Amino acid dipepetide frequency for Bacteroides sp. CAG:714

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.127AlaAla: 6.127 ± 0.114	1.221AlaCys: 1.221 ± 0.039	4.66AlaAsp: 4.66 ± 0.072	4.975AlaGlu: 4.975 ± 0.082	3.239AlaPhe: 3.239 ± 0.062	5.406AlaGly: 5.406 ± 0.08	1.312AlaHis: 1.312 ± 0.038	4.543AlaIle: 4.543 ± 0.073	3.75AlaLys: 3.75 ± 0.082	7.013AlaLeu: 7.013 ± 0.093	1.976AlaMet: 1.976 ± 0.047	2.901AlaAsn: 2.901 ± 0.069	2.364AlaPro: 2.364 ± 0.054	2.919AlaGln: 2.919 ± 0.053	3.338AlaArg: 3.338 ± 0.064	4.411AlaSer: 4.411 ± 0.07	4.003AlaThr: 4.003 ± 0.073	5.132AlaVal: 5.132 ± 0.085	0.877AlaTrp: 0.877 ± 0.033	3.11AlaTyr: 3.11 ± 0.064	0.002AlaXaa: 0.002 ± 0.002
Cys	0.82CysAla: 0.82 ± 0.029	0.244CysCys: 0.244 ± 0.016	0.598CysAsp: 0.598 ± 0.028	0.729CysGlu: 0.729 ± 0.028	0.622CysPhe: 0.622 ± 0.028	1.152CysGly: 1.152 ± 0.036	0.324CysHis: 0.324 ± 0.02	0.943CysIle: 0.943 ± 0.029	0.645CysLys: 0.645 ± 0.029	1.224CysLeu: 1.224 ± 0.037	0.393CysMet: 0.393 ± 0.021	0.532CysAsn: 0.532 ± 0.024	0.607CysPro: 0.607 ± 0.023	0.395CysGln: 0.395 ± 0.022	0.712CysArg: 0.712 ± 0.028	0.755CysSer: 0.755 ± 0.031	0.796CysThr: 0.796 ± 0.033	0.739CysVal: 0.739 ± 0.028	0.184CysTrp: 0.184 ± 0.012	0.546CysTyr: 0.546 ± 0.028	0.0CysXaa: 0.0 ± 0.0
Asp	3.951AspAla: 3.951 ± 0.068	0.634AspCys: 0.634 ± 0.027	2.504AspAsp: 2.504 ± 0.057	4.152AspGlu: 4.152 ± 0.077	2.968AspPhe: 2.968 ± 0.052	4.125AspGly: 4.125 ± 0.086	0.81AspHis: 0.81 ± 0.03	3.903AspIle: 3.903 ± 0.06	3.595AspLys: 3.595 ± 0.069	4.708AspLeu: 4.708 ± 0.074	1.641AspMet: 1.641 ± 0.036	2.651AspAsn: 2.651 ± 0.061	1.889AspPro: 1.889 ± 0.059	1.346AspGln: 1.346 ± 0.039	2.628AspArg: 2.628 ± 0.052	3.061AspSer: 3.061 ± 0.072	2.874AspThr: 2.874 ± 0.067	3.475AspVal: 3.475 ± 0.063	0.9AspTrp: 0.9 ± 0.031	2.848AspTyr: 2.848 ± 0.055	0.0AspXaa: 0.0 ± 0.0
Glu	5.595GluAla: 5.595 ± 0.081	0.626GluCys: 0.626 ± 0.031	3.265GluAsp: 3.265 ± 0.06	5.353GluGlu: 5.353 ± 0.097	2.399GluPhe: 2.399 ± 0.05	4.461GluGly: 4.461 ± 0.081	1.358GluHis: 1.358 ± 0.04	4.467GluIle: 4.467 ± 0.077	5.15GluLys: 5.15 ± 0.084	6.415GluLeu: 6.415 ± 0.1	1.97GluMet: 1.97 ± 0.051	3.49GluAsn: 3.49 ± 0.062	1.927GluPro: 1.927 ± 0.054	2.94GluGln: 2.94 ± 0.067	3.358GluArg: 3.358 ± 0.069	3.031GluSer: 3.031 ± 0.055	3.692GluThr: 3.692 ± 0.077	4.577GluVal: 4.577 ± 0.074	0.845GluTrp: 0.845 ± 0.029	2.555GluTyr: 2.555 ± 0.054	0.0GluXaa: 0.0 ± 0.0
Phe	2.945PheAla: 2.945 ± 0.062	0.739PheCys: 0.739 ± 0.028	2.704PheAsp: 2.704 ± 0.059	2.437PheGlu: 2.437 ± 0.055	2.167PhePhe: 2.167 ± 0.06	3.237PheGly: 3.237 ± 0.062	0.94PheHis: 0.94 ± 0.036	3.011PheIle: 3.011 ± 0.073	2.162PheLys: 2.162 ± 0.055	4.058PheLeu: 4.058 ± 0.08	1.225PheMet: 1.225 ± 0.042	2.097PheAsn: 2.097 ± 0.05	1.793PhePro: 1.793 ± 0.044	1.496PheGln: 1.496 ± 0.041	2.33PheArg: 2.33 ± 0.054	3.2PheSer: 3.2 ± 0.067	2.794PheThr: 2.794 ± 0.058	2.802PheVal: 2.802 ± 0.06	0.548PheTrp: 0.548 ± 0.025	1.914PheTyr: 1.914 ± 0.046	0.0PheXaa: 0.0 ± 0.0
Gly	4.491GlyAla: 4.491 ± 0.075	0.989GlyCys: 0.989 ± 0.035	3.412GlyAsp: 3.412 ± 0.061	4.185GlyGlu: 4.185 ± 0.069	3.237GlyPhe: 3.237 ± 0.052	4.831GlyGly: 4.831 ± 0.095	1.314GlyHis: 1.314 ± 0.043	5.631GlyIle: 5.631 ± 0.096	5.245GlyLys: 5.245 ± 0.085	6.16GlyLeu: 6.16 ± 0.093	2.266GlyMet: 2.266 ± 0.049	3.603GlyAsn: 3.603 ± 0.082	1.503GlyPro: 1.503 ± 0.04	2.191GlyGln: 2.191 ± 0.057	2.913GlyArg: 2.913 ± 0.06	3.911GlySer: 3.911 ± 0.08	4.388GlyThr: 4.388 ± 0.08	4.826GlyVal: 4.826 ± 0.081	1.06GlyTrp: 1.06 ± 0.037	3.395GlyTyr: 3.395 ± 0.064	0.0GlyXaa: 0.0 ± 0.0
His	1.311HisAla: 1.311 ± 0.037	0.326HisCys: 0.326 ± 0.02	0.949HisAsp: 0.949 ± 0.033	1.141HisGlu: 1.141 ± 0.038	1.052HisPhe: 1.052 ± 0.036	1.238HisGly: 1.238 ± 0.037	0.56HisHis: 0.56 ± 0.026	1.466HisIle: 1.466 ± 0.044	0.962HisLys: 0.962 ± 0.034	1.898HisLeu: 1.898 ± 0.062	0.39HisMet: 0.39 ± 0.019	0.866HisAsn: 0.866 ± 0.028	1.256HisPro: 1.256 ± 0.034	0.756HisGln: 0.756 ± 0.028	0.963HisArg: 0.963 ± 0.032	1.054HisSer: 1.054 ± 0.032	1.209HisThr: 1.209 ± 0.038	1.159HisVal: 1.159 ± 0.035	0.268HisTrp: 0.268 ± 0.019	0.919HisTyr: 0.919 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	5.008IleAla: 5.008 ± 0.085	1.006IleCys: 1.006 ± 0.032	4.008IleAsp: 4.008 ± 0.069	4.181IleGlu: 4.181 ± 0.072	2.501IlePhe: 2.501 ± 0.061	4.872IleGly: 4.872 ± 0.078	1.465IleHis: 1.465 ± 0.044	4.036IleIle: 4.036 ± 0.078	3.307IleLys: 3.307 ± 0.07	6.006IleLeu: 6.006 ± 0.097	1.343IleMet: 1.343 ± 0.04	2.949IleAsn: 2.949 ± 0.059	3.19IlePro: 3.19 ± 0.07	2.5IleGln: 2.5 ± 0.055	3.708IleArg: 3.708 ± 0.074	4.228IleSer: 4.228 ± 0.078	3.648IleThr: 3.648 ± 0.061	4.214IleVal: 4.214 ± 0.074	0.663IleTrp: 0.663 ± 0.026	2.559IleTyr: 2.559 ± 0.058	0.0IleXaa: 0.0 ± 0.0
Lys	4.79LysAla: 4.79 ± 0.077	0.529LysCys: 0.529 ± 0.023	3.753LysAsp: 3.753 ± 0.069	5.563LysGlu: 5.563 ± 0.085	1.971LysPhe: 1.971 ± 0.042	4.208LysGly: 4.208 ± 0.074	1.216LysHis: 1.216 ± 0.04	3.473LysIle: 3.473 ± 0.06	4.384LysLys: 4.384 ± 0.08	5.08LysLeu: 5.08 ± 0.08	1.828LysMet: 1.828 ± 0.044	2.957LysAsn: 2.957 ± 0.062	2.097LysPro: 2.097 ± 0.047	2.593LysGln: 2.593 ± 0.062	3.023LysArg: 3.023 ± 0.058	2.902LysSer: 2.902 ± 0.064	3.232LysThr: 3.232 ± 0.062	4.024LysVal: 4.024 ± 0.069	0.684LysTrp: 0.684 ± 0.028	2.597LysTyr: 2.597 ± 0.058	0.0LysXaa: 0.0 ± 0.0
Leu	6.938LeuAla: 6.938 ± 0.093	1.405LeuCys: 1.405 ± 0.048	4.73LeuAsp: 4.73 ± 0.072	5.681LeuGlu: 5.681 ± 0.083	4.397LeuPhe: 4.397 ± 0.079	5.842LeuGly: 5.842 ± 0.082	1.919LeuHis: 1.919 ± 0.054	5.477LeuIle: 5.477 ± 0.091	6.327LeuLys: 6.327 ± 0.079	9.265LeuLeu: 9.265 ± 0.134	2.827LeuMet: 2.827 ± 0.06	4.466LeuAsn: 4.466 ± 0.077	4.305LeuPro: 4.305 ± 0.077	3.8LeuGln: 3.8 ± 0.079	4.183LeuArg: 4.183 ± 0.078	6.391LeuSer: 6.391 ± 0.097	5.747LeuThr: 5.747 ± 0.082	5.719LeuVal: 5.719 ± 0.104	0.997LeuTrp: 0.997 ± 0.034	3.784LeuTyr: 3.784 ± 0.067	0.0LeuXaa: 0.0 ± 0.0
Met	2.191MetAla: 2.191 ± 0.049	0.225MetCys: 0.225 ± 0.017	1.632MetAsp: 1.632 ± 0.042	1.876MetGlu: 1.876 ± 0.052	1.054MetPhe: 1.054 ± 0.034	1.904MetGly: 1.904 ± 0.051	0.506MetHis: 0.506 ± 0.025	1.59MetIle: 1.59 ± 0.05	2.528MetLys: 2.528 ± 0.055	2.53MetLeu: 2.53 ± 0.052	0.851MetMet: 0.851 ± 0.035	1.54MetAsn: 1.54 ± 0.044	1.195MetPro: 1.195 ± 0.034	1.11MetGln: 1.11 ± 0.037	1.275MetArg: 1.275 ± 0.044	1.451MetSer: 1.451 ± 0.042	1.547MetThr: 1.547 ± 0.038	1.6MetVal: 1.6 ± 0.043	0.228MetTrp: 0.228 ± 0.016	0.907MetTyr: 0.907 ± 0.031	0.0MetXaa: 0.0 ± 0.0
Asn	3.265AsnAla: 3.265 ± 0.064	0.463AsnCys: 0.463 ± 0.022	2.37AsnAsp: 2.37 ± 0.047	2.989AsnGlu: 2.989 ± 0.058	2.057AsnPhe: 2.057 ± 0.048	3.789AsnGly: 3.789 ± 0.073	0.941AsnHis: 0.941 ± 0.033	3.211AsnIle: 3.211 ± 0.065	2.553AsnLys: 2.553 ± 0.057	4.419AsnLeu: 4.419 ± 0.075	1.229AsnMet: 1.229 ± 0.037	2.187AsnAsn: 2.187 ± 0.057	2.496AsnPro: 2.496 ± 0.061	1.72AsnGln: 1.72 ± 0.047	2.624AsnArg: 2.624 ± 0.059	2.458AsnSer: 2.458 ± 0.059	2.514AsnThr: 2.514 ± 0.056	2.91AsnVal: 2.91 ± 0.058	0.651AsnTrp: 0.651 ± 0.028	2.242AsnTyr: 2.242 ± 0.063	0.0AsnXaa: 0.0 ± 0.0
Pro	2.961ProAla: 2.961 ± 0.063	0.376ProCys: 0.376 ± 0.023	2.807ProAsp: 2.807 ± 0.057	3.711ProGlu: 3.711 ± 0.074	1.895ProPhe: 1.895 ± 0.053	2.559ProGly: 2.559 ± 0.053	0.793ProHis: 0.793 ± 0.033	2.269ProIle: 2.269 ± 0.062	1.934ProLys: 1.934 ± 0.049	3.46ProLeu: 3.46 ± 0.07	1.036ProMet: 1.036 ± 0.028	1.671ProAsn: 1.671 ± 0.046	0.814ProPro: 0.814 ± 0.034	1.584ProGln: 1.584 ± 0.046	1.28ProArg: 1.28 ± 0.04	2.269ProSer: 2.269 ± 0.047	2.053ProThr: 2.053 ± 0.048	3.247ProVal: 3.247 ± 0.06	0.486ProTrp: 0.486 ± 0.025	1.871ProTyr: 1.871 ± 0.048	0.0ProXaa: 0.0 ± 0.0
Gln	3.099GlnAla: 3.099 ± 0.073	0.315GlnCys: 0.315 ± 0.019	1.646GlnAsp: 1.646 ± 0.05	2.762GlnGlu: 2.762 ± 0.067	1.385GlnPhe: 1.385 ± 0.032	2.343GlnGly: 2.343 ± 0.053	0.753GlnHis: 0.753 ± 0.033	2.363GlnIle: 2.363 ± 0.051	2.483GlnLys: 2.483 ± 0.059	3.785GlnLeu: 3.785 ± 0.082	1.133GlnMet: 1.133 ± 0.039	1.723GlnAsn: 1.723 ± 0.05	1.512GlnPro: 1.512 ± 0.042	1.976GlnGln: 1.976 ± 0.057	1.768GlnArg: 1.768 ± 0.041	1.889GlnSer: 1.889 ± 0.049	2.293GlnThr: 2.293 ± 0.055	2.736GlnVal: 2.736 ± 0.06	0.497GlnTrp: 0.497 ± 0.024	1.471GlnTyr: 1.471 ± 0.038	0.0GlnXaa: 0.0 ± 0.0
Arg	2.798ArgAla: 2.798 ± 0.058	0.52ArgCys: 0.52 ± 0.026	1.996ArgAsp: 1.996 ± 0.043	3.162ArgGlu: 3.162 ± 0.067	2.455ArgPhe: 2.455 ± 0.05	2.389ArgGly: 2.389 ± 0.058	0.94ArgHis: 0.94 ± 0.033	3.865ArgIle: 3.865 ± 0.074	3.517ArgLys: 3.517 ± 0.075	4.921ArgLeu: 4.921 ± 0.095	1.707ArgMet: 1.707 ± 0.046	2.521ArgAsn: 2.521 ± 0.058	1.851ArgPro: 1.851 ± 0.047	2.149ArgGln: 2.149 ± 0.056	2.405ArgArg: 2.405 ± 0.065	2.454ArgSer: 2.454 ± 0.055	2.663ArgThr: 2.663 ± 0.066	2.691ArgVal: 2.691 ± 0.052	0.686ArgTrp: 0.686 ± 0.033	2.333ArgTyr: 2.333 ± 0.053	0.004ArgXaa: 0.004 ± 0.002
Ser	4.062SerAla: 4.062 ± 0.074	0.817SerCys: 0.817 ± 0.03	3.146SerAsp: 3.146 ± 0.06	3.477SerGlu: 3.477 ± 0.071	3.128SerPhe: 3.128 ± 0.058	4.45SerGly: 4.45 ± 0.076	1.127SerHis: 1.127 ± 0.038	3.904SerIle: 3.904 ± 0.069	2.865SerLys: 2.865 ± 0.06	6.05SerLeu: 6.05 ± 0.075	1.549SerMet: 1.549 ± 0.042	2.351SerAsn: 2.351 ± 0.061	2.214SerPro: 2.214 ± 0.049	1.97SerGln: 1.97 ± 0.047	2.751SerArg: 2.751 ± 0.057	3.705SerSer: 3.705 ± 0.075	3.011SerThr: 3.011 ± 0.055	4.077SerVal: 4.077 ± 0.07	0.852SerTrp: 0.852 ± 0.037	2.673SerTyr: 2.673 ± 0.061	0.0SerXaa: 0.0 ± 0.0
Thr	4.274ThrAla: 4.274 ± 0.076	0.709ThrCys: 0.709 ± 0.03	3.79ThrAsp: 3.79 ± 0.07	3.626ThrGlu: 3.626 ± 0.075	2.728ThrPhe: 2.728 ± 0.065	4.532ThrGly: 4.532 ± 0.074	1.112ThrHis: 1.112 ± 0.039	3.456ThrIle: 3.456 ± 0.059	2.268ThrLys: 2.268 ± 0.051	5.921ThrLeu: 5.921 ± 0.086	1.129ThrMet: 1.129 ± 0.038	2.323ThrAsn: 2.323 ± 0.06	2.905ThrPro: 2.905 ± 0.059	1.889ThrGln: 1.889 ± 0.048	2.427ThrArg: 2.427 ± 0.05	3.351ThrSer: 3.351 ± 0.066	3.112ThrThr: 3.112 ± 0.063	4.243ThrVal: 4.243 ± 0.068	0.686ThrTrp: 0.686 ± 0.029	2.596ThrTyr: 2.596 ± 0.059	0.0ThrXaa: 0.0 ± 0.0
Val	4.825ValAla: 4.825 ± 0.083	1.052ValCys: 1.052 ± 0.034	3.598ValAsp: 3.598 ± 0.066	4.194ValGlu: 4.194 ± 0.069	2.85ValPhe: 2.85 ± 0.056	4.215ValGly: 4.215 ± 0.077	1.151ValHis: 1.151 ± 0.035	4.34ValIle: 4.34 ± 0.071	4.073ValLys: 4.073 ± 0.064	5.904ValLeu: 5.904 ± 0.098	1.751ValMet: 1.751 ± 0.042	3.257ValAsn: 3.257 ± 0.057	2.807ValPro: 2.807 ± 0.05	2.208ValGln: 2.208 ± 0.055	3.184ValArg: 3.184 ± 0.068	4.576ValSer: 4.576 ± 0.072	4.003ValThr: 4.003 ± 0.071	4.445ValVal: 4.445 ± 0.078	0.763ValTrp: 0.763 ± 0.029	2.702ValTyr: 2.702 ± 0.058	0.001ValXaa: 0.001 ± 0.001
Trp	0.757TrpAla: 0.757 ± 0.025	0.174TrpCys: 0.174 ± 0.015	0.691TrpAsp: 0.691 ± 0.029	0.833TrpGlu: 0.833 ± 0.029	0.534TrpPhe: 0.534 ± 0.027	1.012TrpGly: 1.012 ± 0.035	0.271TrpHis: 0.271 ± 0.018	0.779TrpIle: 0.779 ± 0.032	0.965TrpLys: 0.965 ± 0.037	1.197TrpLeu: 1.197 ± 0.035	0.482TrpMet: 0.482 ± 0.022	0.796TrpAsn: 0.796 ± 0.029	0.295TrpPro: 0.295 ± 0.02	0.514TrpGln: 0.514 ± 0.023	0.571TrpArg: 0.571 ± 0.027	0.67TrpSer: 0.67 ± 0.029	0.68TrpThr: 0.68 ± 0.027	0.734TrpVal: 0.734 ± 0.033	0.188TrpTrp: 0.188 ± 0.016	0.5TrpTyr: 0.5 ± 0.024	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.069TyrAla: 3.069 ± 0.06	0.59TyrCys: 0.59 ± 0.024	2.405TyrAsp: 2.405 ± 0.054	2.449TyrGlu: 2.449 ± 0.054	1.959TyrPhe: 1.959 ± 0.05	2.988TyrGly: 2.988 ± 0.061	0.932TyrHis: 0.932 ± 0.033	2.668TyrIle: 2.668 ± 0.059	2.192TyrLys: 2.192 ± 0.047	4.185TyrLeu: 4.185 ± 0.078	1.013TyrMet: 1.013 ± 0.036	2.203TyrAsn: 2.203 ± 0.056	2.054TyrPro: 2.054 ± 0.053	1.876TyrGln: 1.876 ± 0.04	2.585TyrArg: 2.585 ± 0.059	2.412TyrSer: 2.412 ± 0.057	2.816TyrThr: 2.816 ± 0.065	2.548TyrVal: 2.548 ± 0.057	0.579TyrTrp: 0.579 ± 0.029	2.029TyrTyr: 2.029 ± 0.054	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.001	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.001	0.0XaaSer: 0.0 ± 0.0	0.001XaaThr: 0.001 ± 0.001	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.001	0.013XaaXaa: 0.013 ± 0.005

Statistics based on 2561 proteins (913119 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---