Amino acid dipepetide frequency for Microcystis phage vB_MaeS-yong1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
18.606AlaAla: 18.606 ± 3.969
0.964AlaCys: 0.964 ± 0.278
7.116AlaAsp: 7.116 ± 0.667
9.859AlaGlu: 9.859 ± 1.283
3.558AlaPhe: 3.558 ± 0.437
9.637AlaGly: 9.637 ± 1.197
1.927AlaHis: 1.927 ± 0.465
5.263AlaIle: 5.263 ± 0.721
3.558AlaLys: 3.558 ± 0.577
12.009AlaLeu: 12.009 ± 1.215
4.003AlaMet: 4.003 ± 0.587
2.595AlaAsn: 2.595 ± 0.433
6.597AlaPro: 6.597 ± 1.166
6.672AlaGln: 6.672 ± 1.307
9.192AlaArg: 9.192 ± 0.877
6.004AlaSer: 6.004 ± 0.77
7.709AlaThr: 7.709 ± 1.127
8.673AlaVal: 8.673 ± 0.76
1.853AlaTrp: 1.853 ± 0.545
2.224AlaTyr: 2.224 ± 0.374
0.0AlaXaa: 0.0 ± 0.0
Cys
1.334CysAla: 1.334 ± 0.372
0.148CysCys: 0.148 ± 0.111
0.667CysAsp: 0.667 ± 0.254
0.593CysGlu: 0.593 ± 0.249
0.222CysPhe: 0.222 ± 0.134
0.667CysGly: 0.667 ± 0.277
0.297CysHis: 0.297 ± 0.168
0.371CysIle: 0.371 ± 0.156
0.297CysLys: 0.297 ± 0.134
0.593CysLeu: 0.593 ± 0.261
0.148CysMet: 0.148 ± 0.15
0.445CysAsn: 0.445 ± 0.192
0.741CysPro: 0.741 ± 0.322
0.445CysGln: 0.445 ± 0.199
1.038CysArg: 1.038 ± 0.316
0.593CysSer: 0.593 ± 0.196
0.371CysThr: 0.371 ± 0.158
0.519CysVal: 0.519 ± 0.2
0.222CysTrp: 0.222 ± 0.13
0.222CysTyr: 0.222 ± 0.161
0.0CysXaa: 0.0 ± 0.0
Asp
6.672AspAla: 6.672 ± 0.79
0.371AspCys: 0.371 ± 0.185
2.965AspAsp: 2.965 ± 0.595
3.855AspGlu: 3.855 ± 0.427
2.15AspPhe: 2.15 ± 0.455
4.299AspGly: 4.299 ± 0.504
0.815AspHis: 0.815 ± 0.268
2.001AspIle: 2.001 ± 0.407
1.112AspLys: 1.112 ± 0.484
5.56AspLeu: 5.56 ± 0.806
0.89AspMet: 0.89 ± 0.23
0.815AspAsn: 0.815 ± 0.225
3.113AspPro: 3.113 ± 0.521
2.298AspGln: 2.298 ± 0.539
4.299AspArg: 4.299 ± 0.624
2.298AspSer: 2.298 ± 0.344
3.558AspThr: 3.558 ± 0.546
3.558AspVal: 3.558 ± 0.481
1.038AspTrp: 1.038 ± 0.274
1.631AspTyr: 1.631 ± 0.414
0.0AspXaa: 0.0 ± 0.0
Glu
9.044GluAla: 9.044 ± 1.312
0.741GluCys: 0.741 ± 0.284
3.706GluAsp: 3.706 ± 0.596
4.077GluGlu: 4.077 ± 0.591
2.595GluPhe: 2.595 ± 0.429
5.337GluGly: 5.337 ± 0.529
1.26GluHis: 1.26 ± 0.353
4.003GluIle: 4.003 ± 0.459
1.779GluLys: 1.779 ± 0.392
9.044GluLeu: 9.044 ± 0.796
1.853GluMet: 1.853 ± 0.324
1.186GluAsn: 1.186 ± 0.242
2.52GluPro: 2.52 ± 0.504
2.817GluGln: 2.817 ± 0.498
6.894GluArg: 6.894 ± 0.608
3.039GluSer: 3.039 ± 0.45
2.817GluThr: 2.817 ± 0.457
3.113GluVal: 3.113 ± 0.417
0.741GluTrp: 0.741 ± 0.231
1.483GluTyr: 1.483 ± 0.248
0.0GluXaa: 0.0 ± 0.0
Phe
3.632PheAla: 3.632 ± 0.547
0.297PheCys: 0.297 ± 0.174
1.557PheAsp: 1.557 ± 0.357
2.595PheGlu: 2.595 ± 0.406
1.038PhePhe: 1.038 ± 0.249
2.52PheGly: 2.52 ± 0.365
0.445PheHis: 0.445 ± 0.157
0.89PheIle: 0.89 ± 0.294
1.186PheLys: 1.186 ± 0.323
2.446PheLeu: 2.446 ± 0.417
0.667PheMet: 0.667 ± 0.203
0.964PheAsn: 0.964 ± 0.235
1.038PhePro: 1.038 ± 0.302
1.26PheGln: 1.26 ± 0.214
2.965PheArg: 2.965 ± 0.49
1.631PheSer: 1.631 ± 0.332
1.408PheThr: 1.408 ± 0.27
1.408PheVal: 1.408 ± 0.332
0.593PheTrp: 0.593 ± 0.223
0.519PheTyr: 0.519 ± 0.188
0.0PheXaa: 0.0 ± 0.0
Gly
8.673GlyAla: 8.673 ± 1.202
0.964GlyCys: 0.964 ± 0.331
3.632GlyAsp: 3.632 ± 0.503
4.744GlyGlu: 4.744 ± 0.513
2.446GlyPhe: 2.446 ± 0.348
6.523GlyGly: 6.523 ± 1.526
1.557GlyHis: 1.557 ± 0.448
3.929GlyIle: 3.929 ± 0.538
2.52GlyLys: 2.52 ± 0.413
7.709GlyLeu: 7.709 ± 0.751
2.298GlyMet: 2.298 ± 0.315
2.595GlyAsn: 2.595 ± 0.528
3.41GlyPro: 3.41 ± 0.524
3.113GlyGln: 3.113 ± 0.395
5.708GlyArg: 5.708 ± 0.651
4.67GlySer: 4.67 ± 0.672
5.189GlyThr: 5.189 ± 0.7
6.079GlyVal: 6.079 ± 0.688
1.26GlyTrp: 1.26 ± 0.33
1.927GlyTyr: 1.927 ± 0.293
0.0GlyXaa: 0.0 ± 0.0
His
2.224HisAla: 2.224 ± 0.502
0.371HisCys: 0.371 ± 0.13
0.89HisAsp: 0.89 ± 0.312
0.964HisGlu: 0.964 ± 0.263
0.222HisPhe: 0.222 ± 0.127
1.334HisGly: 1.334 ± 0.339
0.297HisHis: 0.297 ± 0.132
0.593HisIle: 0.593 ± 0.205
0.371HisLys: 0.371 ± 0.161
2.372HisLeu: 2.372 ± 0.495
0.222HisMet: 0.222 ± 0.128
0.667HisAsn: 0.667 ± 0.213
1.557HisPro: 1.557 ± 0.526
0.593HisGln: 0.593 ± 0.186
1.186HisArg: 1.186 ± 0.294
1.112HisSer: 1.112 ± 0.27
0.593HisThr: 0.593 ± 0.26
1.186HisVal: 1.186 ± 0.375
0.593HisTrp: 0.593 ± 0.298
0.222HisTyr: 0.222 ± 0.161
0.0HisXaa: 0.0 ± 0.0
Ile
6.968IleAla: 6.968 ± 0.725
0.222IleCys: 0.222 ± 0.128
3.039IleAsp: 3.039 ± 0.425
4.448IleGlu: 4.448 ± 0.527
0.815IlePhe: 0.815 ± 0.182
3.706IleGly: 3.706 ± 0.523
0.297IleHis: 0.297 ± 0.141
0.815IleIle: 0.815 ± 0.273
0.964IleLys: 0.964 ± 0.225
2.224IleLeu: 2.224 ± 0.534
0.519IleMet: 0.519 ± 0.196
1.186IleAsn: 1.186 ± 0.291
1.557IlePro: 1.557 ± 0.257
1.483IleGln: 1.483 ± 0.433
3.632IleArg: 3.632 ± 0.447
1.483IleSer: 1.483 ± 0.342
2.076IleThr: 2.076 ± 0.374
2.743IleVal: 2.743 ± 0.461
0.593IleTrp: 0.593 ± 0.247
1.186IleTyr: 1.186 ± 0.308
0.0IleXaa: 0.0 ± 0.0
Lys
3.632LysAla: 3.632 ± 0.726
0.148LysCys: 0.148 ± 0.106
1.112LysAsp: 1.112 ± 0.406
1.038LysGlu: 1.038 ± 0.223
0.667LysPhe: 0.667 ± 0.206
2.817LysGly: 2.817 ± 0.502
0.371LysHis: 0.371 ± 0.184
1.112LysIle: 1.112 ± 0.316
1.557LysLys: 1.557 ± 0.441
2.817LysLeu: 2.817 ± 0.418
0.815LysMet: 0.815 ± 0.182
0.741LysAsn: 0.741 ± 0.29
1.483LysPro: 1.483 ± 0.349
1.927LysGln: 1.927 ± 0.583
2.965LysArg: 2.965 ± 0.454
1.334LysSer: 1.334 ± 0.298
1.927LysThr: 1.927 ± 0.4
2.001LysVal: 2.001 ± 0.391
0.371LysTrp: 0.371 ± 0.133
0.297LysTyr: 0.297 ± 0.176
0.0LysXaa: 0.0 ± 0.0
Leu
12.973LeuAla: 12.973 ± 1.282
1.557LeuCys: 1.557 ± 0.349
6.375LeuAsp: 6.375 ± 0.663
5.856LeuGlu: 5.856 ± 0.46
2.224LeuPhe: 2.224 ± 0.315
7.709LeuGly: 7.709 ± 1.02
1.779LeuHis: 1.779 ± 0.411
3.706LeuIle: 3.706 ± 0.498
2.965LeuLys: 2.965 ± 0.416
9.118LeuLeu: 9.118 ± 0.961
1.483LeuMet: 1.483 ± 0.282
3.262LeuAsn: 3.262 ± 0.707
4.448LeuPro: 4.448 ± 0.599
5.263LeuGln: 5.263 ± 0.585
9.859LeuArg: 9.859 ± 0.681
6.153LeuSer: 6.153 ± 0.699
5.263LeuThr: 5.263 ± 0.544
6.672LeuVal: 6.672 ± 0.655
1.334LeuTrp: 1.334 ± 0.313
1.26LeuTyr: 1.26 ± 0.281
0.0LeuXaa: 0.0 ± 0.0
Met
2.891MetAla: 2.891 ± 0.627
0.148MetCys: 0.148 ± 0.106
0.89MetAsp: 0.89 ± 0.214
1.334MetGlu: 1.334 ± 0.299
0.519MetPhe: 0.519 ± 0.191
1.483MetGly: 1.483 ± 0.293
0.445MetHis: 0.445 ± 0.169
0.519MetIle: 0.519 ± 0.183
0.593MetLys: 0.593 ± 0.173
1.483MetLeu: 1.483 ± 0.401
0.445MetMet: 0.445 ± 0.16
1.038MetAsn: 1.038 ± 0.258
1.334MetPro: 1.334 ± 0.34
1.408MetGln: 1.408 ± 0.315
1.631MetArg: 1.631 ± 0.323
2.298MetSer: 2.298 ± 0.302
1.038MetThr: 1.038 ± 0.247
1.26MetVal: 1.26 ± 0.243
0.297MetTrp: 0.297 ± 0.127
0.519MetTyr: 0.519 ± 0.183
0.0MetXaa: 0.0 ± 0.0
Asn
3.484AsnAla: 3.484 ± 0.61
0.148AsnCys: 0.148 ± 0.108
1.408AsnAsp: 1.408 ± 0.273
1.927AsnGlu: 1.927 ± 0.481
0.667AsnPhe: 0.667 ± 0.232
2.076AsnGly: 2.076 ± 0.395
0.297AsnHis: 0.297 ± 0.129
1.26AsnIle: 1.26 ± 0.348
0.964AsnLys: 0.964 ± 0.257
2.595AsnLeu: 2.595 ± 0.45
0.667AsnMet: 0.667 ± 0.202
0.222AsnAsn: 0.222 ± 0.146
1.334AsnPro: 1.334 ± 0.371
1.26AsnGln: 1.26 ± 0.249
1.631AsnArg: 1.631 ± 0.35
1.557AsnSer: 1.557 ± 0.359
1.705AsnThr: 1.705 ± 0.285
1.26AsnVal: 1.26 ± 0.28
0.148AsnTrp: 0.148 ± 0.103
0.741AsnTyr: 0.741 ± 0.256
0.0AsnXaa: 0.0 ± 0.0
Pro
6.597ProAla: 6.597 ± 0.943
0.297ProCys: 0.297 ± 0.184
3.113ProAsp: 3.113 ± 0.492
4.151ProGlu: 4.151 ± 0.784
1.334ProPhe: 1.334 ± 0.354
4.003ProGly: 4.003 ± 0.604
1.112ProHis: 1.112 ± 0.351
1.186ProIle: 1.186 ± 0.285
2.076ProLys: 2.076 ± 0.52
4.374ProLeu: 4.374 ± 0.726
1.483ProMet: 1.483 ± 0.323
1.112ProAsn: 1.112 ± 0.281
3.558ProPro: 3.558 ± 0.744
2.224ProGln: 2.224 ± 0.396
3.855ProArg: 3.855 ± 0.783
2.595ProSer: 2.595 ± 0.571
2.372ProThr: 2.372 ± 0.538
3.781ProVal: 3.781 ± 0.742
0.964ProTrp: 0.964 ± 0.281
1.26ProTyr: 1.26 ± 0.241
0.0ProXaa: 0.0 ± 0.0
Gln
6.597GlnAla: 6.597 ± 0.796
0.297GlnCys: 0.297 ± 0.218
1.26GlnAsp: 1.26 ± 0.255
2.372GlnGlu: 2.372 ± 0.405
1.705GlnPhe: 1.705 ± 0.327
2.891GlnGly: 2.891 ± 0.494
0.741GlnHis: 0.741 ± 0.31
2.817GlnIle: 2.817 ± 0.509
0.593GlnLys: 0.593 ± 0.216
6.82GlnLeu: 6.82 ± 1.262
0.964GlnMet: 0.964 ± 0.276
1.038GlnAsn: 1.038 ± 0.223
3.113GlnPro: 3.113 ± 0.528
2.743GlnGln: 2.743 ± 0.759
4.893GlnArg: 4.893 ± 0.447
2.52GlnSer: 2.52 ± 0.43
2.001GlnThr: 2.001 ± 0.442
3.188GlnVal: 3.188 ± 0.4
0.964GlnTrp: 0.964 ± 0.209
0.371GlnTyr: 0.371 ± 0.161
0.0GlnXaa: 0.0 ± 0.0
Arg
9.563ArgAla: 9.563 ± 0.894
1.038ArgCys: 1.038 ± 0.312
3.706ArgAsp: 3.706 ± 0.486
6.82ArgGlu: 6.82 ± 0.667
3.262ArgPhe: 3.262 ± 0.466
6.227ArgGly: 6.227 ± 0.582
1.705ArgHis: 1.705 ± 0.38
3.113ArgIle: 3.113 ± 0.496
1.927ArgLys: 1.927 ± 0.476
7.858ArgLeu: 7.858 ± 0.828
1.26ArgMet: 1.26 ± 0.32
2.372ArgAsn: 2.372 ± 0.402
3.188ArgPro: 3.188 ± 0.661
4.374ArgGln: 4.374 ± 0.743
8.228ArgArg: 8.228 ± 0.899
5.115ArgSer: 5.115 ± 0.648
5.263ArgThr: 5.263 ± 0.668
6.375ArgVal: 6.375 ± 1.062
1.779ArgTrp: 1.779 ± 0.355
2.595ArgTyr: 2.595 ± 0.486
0.0ArgXaa: 0.0 ± 0.0
Ser
7.265SerAla: 7.265 ± 0.725
0.519SerCys: 0.519 ± 0.245
2.446SerAsp: 2.446 ± 0.571
3.039SerGlu: 3.039 ± 0.595
1.408SerPhe: 1.408 ± 0.374
4.744SerGly: 4.744 ± 0.819
1.408SerHis: 1.408 ± 0.37
2.743SerIle: 2.743 ± 0.483
1.631SerLys: 1.631 ± 0.322
5.041SerLeu: 5.041 ± 0.799
1.186SerMet: 1.186 ± 0.268
1.853SerAsn: 1.853 ± 0.336
4.151SerPro: 4.151 ± 0.448
2.52SerGln: 2.52 ± 0.472
4.967SerArg: 4.967 ± 1.031
3.781SerSer: 3.781 ± 0.716
2.817SerThr: 2.817 ± 0.374
3.558SerVal: 3.558 ± 0.541
0.964SerTrp: 0.964 ± 0.273
1.26SerTyr: 1.26 ± 0.398
0.0SerXaa: 0.0 ± 0.0
Thr
6.894ThrAla: 6.894 ± 0.884
0.371ThrCys: 0.371 ± 0.205
2.743ThrAsp: 2.743 ± 0.438
4.077ThrGlu: 4.077 ± 0.512
1.483ThrPhe: 1.483 ± 0.394
5.263ThrGly: 5.263 ± 0.688
0.519ThrHis: 0.519 ± 0.175
2.076ThrIle: 2.076 ± 0.352
1.112ThrLys: 1.112 ± 0.289
5.56ThrLeu: 5.56 ± 0.568
0.964ThrMet: 0.964 ± 0.249
1.26ThrAsn: 1.26 ± 0.386
4.003ThrPro: 4.003 ± 0.639
2.076ThrGln: 2.076 ± 0.582
3.632ThrArg: 3.632 ± 0.429
3.039ThrSer: 3.039 ± 0.375
2.446ThrThr: 2.446 ± 0.556
4.596ThrVal: 4.596 ± 0.592
0.89ThrTrp: 0.89 ± 0.31
1.334ThrTyr: 1.334 ± 0.32
0.0ThrXaa: 0.0 ± 0.0
Val
7.709ValAla: 7.709 ± 0.82
1.038ValCys: 1.038 ± 0.34
4.744ValAsp: 4.744 ± 0.633
4.448ValGlu: 4.448 ± 0.518
1.631ValPhe: 1.631 ± 0.382
4.893ValGly: 4.893 ± 0.718
1.334ValHis: 1.334 ± 0.308
2.372ValIle: 2.372 ± 0.371
3.188ValLys: 3.188 ± 0.599
7.487ValLeu: 7.487 ± 0.974
1.26ValMet: 1.26 ± 0.284
1.483ValAsn: 1.483 ± 0.333
2.372ValPro: 2.372 ± 0.486
3.113ValGln: 3.113 ± 0.385
5.56ValArg: 5.56 ± 0.494
5.411ValSer: 5.411 ± 0.642
3.262ValThr: 3.262 ± 0.512
3.113ValVal: 3.113 ± 0.586
0.667ValTrp: 0.667 ± 0.216
1.038ValTyr: 1.038 ± 0.285
0.0ValXaa: 0.0 ± 0.0
Trp
1.112TrpAla: 1.112 ± 0.336
0.371TrpCys: 0.371 ± 0.264
0.815TrpAsp: 0.815 ± 0.267
0.667TrpGlu: 0.667 ± 0.204
0.445TrpPhe: 0.445 ± 0.174
0.741TrpGly: 0.741 ± 0.252
0.297TrpHis: 0.297 ± 0.165
0.667TrpIle: 0.667 ± 0.177
0.445TrpLys: 0.445 ± 0.255
1.853TrpLeu: 1.853 ± 0.407
0.297TrpMet: 0.297 ± 0.146
0.148TrpAsn: 0.148 ± 0.111
0.89TrpPro: 0.89 ± 0.285
1.112TrpGln: 1.112 ± 0.358
1.705TrpArg: 1.705 ± 0.408
1.186TrpSer: 1.186 ± 0.373
1.26TrpThr: 1.26 ± 0.312
1.408TrpVal: 1.408 ± 0.263
0.519TrpTrp: 0.519 ± 0.244
0.222TrpTyr: 0.222 ± 0.111
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.15TyrAla: 2.15 ± 0.419
0.0TyrCys: 0.0 ± 0.0
1.112TyrAsp: 1.112 ± 0.294
1.186TyrGlu: 1.186 ± 0.344
0.667TyrPhe: 0.667 ± 0.185
2.076TyrGly: 2.076 ± 0.455
0.667TyrHis: 0.667 ± 0.269
0.519TyrIle: 0.519 ± 0.192
0.297TyrLys: 0.297 ± 0.116
2.298TyrLeu: 2.298 ± 0.386
0.074TyrMet: 0.074 ± 0.073
0.371TyrAsn: 0.371 ± 0.155
1.038TyrPro: 1.038 ± 0.294
1.186TyrGln: 1.186 ± 0.273
1.927TyrArg: 1.927 ± 0.402
1.483TyrSer: 1.483 ± 0.382
1.26TyrThr: 1.26 ± 0.302
1.631TyrVal: 1.631 ± 0.285
0.371TyrTrp: 0.371 ± 0.151
0.519TyrTyr: 0.519 ± 0.211
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 56 proteins (13491 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski