Amino acid dipepetide frequency for Haematospirillum jordaniae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.624AlaAla: 12.624 ± 0.204
1.52AlaCys: 1.52 ± 0.051
6.228AlaAsp: 6.228 ± 0.107
6.303AlaGlu: 6.303 ± 0.106
3.928AlaPhe: 3.928 ± 0.084
9.484AlaGly: 9.484 ± 0.154
2.147AlaHis: 2.147 ± 0.063
4.988AlaIle: 4.988 ± 0.112
2.852AlaLys: 2.852 ± 0.087
12.671AlaLeu: 12.671 ± 0.201
3.071AlaMet: 3.071 ± 0.068
2.374AlaAsn: 2.374 ± 0.057
4.55AlaPro: 4.55 ± 0.098
2.96AlaGln: 2.96 ± 0.07
8.163AlaArg: 8.163 ± 0.14
6.141AlaSer: 6.141 ± 0.099
5.172AlaThr: 5.172 ± 0.097
9.073AlaVal: 9.073 ± 0.183
1.559AlaTrp: 1.559 ± 0.053
2.05AlaTyr: 2.05 ± 0.063
0.0AlaXaa: 0.0 ± 0.0
Cys
1.1CysAla: 1.1 ± 0.048
0.176CysCys: 0.176 ± 0.017
0.669CysAsp: 0.669 ± 0.028
0.504CysGlu: 0.504 ± 0.027
0.414CysPhe: 0.414 ± 0.024
1.087CysGly: 1.087 ± 0.046
0.369CysHis: 0.369 ± 0.022
0.612CysIle: 0.612 ± 0.033
0.243CysLys: 0.243 ± 0.018
1.273CysLeu: 1.273 ± 0.041
0.247CysMet: 0.247 ± 0.02
0.27CysAsn: 0.27 ± 0.023
0.742CysPro: 0.742 ± 0.034
0.396CysGln: 0.396 ± 0.023
0.89CysArg: 0.89 ± 0.033
0.674CysSer: 0.674 ± 0.034
0.605CysThr: 0.605 ± 0.033
0.796CysVal: 0.796 ± 0.039
0.118CysTrp: 0.118 ± 0.013
0.216CysTyr: 0.216 ± 0.018
0.0CysXaa: 0.0 ± 0.0
Asp
6.187AspAla: 6.187 ± 0.094
0.588AspCys: 0.588 ± 0.034
3.403AspAsp: 3.403 ± 0.089
3.157AspGlu: 3.157 ± 0.075
2.021AspPhe: 2.021 ± 0.068
5.319AspGly: 5.319 ± 0.159
1.451AspHis: 1.451 ± 0.049
3.821AspIle: 3.821 ± 0.085
1.586AspLys: 1.586 ± 0.061
6.414AspLeu: 6.414 ± 0.093
1.556AspMet: 1.556 ± 0.044
1.496AspAsn: 1.496 ± 0.051
3.733AspPro: 3.733 ± 0.09
1.803AspGln: 1.803 ± 0.049
4.379AspArg: 4.379 ± 0.098
3.102AspSer: 3.102 ± 0.061
3.67AspThr: 3.67 ± 0.135
4.716AspVal: 4.716 ± 0.088
0.79AspTrp: 0.79 ± 0.04
1.438AspTyr: 1.438 ± 0.046
0.0AspXaa: 0.0 ± 0.0
Glu
6.366GluAla: 6.366 ± 0.106
0.445GluCys: 0.445 ± 0.027
3.027GluAsp: 3.027 ± 0.074
3.26GluGlu: 3.26 ± 0.089
1.431GluPhe: 1.431 ± 0.049
4.109GluGly: 4.109 ± 0.093
1.445GluHis: 1.445 ± 0.044
2.991GluIle: 2.991 ± 0.078
2.607GluLys: 2.607 ± 0.075
4.681GluLeu: 4.681 ± 0.101
1.327GluMet: 1.327 ± 0.051
1.597GluAsn: 1.597 ± 0.046
2.379GluPro: 2.379 ± 0.073
2.603GluGln: 2.603 ± 0.067
4.531GluArg: 4.531 ± 0.094
2.875GluSer: 2.875 ± 0.064
3.568GluThr: 3.568 ± 0.114
3.399GluVal: 3.399 ± 0.087
0.654GluTrp: 0.654 ± 0.031
1.104GluTyr: 1.104 ± 0.043
0.0GluXaa: 0.0 ± 0.0
Phe
3.234PheAla: 3.234 ± 0.072
0.529PheCys: 0.529 ± 0.027
2.21PheAsp: 2.21 ± 0.057
1.63PheGlu: 1.63 ± 0.053
1.408PhePhe: 1.408 ± 0.05
3.018PheGly: 3.018 ± 0.074
0.79PheHis: 0.79 ± 0.032
1.491PheIle: 1.491 ± 0.054
0.705PheLys: 0.705 ± 0.032
3.852PheLeu: 3.852 ± 0.098
0.826PheMet: 0.826 ± 0.034
0.992PheAsn: 0.992 ± 0.042
1.63PhePro: 1.63 ± 0.05
0.928PheGln: 0.928 ± 0.036
2.546PheArg: 2.546 ± 0.065
2.669PheSer: 2.669 ± 0.065
1.846PheThr: 1.846 ± 0.071
2.694PheVal: 2.694 ± 0.072
0.476PheTrp: 0.476 ± 0.027
0.8PheTyr: 0.8 ± 0.039
0.0PheXaa: 0.0 ± 0.0
Gly
7.923GlyAla: 7.923 ± 0.137
1.04GlyCys: 1.04 ± 0.04
4.844GlyAsp: 4.844 ± 0.162
4.092GlyGlu: 4.092 ± 0.083
3.179GlyPhe: 3.179 ± 0.076
7.314GlyGly: 7.314 ± 0.203
2.264GlyHis: 2.264 ± 0.064
4.874GlyIle: 4.874 ± 0.094
3.336GlyLys: 3.336 ± 0.079
8.664GlyLeu: 8.664 ± 0.134
2.424GlyMet: 2.424 ± 0.066
2.43GlyAsn: 2.43 ± 0.09
3.319GlyPro: 3.319 ± 0.069
3.118GlyGln: 3.118 ± 0.066
5.856GlyArg: 5.856 ± 0.106
5.161GlySer: 5.161 ± 0.163
5.04GlyThr: 5.04 ± 0.144
6.102GlyVal: 6.102 ± 0.106
1.246GlyTrp: 1.246 ± 0.043
2.254GlyTyr: 2.254 ± 0.063
0.0GlyXaa: 0.0 ± 0.0
His
2.477HisAla: 2.477 ± 0.068
0.342HisCys: 0.342 ± 0.025
1.449HisAsp: 1.449 ± 0.048
1.11HisGlu: 1.11 ± 0.037
0.779HisPhe: 0.779 ± 0.035
2.073HisGly: 2.073 ± 0.059
0.756HisHis: 0.756 ± 0.037
1.304HisIle: 1.304 ± 0.047
0.617HisLys: 0.617 ± 0.03
2.322HisLeu: 2.322 ± 0.068
0.595HisMet: 0.595 ± 0.03
0.686HisAsn: 0.686 ± 0.036
1.501HisPro: 1.501 ± 0.049
0.715HisGln: 0.715 ± 0.034
1.577HisArg: 1.577 ± 0.054
1.121HisSer: 1.121 ± 0.04
1.175HisThr: 1.175 ± 0.043
1.815HisVal: 1.815 ± 0.056
0.296HisTrp: 0.296 ± 0.031
0.568HisTyr: 0.568 ± 0.031
0.0HisXaa: 0.0 ± 0.0
Ile
5.576IleAla: 5.576 ± 0.12
0.57IleCys: 0.57 ± 0.029
3.173IleAsp: 3.173 ± 0.074
2.954IleGlu: 2.954 ± 0.082
1.391IlePhe: 1.391 ± 0.055
4.311IleGly: 4.311 ± 0.091
1.071IleHis: 1.071 ± 0.046
2.254IleIle: 2.254 ± 0.067
1.586IleLys: 1.586 ± 0.047
5.395IleLeu: 5.395 ± 0.114
1.187IleMet: 1.187 ± 0.04
1.616IleAsn: 1.616 ± 0.052
2.75IlePro: 2.75 ± 0.068
1.596IleGln: 1.596 ± 0.054
3.849IleArg: 3.849 ± 0.08
3.037IleSer: 3.037 ± 0.067
2.936IleThr: 2.936 ± 0.071
3.621IleVal: 3.621 ± 0.101
0.497IleTrp: 0.497 ± 0.032
0.934IleTyr: 0.934 ± 0.042
0.0IleXaa: 0.0 ± 0.0
Lys
4.202LysAla: 4.202 ± 0.095
0.169LysCys: 0.169 ± 0.015
1.852LysAsp: 1.852 ± 0.058
1.63LysGlu: 1.63 ± 0.065
0.669LysPhe: 0.669 ± 0.034
2.73LysGly: 2.73 ± 0.072
0.635LysHis: 0.635 ± 0.038
1.709LysIle: 1.709 ± 0.054
1.503LysLys: 1.503 ± 0.062
2.551LysLeu: 2.551 ± 0.062
0.78LysMet: 0.78 ± 0.036
0.904LysAsn: 0.904 ± 0.038
1.887LysPro: 1.887 ± 0.064
1.007LysGln: 1.007 ± 0.041
2.029LysArg: 2.029 ± 0.064
1.759LysSer: 1.759 ± 0.057
2.099LysThr: 2.099 ± 0.06
2.423LysVal: 2.423 ± 0.071
0.303LysTrp: 0.303 ± 0.021
0.548LysTyr: 0.548 ± 0.029
0.0LysXaa: 0.0 ± 0.0
Leu
11.722LeuAla: 11.722 ± 0.184
1.31LeuCys: 1.31 ± 0.039
6.873LeuAsp: 6.873 ± 0.117
6.163LeuGlu: 6.163 ± 0.123
3.784LeuPhe: 3.784 ± 0.089
8.158LeuGly: 8.158 ± 0.119
2.356LeuHis: 2.356 ± 0.064
4.128LeuIle: 4.128 ± 0.091
3.461LeuLys: 3.461 ± 0.081
9.708LeuLeu: 9.708 ± 0.192
2.502LeuMet: 2.502 ± 0.06
2.424LeuAsn: 2.424 ± 0.069
5.785LeuPro: 5.785 ± 0.097
3.265LeuGln: 3.265 ± 0.067
7.206LeuArg: 7.206 ± 0.117
7.78LeuSer: 7.78 ± 0.126
5.222LeuThr: 5.222 ± 0.1
8.57LeuVal: 8.57 ± 0.116
1.331LeuTrp: 1.331 ± 0.045
2.289LeuTyr: 2.289 ± 0.061
0.0LeuXaa: 0.0 ± 0.0
Met
3.309MetAla: 3.309 ± 0.085
0.198MetCys: 0.198 ± 0.018
1.4MetAsp: 1.4 ± 0.046
1.361MetGlu: 1.361 ± 0.046
0.648MetPhe: 0.648 ± 0.034
1.935MetGly: 1.935 ± 0.057
0.497MetHis: 0.497 ± 0.025
1.394MetIle: 1.394 ± 0.045
0.962MetLys: 0.962 ± 0.041
2.362MetLeu: 2.362 ± 0.063
0.681MetMet: 0.681 ± 0.033
0.736MetAsn: 0.736 ± 0.03
1.58MetPro: 1.58 ± 0.047
0.888MetGln: 0.888 ± 0.035
1.68MetArg: 1.68 ± 0.057
1.555MetSer: 1.555 ± 0.046
1.832MetThr: 1.832 ± 0.054
2.015MetVal: 2.015 ± 0.059
0.206MetTrp: 0.206 ± 0.017
0.328MetTyr: 0.328 ± 0.021
0.0MetXaa: 0.0 ± 0.0
Asn
2.856AsnAla: 2.856 ± 0.064
0.216AsnCys: 0.216 ± 0.018
1.421AsnAsp: 1.421 ± 0.065
1.15AsnGlu: 1.15 ± 0.04
0.75AsnPhe: 0.75 ± 0.034
2.397AsnGly: 2.397 ± 0.068
0.568AsnHis: 0.568 ± 0.027
1.576AsnIle: 1.576 ± 0.057
0.813AsnLys: 0.813 ± 0.034
2.59AsnLeu: 2.59 ± 0.061
0.637AsnMet: 0.637 ± 0.031
0.772AsnAsn: 0.772 ± 0.038
1.911AsnPro: 1.911 ± 0.053
0.855AsnGln: 0.855 ± 0.038
1.999AsnArg: 1.999 ± 0.061
1.252AsnSer: 1.252 ± 0.047
1.631AsnThr: 1.631 ± 0.052
1.837AsnVal: 1.837 ± 0.078
0.365AsnTrp: 0.365 ± 0.022
0.497AsnTyr: 0.497 ± 0.028
0.0AsnXaa: 0.0 ± 0.0
Pro
5.343ProAla: 5.343 ± 0.112
0.536ProCys: 0.536 ± 0.031
4.6ProAsp: 4.6 ± 0.098
3.668ProGlu: 3.668 ± 0.07
1.935ProPhe: 1.935 ± 0.051
4.796ProGly: 4.796 ± 0.091
1.135ProHis: 1.135 ± 0.039
1.644ProIle: 1.644 ± 0.049
1.265ProLys: 1.265 ± 0.05
5.133ProLeu: 5.133 ± 0.096
1.228ProMet: 1.228 ± 0.045
1.053ProAsn: 1.053 ± 0.041
2.617ProPro: 2.617 ± 0.088
1.408ProGln: 1.408 ± 0.05
2.822ProArg: 2.822 ± 0.071
3.268ProSer: 3.268 ± 0.064
2.087ProThr: 2.087 ± 0.065
5.519ProVal: 5.519 ± 0.126
0.847ProTrp: 0.847 ± 0.038
1.012ProTyr: 1.012 ± 0.043
0.0ProXaa: 0.0 ± 0.0
Gln
4.264GlnAla: 4.264 ± 0.072
0.263GlnCys: 0.263 ± 0.022
2.109GlnAsp: 2.109 ± 0.056
1.81GlnGlu: 1.81 ± 0.052
0.864GlnPhe: 0.864 ± 0.036
2.683GlnGly: 2.683 ± 0.071
0.776GlnHis: 0.776 ± 0.036
1.701GlnIle: 1.701 ± 0.05
1.34GlnLys: 1.34 ± 0.043
2.517GlnLeu: 2.517 ± 0.07
0.827GlnMet: 0.827 ± 0.037
0.941GlnAsn: 0.941 ± 0.037
1.502GlnPro: 1.502 ± 0.041
1.236GlnGln: 1.236 ± 0.044
2.328GlnArg: 2.328 ± 0.057
1.989GlnSer: 1.989 ± 0.053
1.927GlnThr: 1.927 ± 0.048
2.491GlnVal: 2.491 ± 0.065
0.392GlnTrp: 0.392 ± 0.023
0.615GlnTyr: 0.615 ± 0.029
0.0GlnXaa: 0.0 ± 0.0
Arg
6.859ArgAla: 6.859 ± 0.122
0.75ArgCys: 0.75 ± 0.03
4.362ArgAsp: 4.362 ± 0.093
3.955ArgGlu: 3.955 ± 0.088
2.718ArgPhe: 2.718 ± 0.074
4.752ArgGly: 4.752 ± 0.097
1.948ArgHis: 1.948 ± 0.055
4.297ArgIle: 4.297 ± 0.094
2.386ArgLys: 2.386 ± 0.065
8.119ArgLeu: 8.119 ± 0.152
1.923ArgMet: 1.923 ± 0.055
2.073ArgAsn: 2.073 ± 0.055
3.43ArgPro: 3.43 ± 0.074
2.892ArgGln: 2.892 ± 0.066
5.438ArgArg: 5.438 ± 0.125
4.418ArgSer: 4.418 ± 0.092
3.78ArgThr: 3.78 ± 0.078
5.006ArgVal: 5.006 ± 0.102
0.971ArgTrp: 0.971 ± 0.038
1.752ArgTyr: 1.752 ± 0.047
0.0ArgXaa: 0.0 ± 0.0
Ser
6.428SerAla: 6.428 ± 0.106
0.777SerCys: 0.777 ± 0.035
3.24SerAsp: 3.24 ± 0.08
2.721SerGlu: 2.721 ± 0.083
2.274SerPhe: 2.274 ± 0.058
6.515SerGly: 6.515 ± 0.174
1.391SerHis: 1.391 ± 0.053
2.947SerIle: 2.947 ± 0.073
1.562SerLys: 1.562 ± 0.051
7.017SerLeu: 7.017 ± 0.119
1.654SerMet: 1.654 ± 0.052
1.393SerAsn: 1.393 ± 0.05
3.15SerPro: 3.15 ± 0.067
1.789SerGln: 1.789 ± 0.053
4.375SerArg: 4.375 ± 0.088
4.034SerSer: 4.034 ± 0.097
2.95SerThr: 2.95 ± 0.077
5.346SerVal: 5.346 ± 0.145
0.897SerTrp: 0.897 ± 0.033
1.307SerTyr: 1.307 ± 0.042
0.0SerXaa: 0.0 ± 0.0
Thr
5.984ThrAla: 5.984 ± 0.182
0.578ThrCys: 0.578 ± 0.034
3.017ThrAsp: 3.017 ± 0.08
2.866ThrGlu: 2.866 ± 0.071
1.921ThrPhe: 1.921 ± 0.058
5.444ThrGly: 5.444 ± 0.107
1.107ThrHis: 1.107 ± 0.042
2.802ThrIle: 2.802 ± 0.074
1.266ThrLys: 1.266 ± 0.042
6.443ThrLeu: 6.443 ± 0.133
1.198ThrMet: 1.198 ± 0.039
1.289ThrAsn: 1.289 ± 0.047
3.444ThrPro: 3.444 ± 0.084
1.424ThrGln: 1.424 ± 0.051
3.51ThrArg: 3.51 ± 0.078
2.936ThrSer: 2.936 ± 0.08
2.792ThrThr: 2.792 ± 0.098
4.895ThrVal: 4.895 ± 0.178
0.708ThrTrp: 0.708 ± 0.033
1.026ThrTyr: 1.026 ± 0.036
0.0ThrXaa: 0.0 ± 0.0
Val
8.114ValAla: 8.114 ± 0.133
0.999ValCys: 0.999 ± 0.041
4.729ValAsp: 4.729 ± 0.12
4.441ValGlu: 4.441 ± 0.106
2.875ValPhe: 2.875 ± 0.062
5.432ValGly: 5.432 ± 0.109
1.726ValHis: 1.726 ± 0.051
4.101ValIle: 4.101 ± 0.086
2.089ValLys: 2.089 ± 0.085
8.682ValLeu: 8.682 ± 0.124
2.033ValMet: 2.033 ± 0.053
2.022ValAsn: 2.022 ± 0.052
4.307ValPro: 4.307 ± 0.135
2.45ValGln: 2.45 ± 0.068
5.816ValArg: 5.816 ± 0.108
5.829ValSer: 5.829 ± 0.26
4.46ValThr: 4.46 ± 0.144
6.521ValVal: 6.521 ± 0.145
0.993ValTrp: 0.993 ± 0.042
1.584ValTyr: 1.584 ± 0.045
0.0ValXaa: 0.0 ± 0.0
Trp
1.088TrpAla: 1.088 ± 0.042
0.176TrpCys: 0.176 ± 0.015
0.671TrpAsp: 0.671 ± 0.03
0.583TrpGlu: 0.583 ± 0.033
0.53TrpPhe: 0.53 ± 0.028
0.848TrpGly: 0.848 ± 0.033
0.341TrpHis: 0.341 ± 0.023
0.726TrpIle: 0.726 ± 0.038
0.546TrpLys: 0.546 ± 0.028
1.698TrpLeu: 1.698 ± 0.053
0.378TrpMet: 0.378 ± 0.023
0.419TrpAsn: 0.419 ± 0.028
0.659TrpPro: 0.659 ± 0.029
0.512TrpGln: 0.512 ± 0.026
1.057TrpArg: 1.057 ± 0.035
0.912TrpSer: 0.912 ± 0.047
0.632TrpThr: 0.632 ± 0.03
0.831TrpVal: 0.831 ± 0.035
0.203TrpTrp: 0.203 ± 0.018
0.337TrpTyr: 0.337 ± 0.026
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.202TyrAla: 2.202 ± 0.057
0.219TyrCys: 0.219 ± 0.02
1.356TyrAsp: 1.356 ± 0.049
1.042TyrGlu: 1.042 ± 0.04
0.755TyrPhe: 0.755 ± 0.032
2.075TyrGly: 2.075 ± 0.06
0.503TyrHis: 0.503 ± 0.028
0.942TyrIle: 0.942 ± 0.04
0.665TyrLys: 0.665 ± 0.03
1.947TyrLeu: 1.947 ± 0.057
0.492TyrMet: 0.492 ± 0.029
0.608TyrAsn: 0.608 ± 0.031
1.039TyrPro: 1.039 ± 0.043
0.729TyrGln: 0.729 ± 0.034
1.776TyrArg: 1.776 ± 0.051
1.256TyrSer: 1.256 ± 0.046
1.223TyrThr: 1.223 ± 0.049
1.535TyrVal: 1.535 ± 0.046
0.298TyrTrp: 0.298 ± 0.023
0.547TyrTyr: 0.547 ± 0.031
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2130 proteins (703749 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski