Amino acid dipepetide frequency for Brachybacterium phenoliresistens

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	22.89AlaAla: 22.89 ± 0.235	0.839AlaCys: 0.839 ± 0.027	8.541AlaAsp: 8.541 ± 0.093	9.128AlaGlu: 9.128 ± 0.108	3.399AlaPhe: 3.399 ± 0.052	13.391AlaGly: 13.391 ± 0.114	2.834AlaHis: 2.834 ± 0.049	5.148AlaIle: 5.148 ± 0.075	1.819AlaLys: 1.819 ± 0.051	15.4AlaLeu: 15.4 ± 0.137	2.86AlaMet: 2.86 ± 0.046	1.531AlaAsn: 1.531 ± 0.04	8.686AlaPro: 8.686 ± 0.133	4.687AlaGln: 4.687 ± 0.057	10.963AlaArg: 10.963 ± 0.113	7.112AlaSer: 7.112 ± 0.083	6.479AlaThr: 6.479 ± 0.083	11.661AlaVal: 11.661 ± 0.136	1.991AlaTrp: 1.991 ± 0.04	2.174AlaTyr: 2.174 ± 0.042	0.0AlaXaa: 0.0 ± 0.0
Cys	0.809CysAla: 0.809 ± 0.025	0.062CysCys: 0.062 ± 0.007	0.281CysAsp: 0.281 ± 0.019	0.326CysGlu: 0.326 ± 0.015	0.18CysPhe: 0.18 ± 0.012	0.701CysGly: 0.701 ± 0.026	0.131CysHis: 0.131 ± 0.01	0.193CysIle: 0.193 ± 0.012	0.047CysLys: 0.047 ± 0.006	0.528CysLeu: 0.528 ± 0.02	0.073CysMet: 0.073 ± 0.007	0.08CysAsn: 0.08 ± 0.008	0.338CysPro: 0.338 ± 0.019	0.126CysGln: 0.126 ± 0.01	0.402CysArg: 0.402 ± 0.018	0.319CysSer: 0.319 ± 0.015	0.396CysThr: 0.396 ± 0.017	0.443CysVal: 0.443 ± 0.019	0.094CysTrp: 0.094 ± 0.01	0.12CysTyr: 0.12 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	9.242AspAla: 9.242 ± 0.097	0.284AspCys: 0.284 ± 0.017	3.147AspAsp: 3.147 ± 0.064	3.977AspGlu: 3.977 ± 0.076	1.426AspPhe: 1.426 ± 0.035	6.396AspGly: 6.396 ± 0.091	1.366AspHis: 1.366 ± 0.037	1.925AspIle: 1.925 ± 0.049	0.641AspLys: 0.641 ± 0.029	7.166AspLeu: 7.166 ± 0.081	0.872AspMet: 0.872 ± 0.03	0.646AspAsn: 0.646 ± 0.024	5.353AspPro: 5.353 ± 0.086	1.536AspGln: 1.536 ± 0.04	4.603AspArg: 4.603 ± 0.061	2.317AspSer: 2.317 ± 0.039	2.414AspThr: 2.414 ± 0.049	5.254AspVal: 5.254 ± 0.07	0.92AspTrp: 0.92 ± 0.033	1.058AspTyr: 1.058 ± 0.033	0.0AspXaa: 0.0 ± 0.0
Glu	8.125GluAla: 8.125 ± 0.103	0.227GluCys: 0.227 ± 0.012	4.698GluAsp: 4.698 ± 0.067	4.289GluGlu: 4.289 ± 0.066	1.386GluPhe: 1.386 ± 0.037	5.086GluGly: 5.086 ± 0.067	1.957GluHis: 1.957 ± 0.047	2.964GluIle: 2.964 ± 0.063	1.246GluLys: 1.246 ± 0.039	6.492GluLeu: 6.492 ± 0.086	1.011GluMet: 1.011 ± 0.028	1.116GluAsn: 1.116 ± 0.034	3.132GluPro: 3.132 ± 0.065	2.616GluGln: 2.616 ± 0.049	4.993GluArg: 4.993 ± 0.068	2.709GluSer: 2.709 ± 0.052	2.895GluThr: 2.895 ± 0.051	5.128GluVal: 5.128 ± 0.07	0.562GluTrp: 0.562 ± 0.024	0.961GluTyr: 0.961 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	3.722PheAla: 3.722 ± 0.06	0.195PheCys: 0.195 ± 0.012	1.802PheAsp: 1.802 ± 0.044	1.512PheGlu: 1.512 ± 0.033	0.949PhePhe: 0.949 ± 0.032	2.77PheGly: 2.77 ± 0.058	0.6PheHis: 0.6 ± 0.024	0.83PheIle: 0.83 ± 0.028	0.272PheLys: 0.272 ± 0.015	2.812PheLeu: 2.812 ± 0.054	0.409PheMet: 0.409 ± 0.021	0.41PheAsn: 0.41 ± 0.016	1.351PhePro: 1.351 ± 0.038	0.656PheGln: 0.656 ± 0.022	1.713PheArg: 1.713 ± 0.038	1.681PheSer: 1.681 ± 0.038	1.818PheThr: 1.818 ± 0.043	2.328PheVal: 2.328 ± 0.044	0.48PheTrp: 0.48 ± 0.019	0.554PheTyr: 0.554 ± 0.023	0.0PheXaa: 0.0 ± 0.0
Gly	12.509GlyAla: 12.509 ± 0.126	0.615GlyCys: 0.615 ± 0.025	4.841GlyAsp: 4.841 ± 0.074	5.57GlyGlu: 5.57 ± 0.081	2.811GlyPhe: 2.811 ± 0.053	8.488GlyGly: 8.488 ± 0.111	1.906GlyHis: 1.906 ± 0.042	4.628GlyIle: 4.628 ± 0.071	1.521GlyLys: 1.521 ± 0.042	8.959GlyLeu: 8.959 ± 0.104	2.22GlyMet: 2.22 ± 0.044	1.339GlyAsn: 1.339 ± 0.054	5.217GlyPro: 5.217 ± 0.078	2.475GlyGln: 2.475 ± 0.047	7.594GlyArg: 7.594 ± 0.086	5.632GlySer: 5.632 ± 0.07	6.458GlyThr: 6.458 ± 0.08	7.005GlyVal: 7.005 ± 0.073	1.575GlyTrp: 1.575 ± 0.042	1.992GlyTyr: 1.992 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	2.71HisAla: 2.71 ± 0.052	0.129HisCys: 0.129 ± 0.012	1.439HisAsp: 1.439 ± 0.035	1.41HisGlu: 1.41 ± 0.032	0.484HisPhe: 0.484 ± 0.022	2.406HisGly: 2.406 ± 0.045	0.626HisHis: 0.626 ± 0.023	0.603HisIle: 0.603 ± 0.022	0.199HisLys: 0.199 ± 0.014	2.616HisLeu: 2.616 ± 0.05	0.28HisMet: 0.28 ± 0.014	0.268HisAsn: 0.268 ± 0.013	1.614HisPro: 1.614 ± 0.039	0.578HisGln: 0.578 ± 0.024	2.182HisArg: 2.182 ± 0.045	0.829HisSer: 0.829 ± 0.026	0.867HisThr: 0.867 ± 0.027	1.843HisVal: 1.843 ± 0.04	0.321HisTrp: 0.321 ± 0.017	0.415HisTyr: 0.415 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	6.455IleAla: 6.455 ± 0.082	0.241IleCys: 0.241 ± 0.013	3.033IleAsp: 3.033 ± 0.049	2.297IleGlu: 2.297 ± 0.043	0.93IlePhe: 0.93 ± 0.032	4.85IleGly: 4.85 ± 0.073	0.697IleHis: 0.697 ± 0.025	1.587IleIle: 1.587 ± 0.037	0.473IleLys: 0.473 ± 0.02	3.777IleLeu: 3.777 ± 0.063	0.606IleMet: 0.606 ± 0.022	0.613IleAsn: 0.613 ± 0.026	2.383IlePro: 2.383 ± 0.044	0.819IleGln: 0.819 ± 0.027	2.579IleArg: 2.579 ± 0.044	2.222IleSer: 2.222 ± 0.043	2.622IleThr: 2.622 ± 0.049	3.674IleVal: 3.674 ± 0.058	0.469IleTrp: 0.469 ± 0.018	0.597IleTyr: 0.597 ± 0.024	0.0IleXaa: 0.0 ± 0.0
Lys	1.639LysAla: 1.639 ± 0.049	0.054LysCys: 0.054 ± 0.007	0.938LysAsp: 0.938 ± 0.033	0.773LysGlu: 0.773 ± 0.032	0.325LysPhe: 0.325 ± 0.016	1.205LysGly: 1.205 ± 0.038	0.319LysHis: 0.319 ± 0.017	0.639LysIle: 0.639 ± 0.031	0.491LysLys: 0.491 ± 0.024	1.227LysLeu: 1.227 ± 0.036	0.248LysMet: 0.248 ± 0.013	0.38LysAsn: 0.38 ± 0.02	0.734LysPro: 0.734 ± 0.028	0.464LysGln: 0.464 ± 0.02	0.905LysArg: 0.905 ± 0.032	0.712LysSer: 0.712 ± 0.025	0.777LysThr: 0.777 ± 0.028	1.199LysVal: 1.199 ± 0.041	0.124LysTrp: 0.124 ± 0.01	0.308LysTyr: 0.308 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	15.935LeuAla: 15.935 ± 0.172	0.603LeuCys: 0.603 ± 0.023	6.735LeuAsp: 6.735 ± 0.088	6.632LeuGlu: 6.632 ± 0.076	2.587LeuPhe: 2.587 ± 0.055	9.804LeuGly: 9.804 ± 0.101	2.273LeuHis: 2.273 ± 0.046	3.799LeuIle: 3.799 ± 0.071	1.129LeuLys: 1.129 ± 0.038	11.75LeuLeu: 11.75 ± 0.146	1.773LeuMet: 1.773 ± 0.044	1.368LeuAsn: 1.368 ± 0.034	6.331LeuPro: 6.331 ± 0.084	2.654LeuGln: 2.654 ± 0.046	8.818LeuArg: 8.818 ± 0.1	5.512LeuSer: 5.512 ± 0.075	5.831LeuThr: 5.831 ± 0.075	9.568LeuVal: 9.568 ± 0.101	1.336LeuTrp: 1.336 ± 0.039	1.561LeuTyr: 1.561 ± 0.036	0.0LeuXaa: 0.0 ± 0.0
Met	2.196MetAla: 2.196 ± 0.045	0.11MetCys: 0.11 ± 0.009	0.998MetAsp: 0.998 ± 0.028	0.662MetGlu: 0.662 ± 0.023	0.55MetPhe: 0.55 ± 0.023	1.423MetGly: 1.423 ± 0.035	0.428MetHis: 0.428 ± 0.02	1.01MetIle: 1.01 ± 0.031	0.306MetLys: 0.306 ± 0.016	2.189MetLeu: 2.189 ± 0.054	0.392MetMet: 0.392 ± 0.018	0.449MetAsn: 0.449 ± 0.019	1.251MetPro: 1.251 ± 0.032	0.502MetGln: 0.502 ± 0.021	1.433MetArg: 1.433 ± 0.035	1.511MetSer: 1.511 ± 0.038	1.748MetThr: 1.748 ± 0.035	1.453MetVal: 1.453 ± 0.037	0.207MetTrp: 0.207 ± 0.013	0.319MetTyr: 0.319 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	1.757AsnAla: 1.757 ± 0.041	0.086AsnCys: 0.086 ± 0.008	0.729AsnAsp: 0.729 ± 0.025	0.636AsnGlu: 0.636 ± 0.025	0.433AsnPhe: 0.433 ± 0.021	1.282AsnGly: 1.282 ± 0.05	0.314AsnHis: 0.314 ± 0.015	0.659AsnIle: 0.659 ± 0.023	0.221AsnLys: 0.221 ± 0.014	1.565AsnLeu: 1.565 ± 0.037	0.276AsnMet: 0.276 ± 0.015	0.304AsnAsn: 0.304 ± 0.016	1.23AsnPro: 1.23 ± 0.034	0.424AsnGln: 0.424 ± 0.021	0.971AsnArg: 0.971 ± 0.033	0.732AsnSer: 0.732 ± 0.026	0.814AsnThr: 0.814 ± 0.026	1.175AsnVal: 1.175 ± 0.033	0.21AsnTrp: 0.21 ± 0.014	0.341AsnTyr: 0.341 ± 0.018	0.0AsnXaa: 0.0 ± 0.0
Pro	9.755ProAla: 9.755 ± 0.128	0.236ProCys: 0.236 ± 0.013	3.997ProAsp: 3.997 ± 0.06	4.844ProGlu: 4.844 ± 0.078	1.662ProPhe: 1.662 ± 0.037	6.499ProGly: 6.499 ± 0.087	1.306ProHis: 1.306 ± 0.03	1.88ProIle: 1.88 ± 0.046	0.628ProLys: 0.628 ± 0.027	5.32ProLeu: 5.32 ± 0.077	1.213ProMet: 1.213 ± 0.032	0.719ProAsn: 0.719 ± 0.026	2.982ProPro: 2.982 ± 0.072	1.911ProGln: 1.911 ± 0.042	4.454ProArg: 4.454 ± 0.068	3.466ProSer: 3.466 ± 0.07	3.138ProThr: 3.138 ± 0.061	5.075ProVal: 5.075 ± 0.086	0.948ProTrp: 0.948 ± 0.032	1.054ProTyr: 1.054 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	3.528GlnAla: 3.528 ± 0.064	0.106GlnCys: 0.106 ± 0.009	1.783GlnAsp: 1.783 ± 0.037	1.94GlnGlu: 1.94 ± 0.042	0.693GlnPhe: 0.693 ± 0.026	2.467GlnGly: 2.467 ± 0.054	0.643GlnHis: 0.643 ± 0.022	1.397GlnIle: 1.397 ± 0.034	0.53GlnLys: 0.53 ± 0.024	3.106GlnLeu: 3.106 ± 0.053	0.585GlnMet: 0.585 ± 0.022	0.491GlnAsn: 0.491 ± 0.018	1.318GlnPro: 1.318 ± 0.042	1.165GlnGln: 1.165 ± 0.036	2.452GlnArg: 2.452 ± 0.046	1.289GlnSer: 1.289 ± 0.03	1.256GlnThr: 1.256 ± 0.034	2.604GlnVal: 2.604 ± 0.047	0.444GlnTrp: 0.444 ± 0.02	0.559GlnTyr: 0.559 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	10.434ArgAla: 10.434 ± 0.11	0.424ArgCys: 0.424 ± 0.019	4.333ArgAsp: 4.333 ± 0.062	5.648ArgGlu: 5.648 ± 0.068	2.241ArgPhe: 2.241 ± 0.043	6.304ArgGly: 6.304 ± 0.076	1.775ArgHis: 1.775 ± 0.041	4.059ArgIle: 4.059 ± 0.059	0.935ArgLys: 0.935 ± 0.031	7.819ArgLeu: 7.819 ± 0.096	1.855ArgMet: 1.855 ± 0.04	0.964ArgAsn: 0.964 ± 0.032	4.82ArgPro: 4.82 ± 0.064	1.793ArgGln: 1.793 ± 0.045	8.46ArgArg: 8.46 ± 0.107	4.696ArgSer: 4.696 ± 0.06	5.258ArgThr: 5.258 ± 0.074	5.245ArgVal: 5.245 ± 0.066	1.266ArgTrp: 1.266 ± 0.028	1.489ArgTyr: 1.489 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	7.519SerAla: 7.519 ± 0.083	0.308SerCys: 0.308 ± 0.016	2.704SerAsp: 2.704 ± 0.057	2.552SerGlu: 2.552 ± 0.051	1.735SerPhe: 1.735 ± 0.041	5.611SerGly: 5.611 ± 0.074	0.989SerHis: 0.989 ± 0.03	2.216SerIle: 2.216 ± 0.048	0.7SerLys: 0.7 ± 0.028	5.349SerLeu: 5.349 ± 0.068	1.167SerMet: 1.167 ± 0.03	0.738SerAsn: 0.738 ± 0.027	3.512SerPro: 3.512 ± 0.069	1.358SerGln: 1.358 ± 0.036	4.2SerArg: 4.2 ± 0.063	3.388SerSer: 3.388 ± 0.073	3.408SerThr: 3.408 ± 0.063	4.181SerVal: 4.181 ± 0.061	0.942SerTrp: 0.942 ± 0.028	1.029SerTyr: 1.029 ± 0.028	0.0SerXaa: 0.0 ± 0.0
Thr	8.03ThrAla: 8.03 ± 0.092	0.352ThrCys: 0.352 ± 0.017	3.231ThrAsp: 3.231 ± 0.057	2.801ThrGlu: 2.801 ± 0.053	1.675ThrPhe: 1.675 ± 0.043	5.801ThrGly: 5.801 ± 0.077	1.026ThrHis: 1.026 ± 0.03	2.259ThrIle: 2.259 ± 0.044	0.739ThrLys: 0.739 ± 0.027	5.676ThrLeu: 5.676 ± 0.072	1.058ThrMet: 1.058 ± 0.028	0.814ThrAsn: 0.814 ± 0.026	3.747ThrPro: 3.747 ± 0.062	1.327ThrGln: 1.327 ± 0.033	3.817ThrArg: 3.817 ± 0.051	3.286ThrSer: 3.286 ± 0.057	3.46ThrThr: 3.46 ± 0.06	5.245ThrVal: 5.245 ± 0.07	1.017ThrTrp: 1.017 ± 0.031	1.18ThrTyr: 1.18 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	10.436ValAla: 10.436 ± 0.101	0.546ValCys: 0.546 ± 0.023	5.228ValAsp: 5.228 ± 0.058	4.755ValGlu: 4.755 ± 0.069	2.305ValPhe: 2.305 ± 0.048	6.047ValGly: 6.047 ± 0.079	1.955ValHis: 1.955 ± 0.041	3.843ValIle: 3.843 ± 0.068	1.062ValLys: 1.062 ± 0.037	10.818ValLeu: 10.818 ± 0.127	1.597ValMet: 1.597 ± 0.036	1.268ValAsn: 1.268 ± 0.035	5.456ValPro: 5.456 ± 0.078	2.194ValGln: 2.194 ± 0.034	6.513ValArg: 6.513 ± 0.087	4.368ValSer: 4.368 ± 0.064	4.892ValThr: 4.892 ± 0.087	7.745ValVal: 7.745 ± 0.091	0.983ValTrp: 0.983 ± 0.032	1.252ValTyr: 1.252 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.596TrpAla: 1.596 ± 0.038	0.104TrpCys: 0.104 ± 0.01	0.926TrpAsp: 0.926 ± 0.03	0.798TrpGlu: 0.798 ± 0.027	0.497TrpPhe: 0.497 ± 0.021	1.092TrpGly: 1.092 ± 0.028	0.346TrpHis: 0.346 ± 0.016	0.707TrpIle: 0.707 ± 0.024	0.262TrpLys: 0.262 ± 0.013	1.461TrpLeu: 1.461 ± 0.036	0.362TrpMet: 0.362 ± 0.016	0.373TrpAsn: 0.373 ± 0.019	0.688TrpPro: 0.688 ± 0.024	0.533TrpGln: 0.533 ± 0.023	1.199TrpArg: 1.199 ± 0.032	0.915TrpSer: 0.915 ± 0.026	0.984TrpThr: 0.984 ± 0.03	1.023TrpVal: 1.023 ± 0.029	0.359TrpTrp: 0.359 ± 0.019	0.327TrpTyr: 0.327 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.243TyrAla: 2.243 ± 0.046	0.128TyrCys: 0.128 ± 0.01	1.158TyrAsp: 1.158 ± 0.031	1.043TyrGlu: 1.043 ± 0.035	0.596TyrPhe: 0.596 ± 0.025	1.734TyrGly: 1.734 ± 0.041	0.328TyrHis: 0.328 ± 0.018	0.579TyrIle: 0.579 ± 0.024	0.242TyrLys: 0.242 ± 0.014	1.968TyrLeu: 1.968 ± 0.05	0.277TyrMet: 0.277 ± 0.015	0.285TyrAsn: 0.285 ± 0.016	0.942TyrPro: 0.942 ± 0.029	0.539TyrGln: 0.539 ± 0.02	1.569TyrArg: 1.569 ± 0.033	0.912TyrSer: 0.912 ± 0.026	1.027TyrThr: 1.027 ± 0.029	1.414TyrVal: 1.414 ± 0.035	0.306TyrTrp: 0.306 ± 0.017	0.45TyrTyr: 0.45 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3605 proteins (1230214 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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