
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.317TyrAla: 2.317 ± 0.069
0.598TyrCys: 0.598 ± 0.037
2.575TyrAsp: 2.575 ± 0.084
3.329TyrGlu: 3.329 ± 0.09
1.855TyrPhe: 1.855 ± 0.069
2.548TyrGly: 2.548 ± 0.081
0.518TyrHis: 0.518 ± 0.038
4.19TyrIle: 4.19 ± 0.093
3.912TyrLys: 3.912 ± 0.133
3.525TyrLeu: 3.525 ± 0.096
1.168TyrMet: 1.168 ± 0.049
3.326TyrAsn: 3.326 ± 0.102
1.29TyrPro: 1.29 ± 0.053
1.139TyrGln: 1.139 ± 0.057
1.568TyrArg: 1.568 ± 0.065
2.979TyrSer: 2.979 ± 0.089
2.679TyrThr: 2.679 ± 0.079
2.538TyrVal: 2.538 ± 0.081
0.318TyrTrp: 0.318 ± 0.031
1.851TyrTyr: 1.851 ± 0.078
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1330 proteins (403135 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski