Amino acid dipepetide frequency for Eubacterium hallii CAG:12

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.915AlaAla: 6.915 ± 0.129
1.089AlaCys: 1.089 ± 0.043
4.264AlaAsp: 4.264 ± 0.079
5.227AlaGlu: 5.227 ± 0.097
3.018AlaPhe: 3.018 ± 0.063
6.043AlaGly: 6.043 ± 0.11
1.13AlaHis: 1.13 ± 0.039
5.451AlaIle: 5.451 ± 0.103
5.571AlaLys: 5.571 ± 0.098
6.459AlaLeu: 6.459 ± 0.102
2.289AlaMet: 2.289 ± 0.058
2.519AlaAsn: 2.519 ± 0.066
1.956AlaPro: 1.956 ± 0.055
2.254AlaGln: 2.254 ± 0.062
2.659AlaArg: 2.659 ± 0.072
3.924AlaSer: 3.924 ± 0.076
3.395AlaThr: 3.395 ± 0.087
5.82AlaVal: 5.82 ± 0.112
0.554AlaTrp: 0.554 ± 0.027
2.516AlaTyr: 2.516 ± 0.063
0.0AlaXaa: 0.0 ± 0.0
Cys
1.062CysAla: 1.062 ± 0.039
0.279CysCys: 0.279 ± 0.02
0.851CysAsp: 0.851 ± 0.033
0.975CysGlu: 0.975 ± 0.039
0.647CysPhe: 0.647 ± 0.033
1.429CysGly: 1.429 ± 0.053
0.347CysHis: 0.347 ± 0.021
1.219CysIle: 1.219 ± 0.042
0.925CysLys: 0.925 ± 0.037
1.166CysLeu: 1.166 ± 0.046
0.471CysMet: 0.471 ± 0.023
0.632CysAsn: 0.632 ± 0.032
0.673CysPro: 0.673 ± 0.031
0.481CysGln: 0.481 ± 0.027
0.634CysArg: 0.634 ± 0.027
0.928CysSer: 0.928 ± 0.035
0.71CysThr: 0.71 ± 0.03
0.979CysVal: 0.979 ± 0.035
0.117CysTrp: 0.117 ± 0.012
0.617CysTyr: 0.617 ± 0.026
0.0CysXaa: 0.0 ± 0.0
Asp
4.083AspAla: 4.083 ± 0.086
0.845AspCys: 0.845 ± 0.037
2.7AspAsp: 2.7 ± 0.07
4.42AspGlu: 4.42 ± 0.088
2.726AspPhe: 2.726 ± 0.064
4.054AspGly: 4.054 ± 0.081
0.819AspHis: 0.819 ± 0.038
4.864AspIle: 4.864 ± 0.084
4.071AspLys: 4.071 ± 0.079
4.29AspLeu: 4.29 ± 0.082
1.783AspMet: 1.783 ± 0.048
2.271AspAsn: 2.271 ± 0.062
1.412AspPro: 1.412 ± 0.05
1.079AspGln: 1.079 ± 0.038
1.99AspArg: 1.99 ± 0.056
3.096AspSer: 3.096 ± 0.071
3.13AspThr: 3.13 ± 0.073
3.751AspVal: 3.751 ± 0.074
0.449AspTrp: 0.449 ± 0.029
2.781AspTyr: 2.781 ± 0.058
0.0AspXaa: 0.0 ± 0.0
Glu
5.51GluAla: 5.51 ± 0.102
0.879GluCys: 0.879 ± 0.032
4.431GluAsp: 4.431 ± 0.084
8.502GluGlu: 8.502 ± 0.16
2.554GluPhe: 2.554 ± 0.066
4.545GluGly: 4.545 ± 0.082
1.417GluHis: 1.417 ± 0.051
5.602GluIle: 5.602 ± 0.09
8.133GluLys: 8.133 ± 0.134
6.504GluLeu: 6.504 ± 0.11
2.47GluMet: 2.47 ± 0.061
4.374GluAsn: 4.374 ± 0.085
1.74GluPro: 1.74 ± 0.053
2.994GluGln: 2.994 ± 0.079
3.229GluArg: 3.229 ± 0.078
3.482GluSer: 3.482 ± 0.069
3.679GluThr: 3.679 ± 0.075
4.817GluVal: 4.817 ± 0.086
0.613GluTrp: 0.613 ± 0.028
3.098GluTyr: 3.098 ± 0.07
0.0GluXaa: 0.0 ± 0.0
Phe
2.784PheAla: 2.784 ± 0.071
0.824PheCys: 0.824 ± 0.033
2.477PheAsp: 2.477 ± 0.062
2.719PheGlu: 2.719 ± 0.063
1.991PhePhe: 1.991 ± 0.072
3.0PheGly: 3.0 ± 0.078
0.923PheHis: 0.923 ± 0.034
3.081PheIle: 3.081 ± 0.081
2.243PheLys: 2.243 ± 0.058
4.069PheLeu: 4.069 ± 0.095
1.235PheMet: 1.235 ± 0.04
1.488PheAsn: 1.488 ± 0.045
1.42PhePro: 1.42 ± 0.044
1.302PheGln: 1.302 ± 0.043
1.462PheArg: 1.462 ± 0.048
2.935PheSer: 2.935 ± 0.071
2.293PheThr: 2.293 ± 0.064
2.707PheVal: 2.707 ± 0.07
0.331PheTrp: 0.331 ± 0.02
1.746PheTyr: 1.746 ± 0.059
0.0PheXaa: 0.0 ± 0.0
Gly
5.009GlyAla: 5.009 ± 0.109
1.34GlyCys: 1.34 ± 0.045
3.304GlyAsp: 3.304 ± 0.067
4.624GlyGlu: 4.624 ± 0.085
2.964GlyPhe: 2.964 ± 0.067
4.668GlyGly: 4.668 ± 0.096
1.357GlyHis: 1.357 ± 0.048
6.474GlyIle: 6.474 ± 0.1
5.987GlyLys: 5.987 ± 0.098
5.519GlyLeu: 5.519 ± 0.105
2.519GlyMet: 2.519 ± 0.056
2.981GlyAsn: 2.981 ± 0.064
1.338GlyPro: 1.338 ± 0.043
2.172GlyGln: 2.172 ± 0.045
2.934GlyArg: 2.934 ± 0.071
3.868GlySer: 3.868 ± 0.075
4.335GlyThr: 4.335 ± 0.081
4.866GlyVal: 4.866 ± 0.095
0.6GlyTrp: 0.6 ± 0.029
3.181GlyTyr: 3.181 ± 0.068
0.0GlyXaa: 0.0 ± 0.0
His
1.051HisAla: 1.051 ± 0.04
0.328HisCys: 0.328 ± 0.022
0.821HisAsp: 0.821 ± 0.042
1.108HisGlu: 1.108 ± 0.05
0.967HisPhe: 0.967 ± 0.049
1.342HisGly: 1.342 ± 0.046
0.431HisHis: 0.431 ± 0.036
1.583HisIle: 1.583 ± 0.048
1.11HisLys: 1.11 ± 0.04
1.604HisLeu: 1.604 ± 0.047
0.569HisMet: 0.569 ± 0.028
0.787HisAsn: 0.787 ± 0.03
0.883HisPro: 0.883 ± 0.037
0.558HisGln: 0.558 ± 0.028
0.722HisArg: 0.722 ± 0.031
1.011HisSer: 1.011 ± 0.038
0.959HisThr: 0.959 ± 0.042
1.079HisVal: 1.079 ± 0.045
0.158HisTrp: 0.158 ± 0.014
0.802HisTyr: 0.802 ± 0.04
0.0HisXaa: 0.0 ± 0.0
Ile
5.927IleAla: 5.927 ± 0.108
1.322IleCys: 1.322 ± 0.047
4.11IleAsp: 4.11 ± 0.083
5.257IleGlu: 5.257 ± 0.09
3.268IlePhe: 3.268 ± 0.079
5.453IleGly: 5.453 ± 0.106
1.5IleHis: 1.5 ± 0.052
5.764IleIle: 5.764 ± 0.114
5.088IleLys: 5.088 ± 0.089
7.479IleLeu: 7.479 ± 0.114
2.12IleMet: 2.12 ± 0.061
3.063IleAsn: 3.063 ± 0.065
3.138IlePro: 3.138 ± 0.067
2.309IleGln: 2.309 ± 0.063
3.324IleArg: 3.324 ± 0.067
5.115IleSer: 5.115 ± 0.09
4.32IleThr: 4.32 ± 0.081
5.122IleVal: 5.122 ± 0.095
0.552IleTrp: 0.552 ± 0.03
3.049IleTyr: 3.049 ± 0.069
0.0IleXaa: 0.0 ± 0.0
Lys
5.753LysAla: 5.753 ± 0.094
0.838LysCys: 0.838 ± 0.038
4.468LysAsp: 4.468 ± 0.077
8.454LysGlu: 8.454 ± 0.132
2.123LysPhe: 2.123 ± 0.054
4.63LysGly: 4.63 ± 0.096
1.162LysHis: 1.162 ± 0.034
5.608LysIle: 5.608 ± 0.094
8.677LysLys: 8.677 ± 0.157
5.812LysLeu: 5.812 ± 0.09
2.598LysMet: 2.598 ± 0.064
4.469LysAsn: 4.469 ± 0.082
2.048LysPro: 2.048 ± 0.049
2.727LysGln: 2.727 ± 0.077
3.244LysArg: 3.244 ± 0.068
3.69LysSer: 3.69 ± 0.084
4.14LysThr: 4.14 ± 0.095
5.217LysVal: 5.217 ± 0.1
0.603LysTrp: 0.603 ± 0.028
3.241LysTyr: 3.241 ± 0.069
0.0LysXaa: 0.0 ± 0.0
Leu
6.252LeuAla: 6.252 ± 0.11
1.424LeuCys: 1.424 ± 0.052
4.664LeuAsp: 4.664 ± 0.078
6.198LeuGlu: 6.198 ± 0.11
3.801LeuPhe: 3.801 ± 0.089
5.61LeuGly: 5.61 ± 0.108
1.627LeuHis: 1.627 ± 0.051
6.032LeuIle: 6.032 ± 0.097
6.791LeuLys: 6.791 ± 0.114
8.216LeuLeu: 8.216 ± 0.142
2.606LeuMet: 2.606 ± 0.056
3.738LeuAsn: 3.738 ± 0.073
3.389LeuPro: 3.389 ± 0.067
2.562LeuGln: 2.562 ± 0.059
3.459LeuArg: 3.459 ± 0.074
6.392LeuSer: 6.392 ± 0.11
4.733LeuThr: 4.733 ± 0.087
5.038LeuVal: 5.038 ± 0.094
0.66LeuTrp: 0.66 ± 0.032
3.203LeuTyr: 3.203 ± 0.082
0.0LeuXaa: 0.0 ± 0.0
Met
2.568MetAla: 2.568 ± 0.065
0.354MetCys: 0.354 ± 0.023
1.85MetAsp: 1.85 ± 0.049
2.606MetGlu: 2.606 ± 0.061
0.971MetPhe: 0.971 ± 0.035
2.133MetGly: 2.133 ± 0.053
0.457MetHis: 0.457 ± 0.023
2.377MetIle: 2.377 ± 0.056
2.666MetLys: 2.666 ± 0.065
2.64MetLeu: 2.64 ± 0.071
0.96MetMet: 0.96 ± 0.037
1.648MetAsn: 1.648 ± 0.044
1.129MetPro: 1.129 ± 0.04
1.006MetGln: 1.006 ± 0.04
1.234MetArg: 1.234 ± 0.039
1.714MetSer: 1.714 ± 0.049
1.621MetThr: 1.621 ± 0.042
1.833MetVal: 1.833 ± 0.053
0.209MetTrp: 0.209 ± 0.019
0.862MetTyr: 0.862 ± 0.034
0.0MetXaa: 0.0 ± 0.0
Asn
3.093AsnAla: 3.093 ± 0.067
0.649AsnCys: 0.649 ± 0.03
2.118AsnAsp: 2.118 ± 0.058
2.881AsnGlu: 2.881 ± 0.065
1.642AsnPhe: 1.642 ± 0.051
3.478AsnGly: 3.478 ± 0.078
0.926AsnHis: 0.926 ± 0.035
3.781AsnIle: 3.781 ± 0.07
3.238AsnLys: 3.238 ± 0.075
3.856AsnLeu: 3.856 ± 0.082
1.326AsnMet: 1.326 ± 0.041
2.09AsnAsn: 2.09 ± 0.075
1.997AsnPro: 1.997 ± 0.058
1.462AsnGln: 1.462 ± 0.045
1.998AsnArg: 1.998 ± 0.063
2.403AsnSer: 2.403 ± 0.057
2.58AsnThr: 2.58 ± 0.063
2.935AsnVal: 2.935 ± 0.068
0.356AsnTrp: 0.356 ± 0.02
1.843AsnTyr: 1.843 ± 0.058
0.0AsnXaa: 0.0 ± 0.0
Pro
2.362ProAla: 2.362 ± 0.058
0.424ProCys: 0.424 ± 0.025
2.103ProAsp: 2.103 ± 0.055
3.264ProGlu: 3.264 ± 0.074
1.55ProPhe: 1.55 ± 0.049
2.324ProGly: 2.324 ± 0.058
0.515ProHis: 0.515 ± 0.027
2.157ProIle: 2.157 ± 0.059
1.972ProLys: 1.972 ± 0.056
2.639ProLeu: 2.639 ± 0.062
0.826ProMet: 0.826 ± 0.036
1.183ProAsn: 1.183 ± 0.043
0.624ProPro: 0.624 ± 0.029
0.968ProGln: 0.968 ± 0.04
0.891ProArg: 0.891 ± 0.033
1.775ProSer: 1.775 ± 0.055
1.406ProThr: 1.406 ± 0.05
2.877ProVal: 2.877 ± 0.071
0.271ProTrp: 0.271 ± 0.021
1.42ProTyr: 1.42 ± 0.052
0.0ProXaa: 0.0 ± 0.0
Gln
2.331GlnAla: 2.331 ± 0.051
0.418GlnCys: 0.418 ± 0.023
1.438GlnAsp: 1.438 ± 0.046
2.728GlnGlu: 2.728 ± 0.069
1.099GlnPhe: 1.099 ± 0.04
1.897GlnGly: 1.897 ± 0.056
0.462GlnHis: 0.462 ± 0.029
2.768GlnIle: 2.768 ± 0.065
3.053GlnLys: 3.053 ± 0.073
2.624GlnLeu: 2.624 ± 0.058
1.076GlnMet: 1.076 ± 0.039
1.618GlnAsn: 1.618 ± 0.053
0.864GlnPro: 0.864 ± 0.035
1.156GlnGln: 1.156 ± 0.051
1.28GlnArg: 1.28 ± 0.041
1.614GlnSer: 1.614 ± 0.052
1.544GlnThr: 1.544 ± 0.048
1.892GlnVal: 1.892 ± 0.061
0.252GlnTrp: 0.252 ± 0.019
1.383GlnTyr: 1.383 ± 0.041
0.0GlnXaa: 0.0 ± 0.0
Arg
2.42ArgAla: 2.42 ± 0.055
0.506ArgCys: 0.506 ± 0.03
1.965ArgAsp: 1.965 ± 0.055
3.629ArgGlu: 3.629 ± 0.079
1.673ArgPhe: 1.673 ± 0.054
2.348ArgGly: 2.348 ± 0.067
0.694ArgHis: 0.694 ± 0.037
3.252ArgIle: 3.252 ± 0.067
3.69ArgLys: 3.69 ± 0.08
3.351ArgLeu: 3.351 ± 0.069
1.357ArgMet: 1.357 ± 0.04
1.993ArgAsn: 1.993 ± 0.067
1.25ArgPro: 1.25 ± 0.037
1.534ArgGln: 1.534 ± 0.043
1.918ArgArg: 1.918 ± 0.054
1.937ArgSer: 1.937 ± 0.049
2.054ArgThr: 2.054 ± 0.05
2.508ArgVal: 2.508 ± 0.061
0.292ArgTrp: 0.292 ± 0.021
1.646ArgTyr: 1.646 ± 0.051
0.0ArgXaa: 0.0 ± 0.0
Ser
3.985SerAla: 3.985 ± 0.09
0.902SerCys: 0.902 ± 0.036
3.252SerAsp: 3.252 ± 0.081
3.947SerGlu: 3.947 ± 0.093
2.663SerPhe: 2.663 ± 0.07
4.711SerGly: 4.711 ± 0.082
1.034SerHis: 1.034 ± 0.043
4.268SerIle: 4.268 ± 0.076
3.874SerLys: 3.874 ± 0.082
5.039SerLeu: 5.039 ± 0.087
1.767SerMet: 1.767 ± 0.053
2.437SerAsn: 2.437 ± 0.07
1.657SerPro: 1.657 ± 0.043
1.85SerGln: 1.85 ± 0.064
2.386SerArg: 2.386 ± 0.055
3.878SerSer: 3.878 ± 0.106
2.942SerThr: 2.942 ± 0.08
4.367SerVal: 4.367 ± 0.083
0.481SerTrp: 0.481 ± 0.028
2.505SerTyr: 2.505 ± 0.058
0.0SerXaa: 0.0 ± 0.0
Thr
4.18ThrAla: 4.18 ± 0.084
0.729ThrCys: 0.729 ± 0.03
3.0ThrAsp: 3.0 ± 0.07
3.77ThrGlu: 3.77 ± 0.074
2.134ThrPhe: 2.134 ± 0.051
4.622ThrGly: 4.622 ± 0.088
0.876ThrHis: 0.876 ± 0.039
4.073ThrIle: 4.073 ± 0.072
3.733ThrLys: 3.733 ± 0.079
4.768ThrLeu: 4.768 ± 0.079
1.423ThrMet: 1.423 ± 0.044
2.152ThrAsn: 2.152 ± 0.049
1.994ThrPro: 1.994 ± 0.055
1.496ThrGln: 1.496 ± 0.049
1.814ThrArg: 1.814 ± 0.053
3.113ThrSer: 3.113 ± 0.091
3.138ThrThr: 3.138 ± 0.094
4.254ThrVal: 4.254 ± 0.09
0.397ThrTrp: 0.397 ± 0.025
1.964ThrTyr: 1.964 ± 0.06
0.0ThrXaa: 0.0 ± 0.0
Val
4.817ValAla: 4.817 ± 0.103
1.215ValCys: 1.215 ± 0.042
3.823ValAsp: 3.823 ± 0.078
4.668ValGlu: 4.668 ± 0.09
3.003ValPhe: 3.003 ± 0.071
4.341ValGly: 4.341 ± 0.088
1.115ValHis: 1.115 ± 0.039
5.391ValIle: 5.391 ± 0.094
5.107ValLys: 5.107 ± 0.104
6.186ValLeu: 6.186 ± 0.104
2.009ValMet: 2.009 ± 0.059
2.811ValAsn: 2.811 ± 0.053
2.456ValPro: 2.456 ± 0.054
1.888ValGln: 1.888 ± 0.058
2.685ValArg: 2.685 ± 0.059
4.397ValSer: 4.397 ± 0.079
4.063ValThr: 4.063 ± 0.085
4.821ValVal: 4.821 ± 0.097
0.532ValTrp: 0.532 ± 0.026
2.56ValTyr: 2.56 ± 0.054
0.0ValXaa: 0.0 ± 0.0
Trp
0.403TrpAla: 0.403 ± 0.024
0.118TrpCys: 0.118 ± 0.012
0.49TrpAsp: 0.49 ± 0.028
0.563TrpGlu: 0.563 ± 0.028
0.371TrpPhe: 0.371 ± 0.024
0.551TrpGly: 0.551 ± 0.028
0.165TrpHis: 0.165 ± 0.015
0.612TrpIle: 0.612 ± 0.035
0.748TrpLys: 0.748 ± 0.035
0.728TrpLeu: 0.728 ± 0.031
0.296TrpMet: 0.296 ± 0.022
0.502TrpAsn: 0.502 ± 0.027
0.167TrpPro: 0.167 ± 0.014
0.252TrpGln: 0.252 ± 0.017
0.311TrpArg: 0.311 ± 0.021
0.356TrpSer: 0.356 ± 0.023
0.343TrpThr: 0.343 ± 0.022
0.437TrpVal: 0.437 ± 0.025
0.08TrpTrp: 0.08 ± 0.01
0.321TrpTyr: 0.321 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.546TyrAla: 2.546 ± 0.068
0.662TyrCys: 0.662 ± 0.03
2.484TyrAsp: 2.484 ± 0.05
3.033TyrGlu: 3.033 ± 0.081
1.863TyrPhe: 1.863 ± 0.05
2.86TyrGly: 2.86 ± 0.058
0.915TyrHis: 0.915 ± 0.037
2.924TyrIle: 2.924 ± 0.078
2.824TyrLys: 2.824 ± 0.068
3.448TyrLeu: 3.448 ± 0.075
1.138TyrMet: 1.138 ± 0.044
1.893TyrAsn: 1.893 ± 0.058
1.419TyrPro: 1.419 ± 0.041
1.447TyrGln: 1.447 ± 0.048
1.844TyrArg: 1.844 ± 0.052
2.316TyrSer: 2.316 ± 0.065
2.248TyrThr: 2.248 ± 0.051
2.568TyrVal: 2.568 ± 0.063
0.307TyrTrp: 0.307 ± 0.02
1.929TyrTyr: 1.929 ± 0.048
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2309 proteins (735250 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski