Amino acid dipepetide frequency for Pseudozyma hubeiensis (strain SY62) (Yeast)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.765AlaAla: 13.765 ± 0.116	0.972AlaCys: 0.972 ± 0.018	5.495AlaAsp: 5.495 ± 0.042	5.655AlaGlu: 5.655 ± 0.049	3.227AlaPhe: 3.227 ± 0.033	7.014AlaGly: 7.014 ± 0.052	2.116AlaHis: 2.116 ± 0.025	3.938AlaIle: 3.938 ± 0.036	4.708AlaLys: 4.708 ± 0.048	8.214AlaLeu: 8.214 ± 0.058	1.917AlaMet: 1.917 ± 0.02	3.335AlaAsn: 3.335 ± 0.03	5.809AlaPro: 5.809 ± 0.058	4.185AlaGln: 4.185 ± 0.037	6.191AlaArg: 6.191 ± 0.04	11.942AlaSer: 11.942 ± 0.084	6.171AlaThr: 6.171 ± 0.043	5.761AlaVal: 5.761 ± 0.045	1.048AlaTrp: 1.048 ± 0.017	2.051AlaTyr: 2.051 ± 0.028	0.0AlaXaa: 0.0 ± 0.0
Cys	0.849CysAla: 0.849 ± 0.016	0.251CysCys: 0.251 ± 0.01	0.564CysAsp: 0.564 ± 0.013	0.492CysGlu: 0.492 ± 0.01	0.469CysPhe: 0.469 ± 0.011	0.763CysGly: 0.763 ± 0.016	0.285CysHis: 0.285 ± 0.01	0.577CysIle: 0.577 ± 0.012	0.446CysLys: 0.446 ± 0.011	1.047CysLeu: 1.047 ± 0.019	0.212CysMet: 0.212 ± 0.008	0.344CysAsn: 0.344 ± 0.01	0.529CysPro: 0.529 ± 0.013	0.374CysGln: 0.374 ± 0.011	0.785CysArg: 0.785 ± 0.015	0.944CysSer: 0.944 ± 0.021	0.623CysThr: 0.623 ± 0.013	0.674CysVal: 0.674 ± 0.015	0.155CysTrp: 0.155 ± 0.006	0.279CysTyr: 0.279 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	6.571AspAla: 6.571 ± 0.054	0.516AspCys: 0.516 ± 0.011	5.35AspAsp: 5.35 ± 0.077	4.718AspGlu: 4.718 ± 0.047	1.898AspPhe: 1.898 ± 0.02	4.257AspGly: 4.257 ± 0.034	1.29AspHis: 1.29 ± 0.017	2.13AspIle: 2.13 ± 0.023	2.244AspLys: 2.244 ± 0.026	5.041AspLeu: 5.041 ± 0.038	1.063AspMet: 1.063 ± 0.016	1.5AspAsn: 1.5 ± 0.019	3.403AspPro: 3.403 ± 0.031	2.17AspGln: 2.17 ± 0.024	3.555AspArg: 3.555 ± 0.033	4.637AspSer: 4.637 ± 0.045	2.86AspThr: 2.86 ± 0.024	3.811AspVal: 3.811 ± 0.031	0.77AspTrp: 0.77 ± 0.015	1.222AspTyr: 1.222 ± 0.02	0.0AspXaa: 0.0 ± 0.0
Glu	6.025GluAla: 6.025 ± 0.059	0.529GluCys: 0.529 ± 0.011	3.878GluAsp: 3.878 ± 0.044	4.866GluGlu: 4.866 ± 0.059	1.489GluPhe: 1.489 ± 0.019	3.421GluGly: 3.421 ± 0.035	1.346GluHis: 1.346 ± 0.02	2.239GluIle: 2.239 ± 0.026	2.882GluLys: 2.882 ± 0.037	4.969GluLeu: 4.969 ± 0.041	1.299GluMet: 1.299 ± 0.017	1.473GluAsn: 1.473 ± 0.021	2.433GluPro: 2.433 ± 0.024	2.737GluGln: 2.737 ± 0.032	4.154GluArg: 4.154 ± 0.042	4.236GluSer: 4.236 ± 0.038	2.937GluThr: 2.937 ± 0.03	3.213GluVal: 3.213 ± 0.029	0.709GluTrp: 0.709 ± 0.015	1.204GluTyr: 1.204 ± 0.02	0.0GluXaa: 0.0 ± 0.0
Phe	3.274PheAla: 3.274 ± 0.034	0.452PheCys: 0.452 ± 0.011	2.29PheAsp: 2.29 ± 0.027	1.858PheGlu: 1.858 ± 0.023	1.36PhePhe: 1.36 ± 0.021	2.815PheGly: 2.815 ± 0.033	0.782PheHis: 0.782 ± 0.014	1.225PheIle: 1.225 ± 0.02	1.198PheLys: 1.198 ± 0.02	2.886PheLeu: 2.886 ± 0.033	0.583PheMet: 0.583 ± 0.013	1.113PheAsn: 1.113 ± 0.018	1.586PhePro: 1.586 ± 0.022	1.141PheGln: 1.141 ± 0.019	1.933PheArg: 1.933 ± 0.023	2.889PheSer: 2.889 ± 0.029	1.715PheThr: 1.715 ± 0.025	2.288PheVal: 2.288 ± 0.027	0.475PheTrp: 0.475 ± 0.011	0.861PheTyr: 0.861 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	6.512GlyAla: 6.512 ± 0.052	0.726GlyCys: 0.726 ± 0.016	3.493GlyAsp: 3.493 ± 0.029	3.505GlyGlu: 3.505 ± 0.034	2.455GlyPhe: 2.455 ± 0.031	6.347GlyGly: 6.347 ± 0.057	1.575GlyHis: 1.575 ± 0.02	2.823GlyIle: 2.823 ± 0.03	3.568GlyLys: 3.568 ± 0.038	5.751GlyLeu: 5.751 ± 0.045	1.498GlyMet: 1.498 ± 0.022	2.162GlyAsn: 2.162 ± 0.032	3.172GlyPro: 3.172 ± 0.036	2.563GlyGln: 2.563 ± 0.027	4.342GlyArg: 4.342 ± 0.04	7.027GlySer: 7.027 ± 0.062	3.736GlyThr: 3.736 ± 0.03	4.064GlyVal: 4.064 ± 0.036	0.992GlyTrp: 0.992 ± 0.018	1.691GlyTyr: 1.691 ± 0.024	0.0GlyXaa: 0.0 ± 0.0
His	2.294HisAla: 2.294 ± 0.025	0.297HisCys: 0.297 ± 0.008	1.446HisAsp: 1.446 ± 0.022	1.173HisGlu: 1.173 ± 0.018	0.869HisPhe: 0.869 ± 0.015	1.585HisGly: 1.585 ± 0.023	1.059HisHis: 1.059 ± 0.023	1.016HisIle: 1.016 ± 0.017	0.854HisLys: 0.854 ± 0.017	2.435HisLeu: 2.435 ± 0.029	0.425HisMet: 0.425 ± 0.01	0.738HisAsn: 0.738 ± 0.014	1.789HisPro: 1.789 ± 0.026	1.109HisGln: 1.109 ± 0.02	1.847HisArg: 1.847 ± 0.028	2.195HisSer: 2.195 ± 0.027	1.361HisThr: 1.361 ± 0.018	1.417HisVal: 1.417 ± 0.019	0.27HisTrp: 0.27 ± 0.007	0.546HisTyr: 0.546 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	3.966IleAla: 3.966 ± 0.039	0.56IleCys: 0.56 ± 0.013	2.768IleAsp: 2.768 ± 0.028	2.42IleGlu: 2.42 ± 0.029	1.474IlePhe: 1.474 ± 0.021	2.73IleGly: 2.73 ± 0.029	1.003IleHis: 1.003 ± 0.015	1.608IleIle: 1.608 ± 0.026	1.834IleLys: 1.834 ± 0.025	3.524IleLeu: 3.524 ± 0.035	0.718IleMet: 0.718 ± 0.015	1.416IleAsn: 1.416 ± 0.02	2.364IlePro: 2.364 ± 0.027	1.529IleGln: 1.529 ± 0.023	2.654IleArg: 2.654 ± 0.029	3.397IleSer: 3.397 ± 0.033	2.147IleThr: 2.147 ± 0.023	2.817IleVal: 2.817 ± 0.032	0.512IleTrp: 0.512 ± 0.014	0.945IleTyr: 0.945 ± 0.016	0.0IleXaa: 0.0 ± 0.0
Lys	4.583LysAla: 4.583 ± 0.049	0.391LysCys: 0.391 ± 0.011	2.549LysAsp: 2.549 ± 0.028	2.735LysGlu: 2.735 ± 0.036	1.114LysPhe: 1.114 ± 0.017	2.849LysGly: 2.849 ± 0.033	1.081LysHis: 1.081 ± 0.017	1.774LysIle: 1.774 ± 0.021	2.91LysLys: 2.91 ± 0.051	3.931LysLeu: 3.931 ± 0.035	0.976LysMet: 0.976 ± 0.017	1.293LysAsn: 1.293 ± 0.02	2.49LysPro: 2.49 ± 0.029	2.118LysGln: 2.118 ± 0.024	3.573LysArg: 3.573 ± 0.043	3.468LysSer: 3.468 ± 0.034	2.498LysThr: 2.498 ± 0.024	2.751LysVal: 2.751 ± 0.03	0.513LysTrp: 0.513 ± 0.011	0.956LysTyr: 0.956 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	8.629LeuAla: 8.629 ± 0.059	1.081LeuCys: 1.081 ± 0.02	5.407LeuAsp: 5.407 ± 0.042	4.946LeuGlu: 4.946 ± 0.039	2.989LeuPhe: 2.989 ± 0.033	5.588LeuGly: 5.588 ± 0.039	2.266LeuHis: 2.266 ± 0.027	3.453LeuIle: 3.453 ± 0.037	3.558LeuLys: 3.558 ± 0.038	8.37LeuLeu: 8.37 ± 0.081	1.554LeuMet: 1.554 ± 0.018	2.795LeuAsn: 2.795 ± 0.032	5.734LeuPro: 5.734 ± 0.045	3.79LeuGln: 3.79 ± 0.033	6.033LeuArg: 6.033 ± 0.047	8.092LeuSer: 8.092 ± 0.044	4.86LeuThr: 4.86 ± 0.036	5.353LeuVal: 5.353 ± 0.047	0.922LeuTrp: 0.922 ± 0.017	1.925LeuTyr: 1.925 ± 0.026	0.0LeuXaa: 0.0 ± 0.0
Met	1.911MetAla: 1.911 ± 0.025	0.204MetCys: 0.204 ± 0.007	1.128MetAsp: 1.128 ± 0.018	1.002MetGlu: 1.002 ± 0.017	0.568MetPhe: 0.568 ± 0.012	1.268MetGly: 1.268 ± 0.022	0.497MetHis: 0.497 ± 0.01	0.796MetIle: 0.796 ± 0.015	0.701MetLys: 0.701 ± 0.013	1.878MetLeu: 1.878 ± 0.023	0.514MetMet: 0.514 ± 0.014	0.578MetAsn: 0.578 ± 0.012	1.218MetPro: 1.218 ± 0.018	0.953MetGln: 0.953 ± 0.016	1.313MetArg: 1.313 ± 0.016	1.859MetSer: 1.859 ± 0.02	1.159MetThr: 1.159 ± 0.015	1.161MetVal: 1.161 ± 0.019	0.229MetTrp: 0.229 ± 0.008	0.409MetTyr: 0.409 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	3.516AsnAla: 3.516 ± 0.034	0.319AsnCys: 0.319 ± 0.009	1.863AsnAsp: 1.863 ± 0.023	1.613AsnGlu: 1.613 ± 0.019	1.074AsnPhe: 1.074 ± 0.016	2.816AsnGly: 2.816 ± 0.036	0.735AsnHis: 0.735 ± 0.013	1.312AsnIle: 1.312 ± 0.021	1.336AsnLys: 1.336 ± 0.021	2.836AsnLeu: 2.836 ± 0.032	0.623AsnMet: 0.623 ± 0.012	1.165AsnAsn: 1.165 ± 0.024	1.959AsnPro: 1.959 ± 0.025	1.15AsnGln: 1.15 ± 0.017	1.893AsnArg: 1.893 ± 0.023	2.599AsnSer: 2.599 ± 0.03	1.849AsnThr: 1.849 ± 0.021	2.192AsnVal: 2.192 ± 0.029	0.381AsnTrp: 0.381 ± 0.01	0.723AsnTyr: 0.723 ± 0.013	0.0AsnXaa: 0.0 ± 0.0
Pro	6.266ProAla: 6.266 ± 0.061	0.469ProCys: 0.469 ± 0.014	2.896ProAsp: 2.896 ± 0.029	2.926ProGlu: 2.926 ± 0.03	1.987ProPhe: 1.987 ± 0.025	3.525ProGly: 3.525 ± 0.043	1.479ProHis: 1.479 ± 0.021	2.297ProIle: 2.297 ± 0.024	2.294ProLys: 2.294 ± 0.028	4.842ProLeu: 4.842 ± 0.036	0.967ProMet: 0.967 ± 0.017	1.92ProAsn: 1.92 ± 0.021	5.021ProPro: 5.021 ± 0.07	2.359ProGln: 2.359 ± 0.032	3.541ProArg: 3.541 ± 0.035	7.758ProSer: 7.758 ± 0.067	4.248ProThr: 4.248 ± 0.041	3.238ProVal: 3.238 ± 0.033	0.568ProTrp: 0.568 ± 0.01	1.28ProTyr: 1.28 ± 0.019	0.001ProXaa: 0.001 ± 0.0
Gln	4.249GlnAla: 4.249 ± 0.036	0.377GlnCys: 0.377 ± 0.01	2.319GlnAsp: 2.319 ± 0.024	2.189GlnGlu: 2.189 ± 0.026	1.026GlnPhe: 1.026 ± 0.016	2.482GlnGly: 2.482 ± 0.029	1.412GlnHis: 1.412 ± 0.022	1.683GlnIle: 1.683 ± 0.022	1.72GlnLys: 1.72 ± 0.022	3.848GlnLeu: 3.848 ± 0.036	0.874GlnMet: 0.874 ± 0.018	1.308GlnAsn: 1.308 ± 0.02	2.826GlnPro: 2.826 ± 0.037	3.496GlnGln: 3.496 ± 0.084	3.192GlnArg: 3.192 ± 0.032	3.614GlnSer: 3.614 ± 0.031	2.328GlnThr: 2.328 ± 0.024	2.19GlnVal: 2.19 ± 0.028	0.424GlnTrp: 0.424 ± 0.01	0.893GlnTyr: 0.893 ± 0.015	0.0GlnXaa: 0.0 ± 0.0
Arg	5.826ArgAla: 5.826 ± 0.046	0.842ArgCys: 0.842 ± 0.017	3.474ArgAsp: 3.474 ± 0.03	3.526ArgGlu: 3.526 ± 0.038	2.28ArgPhe: 2.28 ± 0.024	3.842ArgGly: 3.842 ± 0.038	1.728ArgHis: 1.728 ± 0.024	3.004ArgIle: 3.004 ± 0.03	3.629ArgLys: 3.629 ± 0.043	5.85ArgLeu: 5.85 ± 0.044	1.38ArgMet: 1.38 ± 0.021	2.257ArgAsn: 2.257 ± 0.024	3.85ArgPro: 3.85 ± 0.037	2.957ArgGln: 2.957 ± 0.031	6.07ArgArg: 6.07 ± 0.065	6.988ArgSer: 6.988 ± 0.055	3.749ArgThr: 3.749 ± 0.03	3.356ArgVal: 3.356 ± 0.025	0.824ArgTrp: 0.824 ± 0.016	1.542ArgTyr: 1.542 ± 0.019	0.0ArgXaa: 0.0 ± 0.0
Ser	10.379SerAla: 10.379 ± 0.075	0.871SerCys: 0.871 ± 0.017	5.205SerAsp: 5.205 ± 0.044	4.257SerGlu: 4.257 ± 0.038	3.144SerPhe: 3.144 ± 0.027	6.485SerGly: 6.485 ± 0.049	2.459SerHis: 2.459 ± 0.03	4.065SerIle: 4.065 ± 0.031	4.111SerLys: 4.111 ± 0.037	8.09SerLeu: 8.09 ± 0.05	1.812SerMet: 1.812 ± 0.021	3.509SerAsn: 3.509 ± 0.035	6.216SerPro: 6.216 ± 0.071	3.854SerGln: 3.854 ± 0.035	6.438SerArg: 6.438 ± 0.059	14.487SerSer: 14.487 ± 0.138	7.511SerThr: 7.511 ± 0.061	5.157SerVal: 5.157 ± 0.039	0.944SerTrp: 0.944 ± 0.017	1.929SerTyr: 1.929 ± 0.025	0.0SerXaa: 0.0 ± 0.0
Thr	6.132ThrAla: 6.132 ± 0.053	0.612ThrCys: 0.612 ± 0.013	2.914ThrAsp: 2.914 ± 0.029	2.621ThrGlu: 2.621 ± 0.029	2.04ThrPhe: 2.04 ± 0.025	3.838ThrGly: 3.838 ± 0.033	1.337ThrHis: 1.337 ± 0.022	2.519ThrIle: 2.519 ± 0.032	2.339ThrLys: 2.339 ± 0.025	5.305ThrLeu: 5.305 ± 0.046	1.1ThrMet: 1.1 ± 0.017	1.901ThrAsn: 1.901 ± 0.025	4.402ThrPro: 4.402 ± 0.038	2.137ThrGln: 2.137 ± 0.025	3.395ThrArg: 3.395 ± 0.032	7.014ThrSer: 7.014 ± 0.054	4.114ThrThr: 4.114 ± 0.037	3.403ThrVal: 3.403 ± 0.031	0.633ThrTrp: 0.633 ± 0.012	1.254ThrTyr: 1.254 ± 0.019	0.0ThrXaa: 0.0 ± 0.0
Val	5.841ValAla: 5.841 ± 0.042	0.725ValCys: 0.725 ± 0.016	3.845ValAsp: 3.845 ± 0.034	3.832ValGlu: 3.832 ± 0.032	1.985ValPhe: 1.985 ± 0.023	4.027ValGly: 4.027 ± 0.035	1.381ValHis: 1.381 ± 0.02	2.332ValIle: 2.332 ± 0.024	2.755ValLys: 2.755 ± 0.024	5.284ValLeu: 5.284 ± 0.052	1.132ValMet: 1.132 ± 0.018	1.843ValAsn: 1.843 ± 0.023	3.413ValPro: 3.413 ± 0.027	2.439ValGln: 2.439 ± 0.023	3.785ValArg: 3.785 ± 0.031	4.925ValSer: 4.925 ± 0.036	3.085ValThr: 3.085 ± 0.031	4.132ValVal: 4.132 ± 0.042	0.747ValTrp: 0.747 ± 0.016	1.37ValTyr: 1.37 ± 0.022	0.0ValXaa: 0.0 ± 0.0
Trp	0.869TrpAla: 0.869 ± 0.013	0.167TrpCys: 0.167 ± 0.006	0.697TrpAsp: 0.697 ± 0.013	0.568TrpGlu: 0.568 ± 0.01	0.42TrpPhe: 0.42 ± 0.011	0.658TrpGly: 0.658 ± 0.013	0.279TrpHis: 0.279 ± 0.008	0.626TrpIle: 0.626 ± 0.013	0.628TrpLys: 0.628 ± 0.013	1.133TrpLeu: 1.133 ± 0.018	0.29TrpMet: 0.29 ± 0.008	0.516TrpAsn: 0.516 ± 0.011	0.498TrpPro: 0.498 ± 0.013	0.516TrpGln: 0.516 ± 0.012	0.78TrpArg: 0.78 ± 0.014	1.091TrpSer: 1.091 ± 0.02	0.77TrpThr: 0.77 ± 0.015	0.593TrpVal: 0.593 ± 0.012	0.209TrpTrp: 0.209 ± 0.008	0.305TrpTyr: 0.305 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.059TyrAla: 2.059 ± 0.026	0.3TyrCys: 0.3 ± 0.008	1.422TyrAsp: 1.422 ± 0.021	1.14TyrGlu: 1.14 ± 0.02	0.856TyrPhe: 0.856 ± 0.015	1.692TyrGly: 1.692 ± 0.023	0.616TyrHis: 0.616 ± 0.013	0.966TyrIle: 0.966 ± 0.017	0.838TyrLys: 0.838 ± 0.015	2.108TyrLeu: 2.108 ± 0.027	0.409TyrMet: 0.409 ± 0.01	0.789TyrAsn: 0.789 ± 0.015	1.171TyrPro: 1.171 ± 0.019	0.872TyrGln: 0.872 ± 0.015	1.501TyrArg: 1.501 ± 0.02	1.762TyrSer: 1.762 ± 0.024	1.289TyrThr: 1.289 ± 0.019	1.308TyrVal: 1.308 ± 0.018	0.288TyrTrp: 0.288 ± 0.008	0.615TyrTyr: 0.615 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.022XaaXaa: 0.022 ± 0.011

Statistics based on 7472 proteins (4147995 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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