Amino acid dipepetide frequency for Nerine latent virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.944AlaAla: 2.944 ± 1.014
0.736AlaCys: 0.736 ± 0.388
2.944AlaAsp: 2.944 ± 1.553
3.312AlaGlu: 3.312 ± 0.725
3.312AlaPhe: 3.312 ± 1.134
1.84AlaGly: 1.84 ± 0.615
0.368AlaHis: 0.368 ± 0.701
5.889AlaIle: 5.889 ± 1.813
5.889AlaLys: 5.889 ± 1.219
4.049AlaLeu: 4.049 ± 0.812
2.576AlaMet: 2.576 ± 0.781
2.576AlaAsn: 2.576 ± 1.123
2.208AlaPro: 2.208 ± 0.919
1.472AlaGln: 1.472 ± 0.507
1.84AlaArg: 1.84 ± 1.684
3.312AlaSer: 3.312 ± 1.499
4.049AlaThr: 4.049 ± 1.794
2.944AlaVal: 2.944 ± 0.59
0.0AlaTrp: 0.0 ± 0.0
2.576AlaTyr: 2.576 ± 0.497
0.0AlaXaa: 0.0 ± 0.0
Cys
1.472CysAla: 1.472 ± 0.507
0.0CysCys: 0.0 ± 0.0
0.368CysAsp: 0.368 ± 0.588
2.208CysGlu: 2.208 ± 0.764
2.576CysPhe: 2.576 ± 1.359
1.472CysGly: 1.472 ± 1.165
0.368CysHis: 0.368 ± 0.701
1.84CysIle: 1.84 ± 0.644
2.208CysLys: 2.208 ± 0.758
0.736CysLeu: 0.736 ± 1.414
0.368CysMet: 0.368 ± 0.194
1.104CysAsn: 1.104 ± 0.55
0.736CysPro: 0.736 ± 0.388
0.736CysGln: 0.736 ± 0.884
1.472CysArg: 1.472 ± 0.884
1.472CysSer: 1.472 ± 0.81
2.208CysThr: 2.208 ± 1.546
1.84CysVal: 1.84 ± 0.827
0.368CysTrp: 0.368 ± 0.194
1.104CysTyr: 1.104 ± 1.597
0.368CysXaa: 0.368 ± 0.701
Asp
4.785AspAla: 4.785 ± 1.428
1.472AspCys: 1.472 ± 0.567
3.681AspAsp: 3.681 ± 1.454
5.153AspGlu: 5.153 ± 2.199
4.049AspPhe: 4.049 ± 1.663
4.785AspGly: 4.785 ± 1.956
1.104AspHis: 1.104 ± 0.825
4.049AspIle: 4.049 ± 0.664
3.312AspLys: 3.312 ± 1.11
4.417AspLeu: 4.417 ± 1.826
0.736AspMet: 0.736 ± 0.459
1.84AspAsn: 1.84 ± 0.942
2.944AspPro: 2.944 ± 0.95
0.736AspGln: 0.736 ± 0.388
1.84AspArg: 1.84 ± 1.324
2.944AspSer: 2.944 ± 1.014
2.944AspThr: 2.944 ± 1.986
1.84AspVal: 1.84 ± 0.86
0.736AspTrp: 0.736 ± 0.388
1.84AspTyr: 1.84 ± 0.855
0.736AspXaa: 0.736 ± 0.388
Glu
4.417GluAla: 4.417 ± 2.329
1.104GluCys: 1.104 ± 0.582
3.312GluAsp: 3.312 ± 1.242
7.729GluGlu: 7.729 ± 1.606
3.312GluPhe: 3.312 ± 1.4
4.049GluGly: 4.049 ± 1.363
1.104GluHis: 1.104 ± 0.582
5.153GluIle: 5.153 ± 1.218
7.729GluLys: 7.729 ± 2.421
3.681GluLeu: 3.681 ± 1.419
1.84GluMet: 1.84 ± 0.615
4.417GluAsn: 4.417 ± 0.961
2.576GluPro: 2.576 ± 0.497
2.576GluGln: 2.576 ± 0.948
3.681GluArg: 3.681 ± 2.073
4.417GluSer: 4.417 ± 1.418
4.417GluThr: 4.417 ± 0.938
5.521GluVal: 5.521 ± 1.336
0.368GluTrp: 0.368 ± 0.194
4.785GluTyr: 4.785 ± 2.129
0.0GluXaa: 0.0 ± 0.0
Phe
3.681PheAla: 3.681 ± 1.533
1.104PheCys: 1.104 ± 0.46
4.417PheAsp: 4.417 ± 0.765
4.049PheGlu: 4.049 ± 2.135
2.944PhePhe: 2.944 ± 1.553
3.681PheGly: 3.681 ± 2.268
1.472PheHis: 1.472 ± 1.516
2.944PheIle: 2.944 ± 1.072
3.312PheLys: 3.312 ± 1.135
8.833PheLeu: 8.833 ± 2.943
1.104PheMet: 1.104 ± 0.582
2.944PheAsn: 2.944 ± 1.092
1.84PhePro: 1.84 ± 1.394
2.576PheGln: 2.576 ± 1.359
2.944PheArg: 2.944 ± 0.736
5.889PheSer: 5.889 ± 1.558
4.049PheThr: 4.049 ± 1.052
3.312PheVal: 3.312 ± 1.452
0.368PheTrp: 0.368 ± 0.194
1.84PheTyr: 1.84 ± 1.197
0.0PheXaa: 0.0 ± 0.0
Gly
0.736GlyAla: 0.736 ± 0.491
1.472GlyCys: 1.472 ± 1.31
5.153GlyAsp: 5.153 ± 0.891
6.257GlyGlu: 6.257 ± 1.999
3.681GlyPhe: 3.681 ± 0.849
2.208GlyGly: 2.208 ± 1.223
1.104GlyHis: 1.104 ± 0.582
1.84GlyIle: 1.84 ± 0.841
5.153GlyLys: 5.153 ± 1.523
4.049GlyLeu: 4.049 ± 2.965
1.472GlyMet: 1.472 ± 0.776
1.84GlyAsn: 1.84 ± 0.518
0.736GlyPro: 0.736 ± 1.414
1.104GlyGln: 1.104 ± 0.582
3.312GlyArg: 3.312 ± 0.657
3.312GlySer: 3.312 ± 1.11
2.944GlyThr: 2.944 ± 1.705
2.944GlyVal: 2.944 ± 0.95
0.736GlyTrp: 0.736 ± 0.491
1.472GlyTyr: 1.472 ± 0.567
0.0GlyXaa: 0.0 ± 0.0
His
0.0HisAla: 0.0 ± 0.0
0.0HisCys: 0.0 ± 0.0
0.368HisAsp: 0.368 ± 0.194
1.84HisGlu: 1.84 ± 0.767
0.368HisPhe: 0.368 ± 0.978
0.368HisGly: 0.368 ± 0.978
1.104HisHis: 1.104 ± 1.162
1.472HisIle: 1.472 ± 0.713
1.104HisLys: 1.104 ± 0.71
1.84HisLeu: 1.84 ± 0.644
0.0HisMet: 0.0 ± 0.0
0.368HisAsn: 0.368 ± 0.194
0.736HisPro: 0.736 ± 0.884
0.368HisGln: 0.368 ± 0.194
0.736HisArg: 0.736 ± 0.931
3.681HisSer: 3.681 ± 1.446
0.368HisThr: 0.368 ± 0.978
0.736HisVal: 0.736 ± 0.599
0.0HisTrp: 0.0 ± 0.0
1.84HisTyr: 1.84 ± 0.97
0.0HisXaa: 0.0 ± 0.0
Ile
3.681IleAla: 3.681 ± 2.138
2.944IleCys: 2.944 ± 1.621
5.521IleAsp: 5.521 ± 0.812
4.785IleGlu: 4.785 ± 1.674
4.049IlePhe: 4.049 ± 1.052
4.049IleGly: 4.049 ± 3.183
1.84IleHis: 1.84 ± 0.841
4.417IleIle: 4.417 ± 2.387
6.257IleLys: 6.257 ± 1.704
6.993IleLeu: 6.993 ± 1.786
2.208IleMet: 2.208 ± 1.165
2.944IleAsn: 2.944 ± 1.885
1.104IlePro: 1.104 ± 0.825
1.84IleGln: 1.84 ± 0.767
3.681IleArg: 3.681 ± 2.682
4.417IleSer: 4.417 ± 1.826
4.049IleThr: 4.049 ± 0.874
2.208IleVal: 2.208 ± 0.469
0.0IleTrp: 0.0 ± 0.0
2.944IleTyr: 2.944 ± 0.8
0.0IleXaa: 0.0 ± 0.0
Lys
4.417LysAla: 4.417 ± 1.338
1.104LysCys: 1.104 ± 1.93
3.312LysAsp: 3.312 ± 2.945
6.993LysGlu: 6.993 ± 2.164
4.785LysPhe: 4.785 ± 2.015
5.153LysGly: 5.153 ± 1.445
0.368LysHis: 0.368 ± 0.194
6.625LysIle: 6.625 ± 1.68
7.361LysLys: 7.361 ± 2.045
8.833LysLeu: 8.833 ± 2.014
2.576LysMet: 2.576 ± 0.92
3.681LysAsn: 3.681 ± 1.454
2.576LysPro: 2.576 ± 0.854
1.472LysGln: 1.472 ± 0.507
5.521LysArg: 5.521 ± 1.317
5.153LysSer: 5.153 ± 2.898
2.944LysThr: 2.944 ± 0.8
4.785LysVal: 4.785 ± 1.441
0.368LysTrp: 0.368 ± 0.194
2.944LysTyr: 2.944 ± 1.132
1.472LysXaa: 1.472 ± 0.982
Leu
4.049LeuAla: 4.049 ± 1.639
4.049LeuCys: 4.049 ± 2.118
5.889LeuAsp: 5.889 ± 1.461
7.361LeuGlu: 7.361 ± 2.67
4.417LeuPhe: 4.417 ± 1.837
5.889LeuGly: 5.889 ± 1.595
0.368LeuHis: 0.368 ± 0.194
6.993LeuIle: 6.993 ± 1.461
6.257LeuLys: 6.257 ± 1.717
6.993LeuLeu: 6.993 ± 1.549
2.576LeuMet: 2.576 ± 1.359
5.521LeuAsn: 5.521 ± 1.783
4.049LeuPro: 4.049 ± 1.611
2.944LeuGln: 2.944 ± 1.092
6.625LeuArg: 6.625 ± 1.238
4.785LeuSer: 4.785 ± 2.682
6.257LeuThr: 6.257 ± 2.872
4.785LeuVal: 4.785 ± 2.37
0.0LeuTrp: 0.0 ± 0.0
2.208LeuTyr: 2.208 ± 2.499
0.0LeuXaa: 0.0 ± 0.0
Met
1.84MetAla: 1.84 ± 0.97
1.104MetCys: 1.104 ± 0.582
1.104MetAsp: 1.104 ± 0.77
1.472MetGlu: 1.472 ± 0.713
1.104MetPhe: 1.104 ± 0.773
1.104MetGly: 1.104 ± 0.582
0.0MetHis: 0.0 ± 0.0
1.472MetIle: 1.472 ± 1.452
2.208MetLys: 2.208 ± 0.863
2.576MetLeu: 2.576 ± 1.359
0.0MetMet: 0.0 ± 0.0
0.0MetAsn: 0.0 ± 0.0
1.84MetPro: 1.84 ± 0.855
0.736MetGln: 0.736 ± 0.388
2.576MetArg: 2.576 ± 0.771
1.84MetSer: 1.84 ± 0.931
0.368MetThr: 0.368 ± 0.194
0.0MetVal: 0.0 ± 0.0
0.0MetTrp: 0.0 ± 0.0
0.736MetTyr: 0.736 ± 0.491
0.368MetXaa: 0.368 ± 0.194
Asn
2.576AsnAla: 2.576 ± 0.497
1.472AsnCys: 1.472 ± 1.04
3.681AsnAsp: 3.681 ± 0.917
2.576AsnGlu: 2.576 ± 1.676
5.153AsnPhe: 5.153 ± 1.378
1.472AsnGly: 1.472 ± 0.776
1.104AsnHis: 1.104 ± 0.582
3.681AsnIle: 3.681 ± 1.005
3.681AsnLys: 3.681 ± 1.286
5.521AsnLeu: 5.521 ± 1.417
0.736AsnMet: 0.736 ± 0.491
2.944AsnAsn: 2.944 ± 0.95
0.368AsnPro: 0.368 ± 0.588
2.208AsnGln: 2.208 ± 0.469
2.576AsnArg: 2.576 ± 0.771
3.681AsnSer: 3.681 ± 2.781
1.84AsnThr: 1.84 ± 2.772
0.736AsnVal: 0.736 ± 0.388
0.368AsnTrp: 0.368 ± 0.588
1.84AsnTyr: 1.84 ± 0.615
0.0AsnXaa: 0.0 ± 0.0
Pro
2.208ProAla: 2.208 ± 1.472
1.104ProCys: 1.104 ± 0.582
2.944ProAsp: 2.944 ± 1.775
2.208ProGlu: 2.208 ± 0.919
1.84ProPhe: 1.84 ± 1.072
1.84ProGly: 1.84 ± 0.518
0.736ProHis: 0.736 ± 1.956
2.576ProIle: 2.576 ± 0.497
1.84ProLys: 1.84 ± 1.01
2.944ProLeu: 2.944 ± 0.983
0.368ProMet: 0.368 ± 0.588
1.472ProAsn: 1.472 ± 1.755
2.944ProPro: 2.944 ± 2.96
1.104ProGln: 1.104 ± 0.46
1.84ProArg: 1.84 ± 0.97
3.312ProSer: 3.312 ± 1.803
2.208ProThr: 2.208 ± 1.213
1.104ProVal: 1.104 ± 0.46
0.368ProTrp: 0.368 ± 0.194
0.736ProTyr: 0.736 ± 0.388
0.0ProXaa: 0.0 ± 0.0
Gln
1.104GlnAla: 1.104 ± 0.46
0.0GlnCys: 0.0 ± 0.0
1.472GlnAsp: 1.472 ± 0.776
2.208GlnGlu: 2.208 ± 0.763
1.472GlnPhe: 1.472 ± 0.776
1.84GlnGly: 1.84 ± 1.324
1.104GlnHis: 1.104 ± 0.825
0.736GlnIle: 0.736 ± 0.599
3.681GlnLys: 3.681 ± 1.941
3.312GlnLeu: 3.312 ± 1.04
0.0GlnMet: 0.0 ± 0.0
2.208GlnAsn: 2.208 ± 0.913
1.472GlnPro: 1.472 ± 0.88
1.104GlnGln: 1.104 ± 0.998
0.0GlnArg: 0.0 ± 0.0
2.944GlnSer: 2.944 ± 1.132
1.84GlnThr: 1.84 ± 0.518
1.472GlnVal: 1.472 ± 0.507
0.368GlnTrp: 0.368 ± 0.194
0.368GlnTyr: 0.368 ± 0.194
0.0GlnXaa: 0.0 ± 0.0
Arg
2.576ArgAla: 2.576 ± 1.883
0.736ArgCys: 0.736 ± 0.758
1.104ArgAsp: 1.104 ± 0.46
4.417ArgGlu: 4.417 ± 1.54
5.153ArgPhe: 5.153 ± 0.815
1.472ArgGly: 1.472 ± 1.199
1.104ArgHis: 1.104 ± 0.55
2.944ArgIle: 2.944 ± 1.264
4.049ArgLys: 4.049 ± 1.164
4.417ArgLeu: 4.417 ± 1.458
1.104ArgMet: 1.104 ± 0.71
5.153ArgAsn: 5.153 ± 2.628
2.208ArgPro: 2.208 ± 1.848
1.472ArgGln: 1.472 ± 1.786
3.681ArgArg: 3.681 ± 2.592
5.889ArgSer: 5.889 ± 1.26
2.576ArgThr: 2.576 ± 0.786
1.84ArgVal: 1.84 ± 0.86
1.104ArgTrp: 1.104 ± 0.55
2.208ArgTyr: 2.208 ± 0.913
0.0ArgXaa: 0.0 ± 0.0
Ser
4.785SerAla: 4.785 ± 1.517
1.84SerCys: 1.84 ± 0.97
5.521SerAsp: 5.521 ± 1.295
5.889SerGlu: 5.889 ± 2.107
3.681SerPhe: 3.681 ± 1.212
4.049SerGly: 4.049 ± 0.938
1.104SerHis: 1.104 ± 0.582
4.785SerIle: 4.785 ± 0.995
8.465SerLys: 8.465 ± 2.252
6.257SerLeu: 6.257 ± 1.733
0.736SerMet: 0.736 ± 1.117
3.312SerAsn: 3.312 ± 2.841
1.84SerPro: 1.84 ± 0.615
2.208SerGln: 2.208 ± 1.403
2.944SerArg: 2.944 ± 2.051
4.785SerSer: 4.785 ± 0.977
3.681SerThr: 3.681 ± 1.902
1.472SerVal: 1.472 ± 0.88
0.0SerTrp: 0.0 ± 0.0
3.312SerTyr: 3.312 ± 0.929
1.472SerXaa: 1.472 ± 0.776
Thr
2.208ThrAla: 2.208 ± 1.628
1.104ThrCys: 1.104 ± 0.77
0.736ThrAsp: 0.736 ± 0.388
1.472ThrGlu: 1.472 ± 1.608
6.993ThrPhe: 6.993 ± 2.103
4.049ThrGly: 4.049 ± 1.322
1.84ThrHis: 1.84 ± 0.615
3.312ThrIle: 3.312 ± 1.625
2.944ThrLys: 2.944 ± 0.736
5.521ThrLeu: 5.521 ± 1.404
1.104ThrMet: 1.104 ± 1.28
2.944ThrAsn: 2.944 ± 2.292
1.104ThrPro: 1.104 ± 1.281
1.472ThrGln: 1.472 ± 0.776
2.944ThrArg: 2.944 ± 2.059
4.417ThrSer: 4.417 ± 1.888
2.576ThrThr: 2.576 ± 1.307
3.681ThrVal: 3.681 ± 1.303
0.368ThrTrp: 0.368 ± 0.194
1.84ThrTyr: 1.84 ± 0.644
0.368ThrXaa: 0.368 ± 0.194
Val
4.049ValAla: 4.049 ± 2.001
1.472ValCys: 1.472 ± 0.567
2.208ValAsp: 2.208 ± 1.165
3.312ValGlu: 3.312 ± 1.907
1.84ValPhe: 1.84 ± 0.841
0.736ValGly: 0.736 ± 0.388
0.368ValHis: 0.368 ± 0.194
4.785ValIle: 4.785 ± 1.173
2.576ValLys: 2.576 ± 0.91
5.889ValLeu: 5.889 ± 2.321
0.736ValMet: 0.736 ± 0.657
1.104ValAsn: 1.104 ± 0.55
2.944ValPro: 2.944 ± 1.71
0.736ValGln: 0.736 ± 0.388
2.576ValArg: 2.576 ± 1.359
3.312ValSer: 3.312 ± 1.747
1.84ValThr: 1.84 ± 1.248
2.944ValVal: 2.944 ± 1.175
0.736ValTrp: 0.736 ± 1.176
1.472ValTyr: 1.472 ± 0.713
0.368ValXaa: 0.368 ± 0.701
Trp
0.0TrpAla: 0.0 ± 0.0
0.368TrpCys: 0.368 ± 0.194
0.368TrpAsp: 0.368 ± 0.588
0.0TrpGlu: 0.0 ± 0.0
0.368TrpPhe: 0.368 ± 0.194
0.368TrpGly: 0.368 ± 0.194
0.0TrpHis: 0.0 ± 0.0
0.368TrpIle: 0.368 ± 0.194
0.368TrpLys: 0.368 ± 0.701
0.736TrpLeu: 0.736 ± 0.388
0.0TrpMet: 0.0 ± 0.0
0.368TrpAsn: 0.368 ± 0.588
0.0TrpPro: 0.0 ± 0.0
0.736TrpGln: 0.736 ± 0.491
0.736TrpArg: 0.736 ± 0.491
1.104TrpSer: 1.104 ± 0.582
0.0TrpThr: 0.0 ± 0.0
0.368TrpVal: 0.368 ± 0.194
0.0TrpTrp: 0.0 ± 0.0
0.368TrpTyr: 0.368 ± 0.194
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.208TyrAla: 2.208 ± 0.795
1.472TyrCys: 1.472 ± 0.947
1.84TyrAsp: 1.84 ± 0.644
2.208TyrGlu: 2.208 ± 0.863
1.472TyrPhe: 1.472 ± 1.165
1.104TyrGly: 1.104 ± 0.46
0.368TyrHis: 0.368 ± 0.849
3.681TyrIle: 3.681 ± 0.917
4.049TyrLys: 4.049 ± 2.215
4.417TyrLeu: 4.417 ± 0.961
1.84TyrMet: 1.84 ± 0.615
1.104TyrAsn: 1.104 ± 0.582
1.472TyrPro: 1.472 ± 0.776
0.736TyrGln: 0.736 ± 0.599
3.312TyrArg: 3.312 ± 0.881
1.472TyrSer: 1.472 ± 1.04
2.208TyrThr: 2.208 ± 1.586
1.472TyrVal: 1.472 ± 0.776
0.368TyrTrp: 0.368 ± 0.194
1.472TyrTyr: 1.472 ± 0.776
0.0TyrXaa: 0.0 ± 0.0
Xaa
1.104XaaAla: 1.104 ± 0.46
0.368XaaCys: 0.368 ± 0.701
0.0XaaAsp: 0.0 ± 0.0
0.736XaaGlu: 0.736 ± 0.388
0.736XaaPhe: 0.736 ± 0.599
0.0XaaGly: 0.0 ± 0.0
0.368XaaHis: 0.368 ± 0.194
0.368XaaIle: 0.368 ± 0.588
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.368XaaAsn: 0.368 ± 0.194
0.0XaaPro: 0.0 ± 0.0
0.368XaaGln: 0.368 ± 0.194
0.368XaaArg: 0.368 ± 0.194
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.368XaaTyr: 0.368 ± 0.194
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6 proteins (2718 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski