Amino acid dipepetide frequency for Ferriphaselus amnicola

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.924AlaAla: 12.924 ± 0.208	1.047AlaCys: 1.047 ± 0.037	5.7AlaAsp: 5.7 ± 0.097	7.031AlaGlu: 7.031 ± 0.119	3.44AlaPhe: 3.44 ± 0.059	7.797AlaGly: 7.797 ± 0.135	2.449AlaHis: 2.449 ± 0.052	5.624AlaIle: 5.624 ± 0.097	4.782AlaLys: 4.782 ± 0.109	12.112AlaLeu: 12.112 ± 0.14	3.146AlaMet: 3.146 ± 0.063	3.468AlaAsn: 3.468 ± 0.067	4.004AlaPro: 4.004 ± 0.079	5.053AlaGln: 5.053 ± 0.104	6.292AlaArg: 6.292 ± 0.085	5.84AlaSer: 5.84 ± 0.098	5.601AlaThr: 5.601 ± 0.095	7.465AlaVal: 7.465 ± 0.109	1.323AlaTrp: 1.323 ± 0.046	2.344AlaTyr: 2.344 ± 0.062	0.0AlaXaa: 0.0 ± 0.0
Cys	0.968CysAla: 0.968 ± 0.034	0.115CysCys: 0.115 ± 0.012	0.521CysAsp: 0.521 ± 0.026	0.553CysGlu: 0.553 ± 0.024	0.328CysPhe: 0.328 ± 0.019	1.002CysGly: 1.002 ± 0.039	0.307CysHis: 0.307 ± 0.021	0.451CysIle: 0.451 ± 0.028	0.321CysLys: 0.321 ± 0.02	0.881CysLeu: 0.881 ± 0.033	0.192CysMet: 0.192 ± 0.015	0.351CysAsn: 0.351 ± 0.019	0.541CysPro: 0.541 ± 0.029	0.336CysGln: 0.336 ± 0.019	0.578CysArg: 0.578 ± 0.028	0.601CysSer: 0.601 ± 0.029	0.465CysThr: 0.465 ± 0.025	0.721CysVal: 0.721 ± 0.028	0.13CysTrp: 0.13 ± 0.013	0.293CysTyr: 0.293 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	5.842AspAla: 5.842 ± 0.087	0.529AspCys: 0.529 ± 0.026	2.797AspAsp: 2.797 ± 0.059	3.796AspGlu: 3.796 ± 0.089	2.211AspPhe: 2.211 ± 0.052	4.22AspGly: 4.22 ± 0.074	1.103AspHis: 1.103 ± 0.039	3.109AspIle: 3.109 ± 0.067	2.29AspLys: 2.29 ± 0.062	5.089AspLeu: 5.089 ± 0.081	1.467AspMet: 1.467 ± 0.041	1.465AspAsn: 1.465 ± 0.047	2.204AspPro: 2.204 ± 0.054	1.785AspGln: 1.785 ± 0.049	2.669AspArg: 2.669 ± 0.059	2.757AspSer: 2.757 ± 0.053	2.717AspThr: 2.717 ± 0.065	3.765AspVal: 3.765 ± 0.068	0.911AspTrp: 0.911 ± 0.035	1.673AspTyr: 1.673 ± 0.045	0.0AspXaa: 0.0 ± 0.0
Glu	6.591GluAla: 6.591 ± 0.1	0.483GluCys: 0.483 ± 0.026	2.441GluAsp: 2.441 ± 0.061	3.173GluGlu: 3.173 ± 0.073	2.43GluPhe: 2.43 ± 0.051	3.528GluGly: 3.528 ± 0.075	1.718GluHis: 1.718 ± 0.048	3.68GluIle: 3.68 ± 0.076	2.692GluLys: 2.692 ± 0.071	6.888GluLeu: 6.888 ± 0.107	1.773GluMet: 1.773 ± 0.044	1.719GluAsn: 1.719 ± 0.046	2.0GluPro: 2.0 ± 0.056	3.353GluGln: 3.353 ± 0.063	4.384GluArg: 4.384 ± 0.089	3.368GluSer: 3.368 ± 0.066	2.862GluThr: 2.862 ± 0.062	4.791GluVal: 4.791 ± 0.087	0.794GluTrp: 0.794 ± 0.028	1.499GluTyr: 1.499 ± 0.048	0.0GluXaa: 0.0 ± 0.0
Phe	3.887PheAla: 3.887 ± 0.067	0.406PheCys: 0.406 ± 0.02	2.44PheAsp: 2.44 ± 0.057	2.167PheGlu: 2.167 ± 0.057	1.469PhePhe: 1.469 ± 0.047	3.169PheGly: 3.169 ± 0.064	0.815PheHis: 0.815 ± 0.034	1.975PheIle: 1.975 ± 0.052	1.494PheLys: 1.494 ± 0.043	3.307PheLeu: 3.307 ± 0.066	0.847PheMet: 0.847 ± 0.034	1.311PheAsn: 1.311 ± 0.044	1.585PhePro: 1.585 ± 0.043	1.205PheGln: 1.205 ± 0.038	1.896PheArg: 1.896 ± 0.045	2.552PheSer: 2.552 ± 0.063	1.982PheThr: 1.982 ± 0.052	2.819PheVal: 2.819 ± 0.064	0.451PheTrp: 0.451 ± 0.025	1.032PheTyr: 1.032 ± 0.035	0.0PheXaa: 0.0 ± 0.0
Gly	6.857GlyAla: 6.857 ± 0.112	0.948GlyCys: 0.948 ± 0.03	3.877GlyAsp: 3.877 ± 0.072	4.619GlyGlu: 4.619 ± 0.077	2.983GlyPhe: 2.983 ± 0.062	5.812GlyGly: 5.812 ± 0.117	1.797GlyHis: 1.797 ± 0.044	4.499GlyIle: 4.499 ± 0.079	4.362GlyLys: 4.362 ± 0.079	7.665GlyLeu: 7.665 ± 0.102	2.43GlyMet: 2.43 ± 0.059	2.468GlyAsn: 2.468 ± 0.068	1.476GlyPro: 1.476 ± 0.043	2.869GlyGln: 2.869 ± 0.066	4.279GlyArg: 4.279 ± 0.073	4.221GlySer: 4.221 ± 0.083	3.601GlyThr: 3.601 ± 0.081	6.068GlyVal: 6.068 ± 0.094	1.254GlyTrp: 1.254 ± 0.037	2.499GlyTyr: 2.499 ± 0.058	0.0GlyXaa: 0.0 ± 0.0
His	2.49HisAla: 2.49 ± 0.055	0.296HisCys: 0.296 ± 0.022	1.401HisAsp: 1.401 ± 0.045	1.386HisGlu: 1.386 ± 0.049	1.02HisPhe: 1.02 ± 0.033	2.041HisGly: 2.041 ± 0.061	0.769HisHis: 0.769 ± 0.032	1.282HisIle: 1.282 ± 0.044	0.803HisLys: 0.803 ± 0.034	2.64HisLeu: 2.64 ± 0.056	0.43HisMet: 0.43 ± 0.026	0.729HisAsn: 0.729 ± 0.027	1.512HisPro: 1.512 ± 0.041	1.013HisGln: 1.013 ± 0.035	1.374HisArg: 1.374 ± 0.044	1.288HisSer: 1.288 ± 0.041	1.155HisThr: 1.155 ± 0.034	1.393HisVal: 1.393 ± 0.038	0.342HisTrp: 0.342 ± 0.02	0.808HisTyr: 0.808 ± 0.034	0.0HisXaa: 0.0 ± 0.0
Ile	6.431IleAla: 6.431 ± 0.087	0.529IleCys: 0.529 ± 0.027	2.93IleAsp: 2.93 ± 0.068	3.896IleGlu: 3.896 ± 0.069	1.771IlePhe: 1.771 ± 0.051	4.691IleGly: 4.691 ± 0.079	1.185IleHis: 1.185 ± 0.039	2.56IleIle: 2.56 ± 0.063	2.361IleLys: 2.361 ± 0.062	4.588IleLeu: 4.588 ± 0.08	1.012IleMet: 1.012 ± 0.039	1.975IleAsn: 1.975 ± 0.055	2.384IlePro: 2.384 ± 0.054	1.78IleGln: 1.78 ± 0.051	3.01IleArg: 3.01 ± 0.054	3.701IleSer: 3.701 ± 0.076	3.159IleThr: 3.159 ± 0.066	3.799IleVal: 3.799 ± 0.069	0.552IleTrp: 0.552 ± 0.023	1.346IleTyr: 1.346 ± 0.044	0.0IleXaa: 0.0 ± 0.0
Lys	4.125LysAla: 4.125 ± 0.098	0.274LysCys: 0.274 ± 0.019	2.017LysAsp: 2.017 ± 0.061	2.153LysGlu: 2.153 ± 0.058	1.306LysPhe: 1.306 ± 0.039	2.545LysGly: 2.545 ± 0.07	1.026LysHis: 1.026 ± 0.032	2.325LysIle: 2.325 ± 0.052	2.004LysLys: 2.004 ± 0.06	5.163LysLeu: 5.163 ± 0.078	1.337LysMet: 1.337 ± 0.046	1.458LysAsn: 1.458 ± 0.046	2.334LysPro: 2.334 ± 0.074	2.254LysGln: 2.254 ± 0.055	2.77LysArg: 2.77 ± 0.068	2.677LysSer: 2.677 ± 0.064	2.238LysThr: 2.238 ± 0.054	3.204LysVal: 3.204 ± 0.072	0.392LysTrp: 0.392 ± 0.028	0.979LysTyr: 0.979 ± 0.039	0.0LysXaa: 0.0 ± 0.0
Leu	12.426LeuAla: 12.426 ± 0.136	1.01LeuCys: 1.01 ± 0.039	6.023LeuAsp: 6.023 ± 0.088	5.961LeuGlu: 5.961 ± 0.093	3.761LeuPhe: 3.761 ± 0.076	7.881LeuGly: 7.881 ± 0.11	2.656LeuHis: 2.656 ± 0.067	5.32LeuIle: 5.32 ± 0.079	4.556LeuLys: 4.556 ± 0.083	12.347LeuLeu: 12.347 ± 0.165	2.683LeuMet: 2.683 ± 0.058	3.775LeuAsn: 3.775 ± 0.064	5.76LeuPro: 5.76 ± 0.091	4.087LeuGln: 4.087 ± 0.073	6.849LeuArg: 6.849 ± 0.093	7.25LeuSer: 7.25 ± 0.108	5.955LeuThr: 5.955 ± 0.097	7.253LeuVal: 7.253 ± 0.093	1.248LeuTrp: 1.248 ± 0.04	2.431LeuTyr: 2.431 ± 0.065	0.0LeuXaa: 0.0 ± 0.0
Met	2.583MetAla: 2.583 ± 0.061	0.191MetCys: 0.191 ± 0.015	1.308MetAsp: 1.308 ± 0.038	1.375MetGlu: 1.375 ± 0.049	0.833MetPhe: 0.833 ± 0.031	1.891MetGly: 1.891 ± 0.046	0.583MetHis: 0.583 ± 0.027	1.135MetIle: 1.135 ± 0.042	1.222MetLys: 1.222 ± 0.043	3.009MetLeu: 3.009 ± 0.062	0.74MetMet: 0.74 ± 0.033	1.005MetAsn: 1.005 ± 0.035	1.376MetPro: 1.376 ± 0.044	1.251MetGln: 1.251 ± 0.037	1.743MetArg: 1.743 ± 0.042	1.935MetSer: 1.935 ± 0.041	1.526MetThr: 1.526 ± 0.042	1.832MetVal: 1.832 ± 0.046	0.237MetTrp: 0.237 ± 0.017	0.474MetTyr: 0.474 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	3.33AsnAla: 3.33 ± 0.077	0.313AsnCys: 0.313 ± 0.022	1.698AsnAsp: 1.698 ± 0.048	1.741AsnGlu: 1.741 ± 0.054	1.197AsnPhe: 1.197 ± 0.041	2.762AsnGly: 2.762 ± 0.072	0.757AsnHis: 0.757 ± 0.028	1.867AsnIle: 1.867 ± 0.058	1.278AsnLys: 1.278 ± 0.047	3.539AsnLeu: 3.539 ± 0.064	0.768AsnMet: 0.768 ± 0.036	1.102AsnAsn: 1.102 ± 0.044	1.952AsnPro: 1.952 ± 0.052	1.294AsnGln: 1.294 ± 0.045	1.978AsnArg: 1.978 ± 0.048	1.878AsnSer: 1.878 ± 0.053	1.743AsnThr: 1.743 ± 0.053	2.318AsnVal: 2.318 ± 0.063	0.47AsnTrp: 0.47 ± 0.025	0.916AsnTyr: 0.916 ± 0.039	0.0AsnXaa: 0.0 ± 0.0
Pro	4.645ProAla: 4.645 ± 0.094	0.345ProCys: 0.345 ± 0.018	2.674ProAsp: 2.674 ± 0.05	3.26ProGlu: 3.26 ± 0.066	1.569ProPhe: 1.569 ± 0.037	2.792ProGly: 2.792 ± 0.06	1.071ProHis: 1.071 ± 0.039	2.207ProIle: 2.207 ± 0.062	1.759ProLys: 1.759 ± 0.049	4.72ProLeu: 4.72 ± 0.078	1.095ProMet: 1.095 ± 0.034	1.523ProAsn: 1.523 ± 0.043	1.832ProPro: 1.832 ± 0.06	1.945ProGln: 1.945 ± 0.043	1.984ProArg: 1.984 ± 0.049	2.557ProSer: 2.557 ± 0.058	2.214ProThr: 2.214 ± 0.049	3.676ProVal: 3.676 ± 0.079	0.554ProTrp: 0.554 ± 0.028	1.213ProTyr: 1.213 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	5.056GlnAla: 5.056 ± 0.095	0.349GlnCys: 0.349 ± 0.02	1.743GlnAsp: 1.743 ± 0.048	2.168GlnGlu: 2.168 ± 0.055	1.554GlnPhe: 1.554 ± 0.049	2.955GlnGly: 2.955 ± 0.062	1.232GlnHis: 1.232 ± 0.045	2.26GlnIle: 2.26 ± 0.058	1.543GlnLys: 1.543 ± 0.047	4.753GlnLeu: 4.753 ± 0.073	1.132GlnMet: 1.132 ± 0.035	1.154GlnAsn: 1.154 ± 0.045	1.993GlnPro: 1.993 ± 0.054	2.472GlnGln: 2.472 ± 0.07	3.137GlnArg: 3.137 ± 0.067	2.473GlnSer: 2.473 ± 0.063	2.098GlnThr: 2.098 ± 0.048	3.115GlnVal: 3.115 ± 0.07	0.505GlnTrp: 0.505 ± 0.026	0.9GlnTyr: 0.9 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	5.747ArgAla: 5.747 ± 0.085	0.564ArgCys: 0.564 ± 0.026	3.354ArgAsp: 3.354 ± 0.072	4.081ArgGlu: 4.081 ± 0.085	2.523ArgPhe: 2.523 ± 0.055	3.842ArgGly: 3.842 ± 0.072	1.651ArgHis: 1.651 ± 0.045	3.746ArgIle: 3.746 ± 0.062	2.501ArgLys: 2.501 ± 0.058	6.727ArgLeu: 6.727 ± 0.116	1.615ArgMet: 1.615 ± 0.052	2.157ArgAsn: 2.157 ± 0.053	2.132ArgPro: 2.132 ± 0.06	2.57ArgGln: 2.57 ± 0.068	3.755ArgArg: 3.755 ± 0.082	3.163ArgSer: 3.163 ± 0.067	2.756ArgThr: 2.756 ± 0.058	4.168ArgVal: 4.168 ± 0.082	0.915ArgTrp: 0.915 ± 0.033	2.01ArgTyr: 2.01 ± 0.056	0.0ArgXaa: 0.0 ± 0.0
Ser	6.226SerAla: 6.226 ± 0.098	0.59SerCys: 0.59 ± 0.028	3.149SerAsp: 3.149 ± 0.064	3.496SerGlu: 3.496 ± 0.069	2.278SerPhe: 2.278 ± 0.05	5.549SerGly: 5.549 ± 0.088	1.432SerHis: 1.432 ± 0.047	3.262SerIle: 3.262 ± 0.057	2.531SerLys: 2.531 ± 0.061	6.329SerLeu: 6.329 ± 0.095	1.462SerMet: 1.462 ± 0.049	2.095SerAsn: 2.095 ± 0.06	2.616SerPro: 2.616 ± 0.05	2.316SerGln: 2.316 ± 0.061	3.379SerArg: 3.379 ± 0.058	3.818SerSer: 3.818 ± 0.079	2.875SerThr: 2.875 ± 0.06	4.341SerVal: 4.341 ± 0.075	0.724SerTrp: 0.724 ± 0.032	1.608SerTyr: 1.608 ± 0.048	0.0SerXaa: 0.0 ± 0.0
Thr	5.218ThrAla: 5.218 ± 0.093	0.414ThrCys: 0.414 ± 0.023	2.606ThrAsp: 2.606 ± 0.065	2.814ThrGlu: 2.814 ± 0.062	1.835ThrPhe: 1.835 ± 0.048	4.222ThrGly: 4.222 ± 0.079	1.237ThrHis: 1.237 ± 0.04	2.576ThrIle: 2.576 ± 0.059	1.69ThrLys: 1.69 ± 0.048	6.763ThrLeu: 6.763 ± 0.103	1.103ThrMet: 1.103 ± 0.038	1.485ThrAsn: 1.485 ± 0.044	3.12ThrPro: 3.12 ± 0.062	2.181ThrGln: 2.181 ± 0.045	2.831ThrArg: 2.831 ± 0.06	2.936ThrSer: 2.936 ± 0.07	2.798ThrThr: 2.798 ± 0.077	3.871ThrVal: 3.871 ± 0.082	0.613ThrTrp: 0.613 ± 0.028	1.265ThrTyr: 1.265 ± 0.052	0.0ThrXaa: 0.0 ± 0.0
Val	8.32ValAla: 8.32 ± 0.132	0.785ValCys: 0.785 ± 0.031	3.742ValAsp: 3.742 ± 0.075	4.616ValGlu: 4.616 ± 0.083	2.637ValPhe: 2.637 ± 0.063	5.122ValGly: 5.122 ± 0.084	1.374ValHis: 1.374 ± 0.045	4.024ValIle: 4.024 ± 0.077	2.986ValLys: 2.986 ± 0.065	7.91ValLeu: 7.91 ± 0.1	2.103ValMet: 2.103 ± 0.045	2.462ValAsn: 2.462 ± 0.061	3.055ValPro: 3.055 ± 0.066	2.659ValGln: 2.659 ± 0.065	4.271ValArg: 4.271 ± 0.077	4.694ValSer: 4.694 ± 0.078	3.98ValThr: 3.98 ± 0.088	6.107ValVal: 6.107 ± 0.118	0.914ValTrp: 0.914 ± 0.033	1.624ValTyr: 1.624 ± 0.047	0.0ValXaa: 0.0 ± 0.0
Trp	1.094TrpAla: 1.094 ± 0.038	0.145TrpCys: 0.145 ± 0.012	0.612TrpAsp: 0.612 ± 0.027	0.614TrpGlu: 0.614 ± 0.028	0.502TrpPhe: 0.502 ± 0.027	0.741TrpGly: 0.741 ± 0.036	0.369TrpHis: 0.369 ± 0.022	0.658TrpIle: 0.658 ± 0.03	0.535TrpLys: 0.535 ± 0.021	1.888TrpLeu: 1.888 ± 0.059	0.422TrpMet: 0.422 ± 0.021	0.448TrpAsn: 0.448 ± 0.026	0.444TrpPro: 0.444 ± 0.025	0.83TrpGln: 0.83 ± 0.037	0.932TrpArg: 0.932 ± 0.034	0.752TrpSer: 0.752 ± 0.033	0.48TrpThr: 0.48 ± 0.024	0.975TrpVal: 0.975 ± 0.032	0.225TrpTrp: 0.225 ± 0.017	0.296TrpTyr: 0.296 ± 0.024	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.68TyrAla: 2.68 ± 0.066	0.326TyrCys: 0.326 ± 0.019	1.366TyrAsp: 1.366 ± 0.061	1.266TyrGlu: 1.266 ± 0.039	1.16TyrPhe: 1.16 ± 0.039	2.024TyrGly: 2.024 ± 0.055	0.641TyrHis: 0.641 ± 0.03	1.101TyrIle: 1.101 ± 0.04	0.872TyrLys: 0.872 ± 0.036	2.913TyrLeu: 2.913 ± 0.064	0.491TyrMet: 0.491 ± 0.024	0.75TyrAsn: 0.75 ± 0.035	1.312TyrPro: 1.312 ± 0.045	1.34TyrGln: 1.34 ± 0.046	1.864TyrArg: 1.864 ± 0.047	1.615TyrSer: 1.615 ± 0.049	1.375TyrThr: 1.375 ± 0.049	1.706TyrVal: 1.706 ± 0.046	0.409TyrTrp: 0.409 ± 0.022	0.739TyrTyr: 0.739 ± 0.033	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2668 proteins (828448 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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