Amino acid dipepetide frequency for Erwinia phage vB_EamP-S2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.332AlaAla: 9.332 ± 1.381
0.579AlaCys: 0.579 ± 0.248
5.643AlaAsp: 5.643 ± 0.622
6.439AlaGlu: 6.439 ± 0.686
2.894AlaPhe: 2.894 ± 0.399
8.609AlaGly: 8.609 ± 0.996
0.94AlaHis: 0.94 ± 0.198
4.702AlaIle: 4.702 ± 0.617
5.209AlaLys: 5.209 ± 0.658
6.149AlaLeu: 6.149 ± 0.796
3.907AlaMet: 3.907 ± 0.639
3.762AlaAsn: 3.762 ± 0.575
2.46AlaPro: 2.46 ± 0.581
4.051AlaGln: 4.051 ± 0.712
4.558AlaArg: 4.558 ± 0.642
6.439AlaSer: 6.439 ± 0.608
5.353AlaThr: 5.353 ± 0.748
5.932AlaVal: 5.932 ± 0.809
1.592AlaTrp: 1.592 ± 0.352
3.183AlaTyr: 3.183 ± 0.494
0.0AlaXaa: 0.0 ± 0.0
Cys
0.362CysAla: 0.362 ± 0.163
0.072CysCys: 0.072 ± 0.069
0.579CysAsp: 0.579 ± 0.208
0.434CysGlu: 0.434 ± 0.203
0.217CysPhe: 0.217 ± 0.128
0.506CysGly: 0.506 ± 0.21
0.434CysHis: 0.434 ± 0.175
0.434CysIle: 0.434 ± 0.173
0.723CysLys: 0.723 ± 0.24
0.868CysLeu: 0.868 ± 0.255
0.362CysMet: 0.362 ± 0.15
0.362CysAsn: 0.362 ± 0.171
0.434CysPro: 0.434 ± 0.188
0.072CysGln: 0.072 ± 0.085
0.434CysArg: 0.434 ± 0.19
0.723CysSer: 0.723 ± 0.253
0.145CysThr: 0.145 ± 0.139
0.579CysVal: 0.579 ± 0.227
0.0CysTrp: 0.0 ± 0.0
0.362CysTyr: 0.362 ± 0.221
0.0CysXaa: 0.0 ± 0.0
Asp
6.077AspAla: 6.077 ± 0.79
0.723AspCys: 0.723 ± 0.202
4.341AspAsp: 4.341 ± 0.789
3.328AspGlu: 3.328 ± 0.621
2.821AspPhe: 2.821 ± 0.496
5.136AspGly: 5.136 ± 0.526
1.302AspHis: 1.302 ± 0.28
3.979AspIle: 3.979 ± 0.385
3.979AspLys: 3.979 ± 0.449
5.353AspLeu: 5.353 ± 0.53
1.953AspMet: 1.953 ± 0.295
2.966AspAsn: 2.966 ± 0.568
2.46AspPro: 2.46 ± 0.448
2.098AspGln: 2.098 ± 0.374
2.677AspArg: 2.677 ± 0.396
3.545AspSer: 3.545 ± 0.513
4.196AspThr: 4.196 ± 0.606
4.196AspVal: 4.196 ± 0.575
1.157AspTrp: 1.157 ± 0.26
2.243AspTyr: 2.243 ± 0.368
0.0AspXaa: 0.0 ± 0.0
Glu
5.932GluAla: 5.932 ± 0.604
0.579GluCys: 0.579 ± 0.211
4.775GluAsp: 4.775 ± 0.559
4.196GluGlu: 4.196 ± 0.619
2.966GluPhe: 2.966 ± 0.407
6.511GluGly: 6.511 ± 0.657
0.94GluHis: 0.94 ± 0.211
3.183GluIle: 3.183 ± 0.496
2.894GluLys: 2.894 ± 0.403
5.787GluLeu: 5.787 ± 0.764
2.532GluMet: 2.532 ± 0.479
2.315GluAsn: 2.315 ± 0.379
1.881GluPro: 1.881 ± 0.379
3.4GluGln: 3.4 ± 0.452
3.255GluArg: 3.255 ± 0.562
3.4GluSer: 3.4 ± 0.539
2.604GluThr: 2.604 ± 0.418
4.341GluVal: 4.341 ± 0.509
1.157GluTrp: 1.157 ± 0.377
2.026GluTyr: 2.026 ± 0.347
0.0GluXaa: 0.0 ± 0.0
Phe
2.17PheAla: 2.17 ± 0.355
0.217PheCys: 0.217 ± 0.12
3.255PheAsp: 3.255 ± 0.582
2.026PheGlu: 2.026 ± 0.345
1.447PhePhe: 1.447 ± 0.366
2.677PheGly: 2.677 ± 0.552
0.796PheHis: 0.796 ± 0.245
1.302PheIle: 1.302 ± 0.257
1.953PheLys: 1.953 ± 0.306
2.532PheLeu: 2.532 ± 0.434
1.592PheMet: 1.592 ± 0.387
1.953PheAsn: 1.953 ± 0.318
1.736PhePro: 1.736 ± 0.395
1.302PheGln: 1.302 ± 0.263
2.315PheArg: 2.315 ± 0.325
2.243PheSer: 2.243 ± 0.342
1.809PheThr: 1.809 ± 0.435
2.749PheVal: 2.749 ± 0.421
0.145PheTrp: 0.145 ± 0.115
0.868PheTyr: 0.868 ± 0.289
0.0PheXaa: 0.0 ± 0.0
Gly
7.379GlyAla: 7.379 ± 1.122
0.868GlyCys: 0.868 ± 0.322
5.136GlyAsp: 5.136 ± 0.556
5.715GlyGlu: 5.715 ± 0.495
3.545GlyPhe: 3.545 ± 0.51
6.077GlyGly: 6.077 ± 1.111
1.592GlyHis: 1.592 ± 0.339
4.268GlyIle: 4.268 ± 0.548
6.439GlyLys: 6.439 ± 0.711
5.57GlyLeu: 5.57 ± 0.487
1.519GlyMet: 1.519 ± 0.35
3.4GlyAsn: 3.4 ± 0.525
2.17GlyPro: 2.17 ± 0.404
2.966GlyGln: 2.966 ± 0.357
3.834GlyArg: 3.834 ± 0.527
4.558GlySer: 4.558 ± 0.676
4.413GlyThr: 4.413 ± 0.673
5.209GlyVal: 5.209 ± 0.607
1.664GlyTrp: 1.664 ± 0.259
2.966GlyTyr: 2.966 ± 0.411
0.0GlyXaa: 0.0 ± 0.0
His
0.868HisAla: 0.868 ± 0.241
0.217HisCys: 0.217 ± 0.13
1.447HisAsp: 1.447 ± 0.298
1.302HisGlu: 1.302 ± 0.279
1.013HisPhe: 1.013 ± 0.232
1.375HisGly: 1.375 ± 0.267
0.723HisHis: 0.723 ± 0.294
1.013HisIle: 1.013 ± 0.237
0.796HisLys: 0.796 ± 0.274
2.17HisLeu: 2.17 ± 0.407
0.434HisMet: 0.434 ± 0.218
0.651HisAsn: 0.651 ± 0.187
0.723HisPro: 0.723 ± 0.208
0.651HisGln: 0.651 ± 0.223
1.157HisArg: 1.157 ± 0.421
0.579HisSer: 0.579 ± 0.216
1.592HisThr: 1.592 ± 0.443
1.881HisVal: 1.881 ± 0.357
0.289HisTrp: 0.289 ± 0.155
0.94HisTyr: 0.94 ± 0.235
0.0HisXaa: 0.0 ± 0.0
Ile
5.643IleAla: 5.643 ± 0.714
0.217IleCys: 0.217 ± 0.139
3.69IleAsp: 3.69 ± 0.555
2.677IleGlu: 2.677 ± 0.443
1.302IlePhe: 1.302 ± 0.307
3.328IleGly: 3.328 ± 0.456
1.085IleHis: 1.085 ± 0.265
2.749IleIle: 2.749 ± 0.57
2.17IleLys: 2.17 ± 0.41
3.69IleLeu: 3.69 ± 0.566
1.085IleMet: 1.085 ± 0.285
2.387IleAsn: 2.387 ± 0.37
1.375IlePro: 1.375 ± 0.278
2.821IleGln: 2.821 ± 0.522
3.979IleArg: 3.979 ± 0.547
3.979IleSer: 3.979 ± 0.474
2.894IleThr: 2.894 ± 0.401
3.69IleVal: 3.69 ± 0.529
0.579IleTrp: 0.579 ± 0.219
1.302IleTyr: 1.302 ± 0.387
0.0IleXaa: 0.0 ± 0.0
Lys
5.715LysAla: 5.715 ± 0.856
0.362LysCys: 0.362 ± 0.174
3.4LysAsp: 3.4 ± 0.546
4.775LysGlu: 4.775 ± 0.66
2.17LysPhe: 2.17 ± 0.388
3.69LysGly: 3.69 ± 0.587
1.157LysHis: 1.157 ± 0.361
2.315LysIle: 2.315 ± 0.45
3.545LysLys: 3.545 ± 0.517
5.426LysLeu: 5.426 ± 0.614
1.447LysMet: 1.447 ± 0.335
2.315LysAsn: 2.315 ± 0.424
2.749LysPro: 2.749 ± 0.362
3.183LysGln: 3.183 ± 0.591
2.894LysArg: 2.894 ± 0.386
3.038LysSer: 3.038 ± 0.408
2.604LysThr: 2.604 ± 0.333
4.992LysVal: 4.992 ± 0.749
1.085LysTrp: 1.085 ± 0.26
2.387LysTyr: 2.387 ± 0.372
0.0LysXaa: 0.0 ± 0.0
Leu
7.668LeuAla: 7.668 ± 0.76
0.868LeuCys: 0.868 ± 0.27
5.281LeuAsp: 5.281 ± 0.499
4.919LeuGlu: 4.919 ± 0.505
1.809LeuPhe: 1.809 ± 0.328
5.064LeuGly: 5.064 ± 0.545
1.809LeuHis: 1.809 ± 0.308
4.196LeuIle: 4.196 ± 0.646
4.485LeuLys: 4.485 ± 0.551
4.847LeuLeu: 4.847 ± 0.572
2.315LeuMet: 2.315 ± 0.317
4.485LeuAsn: 4.485 ± 0.566
3.4LeuPro: 3.4 ± 0.574
3.4LeuGln: 3.4 ± 0.565
4.268LeuArg: 4.268 ± 0.605
6.656LeuSer: 6.656 ± 0.822
4.702LeuThr: 4.702 ± 0.563
5.136LeuVal: 5.136 ± 0.548
0.362LeuTrp: 0.362 ± 0.136
2.604LeuTyr: 2.604 ± 0.395
0.0LeuXaa: 0.0 ± 0.0
Met
3.472MetAla: 3.472 ± 0.506
0.145MetCys: 0.145 ± 0.1
1.881MetAsp: 1.881 ± 0.338
2.17MetGlu: 2.17 ± 0.357
0.796MetPhe: 0.796 ± 0.251
2.387MetGly: 2.387 ± 0.583
0.506MetHis: 0.506 ± 0.2
1.085MetIle: 1.085 ± 0.276
1.881MetLys: 1.881 ± 0.399
2.966MetLeu: 2.966 ± 0.441
1.157MetMet: 1.157 ± 0.314
1.085MetAsn: 1.085 ± 0.292
1.736MetPro: 1.736 ± 0.325
1.519MetGln: 1.519 ± 0.322
1.953MetArg: 1.953 ± 0.445
1.736MetSer: 1.736 ± 0.233
2.315MetThr: 2.315 ± 0.423
1.447MetVal: 1.447 ± 0.237
0.289MetTrp: 0.289 ± 0.14
1.085MetTyr: 1.085 ± 0.272
0.0MetXaa: 0.0 ± 0.0
Asn
3.255AsnAla: 3.255 ± 0.557
0.217AsnCys: 0.217 ± 0.147
2.387AsnAsp: 2.387 ± 0.352
2.749AsnGlu: 2.749 ± 0.482
1.592AsnPhe: 1.592 ± 0.339
3.472AsnGly: 3.472 ± 0.53
0.434AsnHis: 0.434 ± 0.187
1.881AsnIle: 1.881 ± 0.37
2.604AsnLys: 2.604 ± 0.395
3.979AsnLeu: 3.979 ± 0.519
1.953AsnMet: 1.953 ± 0.464
2.026AsnAsn: 2.026 ± 0.26
2.46AsnPro: 2.46 ± 0.484
2.243AsnGln: 2.243 ± 0.45
2.894AsnArg: 2.894 ± 0.484
2.315AsnSer: 2.315 ± 0.417
2.532AsnThr: 2.532 ± 0.512
2.604AsnVal: 2.604 ± 0.383
0.434AsnTrp: 0.434 ± 0.173
1.375AsnTyr: 1.375 ± 0.381
0.0AsnXaa: 0.0 ± 0.0
Pro
3.472ProAla: 3.472 ± 0.512
0.362ProCys: 0.362 ± 0.152
2.387ProAsp: 2.387 ± 0.487
3.69ProGlu: 3.69 ± 0.468
1.447ProPhe: 1.447 ± 0.291
3.4ProGly: 3.4 ± 0.573
0.868ProHis: 0.868 ± 0.283
1.809ProIle: 1.809 ± 0.328
1.664ProLys: 1.664 ± 0.385
2.387ProLeu: 2.387 ± 0.568
0.579ProMet: 0.579 ± 0.214
1.519ProAsn: 1.519 ± 0.307
1.013ProPro: 1.013 ± 0.241
1.447ProGln: 1.447 ± 0.273
1.664ProArg: 1.664 ± 0.302
2.243ProSer: 2.243 ± 0.569
2.677ProThr: 2.677 ± 0.452
3.545ProVal: 3.545 ± 0.427
0.723ProTrp: 0.723 ± 0.185
1.23ProTyr: 1.23 ± 0.352
0.0ProXaa: 0.0 ± 0.0
Gln
6.077GlnAla: 6.077 ± 0.742
0.362GlnCys: 0.362 ± 0.173
2.387GlnAsp: 2.387 ± 0.323
2.821GlnGlu: 2.821 ± 0.4
1.447GlnPhe: 1.447 ± 0.317
3.328GlnGly: 3.328 ± 0.551
1.23GlnHis: 1.23 ± 0.228
1.953GlnIle: 1.953 ± 0.332
2.387GlnLys: 2.387 ± 0.568
2.894GlnLeu: 2.894 ± 0.361
1.664GlnMet: 1.664 ± 0.278
1.302GlnAsn: 1.302 ± 0.275
1.664GlnPro: 1.664 ± 0.306
2.387GlnGln: 2.387 ± 0.399
2.749GlnArg: 2.749 ± 0.552
2.821GlnSer: 2.821 ± 0.452
1.881GlnThr: 1.881 ± 0.403
2.098GlnVal: 2.098 ± 0.431
0.506GlnTrp: 0.506 ± 0.166
1.375GlnTyr: 1.375 ± 0.34
0.0GlnXaa: 0.0 ± 0.0
Arg
5.064ArgAla: 5.064 ± 0.715
0.289ArgCys: 0.289 ± 0.157
3.834ArgAsp: 3.834 ± 0.489
3.328ArgGlu: 3.328 ± 0.643
1.809ArgPhe: 1.809 ± 0.261
4.341ArgGly: 4.341 ± 0.596
1.736ArgHis: 1.736 ± 0.423
3.038ArgIle: 3.038 ± 0.614
2.749ArgLys: 2.749 ± 0.469
4.124ArgLeu: 4.124 ± 0.547
2.894ArgMet: 2.894 ± 0.44
2.387ArgAsn: 2.387 ± 0.287
1.881ArgPro: 1.881 ± 0.351
2.17ArgGln: 2.17 ± 0.304
3.328ArgArg: 3.328 ± 0.424
3.328ArgSer: 3.328 ± 0.354
2.821ArgThr: 2.821 ± 0.359
3.907ArgVal: 3.907 ± 0.47
1.085ArgTrp: 1.085 ± 0.217
2.17ArgTyr: 2.17 ± 0.376
0.0ArgXaa: 0.0 ± 0.0
Ser
4.558SerAla: 4.558 ± 0.534
0.145SerCys: 0.145 ± 0.092
3.617SerAsp: 3.617 ± 0.444
3.255SerGlu: 3.255 ± 0.38
2.604SerPhe: 2.604 ± 0.372
5.498SerGly: 5.498 ± 0.764
0.94SerHis: 0.94 ± 0.226
3.834SerIle: 3.834 ± 0.596
3.979SerLys: 3.979 ± 0.606
4.919SerLeu: 4.919 ± 0.758
1.736SerMet: 1.736 ± 0.313
2.604SerAsn: 2.604 ± 0.506
2.677SerPro: 2.677 ± 0.54
2.387SerGln: 2.387 ± 0.388
4.051SerArg: 4.051 ± 0.503
4.485SerSer: 4.485 ± 0.563
3.907SerThr: 3.907 ± 0.546
5.209SerVal: 5.209 ± 0.792
0.94SerTrp: 0.94 ± 0.241
2.315SerTyr: 2.315 ± 0.548
0.0SerXaa: 0.0 ± 0.0
Thr
4.992ThrAla: 4.992 ± 0.713
0.579ThrCys: 0.579 ± 0.235
3.545ThrAsp: 3.545 ± 0.502
3.762ThrGlu: 3.762 ± 0.632
1.592ThrPhe: 1.592 ± 0.345
4.341ThrGly: 4.341 ± 0.658
1.085ThrHis: 1.085 ± 0.292
2.604ThrIle: 2.604 ± 0.368
2.966ThrLys: 2.966 ± 0.481
5.281ThrLeu: 5.281 ± 0.678
1.157ThrMet: 1.157 ± 0.239
2.315ThrAsn: 2.315 ± 0.376
2.677ThrPro: 2.677 ± 0.447
2.677ThrGln: 2.677 ± 0.428
3.255ThrArg: 3.255 ± 0.467
3.545ThrSer: 3.545 ± 0.74
2.966ThrThr: 2.966 ± 0.469
3.617ThrVal: 3.617 ± 0.644
1.23ThrTrp: 1.23 ± 0.335
1.592ThrTyr: 1.592 ± 0.426
0.0ThrXaa: 0.0 ± 0.0
Val
5.787ValAla: 5.787 ± 0.765
0.579ValCys: 0.579 ± 0.225
4.341ValAsp: 4.341 ± 0.6
4.341ValGlu: 4.341 ± 0.581
2.315ValPhe: 2.315 ± 0.363
5.353ValGly: 5.353 ± 0.878
1.23ValHis: 1.23 ± 0.302
3.69ValIle: 3.69 ± 0.517
4.992ValLys: 4.992 ± 0.736
4.919ValLeu: 4.919 ± 0.645
2.17ValMet: 2.17 ± 0.368
2.821ValAsn: 2.821 ± 0.54
2.532ValPro: 2.532 ± 0.316
2.821ValGln: 2.821 ± 0.413
4.413ValArg: 4.413 ± 0.522
4.992ValSer: 4.992 ± 0.626
3.834ValThr: 3.834 ± 0.555
3.979ValVal: 3.979 ± 0.544
0.796ValTrp: 0.796 ± 0.243
2.46ValTyr: 2.46 ± 0.422
0.0ValXaa: 0.0 ± 0.0
Trp
1.085TrpAla: 1.085 ± 0.271
0.145TrpCys: 0.145 ± 0.104
0.796TrpAsp: 0.796 ± 0.281
0.723TrpGlu: 0.723 ± 0.224
0.579TrpPhe: 0.579 ± 0.15
0.723TrpGly: 0.723 ± 0.199
0.289TrpHis: 0.289 ± 0.172
0.506TrpIle: 0.506 ± 0.195
1.085TrpLys: 1.085 ± 0.263
1.447TrpLeu: 1.447 ± 0.331
0.217TrpMet: 0.217 ± 0.103
1.013TrpAsn: 1.013 ± 0.274
1.013TrpPro: 1.013 ± 0.297
0.723TrpGln: 0.723 ± 0.229
0.723TrpArg: 0.723 ± 0.306
0.94TrpSer: 0.94 ± 0.261
0.651TrpThr: 0.651 ± 0.201
1.23TrpVal: 1.23 ± 0.307
0.145TrpTrp: 0.145 ± 0.105
0.362TrpTyr: 0.362 ± 0.139
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.821TyrAla: 2.821 ± 0.363
0.579TyrCys: 0.579 ± 0.204
1.809TyrAsp: 1.809 ± 0.386
2.026TyrGlu: 2.026 ± 0.41
0.723TyrPhe: 0.723 ± 0.244
3.472TyrGly: 3.472 ± 0.444
0.723TyrHis: 0.723 ± 0.203
2.098TyrIle: 2.098 ± 0.304
2.749TyrLys: 2.749 ± 0.416
2.966TyrLeu: 2.966 ± 0.44
0.868TyrMet: 0.868 ± 0.191
1.736TyrAsn: 1.736 ± 0.455
1.085TyrPro: 1.085 ± 0.275
1.013TyrGln: 1.013 ± 0.26
1.881TyrArg: 1.881 ± 0.396
2.098TyrSer: 2.098 ± 0.413
1.953TyrThr: 1.953 ± 0.432
2.026TyrVal: 2.026 ± 0.407
0.217TyrTrp: 0.217 ± 0.154
0.796TyrTyr: 0.796 ± 0.301
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 49 proteins (13824 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski