Amino acid dipepetide frequency for Polaribacter glomeratus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.231AlaAla: 4.231 ± 0.073	0.494AlaCys: 0.494 ± 0.02	3.359AlaAsp: 3.359 ± 0.062	3.594AlaGlu: 3.594 ± 0.069	3.404AlaPhe: 3.404 ± 0.059	3.874AlaGly: 3.874 ± 0.069	0.97AlaHis: 0.97 ± 0.031	5.851AlaIle: 5.851 ± 0.087	4.857AlaLys: 4.857 ± 0.072	5.575AlaLeu: 5.575 ± 0.075	1.299AlaMet: 1.299 ± 0.038	3.715AlaAsn: 3.715 ± 0.068	1.722AlaPro: 1.722 ± 0.039	2.168AlaGln: 2.168 ± 0.045	1.8AlaArg: 1.8 ± 0.039	4.218AlaSer: 4.218 ± 0.074	3.939AlaThr: 3.939 ± 0.071	3.891AlaVal: 3.891 ± 0.065	0.538AlaTrp: 0.538 ± 0.02	2.188AlaTyr: 2.188 ± 0.044	0.0AlaXaa: 0.0 ± 0.0
Cys	0.416CysAla: 0.416 ± 0.02	0.091CysCys: 0.091 ± 0.009	0.407CysAsp: 0.407 ± 0.022	0.411CysGlu: 0.411 ± 0.019	0.432CysPhe: 0.432 ± 0.02	0.534CysGly: 0.534 ± 0.023	0.164CysHis: 0.164 ± 0.014	0.545CysIle: 0.545 ± 0.021	0.513CysLys: 0.513 ± 0.021	0.573CysLeu: 0.573 ± 0.025	0.127CysMet: 0.127 ± 0.01	0.444CysAsn: 0.444 ± 0.022	0.266CysPro: 0.266 ± 0.018	0.189CysGln: 0.189 ± 0.013	0.169CysArg: 0.169 ± 0.012	0.475CysSer: 0.475 ± 0.027	0.405CysThr: 0.405 ± 0.019	0.405CysVal: 0.405 ± 0.024	0.062CysTrp: 0.062 ± 0.007	0.281CysTyr: 0.281 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	3.787AspAla: 3.787 ± 0.071	0.386AspCys: 0.386 ± 0.02	2.694AspAsp: 2.694 ± 0.059	3.697AspGlu: 3.697 ± 0.059	3.85AspPhe: 3.85 ± 0.051	3.486AspGly: 3.486 ± 0.108	0.68AspHis: 0.68 ± 0.024	4.452AspIle: 4.452 ± 0.073	4.517AspLys: 4.517 ± 0.072	5.074AspLeu: 5.074 ± 0.078	0.904AspMet: 0.904 ± 0.032	2.983AspAsn: 2.983 ± 0.059	1.327AspPro: 1.327 ± 0.035	1.291AspGln: 1.291 ± 0.032	1.593AspArg: 1.593 ± 0.037	3.041AspSer: 3.041 ± 0.057	2.834AspThr: 2.834 ± 0.064	3.729AspVal: 3.729 ± 0.066	0.718AspTrp: 0.718 ± 0.027	2.428AspTyr: 2.428 ± 0.051	0.0AspXaa: 0.0 ± 0.0
Glu	3.953GluAla: 3.953 ± 0.066	0.301GluCys: 0.301 ± 0.017	3.331GluAsp: 3.331 ± 0.062	4.427GluGlu: 4.427 ± 0.075	3.076GluPhe: 3.076 ± 0.055	3.254GluGly: 3.254 ± 0.06	1.008GluHis: 1.008 ± 0.03	6.217GluIle: 6.217 ± 0.085	6.38GluLys: 6.38 ± 0.095	6.038GluLeu: 6.038 ± 0.094	1.522GluMet: 1.522 ± 0.034	5.475GluAsn: 5.475 ± 0.077	1.312GluPro: 1.312 ± 0.032	1.987GluGln: 1.987 ± 0.046	2.208GluArg: 2.208 ± 0.048	3.271GluSer: 3.271 ± 0.046	3.895GluThr: 3.895 ± 0.066	4.103GluVal: 4.103 ± 0.078	0.58GluTrp: 0.58 ± 0.025	2.371GluTyr: 2.371 ± 0.052	0.0GluXaa: 0.0 ± 0.0
Phe	3.029PheAla: 3.029 ± 0.053	0.426PheCys: 0.426 ± 0.019	3.355PheAsp: 3.355 ± 0.054	3.367PheGlu: 3.367 ± 0.053	3.017PhePhe: 3.017 ± 0.065	3.721PheGly: 3.721 ± 0.058	0.798PheHis: 0.798 ± 0.027	4.597PheIle: 4.597 ± 0.086	4.46PheLys: 4.46 ± 0.075	5.382PheLeu: 5.382 ± 0.1	1.115PheMet: 1.115 ± 0.035	3.717PheAsn: 3.717 ± 0.063	1.573PhePro: 1.573 ± 0.039	1.491PheGln: 1.491 ± 0.037	1.564PheArg: 1.564 ± 0.043	4.565PheSer: 4.565 ± 0.082	3.578PheThr: 3.578 ± 0.065	3.113PheVal: 3.113 ± 0.063	0.615PheTrp: 0.615 ± 0.025	2.398PheTyr: 2.398 ± 0.054	0.0PheXaa: 0.0 ± 0.0
Gly	3.937GlyAla: 3.937 ± 0.077	0.484GlyCys: 0.484 ± 0.027	3.046GlyAsp: 3.046 ± 0.072	3.256GlyGlu: 3.256 ± 0.059	3.93GlyPhe: 3.93 ± 0.061	4.211GlyGly: 4.211 ± 0.082	0.928GlyHis: 0.928 ± 0.034	5.311GlyIle: 5.311 ± 0.078	5.004GlyLys: 5.004 ± 0.087	5.364GlyLeu: 5.364 ± 0.074	1.379GlyMet: 1.379 ± 0.04	3.807GlyAsn: 3.807 ± 0.066	1.069GlyPro: 1.069 ± 0.033	1.624GlyGln: 1.624 ± 0.035	1.835GlyArg: 1.835 ± 0.045	3.877GlySer: 3.877 ± 0.065	3.923GlyThr: 3.923 ± 0.085	4.177GlyVal: 4.177 ± 0.069	0.654GlyTrp: 0.654 ± 0.024	2.513GlyTyr: 2.513 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	0.814HisAla: 0.814 ± 0.031	0.146HisCys: 0.146 ± 0.01	0.703HisAsp: 0.703 ± 0.026	0.81HisGlu: 0.81 ± 0.03	1.098HisPhe: 1.098 ± 0.034	0.909HisGly: 0.909 ± 0.033	0.431HisHis: 0.431 ± 0.021	1.351HisIle: 1.351 ± 0.035	1.308HisLys: 1.308 ± 0.038	1.643HisLeu: 1.643 ± 0.036	0.263HisMet: 0.263 ± 0.015	0.853HisAsn: 0.853 ± 0.026	0.797HisPro: 0.797 ± 0.03	0.786HisGln: 0.786 ± 0.028	0.589HisArg: 0.589 ± 0.027	0.946HisSer: 0.946 ± 0.03	0.91HisThr: 0.91 ± 0.028	0.788HisVal: 0.788 ± 0.026	0.169HisTrp: 0.169 ± 0.012	0.707HisTyr: 0.707 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	5.907IleAla: 5.907 ± 0.077	0.662IleCys: 0.662 ± 0.027	5.096IleAsp: 5.096 ± 0.078	5.831IleGlu: 5.831 ± 0.084	4.099IlePhe: 4.099 ± 0.067	5.11IleGly: 5.11 ± 0.081	1.337IleHis: 1.337 ± 0.041	7.065IleIle: 7.065 ± 0.113	6.954IleLys: 6.954 ± 0.087	7.733IleLeu: 7.733 ± 0.104	1.352IleMet: 1.352 ± 0.037	5.553IleAsn: 5.553 ± 0.083	3.131IlePro: 3.131 ± 0.054	2.568IleGln: 2.568 ± 0.046	2.546IleArg: 2.546 ± 0.052	6.41IleSer: 6.41 ± 0.083	5.232IleThr: 5.232 ± 0.077	5.023IleVal: 5.023 ± 0.07	0.753IleTrp: 0.753 ± 0.026	3.041IleTyr: 3.041 ± 0.064	0.0IleXaa: 0.0 ± 0.0
Lys	4.904LysAla: 4.904 ± 0.08	0.348LysCys: 0.348 ± 0.018	4.585LysAsp: 4.585 ± 0.079	7.267LysGlu: 7.267 ± 0.107	3.271LysPhe: 3.271 ± 0.051	4.67LysGly: 4.67 ± 0.07	1.388LysHis: 1.388 ± 0.032	7.571LysIle: 7.571 ± 0.088	8.278LysLys: 8.278 ± 0.112	6.979LysLeu: 6.979 ± 0.097	2.187LysMet: 2.187 ± 0.05	6.703LysAsn: 6.703 ± 0.082	2.444LysPro: 2.444 ± 0.051	2.787LysGln: 2.787 ± 0.053	2.828LysArg: 2.828 ± 0.052	5.091LysSer: 5.091 ± 0.077	5.334LysThr: 5.334 ± 0.079	5.062LysVal: 5.062 ± 0.077	0.829LysTrp: 0.829 ± 0.027	3.354LysTyr: 3.354 ± 0.057	0.0LysXaa: 0.0 ± 0.0
Leu	5.442LeuAla: 5.442 ± 0.079	0.6LeuCys: 0.6 ± 0.024	4.918LeuAsp: 4.918 ± 0.073	6.491LeuGlu: 6.491 ± 0.078	5.315LeuPhe: 5.315 ± 0.098	5.604LeuGly: 5.604 ± 0.075	1.487LeuHis: 1.487 ± 0.036	7.416LeuIle: 7.416 ± 0.118	8.535LeuLys: 8.535 ± 0.106	8.617LeuLeu: 8.617 ± 0.123	1.902LeuMet: 1.902 ± 0.048	6.103LeuAsn: 6.103 ± 0.08	3.179LeuPro: 3.179 ± 0.052	3.317LeuGln: 3.317 ± 0.056	2.825LeuArg: 2.825 ± 0.044	6.483LeuSer: 6.483 ± 0.075	5.11LeuThr: 5.11 ± 0.074	5.305LeuVal: 5.305 ± 0.079	0.746LeuTrp: 0.746 ± 0.028	3.017LeuTyr: 3.017 ± 0.057	0.0LeuXaa: 0.0 ± 0.0
Met	1.375MetAla: 1.375 ± 0.041	0.124MetCys: 0.124 ± 0.011	1.034MetAsp: 1.034 ± 0.036	1.122MetGlu: 1.122 ± 0.033	0.907MetPhe: 0.907 ± 0.03	1.158MetGly: 1.158 ± 0.033	0.379MetHis: 0.379 ± 0.015	1.555MetIle: 1.555 ± 0.042	2.164MetLys: 2.164 ± 0.044	1.83MetLeu: 1.83 ± 0.042	0.556MetMet: 0.556 ± 0.023	1.371MetAsn: 1.371 ± 0.035	0.747MetPro: 0.747 ± 0.022	0.755MetGln: 0.755 ± 0.031	0.745MetArg: 0.745 ± 0.028	1.339MetSer: 1.339 ± 0.034	0.987MetThr: 0.987 ± 0.029	1.158MetVal: 1.158 ± 0.037	0.151MetTrp: 0.151 ± 0.011	0.69MetTyr: 0.69 ± 0.028	0.0MetXaa: 0.0 ± 0.0
Asn	4.04AsnAla: 4.04 ± 0.076	0.518AsnCys: 0.518 ± 0.029	3.271AsnAsp: 3.271 ± 0.069	3.902AsnGlu: 3.902 ± 0.055	3.647AsnPhe: 3.647 ± 0.065	4.248AsnGly: 4.248 ± 0.089	1.073AsnHis: 1.073 ± 0.029	5.457AsnIle: 5.457 ± 0.074	5.193AsnLys: 5.193 ± 0.076	6.171AsnLeu: 6.171 ± 0.089	1.264AsnMet: 1.264 ± 0.035	4.56AsnAsn: 4.56 ± 0.1	2.804AsnPro: 2.804 ± 0.056	2.444AsnGln: 2.444 ± 0.051	2.052AsnArg: 2.052 ± 0.041	4.647AsnSer: 4.647 ± 0.077	4.184AsnThr: 4.184 ± 0.098	3.638AsnVal: 3.638 ± 0.061	0.876AsnTrp: 0.876 ± 0.028	3.165AsnTyr: 3.165 ± 0.056	0.0AsnXaa: 0.0 ± 0.0
Pro	1.705ProAla: 1.705 ± 0.04	0.19ProCys: 0.19 ± 0.012	1.661ProAsp: 1.661 ± 0.04	2.29ProGlu: 2.29 ± 0.047	1.941ProPhe: 1.941 ± 0.05	1.546ProGly: 1.546 ± 0.036	0.522ProHis: 0.522 ± 0.025	2.739ProIle: 2.739 ± 0.052	2.574ProLys: 2.574 ± 0.053	2.734ProLeu: 2.734 ± 0.05	0.587ProMet: 0.587 ± 0.024	2.196ProAsn: 2.196 ± 0.049	0.674ProPro: 0.674 ± 0.027	0.91ProGln: 0.91 ± 0.033	0.829ProArg: 0.829 ± 0.028	1.935ProSer: 1.935 ± 0.041	1.998ProThr: 1.998 ± 0.045	1.923ProVal: 1.923 ± 0.045	0.293ProTrp: 0.293 ± 0.016	1.169ProTyr: 1.169 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	1.659GlnAla: 1.659 ± 0.038	0.147GlnCys: 0.147 ± 0.01	1.516GlnAsp: 1.516 ± 0.037	2.4GlnGlu: 2.4 ± 0.046	1.743GlnPhe: 1.743 ± 0.041	1.628GlnGly: 1.628 ± 0.041	0.523GlnHis: 0.523 ± 0.021	2.833GlnIle: 2.833 ± 0.048	3.213GlnLys: 3.213 ± 0.062	3.29GlnLeu: 3.29 ± 0.054	0.713GlnMet: 0.713 ± 0.023	2.338GlnAsn: 2.338 ± 0.047	0.892GlnPro: 0.892 ± 0.03	1.446GlnGln: 1.446 ± 0.039	1.067GlnArg: 1.067 ± 0.029	1.753GlnSer: 1.753 ± 0.04	1.873GlnThr: 1.873 ± 0.046	1.829GlnVal: 1.829 ± 0.042	0.29GlnTrp: 0.29 ± 0.019	1.189GlnTyr: 1.189 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	1.917ArgAla: 1.917 ± 0.042	0.171ArgCys: 0.171 ± 0.013	1.523ArgAsp: 1.523 ± 0.034	1.983ArgGlu: 1.983 ± 0.038	1.788ArgPhe: 1.788 ± 0.039	1.719ArgGly: 1.719 ± 0.044	0.507ArgHis: 0.507 ± 0.023	2.761ArgIle: 2.761 ± 0.048	2.772ArgLys: 2.772 ± 0.061	2.828ArgLeu: 2.828 ± 0.05	0.757ArgMet: 0.757 ± 0.025	2.059ArgAsn: 2.059 ± 0.05	0.884ArgPro: 0.884 ± 0.026	0.921ArgGln: 0.921 ± 0.028	1.093ArgArg: 1.093 ± 0.031	1.728ArgSer: 1.728 ± 0.035	1.803ArgThr: 1.803 ± 0.039	1.89ArgVal: 1.89 ± 0.048	0.299ArgTrp: 0.299 ± 0.015	1.297ArgTyr: 1.297 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	3.775SerAla: 3.775 ± 0.068	0.589SerCys: 0.589 ± 0.024	3.525SerAsp: 3.525 ± 0.065	4.228SerGlu: 4.228 ± 0.056	4.262SerPhe: 4.262 ± 0.076	4.307SerGly: 4.307 ± 0.072	0.957SerHis: 0.957 ± 0.031	5.627SerIle: 5.627 ± 0.073	5.695SerLys: 5.695 ± 0.072	6.294SerLeu: 6.294 ± 0.083	1.193SerMet: 1.193 ± 0.037	4.203SerAsn: 4.203 ± 0.084	1.823SerPro: 1.823 ± 0.045	1.977SerGln: 1.977 ± 0.048	1.919SerArg: 1.919 ± 0.046	4.714SerSer: 4.714 ± 0.088	3.796SerThr: 3.796 ± 0.065	4.052SerVal: 4.052 ± 0.055	0.752SerTrp: 0.752 ± 0.03	2.783SerTyr: 2.783 ± 0.058	0.0SerXaa: 0.0 ± 0.0
Thr	3.914ThrAla: 3.914 ± 0.076	0.342ThrCys: 0.342 ± 0.017	3.43ThrAsp: 3.43 ± 0.069	3.447ThrGlu: 3.447 ± 0.059	3.44ThrPhe: 3.44 ± 0.067	3.786ThrGly: 3.786 ± 0.063	0.942ThrHis: 0.942 ± 0.029	5.651ThrIle: 5.651 ± 0.079	4.655ThrLys: 4.655 ± 0.072	5.435ThrLeu: 5.435 ± 0.075	0.911ThrMet: 0.911 ± 0.03	3.957ThrAsn: 3.957 ± 0.083	2.25ThrPro: 2.25 ± 0.047	1.859ThrGln: 1.859 ± 0.042	1.549ThrArg: 1.549 ± 0.035	4.235ThrSer: 4.235 ± 0.075	3.787ThrThr: 3.787 ± 0.076	3.69ThrVal: 3.69 ± 0.071	0.605ThrTrp: 0.605 ± 0.023	2.434ThrTyr: 2.434 ± 0.056	0.0ThrXaa: 0.0 ± 0.0
Val	4.09ValAla: 4.09 ± 0.068	0.478ValCys: 0.478 ± 0.023	3.455ValAsp: 3.455 ± 0.058	3.563ValGlu: 3.563 ± 0.064	3.555ValPhe: 3.555 ± 0.073	3.628ValGly: 3.628 ± 0.067	0.96ValHis: 0.96 ± 0.032	4.869ValIle: 4.869 ± 0.069	4.602ValLys: 4.602 ± 0.063	6.106ValLeu: 6.106 ± 0.077	1.124ValMet: 1.124 ± 0.034	3.658ValAsn: 3.658 ± 0.064	1.888ValPro: 1.888 ± 0.045	1.711ValGln: 1.711 ± 0.041	1.757ValArg: 1.757 ± 0.044	4.444ValSer: 4.444 ± 0.075	3.701ValThr: 3.701 ± 0.073	3.922ValVal: 3.922 ± 0.069	0.571ValTrp: 0.571 ± 0.023	2.191ValTyr: 2.191 ± 0.045	0.0ValXaa: 0.0 ± 0.0
Trp	0.536TrpAla: 0.536 ± 0.022	0.089TrpCys: 0.089 ± 0.008	0.54TrpAsp: 0.54 ± 0.023	0.6TrpGlu: 0.6 ± 0.025	0.625TrpPhe: 0.625 ± 0.027	0.638TrpGly: 0.638 ± 0.028	0.201TrpHis: 0.201 ± 0.013	0.783TrpIle: 0.783 ± 0.026	0.778TrpLys: 0.778 ± 0.027	0.901TrpLeu: 0.901 ± 0.028	0.308TrpMet: 0.308 ± 0.016	0.727TrpAsn: 0.727 ± 0.028	0.192TrpPro: 0.192 ± 0.014	0.419TrpGln: 0.419 ± 0.022	0.399TrpArg: 0.399 ± 0.02	0.7TrpSer: 0.7 ± 0.028	0.511TrpThr: 0.511 ± 0.02	0.586TrpVal: 0.586 ± 0.026	0.129TrpTrp: 0.129 ± 0.011	0.423TrpTyr: 0.423 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.252TyrAla: 2.252 ± 0.052	0.322TyrCys: 0.322 ± 0.018	2.021TyrAsp: 2.021 ± 0.05	2.025TyrGlu: 2.025 ± 0.047	2.483TyrPhe: 2.483 ± 0.048	2.299TyrGly: 2.299 ± 0.046	0.767TyrHis: 0.767 ± 0.025	2.753TyrIle: 2.753 ± 0.051	3.424TyrLys: 3.424 ± 0.056	3.842TyrLeu: 3.842 ± 0.059	0.683TyrMet: 0.683 ± 0.025	2.734TyrAsn: 2.734 ± 0.053	1.44TyrPro: 1.44 ± 0.034	1.693TyrGln: 1.693 ± 0.043	1.333TyrArg: 1.333 ± 0.034	2.6TyrSer: 2.6 ± 0.05	2.519TyrThr: 2.519 ± 0.059	1.992TyrVal: 1.992 ± 0.041	0.458TyrTrp: 0.458 ± 0.021	1.746TyrTyr: 1.746 ± 0.049	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3368 proteins (1169193 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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