Amino acid dipepetide frequency for Roseicella frigidaeris

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	28.463AlaAla: 28.463 ± 0.239	1.371AlaCys: 1.371 ± 0.03	6.281AlaAsp: 6.281 ± 0.07	10.303AlaGlu: 10.303 ± 0.101	4.284AlaPhe: 4.284 ± 0.059	15.19AlaGly: 15.19 ± 0.118	2.401AlaHis: 2.401 ± 0.046	5.702AlaIle: 5.702 ± 0.057	2.571AlaLys: 2.571 ± 0.05	18.424AlaLeu: 18.424 ± 0.132	4.073AlaMet: 4.073 ± 0.048	2.293AlaAsn: 2.293 ± 0.04	9.011AlaPro: 9.011 ± 0.099	4.393AlaGln: 4.393 ± 0.058	12.958AlaArg: 12.958 ± 0.11	5.623AlaSer: 5.623 ± 0.067	6.561AlaThr: 6.561 ± 0.075	10.206AlaVal: 10.206 ± 0.089	2.386AlaTrp: 2.386 ± 0.041	2.346AlaTyr: 2.346 ± 0.039	0.001AlaXaa: 0.001 ± 0.001
Cys	1.142CysAla: 1.142 ± 0.028	0.121CysCys: 0.121 ± 0.008	0.497CysAsp: 0.497 ± 0.017	0.389CysGlu: 0.389 ± 0.014	0.307CysPhe: 0.307 ± 0.014	1.024CysGly: 1.024 ± 0.029	0.243CysHis: 0.243 ± 0.013	0.363CysIle: 0.363 ± 0.016	0.114CysLys: 0.114 ± 0.009	0.912CysLeu: 0.912 ± 0.022	0.153CysMet: 0.153 ± 0.009	0.172CysAsn: 0.172 ± 0.011	0.538CysPro: 0.538 ± 0.019	0.199CysGln: 0.199 ± 0.012	0.797CysArg: 0.797 ± 0.023	0.377CysSer: 0.377 ± 0.014	0.449CysThr: 0.449 ± 0.017	0.59CysVal: 0.59 ± 0.018	0.146CysTrp: 0.146 ± 0.01	0.177CysTyr: 0.177 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	6.795AspAla: 6.795 ± 0.07	0.452AspCys: 0.452 ± 0.016	1.879AspAsp: 1.879 ± 0.037	2.205AspGlu: 2.205 ± 0.039	1.627AspPhe: 1.627 ± 0.033	4.779AspGly: 4.779 ± 0.064	1.03AspHis: 1.03 ± 0.026	2.032AspIle: 2.032 ± 0.035	0.74AspLys: 0.74 ± 0.021	5.494AspLeu: 5.494 ± 0.066	0.981AspMet: 0.981 ± 0.025	0.736AspAsn: 0.736 ± 0.024	4.133AspPro: 4.133 ± 0.049	1.297AspGln: 1.297 ± 0.029	4.389AspArg: 4.389 ± 0.056	1.651AspSer: 1.651 ± 0.037	1.983AspThr: 1.983 ± 0.039	2.884AspVal: 2.884 ± 0.04	1.076AspTrp: 1.076 ± 0.026	1.196AspTyr: 1.196 ± 0.029	0.0AspXaa: 0.0 ± 0.0
Glu	10.654GluAla: 10.654 ± 0.113	0.304GluCys: 0.304 ± 0.016	2.425GluAsp: 2.425 ± 0.037	3.286GluGlu: 3.286 ± 0.051	1.461GluPhe: 1.461 ± 0.028	5.266GluGly: 5.266 ± 0.064	1.05GluHis: 1.05 ± 0.026	2.502GluIle: 2.502 ± 0.035	1.159GluLys: 1.159 ± 0.032	4.779GluLeu: 4.779 ± 0.056	1.348GluMet: 1.348 ± 0.029	0.959GluAsn: 0.959 ± 0.027	2.944GluPro: 2.944 ± 0.042	1.866GluGln: 1.866 ± 0.037	5.511GluArg: 5.511 ± 0.071	1.885GluSer: 1.885 ± 0.032	3.086GluThr: 3.086 ± 0.045	4.117GluVal: 4.117 ± 0.046	0.648GluTrp: 0.648 ± 0.019	0.758GluTyr: 0.758 ± 0.022	0.0GluXaa: 0.0 ± 0.0
Phe	4.652PheAla: 4.652 ± 0.059	0.359PheCys: 0.359 ± 0.014	2.007PheAsp: 2.007 ± 0.039	1.719PheGlu: 1.719 ± 0.032	1.039PhePhe: 1.039 ± 0.029	3.58PheGly: 3.58 ± 0.047	0.717PheHis: 0.717 ± 0.018	1.041PheIle: 1.041 ± 0.028	0.429PheLys: 0.429 ± 0.014	3.329PheLeu: 3.329 ± 0.053	0.529PheMet: 0.529 ± 0.018	0.738PheAsn: 0.738 ± 0.022	1.622PhePro: 1.622 ± 0.03	0.825PheGln: 0.825 ± 0.024	2.439PheArg: 2.439 ± 0.037	1.401PheSer: 1.401 ± 0.029	1.68PheThr: 1.68 ± 0.03	2.149PheVal: 2.149 ± 0.033	0.51PheTrp: 0.51 ± 0.018	0.624PheTyr: 0.624 ± 0.019	0.0PheXaa: 0.0 ± 0.0
Gly	12.42GlyAla: 12.42 ± 0.102	0.982GlyCys: 0.982 ± 0.025	3.879GlyAsp: 3.879 ± 0.051	5.186GlyGlu: 5.186 ± 0.053	3.869GlyPhe: 3.869 ± 0.056	9.388GlyGly: 9.388 ± 0.115	2.023GlyHis: 2.023 ± 0.034	4.33GlyIle: 4.33 ± 0.051	2.123GlyLys: 2.123 ± 0.038	11.753GlyLeu: 11.753 ± 0.108	2.664GlyMet: 2.664 ± 0.034	1.855GlyAsn: 1.855 ± 0.041	5.298GlyPro: 5.298 ± 0.06	3.261GlyGln: 3.261 ± 0.05	8.621GlyArg: 8.621 ± 0.078	4.313GlySer: 4.313 ± 0.058	4.994GlyThr: 4.994 ± 0.067	6.104GlyVal: 6.104 ± 0.059	1.826GlyTrp: 1.826 ± 0.033	2.001GlyTyr: 2.001 ± 0.037	0.001GlyXaa: 0.001 ± 0.001
His	2.807HisAla: 2.807 ± 0.044	0.254HisCys: 0.254 ± 0.012	1.018HisAsp: 1.018 ± 0.028	0.834HisGlu: 0.834 ± 0.023	0.665HisPhe: 0.665 ± 0.02	2.127HisGly: 2.127 ± 0.039	0.551HisHis: 0.551 ± 0.02	0.677HisIle: 0.677 ± 0.018	0.284HisLys: 0.284 ± 0.015	2.252HisLeu: 2.252 ± 0.041	0.387HisMet: 0.387 ± 0.015	0.357HisAsn: 0.357 ± 0.015	1.672HisPro: 1.672 ± 0.035	0.483HisGln: 0.483 ± 0.018	1.771HisArg: 1.771 ± 0.028	0.724HisSer: 0.724 ± 0.019	0.719HisThr: 0.719 ± 0.021	1.439HisVal: 1.439 ± 0.028	0.397HisTrp: 0.397 ± 0.015	0.487HisTyr: 0.487 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	6.542IleAla: 6.542 ± 0.066	0.355IleCys: 0.355 ± 0.014	2.22IleAsp: 2.22 ± 0.037	2.79IleGlu: 2.79 ± 0.045	1.04IlePhe: 1.04 ± 0.026	4.585IleGly: 4.585 ± 0.059	0.733IleHis: 0.733 ± 0.022	1.217IleIle: 1.217 ± 0.034	0.63IleLys: 0.63 ± 0.022	3.835IleLeu: 3.835 ± 0.046	0.631IleMet: 0.631 ± 0.02	0.804IleAsn: 0.804 ± 0.024	2.245IlePro: 2.245 ± 0.033	0.957IleGln: 0.957 ± 0.028	3.183IleArg: 3.183 ± 0.044	1.519IleSer: 1.519 ± 0.029	1.94IleThr: 1.94 ± 0.033	2.576IleVal: 2.576 ± 0.04	0.466IleTrp: 0.466 ± 0.016	0.625IleTyr: 0.625 ± 0.019	0.0IleXaa: 0.0 ± 0.0
Lys	2.585LysAla: 2.585 ± 0.052	0.09LysCys: 0.09 ± 0.008	0.891LysAsp: 0.891 ± 0.025	0.923LysGlu: 0.923 ± 0.03	0.416LysPhe: 0.416 ± 0.014	1.681LysGly: 1.681 ± 0.035	0.346LysHis: 0.346 ± 0.014	0.719LysIle: 0.719 ± 0.024	0.457LysLys: 0.457 ± 0.022	1.948LysLeu: 1.948 ± 0.038	0.326LysMet: 0.326 ± 0.012	0.345LysAsn: 0.345 ± 0.015	1.391LysPro: 1.391 ± 0.034	0.599LysGln: 0.599 ± 0.019	1.562LysArg: 1.562 ± 0.041	0.782LysSer: 0.782 ± 0.023	0.947LysThr: 0.947 ± 0.029	1.464LysVal: 1.464 ± 0.035	0.191LysTrp: 0.191 ± 0.011	0.316LysTyr: 0.316 ± 0.013	0.001LysXaa: 0.001 ± 0.001
Leu	19.51LeuAla: 19.51 ± 0.164	1.085LeuCys: 1.085 ± 0.028	5.917LeuAsp: 5.917 ± 0.063	5.314LeuGlu: 5.314 ± 0.055	3.206LeuPhe: 3.206 ± 0.053	10.757LeuGly: 10.757 ± 0.099	2.244LeuHis: 2.244 ± 0.042	3.562LeuIle: 3.562 ± 0.045	2.021LeuLys: 2.021 ± 0.038	13.378LeuLeu: 13.378 ± 0.146	1.946LeuMet: 1.946 ± 0.036	1.904LeuAsn: 1.904 ± 0.033	8.27LeuPro: 8.27 ± 0.08	3.191LeuGln: 3.191 ± 0.045	10.251LeuArg: 10.251 ± 0.1	4.918LeuSer: 4.918 ± 0.061	5.002LeuThr: 5.002 ± 0.053	8.059LeuVal: 8.059 ± 0.079	1.479LeuTrp: 1.479 ± 0.032	1.846LeuTyr: 1.846 ± 0.036	0.001LeuXaa: 0.001 ± 0.001
Met	3.338MetAla: 3.338 ± 0.045	0.13MetCys: 0.13 ± 0.009	0.931MetAsp: 0.931 ± 0.028	0.919MetGlu: 0.919 ± 0.023	0.486MetPhe: 0.486 ± 0.016	1.734MetGly: 1.734 ± 0.036	0.378MetHis: 0.378 ± 0.014	0.842MetIle: 0.842 ± 0.022	0.509MetLys: 0.509 ± 0.018	2.621MetLeu: 2.621 ± 0.041	0.459MetMet: 0.459 ± 0.018	0.466MetAsn: 0.466 ± 0.016	1.79MetPro: 1.79 ± 0.034	0.833MetGln: 0.833 ± 0.021	2.009MetArg: 2.009 ± 0.033	1.131MetSer: 1.131 ± 0.025	1.378MetThr: 1.378 ± 0.029	1.534MetVal: 1.534 ± 0.029	0.15MetTrp: 0.15 ± 0.01	0.225MetTyr: 0.225 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	2.481AsnAla: 2.481 ± 0.039	0.194AsnCys: 0.194 ± 0.011	0.907AsnAsp: 0.907 ± 0.029	0.76AsnGlu: 0.76 ± 0.021	0.606AsnPhe: 0.606 ± 0.021	1.717AsnGly: 1.717 ± 0.034	0.388AsnHis: 0.388 ± 0.014	0.846AsnIle: 0.846 ± 0.024	0.337AsnLys: 0.337 ± 0.014	2.099AsnLeu: 2.099 ± 0.034	0.379AsnMet: 0.379 ± 0.015	0.45AsnAsn: 0.45 ± 0.016	1.568AsnPro: 1.568 ± 0.037	0.526AsnGln: 0.526 ± 0.016	1.634AsnArg: 1.634 ± 0.033	0.74AsnSer: 0.74 ± 0.024	0.957AsnThr: 0.957 ± 0.028	1.18AsnVal: 1.18 ± 0.026	0.303AsnTrp: 0.303 ± 0.016	0.429AsnTyr: 0.429 ± 0.017	0.0AsnXaa: 0.0 ± 0.0
Pro	10.641ProAla: 10.641 ± 0.102	0.436ProCys: 0.436 ± 0.017	3.823ProAsp: 3.823 ± 0.048	4.946ProGlu: 4.946 ± 0.056	1.991ProPhe: 1.991 ± 0.039	7.486ProGly: 7.486 ± 0.067	1.215ProHis: 1.215 ± 0.028	2.028ProIle: 2.028 ± 0.035	1.087ProLys: 1.087 ± 0.026	6.244ProLeu: 6.244 ± 0.067	1.355ProMet: 1.355 ± 0.031	1.164ProAsn: 1.164 ± 0.028	5.114ProPro: 5.114 ± 0.078	1.809ProGln: 1.809 ± 0.035	4.788ProArg: 4.788 ± 0.063	2.515ProSer: 2.515 ± 0.044	2.486ProThr: 2.486 ± 0.04	5.0ProVal: 5.0 ± 0.052	1.015ProTrp: 1.015 ± 0.023	1.17ProTyr: 1.17 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	5.29GlnAla: 5.29 ± 0.064	0.198GlnCys: 0.198 ± 0.011	1.411GlnAsp: 1.411 ± 0.03	1.523GlnGlu: 1.523 ± 0.037	0.824GlnPhe: 0.824 ± 0.021	2.969GlnGly: 2.969 ± 0.044	0.629GlnHis: 0.629 ± 0.02	1.191GlnIle: 1.191 ± 0.028	0.591GlnLys: 0.591 ± 0.019	2.659GlnLeu: 2.659 ± 0.046	0.655GlnMet: 0.655 ± 0.021	0.545GlnAsn: 0.545 ± 0.02	2.122GlnPro: 2.122 ± 0.034	1.174GlnGln: 1.174 ± 0.034	2.764GlnArg: 2.764 ± 0.039	1.225GlnSer: 1.225 ± 0.029	1.194GlnThr: 1.194 ± 0.028	2.437GlnVal: 2.437 ± 0.04	0.343GlnTrp: 0.343 ± 0.014	0.448GlnTyr: 0.448 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	11.617ArgAla: 11.617 ± 0.109	0.718ArgCys: 0.718 ± 0.02	4.275ArgAsp: 4.275 ± 0.058	4.598ArgGlu: 4.598 ± 0.058	3.218ArgPhe: 3.218 ± 0.049	6.745ArgGly: 6.745 ± 0.071	2.109ArgHis: 2.109 ± 0.032	4.078ArgIle: 4.078 ± 0.05	1.462ArgLys: 1.462 ± 0.037	11.19ArgLeu: 11.19 ± 0.098	2.012ArgMet: 2.012 ± 0.035	1.626ArgAsn: 1.626 ± 0.033	5.821ArgPro: 5.821 ± 0.077	3.091ArgGln: 3.091 ± 0.043	8.842ArgArg: 8.842 ± 0.088	3.471ArgSer: 3.471 ± 0.049	3.33ArgThr: 3.33 ± 0.039	5.481ArgVal: 5.481 ± 0.062	1.422ArgTrp: 1.422 ± 0.031	1.585ArgTyr: 1.585 ± 0.032	0.0ArgXaa: 0.0 ± 0.0
Ser	5.081SerAla: 5.081 ± 0.064	0.363SerCys: 0.363 ± 0.016	1.803SerAsp: 1.803 ± 0.034	1.871SerGlu: 1.871 ± 0.04	1.649SerPhe: 1.649 ± 0.029	4.552SerGly: 4.552 ± 0.051	0.87SerHis: 0.87 ± 0.025	1.78SerIle: 1.78 ± 0.033	0.742SerLys: 0.742 ± 0.024	4.913SerLeu: 4.913 ± 0.06	0.865SerMet: 0.865 ± 0.022	0.84SerAsn: 0.84 ± 0.023	2.834SerPro: 2.834 ± 0.042	1.087SerGln: 1.087 ± 0.025	3.154SerArg: 3.154 ± 0.045	1.747SerSer: 1.747 ± 0.042	1.953SerThr: 1.953 ± 0.035	2.889SerVal: 2.889 ± 0.042	0.721SerTrp: 0.721 ± 0.022	0.897SerTyr: 0.897 ± 0.027	0.0SerXaa: 0.0 ± 0.0
Thr	6.336ThrAla: 6.336 ± 0.066	0.352ThrCys: 0.352 ± 0.017	2.289ThrAsp: 2.289 ± 0.042	2.571ThrGlu: 2.571 ± 0.041	1.261ThrPhe: 1.261 ± 0.026	5.232ThrGly: 5.232 ± 0.063	0.92ThrHis: 0.92 ± 0.03	1.947ThrIle: 1.947 ± 0.036	0.771ThrLys: 0.771 ± 0.024	5.857ThrLeu: 5.857 ± 0.069	0.906ThrMet: 0.906 ± 0.024	0.885ThrAsn: 0.885 ± 0.023	3.464ThrPro: 3.464 ± 0.046	1.209ThrGln: 1.209 ± 0.029	3.484ThrArg: 3.484 ± 0.049	1.912ThrSer: 1.912 ± 0.036	2.461ThrThr: 2.461 ± 0.046	3.664ThrVal: 3.664 ± 0.052	0.632ThrTrp: 0.632 ± 0.019	0.883ThrTyr: 0.883 ± 0.026	0.0ThrXaa: 0.0 ± 0.0
Val	10.279ValAla: 10.279 ± 0.086	0.577ValCys: 0.577 ± 0.02	3.059ValAsp: 3.059 ± 0.048	4.332ValGlu: 4.332 ± 0.054	2.31ValPhe: 2.31 ± 0.036	5.04ValGly: 5.04 ± 0.059	1.29ValHis: 1.29 ± 0.027	2.909ValIle: 2.909 ± 0.043	1.363ValLys: 1.363 ± 0.033	8.332ValLeu: 8.332 ± 0.081	1.524ValMet: 1.524 ± 0.031	1.618ValAsn: 1.618 ± 0.038	4.559ValPro: 4.559 ± 0.048	2.189ValGln: 2.189 ± 0.038	5.158ValArg: 5.158 ± 0.065	3.16ValSer: 3.16 ± 0.041	4.29ValThr: 4.29 ± 0.055	5.905ValVal: 5.905 ± 0.067	0.938ValTrp: 0.938 ± 0.024	1.073ValTyr: 1.073 ± 0.024	0.001ValXaa: 0.001 ± 0.001
Trp	1.645TrpAla: 1.645 ± 0.028	0.167TrpCys: 0.167 ± 0.011	0.712TrpAsp: 0.712 ± 0.024	0.682TrpGlu: 0.682 ± 0.02	0.54TrpPhe: 0.54 ± 0.018	1.151TrpGly: 1.151 ± 0.03	0.392TrpHis: 0.392 ± 0.016	0.575TrpIle: 0.575 ± 0.019	0.296TrpLys: 0.296 ± 0.015	1.989TrpLeu: 1.989 ± 0.043	0.35TrpMet: 0.35 ± 0.014	0.369TrpAsn: 0.369 ± 0.016	0.995TrpPro: 0.995 ± 0.024	0.678TrpGln: 0.678 ± 0.021	1.635TrpArg: 1.635 ± 0.031	0.756TrpSer: 0.756 ± 0.022	0.805TrpThr: 0.805 ± 0.024	0.927TrpVal: 0.927 ± 0.025	0.272TrpTrp: 0.272 ± 0.013	0.301TrpTyr: 0.301 ± 0.012	0.001TrpXaa: 0.001 ± 0.001
Tyr	2.562TyrAla: 2.562 ± 0.038	0.203TyrCys: 0.203 ± 0.011	1.133TyrAsp: 1.133 ± 0.027	0.858TyrGlu: 0.858 ± 0.024	0.591TyrPhe: 0.591 ± 0.019	1.885TyrGly: 1.885 ± 0.039	0.373TyrHis: 0.373 ± 0.014	0.552TyrIle: 0.552 ± 0.017	0.296TyrLys: 0.296 ± 0.013	1.851TyrLeu: 1.851 ± 0.037	0.321TyrMet: 0.321 ± 0.014	0.374TyrAsn: 0.374 ± 0.016	0.921TyrPro: 0.921 ± 0.027	0.521TyrGln: 0.521 ± 0.02	1.743TyrArg: 1.743 ± 0.033	0.763TyrSer: 0.763 ± 0.021	0.822TyrThr: 0.822 ± 0.022	1.3TyrVal: 1.3 ± 0.031	0.317TyrTrp: 0.317 ± 0.012	0.431TyrTyr: 0.431 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.002XaaGly: 0.002 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.001	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.001XaaSer: 0.001 ± 0.001	0.001XaaThr: 0.001 ± 0.001	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5221 proteins (1704881 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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