Amino acid dipepetide frequency for Pseudoxanthomonas suwonensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.596AlaAla: 20.596 ± 0.229	1.205AlaCys: 1.205 ± 0.035	7.812AlaAsp: 7.812 ± 0.097	7.514AlaGlu: 7.514 ± 0.106	4.259AlaPhe: 4.259 ± 0.061	12.969AlaGly: 12.969 ± 0.161	2.574AlaHis: 2.574 ± 0.06	5.165AlaIle: 5.165 ± 0.075	2.695AlaLys: 2.695 ± 0.055	16.086AlaLeu: 16.086 ± 0.174	3.146AlaMet: 3.146 ± 0.061	2.599AlaAsn: 2.599 ± 0.053	6.971AlaPro: 6.971 ± 0.116	5.42AlaGln: 5.42 ± 0.089	10.737AlaArg: 10.737 ± 0.134	6.323AlaSer: 6.323 ± 0.077	6.442AlaThr: 6.442 ± 0.106	9.385AlaVal: 9.385 ± 0.116	2.294AlaTrp: 2.294 ± 0.057	2.63AlaTyr: 2.63 ± 0.058	0.0AlaXaa: 0.0 ± 0.0
Cys	0.99CysAla: 0.99 ± 0.035	0.105CysCys: 0.105 ± 0.011	0.411CysAsp: 0.411 ± 0.023	0.392CysGlu: 0.392 ± 0.019	0.208CysPhe: 0.208 ± 0.015	0.854CysGly: 0.854 ± 0.029	0.221CysHis: 0.221 ± 0.014	0.293CysIle: 0.293 ± 0.02	0.129CysLys: 0.129 ± 0.012	0.712CysLeu: 0.712 ± 0.028	0.109CysMet: 0.109 ± 0.01	0.195CysAsn: 0.195 ± 0.016	0.388CysPro: 0.388 ± 0.019	0.189CysGln: 0.189 ± 0.014	0.597CysArg: 0.597 ± 0.028	0.394CysSer: 0.394 ± 0.021	0.408CysThr: 0.408 ± 0.031	0.576CysVal: 0.576 ± 0.025	0.093CysTrp: 0.093 ± 0.009	0.183CysTyr: 0.183 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	8.734AspAla: 8.734 ± 0.115	0.396AspCys: 0.396 ± 0.019	3.311AspAsp: 3.311 ± 0.061	3.4AspGlu: 3.4 ± 0.067	2.098AspPhe: 2.098 ± 0.053	6.379AspGly: 6.379 ± 0.082	1.109AspHis: 1.109 ± 0.034	2.207AspIle: 2.207 ± 0.062	1.245AspLys: 1.245 ± 0.038	5.738AspLeu: 5.738 ± 0.087	1.021AspMet: 1.021 ± 0.029	1.238AspAsn: 1.238 ± 0.034	4.107AspPro: 4.107 ± 0.07	1.578AspGln: 1.578 ± 0.041	4.37AspArg: 4.37 ± 0.079	2.432AspSer: 2.432 ± 0.057	2.757AspThr: 2.757 ± 0.054	4.121AspVal: 4.121 ± 0.077	1.196AspTrp: 1.196 ± 0.038	1.705AspTyr: 1.705 ± 0.047	0.0AspXaa: 0.0 ± 0.0
Glu	7.735GluAla: 7.735 ± 0.119	0.302GluCys: 0.302 ± 0.017	2.72GluAsp: 2.72 ± 0.052	2.646GluGlu: 2.646 ± 0.058	1.774GluPhe: 1.774 ± 0.044	4.195GluGly: 4.195 ± 0.067	1.355GluHis: 1.355 ± 0.039	2.378GluIle: 2.378 ± 0.049	1.383GluLys: 1.383 ± 0.041	6.337GluLeu: 6.337 ± 0.095	1.029GluMet: 1.029 ± 0.034	1.142GluAsn: 1.142 ± 0.038	2.81GluPro: 2.81 ± 0.054	2.732GluGln: 2.732 ± 0.057	5.527GluArg: 5.527 ± 0.088	2.457GluSer: 2.457 ± 0.05	2.465GluThr: 2.465 ± 0.051	4.157GluVal: 4.157 ± 0.062	0.75GluTrp: 0.75 ± 0.029	1.176GluTyr: 1.176 ± 0.039	0.0GluXaa: 0.0 ± 0.0
Phe	4.38PheAla: 4.38 ± 0.07	0.275PheCys: 0.275 ± 0.017	2.655PheAsp: 2.655 ± 0.052	2.0PheGlu: 2.0 ± 0.043	1.164PhePhe: 1.164 ± 0.038	3.49PheGly: 3.49 ± 0.065	0.748PheHis: 0.748 ± 0.028	1.12PheIle: 1.12 ± 0.037	0.726PheLys: 0.726 ± 0.03	3.19PheLeu: 3.19 ± 0.061	0.604PheMet: 0.604 ± 0.024	0.969PheAsn: 0.969 ± 0.033	1.508PhePro: 1.508 ± 0.036	0.953PheGln: 0.953 ± 0.031	2.192PheArg: 2.192 ± 0.05	1.829PheSer: 1.829 ± 0.037	1.531PheThr: 1.531 ± 0.042	2.623PheVal: 2.623 ± 0.058	0.525PheTrp: 0.525 ± 0.025	0.813PheTyr: 0.813 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	9.855GlyAla: 9.855 ± 0.139	0.786GlyCys: 0.786 ± 0.032	5.24GlyAsp: 5.24 ± 0.085	5.308GlyGlu: 5.308 ± 0.076	3.446GlyPhe: 3.446 ± 0.061	8.073GlyGly: 8.073 ± 0.137	2.181GlyHis: 2.181 ± 0.054	3.966GlyIle: 3.966 ± 0.07	2.686GlyLys: 2.686 ± 0.058	9.377GlyLeu: 9.377 ± 0.114	2.244GlyMet: 2.244 ± 0.054	2.399GlyAsn: 2.399 ± 0.072	3.432GlyPro: 3.432 ± 0.07	3.403GlyGln: 3.403 ± 0.064	7.119GlyArg: 7.119 ± 0.086	4.705GlySer: 4.705 ± 0.088	4.528GlyThr: 4.528 ± 0.077	6.808GlyVal: 6.808 ± 0.084	1.86GlyTrp: 1.86 ± 0.055	2.447GlyTyr: 2.447 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	3.044HisAla: 3.044 ± 0.057	0.221HisCys: 0.221 ± 0.016	1.278HisAsp: 1.278 ± 0.038	1.149HisGlu: 1.149 ± 0.037	0.77HisPhe: 0.77 ± 0.03	2.484HisGly: 2.484 ± 0.059	0.582HisHis: 0.582 ± 0.026	0.64HisIle: 0.64 ± 0.025	0.409HisLys: 0.409 ± 0.019	2.155HisLeu: 2.155 ± 0.044	0.368HisMet: 0.368 ± 0.02	0.458HisAsn: 0.458 ± 0.022	1.513HisPro: 1.513 ± 0.042	0.584HisGln: 0.584 ± 0.026	1.744HisArg: 1.744 ± 0.046	0.903HisSer: 0.903 ± 0.029	0.842HisThr: 0.842 ± 0.03	1.605HisVal: 1.605 ± 0.041	0.44HisTrp: 0.44 ± 0.02	0.628HisTyr: 0.628 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	5.921IleAla: 5.921 ± 0.091	0.272IleCys: 0.272 ± 0.015	3.115IleAsp: 3.115 ± 0.062	2.712IleGlu: 2.712 ± 0.054	0.917IlePhe: 0.917 ± 0.034	4.084IleGly: 4.084 ± 0.076	0.774IleHis: 0.774 ± 0.025	1.075IleIle: 1.075 ± 0.038	0.95IleLys: 0.95 ± 0.034	2.907IleLeu: 2.907 ± 0.055	0.429IleMet: 0.429 ± 0.02	1.014IleAsn: 1.014 ± 0.031	1.957IlePro: 1.957 ± 0.048	0.98IleGln: 0.98 ± 0.028	2.584IleArg: 2.584 ± 0.056	1.71IleSer: 1.71 ± 0.047	1.819IleThr: 1.819 ± 0.057	3.164IleVal: 3.164 ± 0.053	0.401IleTrp: 0.401 ± 0.021	0.697IleTyr: 0.697 ± 0.027	0.0IleXaa: 0.0 ± 0.0
Lys	2.986LysAla: 2.986 ± 0.058	0.104LysCys: 0.104 ± 0.011	1.261LysAsp: 1.261 ± 0.042	0.993LysGlu: 0.993 ± 0.041	0.632LysPhe: 0.632 ± 0.026	1.775LysGly: 1.775 ± 0.044	0.476LysHis: 0.476 ± 0.021	0.916LysIle: 0.916 ± 0.032	0.855LysLys: 0.855 ± 0.052	2.596LysLeu: 2.596 ± 0.062	0.471LysMet: 0.471 ± 0.02	0.539LysAsn: 0.539 ± 0.027	1.527LysPro: 1.527 ± 0.039	0.909LysGln: 0.909 ± 0.035	1.798LysArg: 1.798 ± 0.042	1.084LysSer: 1.084 ± 0.043	1.213LysThr: 1.213 ± 0.041	1.995LysVal: 1.995 ± 0.048	0.257LysTrp: 0.257 ± 0.015	0.523LysTyr: 0.523 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	16.875LeuAla: 16.875 ± 0.179	0.835LeuCys: 0.835 ± 0.033	7.022LeuAsp: 7.022 ± 0.106	5.998LeuGlu: 5.998 ± 0.092	3.465LeuPhe: 3.465 ± 0.062	9.005LeuGly: 9.005 ± 0.113	2.407LeuHis: 2.407 ± 0.054	3.128LeuIle: 3.128 ± 0.067	2.677LeuLys: 2.677 ± 0.059	12.702LeuLeu: 12.702 ± 0.174	2.007LeuMet: 2.007 ± 0.048	2.133LeuAsn: 2.133 ± 0.047	7.003LeuPro: 7.003 ± 0.094	4.029LeuGln: 4.029 ± 0.066	9.319LeuArg: 9.319 ± 0.11	5.321LeuSer: 5.321 ± 0.076	4.285LeuThr: 4.285 ± 0.08	8.489LeuVal: 8.489 ± 0.1	1.484LeuTrp: 1.484 ± 0.045	2.339LeuTyr: 2.339 ± 0.052	0.0LeuXaa: 0.0 ± 0.0
Met	2.668MetAla: 2.668 ± 0.054	0.125MetCys: 0.125 ± 0.011	1.076MetAsp: 1.076 ± 0.035	0.867MetGlu: 0.867 ± 0.027	0.592MetPhe: 0.592 ± 0.025	1.429MetGly: 1.429 ± 0.034	0.437MetHis: 0.437 ± 0.021	0.704MetIle: 0.704 ± 0.026	0.625MetLys: 0.625 ± 0.025	2.218MetLeu: 2.218 ± 0.049	0.378MetMet: 0.378 ± 0.02	0.588MetAsn: 0.588 ± 0.022	1.373MetPro: 1.373 ± 0.036	0.796MetGln: 0.796 ± 0.029	1.679MetArg: 1.679 ± 0.042	1.328MetSer: 1.328 ± 0.034	1.105MetThr: 1.105 ± 0.034	1.417MetVal: 1.417 ± 0.048	0.203MetTrp: 0.203 ± 0.017	0.319MetTyr: 0.319 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	2.917AsnAla: 2.917 ± 0.058	0.176AsnCys: 0.176 ± 0.013	1.237AsnAsp: 1.237 ± 0.04	1.062AsnGlu: 1.062 ± 0.031	0.802AsnPhe: 0.802 ± 0.03	2.054AsnGly: 2.054 ± 0.047	0.492AsnHis: 0.492 ± 0.022	0.887AsnIle: 0.887 ± 0.032	0.48AsnLys: 0.48 ± 0.026	2.391AsnLeu: 2.391 ± 0.053	0.376AsnMet: 0.376 ± 0.02	0.64AsnAsn: 0.64 ± 0.029	1.695AsnPro: 1.695 ± 0.05	0.697AsnGln: 0.697 ± 0.028	1.706AsnArg: 1.706 ± 0.044	0.955AsnSer: 0.955 ± 0.037	1.215AsnThr: 1.215 ± 0.061	1.75AsnVal: 1.75 ± 0.047	0.362AsnTrp: 0.362 ± 0.019	0.669AsnTyr: 0.669 ± 0.033	0.0AsnXaa: 0.0 ± 0.0
Pro	8.612ProAla: 8.612 ± 0.129	0.312ProCys: 0.312 ± 0.019	3.692ProAsp: 3.692 ± 0.066	3.529ProGlu: 3.529 ± 0.063	1.667ProPhe: 1.667 ± 0.043	5.576ProGly: 5.576 ± 0.089	1.13ProHis: 1.13 ± 0.034	1.619ProIle: 1.619 ± 0.04	1.147ProLys: 1.147 ± 0.038	5.873ProLeu: 5.873 ± 0.089	1.158ProMet: 1.158 ± 0.036	1.065ProAsn: 1.065 ± 0.039	3.506ProPro: 3.506 ± 0.085	2.162ProGln: 2.162 ± 0.049	3.875ProArg: 3.875 ± 0.065	2.562ProSer: 2.562 ± 0.055	2.307ProThr: 2.307 ± 0.059	4.651ProVal: 4.651 ± 0.077	0.946ProTrp: 0.946 ± 0.034	1.216ProTyr: 1.216 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	5.905GlnAla: 5.905 ± 0.096	0.214GlnCys: 0.214 ± 0.016	1.644GlnAsp: 1.644 ± 0.041	1.55GlnGlu: 1.55 ± 0.048	1.103GlnPhe: 1.103 ± 0.031	2.771GlnGly: 2.771 ± 0.056	0.707GlnHis: 0.707 ± 0.03	1.292GlnIle: 1.292 ± 0.036	0.809GlnLys: 0.809 ± 0.033	3.98GlnLeu: 3.98 ± 0.072	0.691GlnMet: 0.691 ± 0.026	0.657GlnAsn: 0.657 ± 0.028	2.266GlnPro: 2.266 ± 0.049	1.674GlnGln: 1.674 ± 0.05	3.546GlnArg: 3.546 ± 0.061	1.497GlnSer: 1.497 ± 0.037	1.375GlnThr: 1.375 ± 0.039	3.317GlnVal: 3.317 ± 0.052	0.632GlnTrp: 0.632 ± 0.024	0.734GlnTyr: 0.734 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	9.097ArgAla: 9.097 ± 0.121	0.528ArgCys: 0.528 ± 0.025	4.722ArgAsp: 4.722 ± 0.069	5.195ArgGlu: 5.195 ± 0.09	3.056ArgPhe: 3.056 ± 0.055	5.981ArgGly: 5.981 ± 0.087	2.13ArgHis: 2.13 ± 0.052	4.091ArgIle: 4.091 ± 0.066	1.734ArgLys: 1.734 ± 0.045	9.37ArgLeu: 9.37 ± 0.126	1.932ArgMet: 1.932 ± 0.041	1.898ArgAsn: 1.898 ± 0.042	4.066ArgPro: 4.066 ± 0.073	3.24ArgGln: 3.24 ± 0.056	6.825ArgArg: 6.825 ± 0.106	3.534ArgSer: 3.534 ± 0.063	3.579ArgThr: 3.579 ± 0.062	5.616ArgVal: 5.616 ± 0.081	1.488ArgTrp: 1.488 ± 0.04	2.323ArgTyr: 2.323 ± 0.057	0.0ArgXaa: 0.0 ± 0.0
Ser	5.779SerAla: 5.779 ± 0.084	0.322SerCys: 0.322 ± 0.023	2.534SerAsp: 2.534 ± 0.057	2.269SerGlu: 2.269 ± 0.049	1.714SerPhe: 1.714 ± 0.045	5.037SerGly: 5.037 ± 0.083	1.042SerHis: 1.042 ± 0.035	1.943SerIle: 1.943 ± 0.049	1.063SerLys: 1.063 ± 0.034	5.229SerLeu: 5.229 ± 0.074	0.94SerMet: 0.94 ± 0.026	1.174SerAsn: 1.174 ± 0.041	2.834SerPro: 2.834 ± 0.051	1.501SerGln: 1.501 ± 0.045	3.645SerArg: 3.645 ± 0.061	2.442SerSer: 2.442 ± 0.057	2.395SerThr: 2.395 ± 0.057	3.522SerVal: 3.522 ± 0.072	0.787SerTrp: 0.787 ± 0.029	1.243SerTyr: 1.243 ± 0.042	0.0SerXaa: 0.0 ± 0.0
Thr	5.885ThrAla: 5.885 ± 0.109	0.355ThrCys: 0.355 ± 0.032	2.418ThrAsp: 2.418 ± 0.054	2.024ThrGlu: 2.024 ± 0.046	1.452ThrPhe: 1.452 ± 0.044	4.83ThrGly: 4.83 ± 0.079	0.936ThrHis: 0.936 ± 0.03	1.85ThrIle: 1.85 ± 0.054	0.752ThrLys: 0.752 ± 0.03	5.861ThrLeu: 5.861 ± 0.089	0.77ThrMet: 0.77 ± 0.03	0.896ThrAsn: 0.896 ± 0.053	3.286ThrPro: 3.286 ± 0.077	1.352ThrGln: 1.352 ± 0.04	3.419ThrArg: 3.419 ± 0.049	2.043ThrSer: 2.043 ± 0.059	2.346ThrThr: 2.346 ± 0.076	4.136ThrVal: 4.136 ± 0.088	0.7ThrTrp: 0.7 ± 0.032	1.007ThrTyr: 1.007 ± 0.049	0.0ThrXaa: 0.0 ± 0.0
Val	10.401ValAla: 10.401 ± 0.108	0.585ValCys: 0.585 ± 0.022	4.745ValAsp: 4.745 ± 0.069	4.623ValGlu: 4.623 ± 0.07	2.71ValPhe: 2.71 ± 0.058	5.751ValGly: 5.751 ± 0.086	1.663ValHis: 1.663 ± 0.038	2.724ValIle: 2.724 ± 0.06	1.664ValLys: 1.664 ± 0.046	8.831ValLeu: 8.831 ± 0.113	1.492ValMet: 1.492 ± 0.039	1.876ValAsn: 1.876 ± 0.055	4.305ValPro: 4.305 ± 0.065	2.633ValGln: 2.633 ± 0.06	5.947ValArg: 5.947 ± 0.079	3.82ValSer: 3.82 ± 0.074	3.662ValThr: 3.662 ± 0.118	6.576ValVal: 6.576 ± 0.093	0.964ValTrp: 0.964 ± 0.033	1.633ValTyr: 1.633 ± 0.042	0.0ValXaa: 0.0 ± 0.0
Trp	1.372TrpAla: 1.372 ± 0.039	0.138TrpCys: 0.138 ± 0.011	0.775TrpAsp: 0.775 ± 0.029	0.646TrpGlu: 0.646 ± 0.024	0.623TrpPhe: 0.623 ± 0.029	0.993TrpGly: 0.993 ± 0.034	0.38TrpHis: 0.38 ± 0.021	0.77TrpIle: 0.77 ± 0.031	0.433TrpLys: 0.433 ± 0.019	2.443TrpLeu: 2.443 ± 0.065	0.403TrpMet: 0.403 ± 0.02	0.498TrpAsn: 0.498 ± 0.025	0.884TrpPro: 0.884 ± 0.03	0.729TrpGln: 0.729 ± 0.028	1.593TrpArg: 1.593 ± 0.047	0.929TrpSer: 0.929 ± 0.036	0.825TrpThr: 0.825 ± 0.032	0.966TrpVal: 0.966 ± 0.035	0.354TrpTrp: 0.354 ± 0.02	0.393TrpTyr: 0.393 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.07TyrAla: 3.07 ± 0.053	0.19TyrCys: 0.19 ± 0.014	1.474TyrAsp: 1.474 ± 0.045	1.193TyrGlu: 1.193 ± 0.037	0.845TyrPhe: 0.845 ± 0.029	2.134TyrGly: 2.134 ± 0.049	0.47TyrHis: 0.47 ± 0.024	0.713TyrIle: 0.713 ± 0.026	0.445TyrLys: 0.445 ± 0.022	2.527TyrLeu: 2.527 ± 0.053	0.355TyrMet: 0.355 ± 0.019	0.588TyrAsn: 0.588 ± 0.025	1.173TyrPro: 1.173 ± 0.036	0.803TyrGln: 0.803 ± 0.026	2.184TyrArg: 2.184 ± 0.046	1.148TyrSer: 1.148 ± 0.038	1.222TyrThr: 1.222 ± 0.045	1.732TyrVal: 1.732 ± 0.039	0.411TyrTrp: 0.411 ± 0.019	0.602TyrTyr: 0.602 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3063 proteins (1044796 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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