Amino acid dipepetide frequency for Pterula gracilis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.72AlaAla: 8.72 ± 0.084	1.121AlaCys: 1.121 ± 0.015	4.072AlaAsp: 4.072 ± 0.03	4.702AlaGlu: 4.702 ± 0.031	3.21AlaPhe: 3.21 ± 0.027	5.785AlaGly: 5.785 ± 0.043	2.144AlaHis: 2.144 ± 0.021	3.859AlaIle: 3.859 ± 0.03	3.693AlaLys: 3.693 ± 0.034	8.331AlaLeu: 8.331 ± 0.045	1.969AlaMet: 1.969 ± 0.018	2.79AlaAsn: 2.79 ± 0.023	5.313AlaPro: 5.313 ± 0.045	3.444AlaGln: 3.444 ± 0.034	4.965AlaArg: 4.965 ± 0.033	8.141AlaSer: 8.141 ± 0.046	5.034AlaThr: 5.034 ± 0.037	5.484AlaVal: 5.484 ± 0.036	1.105AlaTrp: 1.105 ± 0.016	2.144AlaTyr: 2.144 ± 0.021	0.0AlaXaa: 0.0 ± 0.0
Cys	1.008CysAla: 1.008 ± 0.015	0.278CysCys: 0.278 ± 0.009	0.655CysAsp: 0.655 ± 0.013	0.564CysGlu: 0.564 ± 0.01	0.553CysPhe: 0.553 ± 0.011	0.916CysGly: 0.916 ± 0.018	0.334CysHis: 0.334 ± 0.008	0.685CysIle: 0.685 ± 0.012	0.532CysLys: 0.532 ± 0.01	1.276CysLeu: 1.276 ± 0.017	0.314CysMet: 0.314 ± 0.008	0.468CysAsn: 0.468 ± 0.012	0.781CysPro: 0.781 ± 0.013	0.464CysGln: 0.464 ± 0.011	0.804CysArg: 0.804 ± 0.014	1.148CysSer: 1.148 ± 0.016	0.828CysThr: 0.828 ± 0.016	0.868CysVal: 0.868 ± 0.013	0.209CysTrp: 0.209 ± 0.007	0.344CysTyr: 0.344 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	4.84AspAla: 4.84 ± 0.034	0.623AspCys: 0.623 ± 0.01	4.122AspAsp: 4.122 ± 0.045	4.199AspGlu: 4.199 ± 0.036	2.029AspPhe: 2.029 ± 0.021	3.906AspGly: 3.906 ± 0.03	1.279AspHis: 1.279 ± 0.016	2.674AspIle: 2.674 ± 0.028	2.016AspLys: 2.016 ± 0.022	4.892AspLeu: 4.892 ± 0.036	1.173AspMet: 1.173 ± 0.017	1.604AspAsn: 1.604 ± 0.019	3.297AspPro: 3.297 ± 0.023	1.647AspGln: 1.647 ± 0.018	2.775AspArg: 2.775 ± 0.025	4.168AspSer: 4.168 ± 0.032	2.987AspThr: 2.987 ± 0.022	3.93AspVal: 3.93 ± 0.027	0.861AspTrp: 0.861 ± 0.015	1.443AspTyr: 1.443 ± 0.018	0.0AspXaa: 0.0 ± 0.0
Glu	4.799GluAla: 4.799 ± 0.035	0.628GluCys: 0.628 ± 0.012	4.074GluAsp: 4.074 ± 0.036	5.353GluGlu: 5.353 ± 0.047	1.817GluPhe: 1.817 ± 0.022	3.883GluGly: 3.883 ± 0.034	1.409GluHis: 1.409 ± 0.016	2.501GluIle: 2.501 ± 0.022	3.055GluLys: 3.055 ± 0.03	5.064GluLeu: 5.064 ± 0.039	1.363GluMet: 1.363 ± 0.016	1.77GluAsn: 1.77 ± 0.021	2.527GluPro: 2.527 ± 0.024	2.221GluGln: 2.221 ± 0.023	3.835GluArg: 3.835 ± 0.034	3.997GluSer: 3.997 ± 0.032	2.916GluThr: 2.916 ± 0.025	3.608GluVal: 3.608 ± 0.03	0.854GluTrp: 0.854 ± 0.014	1.478GluTyr: 1.478 ± 0.018	0.0GluXaa: 0.0 ± 0.0
Phe	3.101PheAla: 3.101 ± 0.024	0.564PheCys: 0.564 ± 0.012	2.174PheAsp: 2.174 ± 0.021	1.921PheGlu: 1.921 ± 0.021	1.629PhePhe: 1.629 ± 0.023	2.764PheGly: 2.764 ± 0.03	0.963PheHis: 0.963 ± 0.013	1.785PheIle: 1.785 ± 0.019	1.453PheLys: 1.453 ± 0.016	3.566PheLeu: 3.566 ± 0.031	0.799PheMet: 0.799 ± 0.014	1.362PheAsn: 1.362 ± 0.016	2.121PhePro: 2.121 ± 0.024	1.27PheGln: 1.27 ± 0.016	1.9PheArg: 1.9 ± 0.022	3.37PheSer: 3.37 ± 0.029	2.324PheThr: 2.324 ± 0.021	2.5PheVal: 2.5 ± 0.024	0.578PheTrp: 0.578 ± 0.012	1.049PheTyr: 1.049 ± 0.013	0.0PheXaa: 0.0 ± 0.0
Gly	5.436GlyAla: 5.436 ± 0.044	0.915GlyCys: 0.915 ± 0.016	3.472GlyAsp: 3.472 ± 0.03	3.701GlyGlu: 3.701 ± 0.031	2.599GlyPhe: 2.599 ± 0.026	6.38GlyGly: 6.38 ± 0.069	1.678GlyHis: 1.678 ± 0.021	3.018GlyIle: 3.018 ± 0.024	3.376GlyLys: 3.376 ± 0.031	5.751GlyLeu: 5.751 ± 0.038	1.653GlyMet: 1.653 ± 0.022	2.285GlyAsn: 2.285 ± 0.025	3.31GlyPro: 3.31 ± 0.029	2.339GlyGln: 2.339 ± 0.028	4.116GlyArg: 4.116 ± 0.032	6.111GlySer: 6.111 ± 0.039	4.027GlyThr: 4.027 ± 0.032	4.535GlyVal: 4.535 ± 0.031	1.137GlyTrp: 1.137 ± 0.016	2.012GlyTyr: 2.012 ± 0.03	0.0GlyXaa: 0.0 ± 0.0
His	2.112HisAla: 2.112 ± 0.021	0.376HisCys: 0.376 ± 0.009	1.327HisAsp: 1.327 ± 0.017	1.265HisGlu: 1.265 ± 0.019	0.976HisPhe: 0.976 ± 0.015	1.726HisGly: 1.726 ± 0.018	1.068HisHis: 1.068 ± 0.02	1.28HisIle: 1.28 ± 0.016	0.88HisLys: 0.88 ± 0.012	2.708HisLeu: 2.708 ± 0.027	0.48HisMet: 0.48 ± 0.01	0.835HisAsn: 0.835 ± 0.013	2.101HisPro: 2.101 ± 0.024	1.012HisGln: 1.012 ± 0.016	1.742HisArg: 1.742 ± 0.019	2.323HisSer: 2.323 ± 0.026	1.586HisThr: 1.586 ± 0.018	1.586HisVal: 1.586 ± 0.018	0.343HisTrp: 0.343 ± 0.008	0.684HisTyr: 0.684 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	3.987IleAla: 3.987 ± 0.032	0.699IleCys: 0.699 ± 0.013	2.52IleAsp: 2.52 ± 0.022	2.345IleGlu: 2.345 ± 0.02	1.812IlePhe: 1.812 ± 0.02	2.854IleGly: 2.854 ± 0.027	1.247IleHis: 1.247 ± 0.016	2.293IleIle: 2.293 ± 0.024	1.844IleLys: 1.844 ± 0.025	4.373IleLeu: 4.373 ± 0.032	0.936IleMet: 0.936 ± 0.016	1.542IleAsn: 1.542 ± 0.02	3.073IlePro: 3.073 ± 0.028	1.709IleGln: 1.709 ± 0.019	2.691IleArg: 2.691 ± 0.026	3.858IleSer: 3.858 ± 0.028	2.818IleThr: 2.818 ± 0.026	3.037IleVal: 3.037 ± 0.025	0.666IleTrp: 0.666 ± 0.014	1.212IleTyr: 1.212 ± 0.017	0.0IleXaa: 0.0 ± 0.0
Lys	3.956LysAla: 3.956 ± 0.038	0.474LysCys: 0.474 ± 0.011	2.443LysAsp: 2.443 ± 0.026	2.973LysGlu: 2.973 ± 0.028	1.354LysPhe: 1.354 ± 0.019	2.868LysGly: 2.868 ± 0.028	1.136LysHis: 1.136 ± 0.014	1.89LysIle: 1.89 ± 0.021	2.885LysLys: 2.885 ± 0.041	3.886LysLeu: 3.886 ± 0.033	0.953LysMet: 0.953 ± 0.015	1.455LysAsn: 1.455 ± 0.019	2.517LysPro: 2.517 ± 0.025	1.666LysGln: 1.666 ± 0.017	3.233LysArg: 3.233 ± 0.029	3.219LysSer: 3.219 ± 0.026	2.514LysThr: 2.514 ± 0.022	2.604LysVal: 2.604 ± 0.026	0.601LysTrp: 0.601 ± 0.011	1.195LysTyr: 1.195 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	8.131LeuAla: 8.131 ± 0.046	1.354LeuCys: 1.354 ± 0.02	5.198LeuAsp: 5.198 ± 0.036	5.303LeuGlu: 5.303 ± 0.045	3.481LeuPhe: 3.481 ± 0.032	5.819LeuGly: 5.819 ± 0.039	2.589LeuHis: 2.589 ± 0.024	3.92LeuIle: 3.92 ± 0.032	3.957LeuLys: 3.957 ± 0.034	9.074LeuLeu: 9.074 ± 0.063	1.767LeuMet: 1.767 ± 0.018	3.056LeuAsn: 3.056 ± 0.026	6.151LeuPro: 6.151 ± 0.04	3.665LeuGln: 3.665 ± 0.029	5.992LeuArg: 5.992 ± 0.039	8.218LeuSer: 8.218 ± 0.046	5.314LeuThr: 5.314 ± 0.034	5.928LeuVal: 5.928 ± 0.037	1.185LeuTrp: 1.185 ± 0.015	2.302LeuTyr: 2.302 ± 0.025	0.0LeuXaa: 0.0 ± 0.0
Met	1.842MetAla: 1.842 ± 0.022	0.254MetCys: 0.254 ± 0.007	1.287MetAsp: 1.287 ± 0.018	1.227MetGlu: 1.227 ± 0.016	0.82MetPhe: 0.82 ± 0.014	1.469MetGly: 1.469 ± 0.02	0.557MetHis: 0.557 ± 0.011	0.969MetIle: 0.969 ± 0.014	0.995MetLys: 0.995 ± 0.014	1.922MetLeu: 1.922 ± 0.019	0.575MetMet: 0.575 ± 0.011	0.767MetAsn: 0.767 ± 0.012	1.231MetPro: 1.231 ± 0.015	0.841MetGln: 0.841 ± 0.013	1.325MetArg: 1.325 ± 0.017	2.038MetSer: 2.038 ± 0.021	1.237MetThr: 1.237 ± 0.018	1.234MetVal: 1.234 ± 0.017	0.288MetTrp: 0.288 ± 0.007	0.606MetTyr: 0.606 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	3.127AsnAla: 3.127 ± 0.026	0.402AsnCys: 0.402 ± 0.01	1.735AsnAsp: 1.735 ± 0.022	1.664AsnGlu: 1.664 ± 0.018	1.24AsnPhe: 1.24 ± 0.016	2.647AsnGly: 2.647 ± 0.028	0.862AsnHis: 0.862 ± 0.015	1.692AsnIle: 1.692 ± 0.02	1.275AsnLys: 1.275 ± 0.018	3.031AsnLeu: 3.031 ± 0.026	0.728AsnMet: 0.728 ± 0.011	1.333AsnAsn: 1.333 ± 0.024	2.324AsnPro: 2.324 ± 0.023	1.155AsnGln: 1.155 ± 0.016	1.756AsnArg: 1.756 ± 0.02	2.654AsnSer: 2.654 ± 0.027	2.125AsnThr: 2.125 ± 0.022	2.362AsnVal: 2.362 ± 0.024	0.483AsnTrp: 0.483 ± 0.01	0.895AsnTyr: 0.895 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	5.562ProAla: 5.562 ± 0.046	0.592ProCys: 0.592 ± 0.011	3.03ProAsp: 3.03 ± 0.024	3.436ProGlu: 3.436 ± 0.027	2.208ProPhe: 2.208 ± 0.022	3.915ProGly: 3.915 ± 0.033	1.705ProHis: 1.705 ± 0.022	2.616ProIle: 2.616 ± 0.025	2.454ProLys: 2.454 ± 0.027	5.338ProLeu: 5.338 ± 0.037	1.126ProMet: 1.126 ± 0.013	2.15ProAsn: 2.15 ± 0.021	6.395ProPro: 6.395 ± 0.086	2.374ProGln: 2.374 ± 0.026	3.636ProArg: 3.636 ± 0.034	7.591ProSer: 7.591 ± 0.063	4.696ProThr: 4.696 ± 0.036	3.733ProVal: 3.733 ± 0.033	0.727ProTrp: 0.727 ± 0.013	1.514ProTyr: 1.514 ± 0.019	0.0ProXaa: 0.0 ± 0.0
Gln	3.349GlnAla: 3.349 ± 0.031	0.495GlnCys: 0.495 ± 0.01	1.953GlnAsp: 1.953 ± 0.02	2.157GlnGlu: 2.157 ± 0.025	1.214GlnPhe: 1.214 ± 0.014	2.244GlnGly: 2.244 ± 0.021	1.147GlnHis: 1.147 ± 0.017	1.64GlnIle: 1.64 ± 0.018	1.58GlnLys: 1.58 ± 0.02	3.53GlnLeu: 3.53 ± 0.031	0.836GlnMet: 0.836 ± 0.013	1.26GlnAsn: 1.26 ± 0.019	2.407GlnPro: 2.407 ± 0.028	2.096GlnGln: 2.096 ± 0.04	2.502GlnArg: 2.502 ± 0.024	3.185GlnSer: 3.185 ± 0.029	2.206GlnThr: 2.206 ± 0.022	2.203GlnVal: 2.203 ± 0.023	0.528GlnTrp: 0.528 ± 0.011	1.027GlnTyr: 1.027 ± 0.014	0.0GlnXaa: 0.0 ± 0.0
Arg	4.893ArgAla: 4.893 ± 0.034	0.886ArgCys: 0.886 ± 0.015	3.084ArgAsp: 3.084 ± 0.03	3.518ArgGlu: 3.518 ± 0.03	2.185ArgPhe: 2.185 ± 0.019	3.772ArgGly: 3.772 ± 0.04	1.599ArgHis: 1.599 ± 0.017	2.814ArgIle: 2.814 ± 0.024	3.18ArgLys: 3.18 ± 0.03	5.553ArgLeu: 5.553 ± 0.039	1.431ArgMet: 1.431 ± 0.016	2.018ArgAsn: 2.018 ± 0.019	3.6ArgPro: 3.6 ± 0.032	2.306ArgGln: 2.306 ± 0.022	5.218ArgArg: 5.218 ± 0.044	5.409ArgSer: 5.409 ± 0.044	3.663ArgThr: 3.663 ± 0.03	3.733ArgVal: 3.733 ± 0.029	0.965ArgTrp: 0.965 ± 0.015	1.622ArgTyr: 1.622 ± 0.016	0.0ArgXaa: 0.0 ± 0.0
Ser	7.47SerAla: 7.47 ± 0.043	1.064SerCys: 1.064 ± 0.016	4.263SerAsp: 4.263 ± 0.031	4.041SerGlu: 4.041 ± 0.03	3.398SerPhe: 3.398 ± 0.029	5.886SerGly: 5.886 ± 0.04	2.328SerHis: 2.328 ± 0.026	4.07SerIle: 4.07 ± 0.032	3.645SerLys: 3.645 ± 0.03	8.165SerLeu: 8.165 ± 0.056	1.86SerMet: 1.86 ± 0.02	2.991SerAsn: 2.991 ± 0.028	6.762SerPro: 6.762 ± 0.069	3.305SerGln: 3.305 ± 0.031	5.48SerArg: 5.48 ± 0.045	11.761SerSer: 11.761 ± 0.097	6.688SerThr: 6.688 ± 0.046	5.204SerVal: 5.204 ± 0.035	1.114SerTrp: 1.114 ± 0.018	2.109SerTyr: 2.109 ± 0.018	0.0SerXaa: 0.0 ± 0.0
Thr	5.196ThrAla: 5.196 ± 0.034	0.8ThrCys: 0.8 ± 0.014	2.649ThrAsp: 2.649 ± 0.023	2.802ThrGlu: 2.802 ± 0.025	2.427ThrPhe: 2.427 ± 0.024	4.02ThrGly: 4.02 ± 0.032	1.622ThrHis: 1.622 ± 0.019	2.945ThrIle: 2.945 ± 0.027	2.407ThrLys: 2.407 ± 0.021	5.958ThrLeu: 5.958 ± 0.037	1.244ThrMet: 1.244 ± 0.016	2.071ThrAsn: 2.071 ± 0.02	4.863ThrPro: 4.863 ± 0.036	2.138ThrGln: 2.138 ± 0.022	3.43ThrArg: 3.43 ± 0.03	6.299ThrSer: 6.299 ± 0.045	4.641ThrThr: 4.641 ± 0.05	3.869ThrVal: 3.869 ± 0.029	0.804ThrTrp: 0.804 ± 0.013	1.584ThrTyr: 1.584 ± 0.018	0.0ThrXaa: 0.0 ± 0.0
Val	5.276ValAla: 5.276 ± 0.033	0.91ValCys: 0.91 ± 0.015	3.954ValAsp: 3.954 ± 0.03	3.831ValGlu: 3.831 ± 0.029	2.573ValPhe: 2.573 ± 0.027	4.152ValGly: 4.152 ± 0.035	1.634ValHis: 1.634 ± 0.019	2.905ValIle: 2.905 ± 0.026	2.869ValLys: 2.869 ± 0.026	6.257ValLeu: 6.257 ± 0.047	1.358ValMet: 1.358 ± 0.016	2.141ValAsn: 2.141 ± 0.021	3.841ValPro: 3.841 ± 0.028	2.431ValGln: 2.431 ± 0.022	3.521ValArg: 3.521 ± 0.027	4.961ValSer: 4.961 ± 0.029	3.515ValThr: 3.515 ± 0.031	4.794ValVal: 4.794 ± 0.041	0.945ValTrp: 0.945 ± 0.017	1.823ValTyr: 1.823 ± 0.019	0.0ValXaa: 0.0 ± 0.0
Trp	1.069TrpAla: 1.069 ± 0.017	0.207TrpCys: 0.207 ± 0.007	0.878TrpAsp: 0.878 ± 0.015	0.804TrpGlu: 0.804 ± 0.013	0.573TrpPhe: 0.573 ± 0.01	0.921TrpGly: 0.921 ± 0.015	0.333TrpHis: 0.333 ± 0.009	0.706TrpIle: 0.706 ± 0.011	0.76TrpLys: 0.76 ± 0.012	1.207TrpLeu: 1.207 ± 0.017	0.363TrpMet: 0.363 ± 0.008	0.593TrpAsn: 0.593 ± 0.012	0.599TrpPro: 0.599 ± 0.011	0.464TrpGln: 0.464 ± 0.01	0.993TrpArg: 0.993 ± 0.016	1.089TrpSer: 1.089 ± 0.017	0.933TrpThr: 0.933 ± 0.014	0.88TrpVal: 0.88 ± 0.012	0.266TrpTrp: 0.266 ± 0.008	0.395TrpTyr: 0.395 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.151TyrAla: 2.151 ± 0.021	0.389TyrCys: 0.389 ± 0.009	1.573TyrAsp: 1.573 ± 0.016	1.345TyrGlu: 1.345 ± 0.018	1.094TyrPhe: 1.094 ± 0.015	1.923TyrGly: 1.923 ± 0.027	0.777TyrHis: 0.777 ± 0.013	1.25TyrIle: 1.25 ± 0.017	0.965TyrLys: 0.965 ± 0.014	2.525TyrLeu: 2.525 ± 0.022	0.555TyrMet: 0.555 ± 0.012	1.0TyrAsn: 1.0 ± 0.015	1.584TyrPro: 1.584 ± 0.024	1.015TyrGln: 1.015 ± 0.014	1.535TyrArg: 1.535 ± 0.019	2.06TyrSer: 2.06 ± 0.021	1.719TyrThr: 1.719 ± 0.02	1.602TyrVal: 1.602 ± 0.02	0.375TyrTrp: 0.375 ± 0.008	0.817TyrTyr: 0.817 ± 0.013	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.003XaaXaa: 0.003 ± 0.002

Statistics based on 12852 proteins (5104399 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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